Colm M P O'Tuathaigh

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. doi request reprint Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1
    J Walsh
    School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Brain Res 1348:114-9. 2010
  2. doi request reprint Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Curr Top Behav Neurosci 7:87-119. 2011
  3. doi request reprint Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice
    C M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Eur J Neurosci 31:349-58. 2010
  4. pmc Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes
    Colm M P O'Tuathaigh
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 35:2262-73. 2010
  5. pmc Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Bull 36:243-5. 2010
  6. ncbi request reprint Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice
    Colm M O'Tuathaigh
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuroreport 17:79-83. 2006
  7. ncbi request reprint Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Prog Neuropsychopharmacol Biol Psychiatry 32:462-6. 2008
  8. pmc Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Bull 36:271-88. 2010
  9. doi request reprint Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin, Ireland
    Int J Neuropsychopharmacol 15:1331-42. 2012
  10. pmc Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways
    Aine T Behan
    Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 37:1773-83. 2012

Collaborators

Detail Information

Publications52

  1. doi request reprint Disruption of thermal nociceptive behaviour in mice mutant for the schizophrenia-associated genes NRG1, COMT and DISC1
    J Walsh
    School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland
    Brain Res 1348:114-9. 2010
    ..0mg/kg). These results indicate a differential contribution of NRG1 and DISC1 vis-à-vis COMT to the processing of thermal nociceptive stimuli and extend their phenotypic relationship to psychotic illness...
  2. doi request reprint Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    Curr Top Behav Neurosci 7:87-119. 2011
    ....
  3. doi request reprint Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice
    C M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Eur J Neurosci 31:349-58. 2010
    ..These data indicate a subtle role for NRG1 in modulating several schizophrenia-relevant processes including the effects of psychotomimetic N-methyl-D-aspartate receptor antagonists...
  4. pmc Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes
    Colm M P O'Tuathaigh
    Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 35:2262-73. 2010
    ..These findings illuminate the interaction between genes and adverse environmental exposures over a particular stage of development in the expression of the psychosis phenotype...
  5. pmc Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Bull 36:243-5. 2010
    ....
  6. ncbi request reprint Sexually dimorphic changes in the exploratory and habituation profiles of heterozygous neuregulin-1 knockout mice
    Colm M O'Tuathaigh
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuroreport 17:79-83. 2006
    ..These studies elaborate a pleiotropic role of neuregulin-1 in development, plasticity and function, including sexual dimorphism, by defining the elemental, temporal and sex-specific characteristics of the neuregulin-1 mutant ethogram...
  7. ncbi request reprint Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Prog Neuropsychopharmacol Biol Psychiatry 32:462-6. 2008
    ..They indicate that NRG1 is involved in the regulation of reciprocal social interaction behaviour and thus suggest a putative role for NRG1 in a schizophrenia-related endophenotype...
  8. pmc Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Bull 36:271-88. 2010
    ..The breadth and depth of ongoing studies in mutants hold the prospect of addressing these shortcomings...
  9. doi request reprint Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin, Ireland
    Int J Neuropsychopharmacol 15:1331-42. 2012
    ....
  10. pmc Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways
    Aine T Behan
    Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 37:1773-83. 2012
    ..These findings illuminate how COMT deletion and adolescent cannabis use can interact to modulate the function of neurotransmitters systems implicated in schizophrenia...
  11. doi request reprint Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice
    Lieve Desbonnet
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Behav Brain Res 228:351-8. 2012
    ..These data elaborate earlier findings of increased anxiety in female COMT KO mice and also clarify a role for COMT in modulating stress-related hormonal and immune parameters in a manner that depends on chronicity of the stressor...
  12. doi request reprint Advancing a functional genomics for schizophrenia: psychopathological and cognitive phenotypes in mutants with gene disruption
    Brian P Kirby
    School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Brain Res Bull 83:162-76. 2010
    ....
  13. ncbi request reprint Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour
    Daniela Babovic
    Molecular and Cellular Therapeutics and Research Institute, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Neurosci Biobehav Rev 31:60-78. 2007
    ..We also consider methodological issues that are likely to influence phenotypic effects, as well as the limitations associated with existing molecular techniques...
