Dermot Cox

Summary

Affiliation: Royal College of Surgeons in Ireland
Country: Ireland

Publications

  1. ncbi request reprint Characterization of the binding of FK633 to the platelet fibrinogen receptor
    D Cox
    Centre for Cardiovascular Science, Royal College of Surgeons, Dublin, Ireland
    Thromb Res 91:129-36. 1998
  2. ncbi request reprint Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes
    D Cox
    Centre for Cardiovascular Science, Royal College of Surgeons in Ireland, Dublin
    J Am Coll Cardiol 36:1514-9. 2000
  3. doi request reprint Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation
    D Cox
    Molecular and Cellular Therapeutics School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Thromb Haemost 9:1097-107. 2011
  4. doi request reprint Integrins as therapeutic targets: lessons and opportunities
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Nat Rev Drug Discov 9:804-20. 2010
  5. doi request reprint The role of platelets in the pathogenesis of cerebral malaria
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Cell Mol Life Sci 67:557-68. 2010
  6. ncbi request reprint Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers
    Dermot Cox
    Department of Clinical Pharmacology, Royal College of Surgeons, 123 St Stephens Green, Dublin 2, Ireland
    Stroke 37:2153-8. 2006
  7. ncbi request reprint Oral GPIIb/IIIa antagonists: what went wrong?
    Dermot Cox
    Department of Clinical Pharmacology, School of Pharmacy, Royal College of Surgeons, St Stephens Green, Dublin, Ireland
    Curr Pharm Des 10:1587-96. 2004
  8. ncbi request reprint Fibronectin-binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcgammaRIIa receptor
    J Ross Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Mol Microbiol 59:212-30. 2006
  9. doi request reprint Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii
    Ciara Keane
    Cardiovascular Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin
    Arterioscler Thromb Vasc Biol 30:2408-15. 2010
  10. pmc Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B
    Helen Miajlovic
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 75:3335-43. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Characterization of the binding of FK633 to the platelet fibrinogen receptor
    D Cox
    Centre for Cardiovascular Science, Royal College of Surgeons, Dublin, Ireland
    Thromb Res 91:129-36. 1998
    ..5+/-1.6 x 10(7) M(-1) at 300 microg/ml and decreasing to 0.3+/-0.2 x 10(7) M(-1) at 2.4 mg/ml. Thus, FK633 is a reversible, noncompetitive antagonist of fibrinogen binding to the platelet GPIIb/IIIa receptor...
  2. ncbi request reprint Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes
    D Cox
    Centre for Cardiovascular Science, Royal College of Surgeons in Ireland, Dublin
    J Am Coll Cardiol 36:1514-9. 2000
    ..The study was done to determine the role of partial agonist activity in the lack of effectiveness of the oral GPIIb/IIIa antagonist orbofiban...
  3. doi request reprint Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation
    D Cox
    Molecular and Cellular Therapeutics School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Thromb Haemost 9:1097-107. 2011
    ..Here, we review the variety of interactions between platelets and bacteria, and look at the potential for inhibiting these interactions in diseases such as infective endocarditis and sepsis...
  4. doi request reprint Integrins as therapeutic targets: lessons and opportunities
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Nat Rev Drug Discov 9:804-20. 2010
    ..Recent advances in the understanding of integrin function, ligand interaction and signalling pathways suggest novel strategies for inhibiting integrin function that could help harness their full potential as therapeutic targets...
  5. doi request reprint The role of platelets in the pathogenesis of cerebral malaria
    Dermot Cox
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Cell Mol Life Sci 67:557-68. 2010
    ..It can lead to the formation of micro-aggregates of infected red blood cells and platelets which can occlude blood vessels and it also leads to binding to and activation of the endothelium...
  6. ncbi request reprint Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers
    Dermot Cox
    Department of Clinical Pharmacology, Royal College of Surgeons, 123 St Stephens Green, Dublin 2, Ireland
    Stroke 37:2153-8. 2006
    ..This study was designed to determine whether enteric-coated aspirin is as effective as plain aspirin in healthy volunteers...
  7. ncbi request reprint Oral GPIIb/IIIa antagonists: what went wrong?
    Dermot Cox
    Department of Clinical Pharmacology, School of Pharmacy, Royal College of Surgeons, St Stephens Green, Dublin, Ireland
    Curr Pharm Des 10:1587-96. 2004
    ..By addressing these issues it is possible for a new generation of oral GPIIb/IIIa antagonist to be developed...
  8. ncbi request reprint Fibronectin-binding proteins of Staphylococcus aureus mediate activation of human platelets via fibrinogen and fibronectin bridges to integrin GPIIb/IIIa and IgG binding to the FcgammaRIIa receptor
    J Ross Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, University of Dublin, Trinity College, Dublin, Ireland
    Mol Microbiol 59:212-30. 2006
    ..This suggests new avenues for development of therapeutics against vascular infections...
  9. doi request reprint Mechanism of outside-in {alpha}IIb{beta}3-mediated activation of human platelets by the colonizing Bacterium, Streptococcus gordonii
    Ciara Keane
    Cardiovascular Infection Group, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin
    Arterioscler Thromb Vasc Biol 30:2408-15. 2010
    ..The mechanism of platelet recruitment and activation by S. gordonii is poorly understood...
  10. pmc Both complement- and fibrinogen-dependent mechanisms contribute to platelet aggregation mediated by Staphylococcus aureus clumping factor B
    Helen Miajlovic
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Infect Immun 75:3335-43. 2007
    ..However, bacteria expressing ClfB Q235A caused platelet aggregation in a complement-dependent manner which required specific anti-ClfB antibodies...
  11. ncbi request reprint Molecular basis for Staphylococcus aureus-mediated platelet aggregate formation under arterial shear in vitro
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Arterioscler Thromb Vasc Biol 28:335-40. 2008
