Catherine Greene

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. pmc Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency
    Caitriona McLean
    Respiratory Research Division, Dept Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Biologics 3:63-75. 2009
  2. pmc Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique
    Tidi Hassan
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Republic of Ireland
    Nucleic Acids Res 41:e71. 2013
  3. pmc Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung
    Teck Boon Low
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Pulm Med 2011:826160. 2011
  4. pmc Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Nutrients 5:758-70. 2013
  5. doi request reprint microRNAs in asthma: potential therapeutic targets
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Curr Opin Pulm Med 19:66-72. 2013
  6. pmc MicroRNAs in inflammatory lung disease--master regulators or target practice?
    Irene K Oglesby
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Respir Res 11:148. 2010
  7. pmc Antimicrobial proteins and polypeptides in pulmonary innate defence
    Mark P Rogan
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Respir Res 7:29. 2006
  8. pmc Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
    Ruth E MacRedmond
    Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Respir Res 8:84. 2007
  9. pmc Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells
    Catherine M Greene
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Infect Immun 72:3684-7. 2004
  10. doi request reprint Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease
    Catherine M Greene
    Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Am J Respir Crit Care Med 181:31-5. 2010

Collaborators

Detail Information

Publications54

  1. pmc Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency
    Caitriona McLean
    Respiratory Research Division, Dept Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Biologics 3:63-75. 2009
    ....
  2. pmc Isolation and identification of cell-specific microRNAs targeting a messenger RNA using a biotinylated anti-sense oligonucleotide capture affinity technique
    Tidi Hassan
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Republic of Ireland
    Nucleic Acids Res 41:e71. 2013
    ..This is a simple and an efficient method to potentially identify miRNAs targeting sequences within the full length of a given mRNA transcript...
  3. pmc Quantification and evaluation of the role of antielastin autoantibodies in the emphysematous lung
    Teck Boon Low
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Pulm Med 2011:826160. 2011
    ....
  4. pmc Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Nutrients 5:758-70. 2013
    ..Together these ER stress-relieving and anti-inflammatory properties suggest a therapeutic potential for selenium supplementation in genetic emphysema...
  5. doi request reprint microRNAs in asthma: potential therapeutic targets
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Curr Opin Pulm Med 19:66-72. 2013
    ..microRNAs (miRNAs/miRs) are regulatory RNAs that affect protein synthesis. They represent new therapeutic targets, and medicines that target specific miRNAs may have potential in the treatment of asthma...
  6. pmc MicroRNAs in inflammatory lung disease--master regulators or target practice?
    Irene K Oglesby
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Respir Res 11:148. 2010
    ..miRNA in lung cancer and IPF are also reviewed...
  7. pmc Antimicrobial proteins and polypeptides in pulmonary innate defence
    Mark P Rogan
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Respir Res 7:29. 2006
    ..The potential therapeutic applications of these proteins and peptides in combating infection and preventing inflammation are the subject of ongoing research that holds much promise for the future...
  8. pmc Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke
    Ruth E MacRedmond
    Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Respir Res 8:84. 2007
    ..Modulation of TLR4 in respiratory epithelium may have important implications for airway inflammation and infection in response to inhaled pathogens...
  9. pmc Secretory leucoprotease inhibitor impairs Toll-like receptor 2- and 4-mediated responses in monocytic cells
    Catherine M Greene
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Infect Immun 72:3684-7. 2004
    ....
  10. doi request reprint Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease
    Catherine M Greene
    Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Am J Respir Crit Care Med 181:31-5. 2010
    ..Antielastin peptide antibodies have been implicated in the pathogenesis of tobacco-smoke-induced emphysema. Collagen-derived peptides may also play a role...
  11. doi request reprint Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells
    C M Greene
    Dept of Medicine Respiratory Research Division, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Eur Respir J 35:1155-63. 2010
    ..cIAP1 expression was increased in ZAAT versus MAAT bronchial biopsies. The data suggest a novel mechanism by which ZAAT may promote human bronchial epithelial cell survival...