  14. doi request reprint Mutant models for genes associated with schizophrenia
    Lieve Desbonnet
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Biochem Soc Trans 37:308-12. 2009
    ..Finally, we identify current challenges associated with the use of genetic mutant models and highlight their potential value for exploring gene-gene and gene-environment interactions in relation to schizophrenia...
  15. ncbi request reprint Topographical Assessment of Ethological and Dopamine Receptor Agonist-Induced Behavioral Phenotype in Mutants with Congenic DARPP-32 'Knockout'
    Rachel E Nally
    Department of Clinical Pharmacology, and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    Neuropsychopharmacology 28:2055-63. 2003
    ....
  16. ncbi request reprint Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia
    Robin J Hennessy
    Stanley Research Unit, Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin
    Biol Psychiatry 61:1187-94. 2007
    ..The brain and face emerge in embryologic intimacy, such that in neurodevelopmental disorders, brain dysmorphogenesis is accompanied by facial dysmorphogenesis...
  17. pmc Frontonasal dysmorphology in bipolar disorder by 3D laser surface imaging and geometric morphometrics: comparisons with schizophrenia
    Robin J Hennessy
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Res 122:63-71. 2010
    ..Bipolar disorder and schizophrenia might reflect similar insult(s) acting over slightly differing time-frames or slightly differing insult(s) acting over a similar time-frame...
  18. ncbi request reprint Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?
    Lieve Desbonnet
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Behav Brain Res 204:258-73. 2009
    ..Emphasis is also placed on the importance of studying gene x environment and gene x gene interactions, as well as addressing methodological issues related to genetic modelling and phenotyping strategies...
  19. ncbi request reprint Catechol-O-methyl transferase as a drug target for schizophrenia
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    CNS Neurol Disord Drug Targets 11:282-91. 2012
    ....
  20. ncbi request reprint Congenic D1A dopamine receptor mutants: ethologically based resolution of behavioural topography indicates genetic background as a determinant of knockout phenotype
    Fergal N McNamara
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
    Neuropsychopharmacology 28:86-99. 2003
    ..Genetic background appears to modulate critically the magnitude but not the general nature of the D(1A)-null phenotype, which may involve compensatory processes independent of other D(1)-like or D(2)-like receptors...
  21. ncbi request reprint Phenotypic, ethologically based resolution of spontaneous and D(2)-like vs D(1)-like agonist-induced behavioural topography in mice with congenic D(3) dopamine receptor "knockout"
    Fergal N McNamara
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Synapse 46:19-31. 2002
    ..A role for D(3) receptors in inhibitory processes appeared topographically circumscribed and only when baseline levels of behaviour were low...
  22. doi request reprint Confirmation that the renin gene distal enhancer polymorphism REN-5312C/T is associated with increased blood pressure
    Ciara Vangjeli
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Belfield, Dublin, Ireland
    Circ Cardiovasc Genet 3:53-9. 2010
    ..However, whether polymorphisms in these genes contribute to the cause of essential hypertension in humans is still a matter of debate...
  23. doi request reprint Congenital anomalies and early functional impairments in a prospective birth cohort: risk of schizophrenia-spectrum disorder in adulthood
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Br J Psychiatry 192:264-7. 2008
    ..Adversities operating over intrauterine life have been associated with risk of schizophrenia, but the biology of resultant developmental perturbation is poorly understood...
  24. doi request reprint Age-related behavioural phenotype and cellular characterisation of mice with progressive ablation of D1 dopamine receptor-expressing cells
    Daniela Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Behav Brain Res 206:78-87. 2010
    ..Understanding the mechanistic bases of mitigation vs persistence of individual phenotypes in relation to neural adaptation consequent to cell loss may lead to novel therapeutic strategies for basal ganglia disorders...
  25. ncbi request reprint Facial shape and asymmetry by three-dimensional laser surface scanning covary with cognition in a sexually dimorphic manner
    Robin J Hennessy
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    J Neuropsychiatry Clin Neurosci 18:73-80. 2006
    ..Events over early fetal life may be an important determinant of sexually dimorphic covariance of anterior facial shape and asymmetry with aspects of cognition that involve the anterior brain...
