A V Stanton

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. pmc Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
    Ciara Dolan
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    BMC Med Genet 6:41. 2005
  2. doi request reprint Aliskiren monotherapy does not cause paradoxical blood pressure rises: meta-analysis of data from 8 clinical trials
    Alice V Stanton
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Hypertension 55:54-60. 2010
  3. doi request reprint Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high- and low-baseline PRA levels, respectively
    Alice V Stanton
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Hypertens 22:954-7. 2009
  4. ncbi request reprint Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery
    A V Stanton
    Peart Rose Clinic, Department of Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Medicine, St Mary s Hospital, London W2 1PG, UK
    Clin Sci (Lond) 101:455-64. 2001
  5. ncbi request reprint Now that we have a direct renin inhibitor, what should we do with it?
    Alice Stanton
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Curr Hypertens Rep 10:194-200. 2008
  6. ncbi request reprint Therapeutic potential of renin inhibitors in the management of cardiovascular disorders
    Alice Stanton
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Cardiovasc Drugs 3:389-94. 2003
  7. ncbi request reprint Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
    Alice Stanton
    Blood Pressure Unit, Beaumont Hospital, Dublin, Ireland
    Hypertension 42:1137-43. 2003
  8. ncbi request reprint Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects
    N Chapman
    Department of Clinical Pharmacology, School of Medicine at NHLI, Imperial College of Science, Technology and Medicine, QEQM Wing, St Mary s Hospital, South Wharf Road, London W2 1NY, UK
    Clin Sci (Lond) 99:483-8. 2000
  9. pmc Computer algorithms for the automated measurement of retinal arteriolar diameters
    N Chapman
    Department of Clinical Pharmacology, School of Medicine at NHLI, Imperial College of Science, Technology and Medicine, St Mary s Hospital, London W2 1NY, UK
    Br J Ophthalmol 85:74-9. 2001
  10. ncbi request reprint Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006