  12. pmc Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Br J Pharmacol 158:1048-58. 2009
    ..These proteases, antiproteases and their modifiers represent interesting targets for therapeutic intervention...
  13. ncbi request reprint Toll-like receptors as therapeutic targets in cystic fibrosis
    Catherine M Greene
    Beaumont Hospital, Education and Research Centre, Respiratory Research Division, Royal College of Surgeons in Ireland, 9 Dublin, Ireland
    Expert Opin Ther Targets 12:1481-95. 2008
    ..Results/conclusion: Modulation of TLRs has therapeutic potential for the inflammatory lung manifestations of CF...
  14. doi request reprint Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations
    C M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    J Inherit Metab Dis 31:21-34. 2008
    ..Here we review the current understanding of the molecular pathogenesis of A1AT deficiency and the best clinical management protocols...
  15. ncbi request reprint Tumor necrosis factor-alpha-converting enzyme: its role in community-acquired pneumonia
    Catherine Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Infect Dis 186:1790-6. 2002
    ..These data demonstrate that, in vivo during CAP, TACE has a role in regulating resolution of the local inflammatory response by modulating levels of pro- and counterinflammatory mediators...
  16. pmc Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor
    Catherine M Greene
    Department of Medicine, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Mediators Inflamm 2010:423241. 2010
    ....
  17. doi request reprint Protein misfolding and obstructive lung disease
    Catherine M Greene
    Respiratory Research Division, Dept Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Proc Am Thorac Soc 7:346-55. 2010
    ....
  18. ncbi request reprint TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 174:1638-46. 2005
    ..This effect was abrogated by expression of dominant-negative versions of MyD88 or Mal, key signal transducers for TLRs, thereby implicating them as potential anti-inflammatory agents for CF...
  19. doi request reprint The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency
    Catherine M Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Expert Rev Respir Med 5:395-411. 2011
    ..In addition, we explore how SERPINA1 heterozygosity could contribute to smoking-induced chronic obstructive pulmonary diseases and consider the consequences...
  20. ncbi request reprint Toll-like receptor expression and function in airway epithelial cells
    Catherine M Greene
    Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Arch Immunol Ther Exp (Warsz) 53:418-27. 2005
    ..The expression and function of TLRs on airway epithelial cells has been an area of increasing interest in the recent past. This review will summarize advances in our understanding of the role of TLRs in airway epithelial cells...
  21. ncbi request reprint Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia
    Catherine Greene
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Infect Dis 188:769-76. 2003
    ..Both A1AT and SLPI were cleaved or complexed in infected lobes, and A1AT was oxidized in infected lobes. We conclude that mean elastase levels are increased and that mean anti-elastase capacity is decreased in pneumonic lobes...
  22. ncbi request reprint Viral inhibition of IL-1- and neutrophil elastase-induced inflammatory responses in bronchial epithelial cells
    Tomas P Carroll
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 175:7594-601. 2005
    ..These findings identify vaccinia virus proteins as possible therapeutic agents for the manifestations of several inflammatory lung diseases...
  23. ncbi request reprint Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency
    Matthew W Lawless
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 172:5722-6. 2004
    ..These findings have important implications for the design of future therapeutics for Z A1AT liver disease and may also impact on drug design for other conformational diseases...
  24. pmc Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharide
    Ruth MacRedmond
    Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Respir Res 6:116. 2005
    ..Here we provide evidence for the critical role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced HBD2 expression by human A549 epithelial cells...
  25. doi request reprint Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway
    David A Bergin
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 283:31736-44. 2008
    ..The data describe a previously unidentified lung metalloprotease meprin alpha, and its role in NE-induced EGFR and TLR4 activation and IL-8 production...
  26. ncbi request reprint Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4
    James M Devaney
    Respiratory Research, Department of Medicine, RCSI Education and Research Centre, Smurfit Building, Beaumont Hospital, Dublin 9, Ireland
    FEBS Lett 544:129-32. 2003
    ..Furthermore, a TLR4 neutralising antibody abrogates NE-induced IL-8 production, and induces tolerance to a secondary lipopolysaccharide stimulus. These data implicate TLR4 in NE induced IL-8 expression in bronchial epithelium...