  26. ncbi request reprint Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface
    John L Waddington
    Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 181:611-38. 2005
    ..Furthermore, there are poorly understood methodological factors that contribute to inconsistent phenotypic findings between laboratories...
  27. ncbi request reprint D1-like dopamine receptor-mediated function in congenic mutants with D1 vs. D5 receptor "knockout"
    Gerard J O'Sullivan
    Department of Clinical Pharmacology, Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Recept Signal Transduct Res 24:107-16. 2004
    ....
  28. ncbi request reprint 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia
    Robin J Hennessy
    Stanley Research Unit, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Schizophr Res 67:261-8. 2004
    ....
  29. ncbi request reprint Neuroimaging and other neurobiological indices in schizophrenia: relationship to measurement of functional outcome
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons, Dublin, Ireland
    Br J Psychiatry Suppl 50:s52-7. 2007
    ..As understanding of the pathobiology of schizophrenia increases, the challenge is to relate such measures to outcome at a functional level...
  30. doi request reprint Susceptibility genes for schizophrenia: mutant models, endophenotypes and psychobiology
    Colm M P O'Tuathaigh
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Curr Top Behav Neurosci 12:209-50. 2012
    ....
  31. ncbi request reprint Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice
    Daniela Babovic
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Behav Brain Res 183:236-9. 2007
    ..Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1...
  32. ncbi request reprint Ethological resolution of behavioural topography and D1-like versus D2-like agonist responses in congenic D5 dopamine receptor mutants: identification of D5:D2-like interactions
    Gerard J O'Sullivan
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Synapse 55:201-11. 2005
    ..Additionally, they indicate the involvement of phosphoinositide hydrolysis and D(5):D(2)-like interactions in regulating these processes...
  33. ncbi request reprint 3D laser surface scanning and geometric morphometric analysis of craniofacial shape as an index of cerebro-craniofacial morphogenesis: initial application to sexual dimorphism
    Robin J Hennessy
    Stanley Foundation Research Unit, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Biol Psychiatry 51:507-14. 2002
    ..Digitization technologies now allow 3D recording of craniofacial surface landmarks and modeling of craniofacial shape differences using geometric morphometrics...
  34. ncbi request reprint Functional genomics and schizophrenia: endophenotypes and mutant models
    John L Waddington
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Psychiatr Clin North Am 30:365-99. 2007
    ..It examines gene-gene and gene-environment interactions. Finally, it looks at future directions for research...
  35. ncbi request reprint Dimensions of psychopathology in bipolar disorder versus other affective and non-affective psychoses among an epidemiologically complete population
    P J Scully
    Jonathan Swift Clinic, St James s Hospital, Dublin, Ireland
    Bipolar Disord 4:43-4. 2002
  36. ncbi request reprint Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawal
    Ian E J De Souza
    Department of Anatomy, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 169:28-34. 2003
    ..Given their common action to block dopamine D2-like receptors, VCMs may be related to changes in dopaminergic function; if so, other typical dopamine-mediated behaviours might be altered also...
  37. ncbi request reprint SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography
    Gerard J O'Sullivan
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Eur J Pharmacol 486:273-80. 2004
    ..For example, the seizure and vacuous chewing responses appear to involve dopamine D1-like receptors that stimulate adenylyl cyclase, while intense grooming involves those which do not...
  38. pmc Facial surface analysis by 3D laser scanning and geometric morphometrics in relation to sexual dimorphism in cerebral--craniofacial morphogenesis and cognitive function
    Robin J Hennessy
    Stanley Research Unit, Department of Clinical Pharmacology, and Research Institute, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Anat 207:283-95. 2005
    ....
  39. pmc Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology
    Peter F Whitty
    Department of Psychiatry, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Schizophr Bull 35:415-24. 2009
    ....
  40. ncbi request reprint Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions
    Gerard J O'Sullivan
    Department of Clinical Pharmacology and Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Synapse 59:107-18. 2006
    ..These studies identify novel functional roles for the D4 receptor that are distinct from those of closely related D2-like family members and involve interactions with their D1-like counterparts...
