Darren M Griffith

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. doi request reprint Suberoylanilide hydroxamic acid, a potent histone deacetylase inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes
    Darren M Griffith
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Inorg Biochem 105:763-9. 2011
  2. doi request reprint Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity
    Darren M Griffith
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Inorg Biochem 105:793-9. 2011
  3. doi request reprint A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity
    James P Parker
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    J Inorg Biochem 124:70-7. 2013

Collaborators

Detail Information

Publications3

  1. doi request reprint Suberoylanilide hydroxamic acid, a potent histone deacetylase inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes
    Darren M Griffith
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Inorg Biochem 105:763-9. 2011
    ..Stability constants of the metal complexes formed with SAHA and N-Me-SAHA in a DMSO/H(2)O 70/30%(v/v) mixture are described. A novel crystal structure of SAHA together with a novel synthesis for N-Me-SAHA are also reported...
  2. doi request reprint Novel trans-platinum complexes of the histone deacetylase inhibitor valproic acid; synthesis, in vitro cytotoxicity and mutagenicity
    Darren M Griffith
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Inorg Biochem 105:793-9. 2011
    ..The mutagenicity of trans-[Pt(VPA(-1H))(2)(NH(3))(py)] and trans-[Pt(VPA(-1H))(2)(py)(2)] was determined using the Ames test and is also reported...
  3. doi request reprint A novel platinum complex of the histone deacetylase inhibitor belinostat: rational design, development and in vitro cytotoxicity
    James P Parker
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    J Inorg Biochem 124:70-7. 2013
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