Collaborators

Detail Information

Publications23

  1. pmc Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians
    Ciara Dolan
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    BMC Med Genet 6:41. 2005
    ..We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension...
  2. doi request reprint Aliskiren monotherapy does not cause paradoxical blood pressure rises: meta-analysis of data from 8 clinical trials
    Alice V Stanton
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Hypertension 55:54-60. 2010
    ..Blood pressure rises on aliskiren treatment were not associated with increases in plasma renin activity. This meta-analysis found no evidence that aliskiren uniquely causes paradoxical rises in blood pressure...
  3. doi request reprint Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high- and low-baseline PRA levels, respectively
    Alice V Stanton
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Hypertens 22:954-7. 2009
    ..We conclude, therefore, that there is only evidence for one type of resistance to aliskiren--as with all blockers of the RAS, lesser BP-lowering responses to aliskiren occur in those with the least renin to block...
  4. ncbi request reprint Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery
    A V Stanton
    Peart Rose Clinic, Department of Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Medicine, St Mary s Hospital, London W2 1PG, UK
    Clin Sci (Lond) 101:455-64. 2001
    ..However, carotid artery wall mass, as indicated by intima-media area, was reduced to a similar extent by the two treatments. It remains to be established whether such differences confer a prognostic advantage...
  5. ncbi request reprint Now that we have a direct renin inhibitor, what should we do with it?
    Alice Stanton
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Curr Hypertens Rep 10:194-200. 2008
    ..It has also been suggested that dual blockade of the RAS might be particularly advantageous. This review discusses the currently available evidence, and concludes with speculation concerning the future of direct renin inhibition...
  6. ncbi request reprint Therapeutic potential of renin inhibitors in the management of cardiovascular disorders
    Alice Stanton
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Cardiovasc Drugs 3:389-94. 2003
    ..It appears likely that aliskiren is the first of a new class of agents that may prove useful in the management of patients with nephropathy, heart failure and atherosclerosis in addition to hypertension...
  7. ncbi request reprint Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
    Alice Stanton
    Blood Pressure Unit, Beaumont Hospital, Dublin, Ireland
    Hypertension 42:1137-43. 2003
    ..Whether renin inhibition results in protection from heart attack, stroke, and nephropathy, similar to angiotensin-converting enzyme inhibition and angiotensin receptor blockade, needs to be researched...
  8. ncbi request reprint Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects
    N Chapman
    Department of Clinical Pharmacology, School of Medicine at NHLI, Imperial College of Science, Technology and Medicine, QEQM Wing, St Mary s Hospital, South Wharf Road, London W2 1NY, UK
    Clin Sci (Lond) 99:483-8. 2000
    ..As vasoconstriction is associated with the narrowing of bifurcation angles, previous observations showing narrowed angles in hypertensive subjects could be explained by increased tone in the retinal arteriolar bed...
  9. pmc Computer algorithms for the automated measurement of retinal arteriolar diameters
    N Chapman
    Department of Clinical Pharmacology, School of Medicine at NHLI, Imperial College of Science, Technology and Medicine, St Mary s Hospital, London W2 1NY, UK
    Br J Ophthalmol 85:74-9. 2001
    ..These problems may be overcome using computer algorithms. Three automated methods and a manual method for measurement of arteriolar diameters from digitised red-free retinal photographs were compared...
  10. ncbi request reprint Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study
    Bryan Williams
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Circulation 113:1213-25. 2006
    ....
  11. ncbi request reprint Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study
    Gianpiero L Cavalleri
    Department of Clinical Neurological Sciences and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland Research Institute, and Division of Neurology, Beaumont Hospital, Dublin, Ireland
    Lancet Neurol 6:970-80. 2007
    ..The Epilepsy Genetics (EPIGEN) Consortium was established to undertake genetic mapping analyses with augmented statistical power to detect variants that influence the development and treatment of common forms of epilepsy...
  12. ncbi request reprint Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker
    Eoin O'Brien
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Hypertension 49:276-84. 2007
    ....
  13. ncbi request reprint Candesartan- and atenolol-based treatments induce different patterns of carotid artery and left ventricular remodeling in hypertension
    Ben Ariff
    Department of Clinical Pharmacology, International Centre for Circulatory Health, National Heart and Lung Division, Faculty of Medicine, Imperial College, London, England
    Stroke 37:2381-4. 2006
    ..We investigated whether these treatments have different effects on cardiac and large-artery remodelling and evaluated the relation of arterial remodelling to hemodynamic changes in subjects with hypertension...
  14. ncbi request reprint Ambulatory arterial stiffness index: determinants and outcome
    Yan Li
    Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Second Medical University, Shanghai, China
    Blood Press Monit 11:107-10. 2006
    ....
  15. ncbi request reprint Ambulatory arterial stiffness index: rationale and methodology
    Eamon Dolan
    ADAPT Centre and Blood Pressure Unit, Beaumont Hospital, and Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Blood Press Monit 11:103-5. 2006
    ....
  16. ncbi request reprint Potential of renin inhibition in cardiovascular disease
    Alice Stanton
    J Renin Angiotensin Aldosterone Syst 4:6-10. 2003
    ..While, to date, aliskiren has only been shown to reduce BP, it appears likely that orally-active renin inhibitors could prove useful in the management of a wide range of cardiovascular pathologies...
  17. ncbi request reprint Structure-based design of aliskiren, a novel orally effective renin inhibitor
    Jeanette M Wood
    Novartis Institute for Biomedical Research, Klybeckstrasse 220, CH 4002 Basel, Switzerland
    Biochem Biophys Res Commun 308:698-705. 2003
    ..Aliskiren represents the first in a novel class of renin inhibitors with the potential for treatment of hypertension and related cardiovascular diseases...
  18. ncbi request reprint Superiority of ambulatory over clinic blood pressure measurement in predicting mortality: the Dublin outcome study
    Eamon Dolan
    ADAPT Centre, Beaumont Hospital, Department of Clinical Pharmacology, Royal College of Surgeons, Dublin, Ireland
    Hypertension 46:156-61. 2005
    ..These results have 2 important clinical messages: ambulatory measurement of blood pressure is superior to clinic measurement in predicting cardiovascular mortality, and nighttime blood pressure is the most potent predictor of outcome...
  19. ncbi request reprint Comparison of the effects of antihypertensive treatment with angiotensin II blockade and beta-blockade on carotid wall structure and haemodynamics: protocol and baseline demographics
    Ben Ariff
    Department of Clinical Pharmacology Therapeutics, St Marys Hospital, Imperial College, London, UK
    J Renin Angiotensin Aldosterone Syst 3:116-22. 2002
    ..This will lead to a greater understanding of the relationship of these factors to atheroma formation and regression...
  20. doi request reprint Retinal vascular lesions in patients of Caucasian and Asian origin with type 2 diabetes: baseline results from the ADVANCE Retinal Measurements (AdRem) study
    Ronald P Stolk
    Department of Epidemiology, University Medical Center Groningen, P O Box 30 001, 9700RB Groningen, The Netherlands
    Diabetes Care 31:708-13. 2008
    ....
  21. ncbi request reprint An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
    Colm T O'Dushlaine
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Eur J Hum Genet 16:176-83. 2008
    ..This analysis therefore confirms that the genetic architecture of the Irish population is well suited to the study of complex traits and that tSNPs selected using the HapMap data can be confidently applied to the Irish population...
  22. ncbi request reprint Rationale and design of the AdRem study: evaluating the effects of blood pressure lowering and intensive glucose control on vascular retinal disorders in patients with type 2 diabetes mellitus
    Ronald P Stolk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Contemp Clin Trials 28:6-17. 2007
    ....
  23. ncbi request reprint Ambulatory blood pressure measurement as a predictor of outcome in an Irish population: methodology for ascertaining mortality outcome
    Eamon Dolan
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland and ADAPT Centre, Beaumont Hospital, Dublin, Ireland
    Blood Press Monit 8:143-5. 2003
    ..The purpose of this study was to evaluate the predictive value of ABPM in a sample of 14 414 people referred for management of cardiovascular risk...