  41. ncbi request reprint Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout"
    Katsunori Tomiyama
    Department of Clinical Pharmacology and Institute of Biopharmaceutical Sciences, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Synapse 51:71-81. 2004
    ..D2 receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1A counterparts, while D3 receptors exert only minor regulation of such movements...
  42. ncbi request reprint Ethologically based resolution of D2-like dopamine receptor agonist-versus antagonist-induced behavioral topography in dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of 32 kDa "knockout" mutants congenic on the C57BL/6 gene
    Rachel E Nally
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    J Pharmacol Exp Ther 310:1281-7. 2004
    ..Critically, the present data indicate that phenotypic effects of a given gene deletion using an agonist acting on the system disrupted cannot be generalized to a corresponding antagonist, and vice versa...
  43. pmc Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling
    Gerard J O'Sullivan
    Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Neuropharmacology 54:1051-61. 2008
    ..These findings indicate that D(1), and to a lesser extent D(5), receptor coupling to DARPP-32, ERK1/2 and glutamatergic signalling is involved in mediating the convulsant effects of SKF 83822...
  44. doi request reprint Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis
    Niall Crumlish
    Stanley Research Unit, Cluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Dublin, Ireland
    Br J Psychiatry 194:18-24. 2009
    ..Thus, interventions that shorten the duration of untreated psychosis (DUP) and arrest early deterioration may have long-term benefits...
  45. ncbi request reprint Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College, Dublin, Ireland
    Biol Psychiatry 63:24-31. 2008
    ....
  46. doi request reprint Nonadherence to medication four years after a first episode of psychosis and associated risk factors
    Michele Hill
    St John of God Adult Psychiatric Service, Cluain Mhuire Family Centre, Dublin, Ireland
    Psychiatr Serv 61:189-92. 2010
    ..This study examined concurrent associations and predictors at first indication of nonadherence to antipsychotic medication four years after a first episode of psychosis...
  47. ncbi request reprint Untreated illness and outcome of psychosis
    Mary Clarke
    Department of Psychiatry, University College Dublin, and Stanley Resuearch Unit, Cluain Mhuire Family Centre, St John of God Adult Psychiatric Service, Dublin, Ireland
    Br J Psychiatry 189:235-40. 2006
    ..There has been controversy as to whether early intervention in psychosis can improve the outcome of the disorder...
  48. ncbi request reprint Confirming RGS4 as a susceptibility gene for schizophrenia
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet B Neuropsychiatr Genet 125:50-3. 2004
    ..The same haplotype is in excess in the Caucasian schizophrenia sample used by Chowdari et al. [2002: Hum Mol Genet 11: 1373-1380]. This study provides further support for the contribution of RGS4 to schizophrenia susceptibility...
  49. ncbi request reprint Suicidality in first episode psychosis
    Mary Clarke
    Stanley Research Unit, Department of Adult Psychiatry, Hospitaller Order of St John of God, Cluain Mhuire Service, Blackrock, Dublin, Ireland
    Schizophr Res 86:221-5. 2006
    ..Four years later 18% had made a suicide attempt and 3% completed suicide. Suicide attempts prior to presentation were associated with a longer duration of untreated psychosis...
  50. ncbi request reprint No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study
    Derek W Morris
    Neuropsychiatric Genetics Group, Department of Genetics, Trinity College, 2, Dublin, Ireland
    Schizophr Res 60:167-72. 2003
    ..No evidence was found to suggest an association between the DTNBP1 gene and schizophrenia in our sample. Possible reasons for these findings are discussed...
  51. ncbi request reprint Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization
    Donncha S Dunican
    Department of Biochemistry, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Oncogene 21:3253-7. 2002
    ..These six genes are involved in diverse processes, such as maintenance of chromatin architecture, DNA-damage checkpoint and cell cycle regulation, which may contribute to the CIN and MIN phenotypes...
  52. ncbi request reprint Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'
    Katsunori Tomiyama
    Nihon University Advanced Research Institute for the Sciences and Humanities, Tokyo 102, Japan
    Eur Neuropsychopharmacol 16:437-45. 2006
    ..In assuming that the well-recognised role of the D(1)-like family in regulating orofacial movements involves primarily D(1) receptors, a role for their D(5) counterparts may have been overlooked...