  27. ncbi request reprint Secretory leucocyte protease inhibitor inhibits interferon-gamma-induced cathepsin S expression
    Patrick Geraghty
    Pulmonary Research Division, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin 9, Ireland
    J Biol Chem 282:33389-95. 2007
    ..Secretory leukocyte protease inhibitor may prove to be therapeutically important as a potential inhibitor of protease expression in chronic obstructive pulmonary disease...
  28. ncbi request reprint Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression
    Patrick Geraghty
    Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    J Immunol 178:5871-8. 2007
    ..This has important implications for therapeutic intervention in protease-mediated diseases...
  29. doi request reprint 17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor
    Sanjay H Chotirmall
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland
    Am J Respir Crit Care Med 182:62-72. 2010
    ..An unexplained gender gap is observed in cystic fibrosis (CF). Females have poorer lung function, decreased survival, and earlier Pseudomonas colonization...
  30. ncbi request reprint Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway
    Marcus W Butler
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 281:34730-5. 2006
    ..These results suggest that inhibition by elafin of lipopolysaccharide-induced AP-1 and NF-kappaB activation occurs via an effect on the ubiquitin-proteasome pathway...
  31. doi request reprint Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency
    Tomas P Carroll
    Respiratory Research Division, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Immunol 184:4538-46. 2010
    ....
  32. doi request reprint miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression
    Irene K Oglesby
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Ireland
    J Immunol 184:1702-9. 2010
    ..To our knowledge, this study is the first to report of a role for TOM1 in the TLR2/4 signaling pathways and the first to describe microRNA involvement in CF...
  33. ncbi request reprint Alpha-1 antitrypsin deficiency
    Emer Kelly
    Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Education Research Building, Beaumont Road, Dublin, Ireland
    Respir Med 104:763-72. 2010
    ..To review the topic of alpha-1 antitrypsin (AAT) deficiency...
  34. ncbi request reprint Secretory leucoprotease inhibitor prevents lipopolysaccharide-induced IkappaBalpha degradation without affecting phosphorylation or ubiquitination
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 277:33648-53. 2002
    ..These results suggest that SLPI may be inhibiting proteasomal degradation of NF-kappaB regulatory proteins, an effect that is dependent on the antiprotease activity of SLPI...
  35. doi request reprint Community-acquired pneumonia in older patients: does age influence systemic cytokine levels in community-acquired pneumonia?
    Emer Kelly
    Division of Respiratory Research, Department of Medicine, RCSI Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Respirology 14:210-6. 2009
    ..We aimed to evaluate patients with CAP for evidence of a muted response to infection in elderly patients admitted to hospital compared with a younger patient group...
  36. doi request reprint Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2
    Niall T Stevens
    Department of Clinical Microbiology, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Cell Microbiol 11:421-32. 2009
    ..These data implicate PIA as an important immunogenic component of the S. epidermidis biofilm that can regulate pro-inflammatory cytokine production from human astrocytes, in part, via TLR2...
  37. doi request reprint Candida species in cystic fibrosis: A road less travelled
    Sanjay H Chotirmall
    Department of Medicine, Royal College of Surgeons, Ireland
    Med Mycol 48:S114-24. 2010
    ..Finally, we outline the current understanding of the innate, cellular and humoral immune responses associated with this genus which has been the major focus of work performed to date...
  38. ncbi request reprint Targeting neutrophil elastase in cystic fibrosis
    Emer Kelly
    Beaumont Hospital, Department of Respiratory Research, RCSI Smurfit Building, Beaumont, Dublin 9, Ireland
    Expert Opin Ther Targets 12:145-57. 2008
    ..These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection...
