C E Mothersill

Summary

Affiliation: Radiation and Environmental Science Centre
Country: Ireland

Publications

  1. ncbi Apoptosis and other effects of radiation in normal human urothelial cells
    C Mothersill
    Radiation Science Centre, Dublin Institute of Technology, Ireland
    Radiat Oncol Investig 5:150-3. 1997
  2. ncbi Relevance of radiation-induced bystander effects for environmental risk assessment
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Str, Dublin 8, Ireland
    Radiats Biol Radioecol 42:585-7. 2002
  3. ncbi Bystander and delayed effects after fractionated radiation exposure
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Fitzwilliam House, 30 Upper Pembroke Street, Dublin 2, Ireland
    Radiat Res 158:626-33. 2002
  4. ncbi Characterisation of a bystander effect induced in human tissue explant cultures by low let radiation
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Radiat Prot Dosimetry 99:163-7. 2002
  5. ncbi Relationship between radiation-induced low-dose hypersensitivity and the bystander effect
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Fitzwilliam House, 30 Upper Pembroke Street, Dublin 2, Ireland
    Radiat Res 157:526-32. 2002
  6. ncbi Radiotherapy and the potential exploitation of bystander effects
    C E Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Dublin, Ireland
    Int J Radiat Oncol Biol Phys 58:575-9. 2004
  7. ncbi Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Republic of Ireland
    Carcinogenesis 22:1465-71. 2001
  8. ncbi Effect of low doses of ionizing radiation on cells cultured from the hematopoietic tissue of the Dublin Bay prawn, Nephrops norvegicus
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Fitzwilliam House, 30 Upper Pembroke Street, Dublin 2, Ireland
    Radiat Res 156:241-50. 2001
  9. ncbi Genomic instability, bystander effects and radiation risks: implications for development of protection strategies for man and the environment
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Ireland
    Radiats Biol Radioecol 40:615-20. 2000
  10. ncbi Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens
    C Mothersill
    Radiation Science Centre, Dublin Institute of Technology, Ireland
    Int J Radiat Biol 74:673-80. 1998

