James P K Rooney
Affiliation: Royal College of Surgeons in Ireland
Rooney J, Vajda A, Heverin M, Elamin M, Crampsie A, McLaughlin R, et al
. Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland. Neurology. 2015;84:1537-44 pubmed publisher
..No obvious ascertainment, demographic, or common environmental factors explain this finding. However, we postulate that historical factors may have led to altered genetic admixture in these regions, possibly contributing to lower rates. ..
Rooney J, Woods N, Martin M, Woods J. Genetic polymorphisms of GRIN2A and GRIN2B modify the neurobehavioral effects of low-level lead exposure in children. Environ Res. 2018;165:1-10 pubmed publisher
Rooney J, Vajda A, Heverin M, Crampsie A, Tobin K, McLaughlin R, et al
. No association between soil constituents and amyotrophic lateral sclerosis relative risk in Ireland. Environ Res. 2016;147:102-7 pubmed publisher
..We did not find any evidence to support soil mineral and toxin levels as risk factors for ALS. However as soil parameters are an ecological assessment of exposure in a given area, individual level measures of exposure are required. ..
Rooney J. The retention time of inorganic mercury in the brain--a systematic review of the evidence. Toxicol Appl Pharmacol. 2014;274:425-35 pubmed publisher
..This finding carries important implications for pharmcokinetic modelling of mercury and potentially for the regulatory toxicology of mercury...
Rooney J, Brayne C, Tobin K, Logroscino G, Glymour M, Hardiman O. Benefits, pitfalls, and future design of population-based registers in neurodegenerative disease. Neurology. 2017;88:2321-2329 pubmed publisher
Rooney J, Visser A, D Ovidio F, Vermeulen R, Beghi E, Chio A, et al
. A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR. Neurology. 2017;89:1283-1290 pubmed publisher
..Our results indicate that hormonal factors may be important etiologic factors in ALS; however, a full understanding requires further investigation. ..