Simon Cronin

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
  2. ncbi request reprint Elevated serum angiogenin levels in ALS
    S Cronin
    Department of Physiology, Royal College of Surgeons in Ireland, Ireland
    Neurology 67:1833-6. 2006
  3. pmc Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis
    Simon Cronin
    The Irish ALS Research Group, Department of Neurology, Beaumont Hospital, Dublin 9, Ireland
    J Neurol Neurosurg Psychiatry 78:984-6. 2007
  4. ncbi request reprint A genome-wide association study of sporadic ALS in a homogenous Irish population
    Simon Cronin
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Hum Mol Genet 17:768-74. 2008
  5. pmc Screening for replication of genome-wide SNP associations in sporadic ALS
    Simon Cronin
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Eur J Hum Genet 17:213-8. 2009
  6. doi request reprint Analysis of genome-wide copy number variation in Irish and Dutch ALS populations
    Simon Cronin
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    Hum Mol Genet 17:3392-8. 2008
  7. doi request reprint Screening of hypoxia-inducible genes in sporadic ALS
    Simon Cronin
    Department of Neurology, Beaumont Hospital, Dublin, Ireland
    Amyotroph Lateral Scler 9:299-305. 2008
  8. pmc Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis
    Russell Lewis McLaughlin
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 5:e15402. 2010
  9. ncbi request reprint Ethnic variation in the incidence of ALS: a systematic review
    Simon Cronin
    Irish ALS Research Group, Neurology Department, Beaumont Hospital, Dublin 9, Ireland
    Neurology 68:1002-7. 2007
  10. ncbi request reprint Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis
    Simon Cronin
    Neurovascular Clinical Science Unit, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland
    Stroke 36:1581-7. 2005

Collaborators

Detail Information

Publications10

  1. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
    ....
  2. ncbi request reprint Elevated serum angiogenin levels in ALS
    S Cronin
    Department of Physiology, Royal College of Surgeons in Ireland, Ireland
    Neurology 67:1833-6. 2006
    ..In endothelium, angiogenin can regulate expression of VEGF. To date, the patterns of serum angiogenin expression among patients with ALS have not been assessed...
  3. pmc Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis
    Simon Cronin
    The Irish ALS Research Group, Department of Neurology, Beaumont Hospital, Dublin 9, Ireland
    J Neurol Neurosurg Psychiatry 78:984-6. 2007
    ..A separate trio based study described a detrimental allele at the PON3 intronic variant INS2+3651 (rs10487132). Association between PON gene cluster variants and SALS requires external validation in an independent dataset...
  4. ncbi request reprint A genome-wide association study of sporadic ALS in a homogenous Irish population
    Simon Cronin
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Hum Mol Genet 17:768-74. 2008
    ..We have made our individual genotyping data publicly available, contributing to a powerful world-wide resource to refine our understanding of the genetics of sporadic ALS...
  5. pmc Screening for replication of genome-wide SNP associations in sporadic ALS
    Simon Cronin
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Eur J Hum Genet 17:213-8. 2009
    ..The result for DPP6 is surprising, as it has been replicated elsewhere. We discuss the possible interpretations and implications of these findings for future ALS GWA studies both within and between populations...
  6. doi request reprint Analysis of genome-wide copy number variation in Irish and Dutch ALS populations
    Simon Cronin
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    Hum Mol Genet 17:3392-8. 2008
    ..Our data support the hypothesis that multiple rare CNVs may contribute risk for SALS. Future work should seek to profile the contribution of CNVs located in regions not covered on the present SNP platforms...
  7. doi request reprint Screening of hypoxia-inducible genes in sporadic ALS
    Simon Cronin
    Department of Neurology, Beaumont Hospital, Dublin, Ireland
    Amyotroph Lateral Scler 9:299-305. 2008
    ..the Irish cohort. We failed to detect association of common variation across 24 candidate hypoxia-inducible angiogenic genes with SALS...
  8. pmc Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis
    Russell Lewis McLaughlin
    Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland
    PLoS ONE 5:e15402. 2010
    ..To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF...
  9. ncbi request reprint Ethnic variation in the incidence of ALS: a systematic review
    Simon Cronin
    Irish ALS Research Group, Neurology Department, Beaumont Hospital, Dublin 9, Ireland
    Neurology 68:1002-7. 2007
    ..It is now widely accepted that the incidence of ALS is uniform across Caucasian populations, but whether racial variation across other ethnicities exists remains unknown...
  10. ncbi request reprint Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis
    Simon Cronin
    Neurovascular Clinical Science Unit, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland
    Stroke 36:1581-7. 2005
    ..Data are conflicting concerning ischemic stroke risk associated with a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (MTHFR 677C-->T), which predisposes to hyperhomocystinemia in vivo...