Graham P Pidgeon
Affiliation: Royal College of Surgeons in Ireland
- Intravascular thrombosis after hypoxia-induced pulmonary hypertension: regulation by cyclooxygenase-2Graham P Pidgeon
Department of Clinical Pharmacology, Royal College of Surgeons Ireland, 123 St Stephens Green, Dublin 2, Ireland
Circulation 110:2701-7. 2004..Prostacyclin analogues reduce pulmonary pressures in this condition; raising the possibility that cycloxygenase-2 (COX-2) modulates the response of the pulmonary vasculature to hypoxia...
- Cyclooxygenase-2-linked attenuation of hypoxia-induced pulmonary hypertension and intravascular thrombosisMary Clare Cathcart
Department of Molecular and Cellular Therapeutics, Royal College of Surgeons Ireland, Dublin, Ireland
J Pharmacol Exp Ther 326:51-8. 2008..The data provide evidence that endogenous prostaglandins modulate the pulmonary response to hypoxia...
- COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathyLorna M Cryan
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
Mol Vis 12:405-14. 2006..In the eye, both selective inhibitors of COX-2 and nonselective COX inhibitors are reported to suppress ischemia-related retinal angiogenesis. Such studies however, may be confounded by the nonspecific effects of inhibitors...