Siobhán M O'Sullivan

Summary

Country: Ireland

Publications

  1. ncbi request reprint Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma death
    S O'Sullivan
    Department of Respiratory Medicine, James Connolly Memorial Hospital, Dublin, Ireland
    Am J Respir Crit Care Med 164:560-4. 2001
  2. ncbi request reprint Effects of varying doses of fluticasone propionate on the physiology and bronchial wall immunopathology in mild-to-moderate asthma
    Siobhan O'Sullivan
    Department of Clinical Immunology, Royal Free and University College Hospital Medical School, Pond Street, London NW3 2QG, UK
    Chest 122:1966-72. 2002
  3. ncbi request reprint Effect of the addition of montelukast to inhaled fluticasone propionate on airway inflammation
    Siobhan O'Sullivan
    Department of Clinical Immunology, Royal Free and University College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 167:745-50. 2003
  4. pmc Fluticasone induces T cell apoptosis in the bronchial wall of mild to moderate asthmatics
    S O'Sullivan
    Department of Immunology, Royal Free and University College Hospital Medical School, London NW3 2QG, UK
    Thorax 59:657-61. 2004
  5. ncbi request reprint Asthma death, CD8+ T cells, and viruses
    Siobhán M O'Sullivan
    Royal Irish Academy, 19 Dawson St, Dublin 2 Ireland
    Proc Am Thorac Soc 2:162-5. 2005

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Activated, cytotoxic CD8(+) T lymphocytes contribute to the pathology of asthma death
    S O'Sullivan
    Department of Respiratory Medicine, James Connolly Memorial Hospital, Dublin, Ireland
    Am J Respir Crit Care Med 164:560-4. 2001
    ..No viral genome was detected in the lungs of the control group. In conclusion, this study provides novel evidence of an aberrant CD8(+) T-cell population, possibly in response to viral infection in subjects who die of acute asthma...
  2. ncbi request reprint Effects of varying doses of fluticasone propionate on the physiology and bronchial wall immunopathology in mild-to-moderate asthma
    Siobhan O'Sullivan
    Department of Clinical Immunology, Royal Free and University College Hospital Medical School, Pond Street, London NW3 2QG, UK
    Chest 122:1966-72. 2002
    ..The aim of the present study was to investigate if a dose-response relationship exists for lung function and inflammatory cell numbers in bronchial biopsy specimens...
  3. ncbi request reprint Effect of the addition of montelukast to inhaled fluticasone propionate on airway inflammation
    Siobhan O'Sullivan
    Department of Clinical Immunology, Royal Free and University College School of Medicine, London, United Kingdom
    Am J Respir Crit Care Med 167:745-50. 2003
    ..61) between treatments. Reduction of inflammatory cell numbers in the bronchial mucosa achieved with FP plus montelukast was not significantly different from the reduction observed with FP alone in individuals with mild asthma...
  4. pmc Fluticasone induces T cell apoptosis in the bronchial wall of mild to moderate asthmatics
    S O'Sullivan
    Department of Immunology, Royal Free and University College Hospital Medical School, London NW3 2QG, UK
    Thorax 59:657-61. 2004
    ..Cytokines which signal via the gamma chain of the interleukin (IL)-2 receptor and the interferons (IFNs) have been shown to enhance T cell survival in vitro by rescuing cells from apoptosis...
  5. ncbi request reprint Asthma death, CD8+ T cells, and viruses
    Siobhán M O'Sullivan
    Royal Irish Academy, 19 Dawson St, Dublin 2 Ireland
    Proc Am Thorac Soc 2:162-5. 2005
    ..However, it would appear that an aberrant CD8+ T cell response in the context of a viral infection may place individuals with asthma at risk for fatal asthma...