Jochen Hm Prehn

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. pmc Real-time single cell analysis of Smac/DIABLO release during apoptosis
    Markus Rehm
    Interdisciplinary Center for Clinical Research, University Münster Clinics, Munster, Germany
    J Cell Biol 162:1031-43. 2003
  2. pmc Paracrine control of tissue regeneration and cell proliferation by Caspase-3
    K Boland
    Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Cell Death Dis 4:e725. 2013
  3. pmc Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase
    Isabela M Aparicio-Erriu
    Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland Dublin, Ireland
    Front Neurosci 6:167. 2012
  4. pmc Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer
    S Hector
    Department of Physiology and Medical Physics, Dublin, Ireland
    Br J Cancer 106:1499-1505. 2012
  5. pmc BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus
    E C Bunk
    Department of Physiology and Medical Physics, RCSI Neuroscience Research Centre, Dublin, Ireland
    Cell Death Dis 1:e15. 2010
  6. pmc Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release
    Heinrich J Huber
    Systems Biology Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Mol Syst Biol 7:470. 2011
  7. pmc INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells
    Caroline Bonner
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Diabetes 59:2799-808. 2010
  8. pmc AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis
    Caoimhin G Concannon
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Research Institute, Dublin 2, Ireland
    J Cell Biol 189:83-94. 2010
  9. pmc Expanding the substantial interactome of NEMO using protein microarrays
    Beau J Fenner
    Centre for Human Proteomics and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 5:e8799. 2010
  10. pmc Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects
    Barbara Köhler
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 3:e2844. 2008

Collaborators

  • Manus W Ward
  • Abdelhaq Rami
  • Hans Georg König
  • Rolf Graf
  • T Engel
  • B P Kirby
  • D C Henshall
  • Heinrich J Huber
  • Claes B Wollheim
  • Caoimhin G Concannon
  • Markus Rehm
  • Caroline Bonner
  • P Weisová
  • K Boland
  • Suzanne Hector
  • S Hector
  • Isabela M Aparicio-Erriu
  • T Bernas
  • E C Bunk
  • Beau J Fenner
  • Barbara Köhler
  • Heiko Dussmann
  • S P Alvarez
  • J Jordan
  • L Flanagan
  • B Baumann
  • S M Kilbride
  • H Dussmann
  • U Anilkumar
  • Joan Kehoe
  • P Dicker
  • E W Kay
  • Patrick Dicker
  • Frank Murray
  • S Conlon
  • P G Johnston
  • Deborah McNamara
  • Jasmin Schmid
  • R J Cummins
  • Niamh McCawley
  • J Schmid
  • Elaine W Kay
  • C G Concannon
  • Siobhán Bacon
  • Maria M Byrne
  • David Davila
  • Liam P Tuffy
  • Seán M Kilbride
  • Syed R Rizvi
  • Marc C Devocelle
  • Andreas Strasser
  • Angela M Farrelly
  • Michael Scannell
  • Helena P Bonner
  • Mathurin Baquie
  • Chantal M Boulanger
  • Petronela Weisová
  • Sergio Anguissola
  • Donat Kogel

Detail Information

Publications15

  1. pmc Real-time single cell analysis of Smac/DIABLO release during apoptosis
    Markus Rehm
    Interdisciplinary Center for Clinical Research, University Münster Clinics, Munster, Germany
    J Cell Biol 162:1031-43. 2003
    ..Simultaneous measurement of DEVDase activation and Smac/DIABLO-YFP release demonstrated that DEVDase activation occurred within 10 min of release, even in the absence of Casp-3...
  2. pmc Paracrine control of tissue regeneration and cell proliferation by Caspase-3
    K Boland
    Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Cell Death Dis 4:e725. 2013
    ..We discuss recent evidence in support of such a role for Caspase-3, and discuss its therapeutic implication. ..
  3. pmc Molecular Mechanisms in Amyotrophic Lateral Sclerosis: The Role of Angiogenin, a Secreted RNase
    Isabela M Aparicio-Erriu
    Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland Dublin, Ireland
    Front Neurosci 6:167. 2012
    ..We also discuss recent evidence demonstrating that angiogenin secreted from stressed motoneurons may alter RNA metabolism in astrocytes...
  4. pmc Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer
    S Hector
    Department of Physiology and Medical Physics, Dublin, Ireland
    Br J Cancer 106:1499-1505. 2012
    ..Defects in this pathway have an important role in colorectal carcinogenesis and chemoresistance; therefore, the expression of apoptosome-associated proteins may be associated with clinical outcome and response to chemotherapy...
  5. pmc BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus
    E C Bunk
    Department of Physiology and Medical Physics, RCSI Neuroscience Research Centre, Dublin, Ireland
    Cell Death Dis 1:e15. 2010
    ....
  6. pmc Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release
    Heinrich J Huber
    Systems Biology Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Mol Syst Biol 7:470. 2011
    ..Our results provide a quantitative and mechanistic explanation for the protective role of enhanced glucose utilisation for cancer cells to avert the otherwise lethal bioenergetic crisis associated with apoptosis initiation...
  7. pmc INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells
    Caroline Bonner
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Diabetes 59:2799-808. 2010
    ..Here, we investigated the effect of a dominant-negative HNF1A mutant (DN-HNF1A) induced apoptosis on the regenerative capacity of INS-1 cells...
  8. pmc AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis
    Caoimhin G Concannon
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Research Institute, Dublin 2, Ireland
    J Cell Biol 189:83-94. 2010
    ..Collectively, our data demonstrate that AMPK activation and the BH3-only protein Bim couple transient energy depletion to stress-induced neuronal apoptosis...
  9. pmc Expanding the substantial interactome of NEMO using protein microarrays
    Beau J Fenner
    Centre for Human Proteomics and Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 5:e8799. 2010
    ..The identification of a host of new NEMO interactors opens up new research opportunities to improve understanding of this essential cell signaling pathway...
  10. pmc Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects
    Barbara Köhler
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 3:e2844. 2008
    ..Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be cleaved by other proteases...
  11. pmc TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling
    Hans Georg König
    Experimental Neurosurgery, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe University Clinics, D 60590 Frankfurt, Germany
    J Cell Biol 168:1077-86. 2005
    ..Our data suggest that TGF-beta1 simultaneously activates two distinct receptor pathways in neurons and that the ALK1 pathway mediates TGF-beta1-induced NF-kappaB survival signaling...
  12. pmc Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability
    P Weisová
    1 Department of Physiology and Medical Physics, Centre for the Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland 2 Max F Perutz Laboratories, University of Vienna, Vienna, Austria
    Transl Psychiatry 3:e317. 2013
    ..In conclusion, our experiments demonstrate that latrepirdine is a potent activator of AMPK, and suggest that one of the main pharmacological activities of latrepirdine is a reduction in neuronal excitability...
  13. doi Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy
    Suzanne Hector
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 Saint Stephen s Green, Dublin 2, Ireland
    Gut 61:725-33. 2012
    ....
  14. pmc Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death
    Heinrich J Huber
    Sytems Biology Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    BMC Syst Biol 4:9. 2010
    ....
  15. pmc Full length Bid is sufficient to induce apoptosis of cultured rat hippocampal neurons
    Hans Georg König
    Department of Physiology and RCSI Neuroscience Research Centre, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    BMC Cell Biol 8:7. 2007
    ..We induced a delayed excitotoxic cell death in cultured rat hippocampal neurons by a 5-min exposure to the glutamate receptor agonist N-methyl-D-aspartate (NMDA; 300 microM)...