    ..Previously, we showed that S. aureus clumping factor A (ClfA) and fibronectin-binding protein A (FnBPA) can stimulate rapid platelet aggregation...
  12. ncbi request reprint Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease
    Andrew O Maree
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Am Coll Cardiol 46:1258-63. 2005
    ..We investigated whether use of low-dose enteric-coated (EC) aspirin for secondary prevention of cardiovascular events has sufficient bioavailability to achieve complete platelet cyclooxygenase (COX) inhibition in all individuals...
  13. ncbi request reprint Ligand-binding assays: fibrinogen
    Dermot Cox
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Methods Mol Biol 273:125-38. 2004
  14. ncbi request reprint Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A
    Anthony Loughman
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 57:804-18. 2005
    ..The fibrinogen-independent pathway required IgG and complement deposition to trigger platelet aggregation...
  15. ncbi request reprint Characterization of a ligand-attenuated binding site on glycoprotein IIb/IIIa
    Martin J Quinn
    Centre for Cardiovascular Science, The Royal College of Surgeons in Ireland, Dublin, Ireland
    Thromb Haemost 88:811-6. 2002
    ..These results suggest a model where disappearance of the 4F8 epitope is a secondary event required for full "outside-in" signaling through GPIIb/IIIa...
  16. ncbi request reprint Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions
    Maghnus O'Seaghdha
    Microbiology Department, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    FEBS J 273:4831-41. 2006
    ..This indicated that both vWF regions recognized a region on helices I and II that overlapped the IgG Fc binding site...
  17. ncbi request reprint Optimal suppression of thromboxane A(2) formation by aspirin during percutaneous transluminal coronary angioplasty: no additional effect of a selective cyclooxygenase-2 inhibitor
    Dermot Kearney
    Department of Clinical Pharmacology, RCSI, Dublin, Ireland
    J Am Coll Cardiol 43:526-31. 2004
    ..We examined the contribution of cyclooxygenase (COX)-1 and -2 to the generation of prostacyclin, thromboxane (Tx) A(2), and 8-epi prostaglandin (PG) F(2alpha) during percutaneous transluminal coronary angioplasty (PTCA)...
  18. ncbi request reprint A role for glycoprotein Ib in Streptococcus sanguis-induced platelet aggregation
    Steven W Kerrigan
    Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
    Blood 100:509-16. 2002
    ..It is suggested that the interaction between S sanguis and GPIb is important in the pathogenesis of infective endocarditis and may also play a contributory role in some cases of myocardial infarction...
  19. doi request reprint Platelet-bacterial interactions
    Steven W Kerrigan
    School of Pharmacy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland
    Cell Mol Life Sci 67:513-23. 2010
    ..Secreted bacterial products such as gingipains and lipopolysaccharide may also be capable of triggering platelet activation...
  20. pmc Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function
    Steven W Kerrigan
    Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland
    Infect Immun 75:5740-7. 2007
    ..Differential protein expression between strains may be important for the pathogenesis of invasive diseases such as infective endocarditis...
  21. doi request reprint Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction
    Nicholas P Tobin
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 295:H1403-13. 2008
    ..Specifically, the VacA-dependent reduction in endothelial NO is indicated in these events. The atheroprotective impact of laminar shear stress in this context is also evident...
  22. ncbi request reprint Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A
    Louise O'Brien
    Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College, Dublin 2, Ireland
    Mol Microbiol 44:1033-44. 2002
    ..aureus. Thus, S. aureus has multiple mechanisms for stimulating platelet aggregation. Such functional redundancy suggests that this phenomenon may be important in the pathogenesis of invasive diseases such as infective endocarditis...
  23. doi request reprint TIN - A Combinatorial Compound Collection of Synthetically Feasible Multicomponent Synthesis Products
    Kristl V Dorschner
    Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    J Chem Inf Model 51:986-95. 2011
    ..Subsets include a 10% diversity subset, a drug-like subset, and a lead-like subset that are also freely available for download and virtual screening ( http://mmg.rcsi.ie:8080/tin ). ..
  24. ncbi request reprint Drug insight: aspirin resistance-fact or fashion?
    Andrew O Maree
    Nat Clin Pract Cardiovasc Med 4:E1; author reply E2. 2007
  25. ncbi request reprint Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release
    Subrata Chakrabarti
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, 715 Albany Street, W507, Boston, MA 02481, USA
    Thromb Res 113:225-33. 2004
    ..Blocking the GPIIb/IIIa receptor prevents platelet aggregation but not activation and the subsequent effect on other platelet pathways is largely unknown...
  26. ncbi request reprint The interaction of bacterial pathogens with platelets
    J Ross Fitzgerald
    Centre for Infectious Diseases, The Chancellor s Building, New Royal Infirmary, University of Edinburgh, Edinburgh EH16 4SB, Scotland, UK
    Nat Rev Microbiol 4:445-57. 2006
    ..Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases...
  27. ncbi request reprint Thrombosis and nitric oxide donor drugs
    Andrew O Maree
    Thromb Haemost 91:848-50. 2004
  28. ncbi request reprint Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network
    Donald E Mager
    Laboratory of Clinical Investigation, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland, USA
    J Pharm Sci 94:2475-86. 2005
    ..Although the population model showed greater precision, these results suggest that NNs may be useful for individualizing pharmacotherapy when drug concentrations are relatively unpredictable or unavailable...
  29. ncbi request reprint A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb
    Christopher Plummer
    Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    Br J Haematol 129:101-9. 2005
    ..Platelets did not bind to wild-type bacterial cells at high shear (1500/s). These findings help to understand the mechanisms by which the organism might colonize platelet-fibrin vegetations...