Collaborators

Detail Information

Publications38

  1. ncbi Apoptosis and other effects of radiation in normal human urothelial cells
    C Mothersill
    Radiation Science Centre, Dublin Institute of Technology, Ireland
    Radiat Oncol Investig 5:150-3. 1997
    ....
  2. ncbi Relevance of radiation-induced bystander effects for environmental risk assessment
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Str, Dublin 8, Ireland
    Radiats Biol Radioecol 42:585-7. 2002
    ....
  3. ncbi Bystander and delayed effects after fractionated radiation exposure
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Fitzwilliam House, 30 Upper Pembroke Street, Dublin 2, Ireland
    Radiat Res 158:626-33. 2002
    ..In certain protocols using mixtures of direct irradiation and ICCM, it was possible to eliminate the bystander effect. If bystander factors are produced in vivo, then they may reduce the sparing effect of the dose fractionation...
  4. ncbi Characterisation of a bystander effect induced in human tissue explant cultures by low let radiation
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Radiat Prot Dosimetry 99:163-7. 2002
    ..The results may be important not only for understanding radiation risk mechanisms for protection but also for radiotherapy treatment planning where they may open new avenues for development of drugs for combined therapy...
  5. ncbi Relationship between radiation-induced low-dose hypersensitivity and the bystander effect
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Fitzwilliam House, 30 Upper Pembroke Street, Dublin 2, Ireland
    Radiat Res 157:526-32. 2002
    ..The results may suggest new approaches to understanding the factors that control cell death or the sectoring of survival at low radiation doses...
  6. ncbi Radiotherapy and the potential exploitation of bystander effects
    C E Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Dublin, Ireland
    Int J Radiat Oncol Biol Phys 58:575-9. 2004
    ..The final part of this paper is devoted to this point...
  7. ncbi Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Republic of Ireland
    Carcinogenesis 22:1465-71. 2001
    ..The results may be important not only for understanding radiation risk mechanisms for protection but also for radiotherapy treatment planning where they may open new avenues for development of drugs for combined therapy...
  8. ncbi Effect of low doses of ionizing radiation on cells cultured from the hematopoietic tissue of the Dublin Bay prawn, Nephrops norvegicus
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Fitzwilliam House, 30 Upper Pembroke Street, Dublin 2, Ireland
    Radiat Res 156:241-50. 2001
    ..It is suggested that these crustaceans may be highly sensitive to radiation, unlike terrestrial arthropods and certain other invertebrates, which are generally considered to be radioresistant...
  9. ncbi Genomic instability, bystander effects and radiation risks: implications for development of protection strategies for man and the environment
    C Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Ireland
    Radiats Biol Radioecol 40:615-20. 2000
    ..The paper also considers the impact of the new concepts on environmental protection and discusses the need for research in the field of comparative radiobiology if we are to develop policies which can adequately protect biodiversity...
  10. ncbi Expression of delayed toxicity and lethal mutations in the progeny of human cells surviving exposure to radiation and other environmental mutagens
    C Mothersill
    Radiation Science Centre, Dublin Institute of Technology, Ireland
    Int J Radiat Biol 74:673-80. 1998
    ....
  11. ncbi Mechanisms and implications of genomic instability and other delayed effects of ionizing radiation exposure
    C Mothersill
    Radiation Science Centre, Dublin Institute of Technology, Ireland
    Mutagenesis 13:421-6. 1998
    ....
  12. ncbi Low-dose radiation effects: experimental hematology and the changing paradigm
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Exp Hematol 31:437-45. 2003
    ..Throughout, we make a plea to think "outside the box" since the very construction of a framework necessarily limits our thinking and our experimental design...
  13. doi Bystander effect induced changes in apoptosis related proteins and terminal differentiation in in vitro murine bladder cultures
    A M Vines
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Dublin
    Int J Radiat Biol 85:48-56. 2009
    ..The aim of this investigation was to examine the bystander signal and response in a multicellular primary tissue culture system in vitro...
  14. ncbi Identification and characterization of three subtypes of radiation response in normal human urothelial cultures exposed to ionizing radiation
    C E Mothersill
    Radiation Science Centre, Dublin Institute of Technology, Kevin Street, Dublin, Republic of Ireland, UK
    Carcinogenesis 20:2273-8. 1999
    ..The mouse experiments demonstrate the importance of genetic factors in determining these responses...
  15. pmc Particulate debris from a titanium metal prosthesis induces genomic instability in primary human fibroblast cells
    N Coen
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Ireland
    Br J Cancer 88:548-52. 2003
    ..These findings may have important implications with regard to the long-term risks of joint replacement surgery. This highlights the need for long-term epidemiological studies of patients with surgical implants...
  16. ncbi Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells
    James E J Murphy
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin St Dublin 8, Ireland
    Mutat Res 585:127-36. 2005
    ....
  17. ncbi Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells
    Fiona M Lyng
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Dublin, Ireland
    Int J Radiat Biol 82:393-9. 2006
    ..Demonstration of a commonality of mechanisms would support the idea that the process is not artifactual...
  18. ncbi Modulation of radiation responses by pre-exposure to irradiated cell conditioned medium
    Paula Maguire
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Ireland
    Radiat Res 167:485-92. 2007
    ..This study has shown that a priming dose of ICCM has the ability to induce an adaptive response in HPV-G cells subsequently exposed to a challenge dose of ICCM...
  19. ncbi Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes
    Paula Maguire
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Dublin, Ireland
    Radiat Res 163:384-90. 2005
    ..The dose dependence of the mitochondrial changes and BCL2 expression suggests that the mechanisms may be aimed at control of response to radiation at the population level through signaling pathways...
  20. ncbi Radiation-induced bystander effects and adaptive responses--the Yin and Yang of low dose radiobiology?
    Carmel Mothersill
    Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, Ont, Canada L8S 4K1
    Mutat Res 568:121-8. 2004
    ..This model may be important when attempting to predict the consequences of mixed exposures involving low doses of radiation and other environmental stressors...
  21. ncbi Bystander effects in repair-deficient cell lines
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Radiat Res 161:256-63. 2004
    ..The results suggest that repair- deficient human cell lines, irrespective of the actual repair defect, may respond to the occurrence of DNA damage in the population by removing large numbers of cells from the proliferating pool...
  22. ncbi Radiation-induced bystander effects--implications for cancer
    Carmel Mothersill
    Department of Medical Physics and Applied Radiation Science Unit, McMaster University, Hamilton, Ontario, Canada
    Nat Rev Cancer 4:158-64. 2004
  23. ncbi Radiation-induced bystander effects and the DNA paradigm: an "out of field" perspective
    Carmel Mothersill
    Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, Ont, Canada L8S 4K1
    Mutat Res 597:5-10. 2006
    ..The fundamental thesis we present is that at low doses fundamentally different mechanisms underlie radiation action and that at these doses, effect is not quantitatively related to dose...
  24. ncbi Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
    Edward J Calabrese
    School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Toxicol Appl Pharmacol 222:122-8. 2007
    ....
  25. ncbi Characterization of a radiation-induced stress response communicated in vivo between zebrafish
    Carmel Mothersill
    Medical Physics and Applied Radiation Sciences Department, McMaster University, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada
    Environ Sci Technol 41:3382-7. 2007
    ..This suggests the signal is not retained by water for long periods of time. Individual fish data reveal unique responses by bystander fish which could indicate varying levels of sensitivity to signal strength among individuals...
  26. ncbi Bystander effects induced by serum from survivors of the Chernobyl accident
    Pavel Marozik
    Sakarov University, Minsk, Belarus
    Exp Hematol 35:55-63. 2007
    ....
  27. ncbi Comparison of direct and bystander effects induced by ionizing radiation in eight fish cell lines
    Michael Kilemade
    McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Biol 83:593-602. 2007
    ..To determine bystander and direct effects of ionizing radiation on eight fish cell lines...
  28. ncbi Targeted radiotherapy: is the "Holy Grail" in sight?
    Carmel Mothersill
    McMaster University Hamilton, Ontario, Canada
    J Nucl Med 47:899-900. 2006
  29. ncbi A two-species biomarker model for the assessment of sediment toxicity in the marine and estuarine environment using the comet assay
    Mark G J Hartl
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:939-53. 2006
    ..This suggests that turbot, rather than clams, are more suitable as a sentinel species for the assessment of genotoxic impact of low-level contamination in aquatic sediments and highlights the need for a two- or multi-species approach...
  30. ncbi Cell death mechanisms associated with G2 radiosensitivity in patients with prostate cancer and benign prostatic hyperplasia
    Orla Howe
    Radiation and Environmental Science Centre, Focus Institute, Dublin Institute of Technology, Dublin 8, Ireland
    Radiat Res 164:627-34. 2005
    ....
  31. ncbi Radiation-induced bystander effects: are they good, bad or both?
    Carmel Mothersill
    Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, Ontario, Canada
    Med Confl Surviv 21:101-10. 2005
    ..This model may be important when attempting to predict the consequences of mixed exposures involving radiation and other environmental stressors...
  32. ncbi Expression of delayed cell death (DCD) in the progeny of fish cells surviving 2,4-dichloroaniline (2,4-DCA) exposure
    Michael Kilemade
    Department of Zoology and Animal Ecology, Environmental Research Institute, University College Cork, Lee Maltings, Prospect Row, Cork, Ireland
    Aquat Toxicol 63:207-19. 2003
    ..Results showed that the expression of DCD occurred persistently post-treatment and was relatively independent of dose once a threshold level of 40 microM (Fig. 1) had been reached...
  33. ncbi Cytoskeletal reorganization and altered phagocytotic ability in primary cultures of rainbow trout hemopoietic tissue exposed to low-level ionizing radiation
    Peter M Olwell
    Radiation and Environmental Science Centre, FOCAS, Dublin Institute of Technology, Dublin 8, Ireland
    Radiat Res 164:45-52. 2005
    ..Radiation was also shown to cause a dose-dependent increase in the amounts of apoptosis in these cells over time. The phagocytotic efficacy of these cells was shown to inhibited by the exposure to low doses of radiation...
  34. ncbi Delayed cell death and bystander effects in the progeny of Chinook salmon embryo cells exposed to radiation and a range of aquatic pollutants
    Kevin Dowling
    Medical Physics and Applied Radiation Sciences Unit, McMaster University, Hamilton, Ontario L8S 4KI, Canada
    Int J Radiat Biol 81:89-96. 2005
    ..To determine whether delayed and bystander effects can be seen in both a non malignant teleost fish cell line, (CHSE) and a malignant teleost fish cell line (EPC) when exposed to low doses of ionising radiation and genotoxic pollutants...
  35. ncbi Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in vivo
    Carmel Mothersill
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Dublin, Ireland
    Radiat Res 163:391-9. 2005
    ..The results clearly demonstrate the in vivo induction of bystander signals that are strongly influenced by genetic factors and have implications for radiation protection, medical imaging, and radiotherapy...
  36. ncbi In regard to Denham et al., is it time for a new formalism to categorize normal tissue radiation injury? IJROBP 2001;50:1105-1106
    Colin B Seymour
    Int J Radiat Oncol Biol Phys 52:1147-8; author reply 1148. 2002
  37. ncbi Radiation-induced bystander effects, carcinogenesis and models
    Carmel Mothersill
    Radiation and Environmental Science Center, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Oncogene 22:7028-33. 2003
    ..Carcinogenesis may then be thought of as the result of a disturbance of the genetic/epigenetic balance occurring within the organ. Ultimate clonality may reflect domination due to selection processes rather than the initiating damage...
  38. ncbi Radiosensitization of colon cancer cell lines by docetaxel: mechanisms of action
    Amanda L Dunne
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, BT52 1AS, UK
    Oncol Res 14:447-54. 2004
    ..After 24 h, 55-70% of the cells were in G2/M. It is likely, therefore, that accumulation in this radiosensitive phase of the cell cycle contributes significantly to radiosensitization by the drug...