  39. ncbi request reprint Elastolytic proteases: inflammation resolution and dysregulation in chronic infective lung disease
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 171:1070-6. 2005
  40. pmc Secretory leucoprotease inhibitor binds to NF-kappaB binding sites in monocytes and inhibits p65 binding
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Education and Research Centre, Beaumont Hospital, Dublin 2, Ireland
    J Exp Med 202:1659-68. 2005
    ..Therefore, SLPI inhibition of NF-kappaB activation is mediated, in part, by competitive binding to the NF-kappaB consensus-binding site...
  41. ncbi request reprint Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant
    Alan T Mulgrew
    Department of Medicine, Respiratory Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Chest 125:1952-7. 2004
    ....
  42. pmc Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis
    Nicolas Guyot
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 283:32377-85. 2008
    ..aeruginosa infection promotes this effect. Such cleavage may have repercussions on the innate immune function of elafin...
  43. ncbi request reprint Effect of pro-inflammatory stimuli on mucin expression and inhibition by secretory leucoprotease inhibitor
    Siobhan Griffin
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Cell Microbiol 9:670-9. 2007
    ....
  44. doi request reprint LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline
    Gudmundur Bergsson
    Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Immunol 183:543-51. 2009
    ....
  45. pmc Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant alpha1-antitrypsin deficiency
    Emer Kelly
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    J Biol Chem 284:16891-7. 2009
    ..This finding demonstrates a role for SEPS1 in ZAAT deficiency and suggests a possible therapeutic potential for selenium supplementation...
  46. ncbi request reprint Neutrophil elastase up-regulates human beta-defensin-2 expression in human bronchial epithelial cells
    Siobhan Griffin
    Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    FEBS Lett 546:233-6. 2003
    ..An increase in HBD-2 protein expression was observed in primary NHBE cells after incubation with NE as assessed by laser scanning cytometry. In conclusion, NE up-regulates HBD-2 expression in bronchial epithelial cells...
  47. pmc In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens
    Stephane Desgranges
    Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St Stephen s Green, Dublin 2, Ireland
    Antimicrob Agents Chemother 55:2487-9. 2011
    ....
  48. ncbi request reprint Endotoxin up-regulates interleukin-18: potential role for gram-negative colonization in sarcoidosis
    Deirdre M Kelly
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Am J Respir Crit Care Med 172:1299-307. 2005
    ..Previously we demonstrated a role for interleukin-18 in sarcoidosis. Here we examine the regulation of interleukin-18 in this condition...
  49. ncbi request reprint Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins
    Clifford C Taggart
    Pulmonary Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Center, Beaumont Hospital, Dublin, Ireland
    J Immunol 171:931-7. 2003
    ..In chronic lung diseases associated with infection, overexpression of cathepsins may lead to increased degradation of HBD-2 and -3, thereby favoring bacterial infection and colonization...
  50. ncbi request reprint Loss of microbicidal activity and increased formation of biofilm due to decreased lactoferrin activity in patients with cystic fibrosis
    Mark P Rogan
    Pulmonary Research Division, Department of Medicine, The Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Infect Dis 190:1245-53. 2004
    ..Loss of such a vital innate immunity protein clearly has important implications for the pathogenesis of chronic P. aeruginosa lung infection in patients with CF...
  51. ncbi request reprint Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad
    Stanley D W Miller
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    Hepatology 46:496-503. 2007
    ..CONCLUSION: These data show that caspase-4 is not essential for ZAAT-induced apoptosis in HEK293 cells and implicates P-I-3-kinase and Bad as potential therapeutic targets for the liver disease associated with ZAAT deficiency...
  52. doi request reprint Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis
    Niall T Stevens
    Department of Clinical Microbiology, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin, Ireland
    J Med Microbiol 58:855-62. 2009
    ..epidermidis isolates clinically associated with meningitis that were studied, PIA contributed to the strong biofilm-positive phenotype, whereas protein factors appeared to have a secondary role...
  53. pmc Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases
    Nicolas Guyot
    Department of Medicine, Pulmonary Research Division, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland
    Biol Chem 391:705-16. 2010
    ..In conclusion, this study provides evidence that elafin is susceptible to proteolytic cleavage at alternative sites by P. aeruginosa metalloproteinases, which can affect different biological functions of elafin...