Linda Sharp

Summary

Affiliation: National Cancer Registry
Country: Ireland

Publications

  1. pmc Risk of several cancers is higher in urban areas after adjusting for socioeconomic status. Results from a two-country population-based study of 18 common cancers
    Linda Sharp
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    J Urban Health 91:510-25. 2014
  2. pmc Psychosocial Impact of Alternative Management Policies for Low-Grade Cervical Abnormalities: Results from the TOMBOLA Randomised Controlled Trial
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    PLoS ONE 8:e80092. 2013
  3. pmc Inequity in colorectal cancer treatment and outcomes: a population-based study
    A E Carsin
    National Cancer Registry, Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Br J Cancer 99:266-74. 2008
  4. doi request reprint Associations between cancer-related financial stress and strain and psychological well-being among individuals living with cancer
    Linda Sharp
    National Cancer Registry, Cork, Ireland
    Psychooncology 22:745-55. 2013
  5. doi request reprint Factors associated with psychological distress following colposcopy among women with low-grade abnormal cervical cytology: a prospective study within the Trial Of Management of Borderline and Other Low-grade Abnormal smears (TOMBOLA)
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Psychooncology 22:368-80. 2013
  6. doi request reprint Who defaults from colposcopy? A multi-centre, population-based, prospective cohort study of predictors of non-attendance for follow-up among women with low-grade abnormal cervical cytology
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Eur J Obstet Gynecol Reprod Biol 165:318-25. 2012
  7. doi request reprint Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial
    L Sharp
    National Cancer Registry Ireland, Cork, Ireland
    Cytopathology 23:150-60. 2012
  8. pmc Cost-effectiveness of population-based screening for colorectal cancer: a comparison of guaiac-based faecal occult blood testing, faecal immunochemical testing and flexible sigmoidoscopy
    L Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Building 6800, Kinsale Road, Cork, Ireland
    Br J Cancer 106:805-16. 2012
  9. pmc Pedigree analysis and epidemiological features of idiopathic congenital talipes equinovarus in the United Kingdom: a case-control study
    A H Cardy
    Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen, UK
    BMC Musculoskelet Disord 8:62. 2007
  10. ncbi request reprint Where do people with lung cancer die and how is this changing? A population-based study
    L Sharp
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Rd, Cork
    Ir Med J 103:262-4, 266. 2010

Detail Information

Publications78

  1. pmc Risk of several cancers is higher in urban areas after adjusting for socioeconomic status. Results from a two-country population-based study of 18 common cancers
    Linda Sharp
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    J Urban Health 91:510-25. 2014
    ..Variations in healthcare utilization and known risk factors likely explain some of the observed associations. Explanations for others are unclear and, in the interests of equity, warrant further investigation...
  2. pmc Psychosocial Impact of Alternative Management Policies for Low-Grade Cervical Abnormalities: Results from the TOMBOLA Randomised Controlled Trial
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    PLoS ONE 8:e80092. 2013
    ..We compared, over 30-months, psychosocial outcomes of two policies: cytological surveillance (repeat cervical cytology tests in primary care) and a hospital-based colposcopy examination...
  3. pmc Inequity in colorectal cancer treatment and outcomes: a population-based study
    A E Carsin
    National Cancer Registry, Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Br J Cancer 99:266-74. 2008
    ..The observed inequities in treatment and outcomes suggest that there is potential for further dissemination of therapies in routine practice. Improving treatment availability overall, and equity, has the potential to reduce mortality...
  4. doi request reprint Associations between cancer-related financial stress and strain and psychological well-being among individuals living with cancer
    Linda Sharp
    National Cancer Registry, Cork, Ireland
    Psychooncology 22:745-55. 2013
    ..Cancer places a financial and economic burden on individuals, but relatively little is known about the consequences. We investigated associations between cancer-related financial stress and strain and psychological well-being...
  5. doi request reprint Factors associated with psychological distress following colposcopy among women with low-grade abnormal cervical cytology: a prospective study within the Trial Of Management of Borderline and Other Low-grade Abnormal smears (TOMBOLA)
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Psychooncology 22:368-80. 2013
    ..We investigated psychological distress following colposcopy and related procedures...
  6. doi request reprint Who defaults from colposcopy? A multi-centre, population-based, prospective cohort study of predictors of non-attendance for follow-up among women with low-grade abnormal cervical cytology
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Eur J Obstet Gynecol Reprod Biol 165:318-25. 2012
    ..The objective of this study was to identify factors associated with non-attendance at an initial colposcopy examination among women with low-grade abnormal cervical cytology...
  7. doi request reprint Which women default from follow-up cervical cytology tests? A cohort study within the TOMBOLA trial
    L Sharp
    National Cancer Registry Ireland, Cork, Ireland
    Cytopathology 23:150-60. 2012
    ..To identify factors associated with default from follow-up cervical cytology tests...
  8. pmc Cost-effectiveness of population-based screening for colorectal cancer: a comparison of guaiac-based faecal occult blood testing, faecal immunochemical testing and flexible sigmoidoscopy
    L Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Building 6800, Kinsale Road, Cork, Ireland
    Br J Cancer 106:805-16. 2012
    ....
  9. pmc Pedigree analysis and epidemiological features of idiopathic congenital talipes equinovarus in the United Kingdom: a case-control study
    A H Cardy
    Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen, UK
    BMC Musculoskelet Disord 8:62. 2007
    ..5 per 1000 live births. The aetiology is not well elucidated. While both genetic and environmental factors are implicated, no specific genes have been identified and little is known about environmental risk factors...
  10. ncbi request reprint Where do people with lung cancer die and how is this changing? A population-based study
    L Sharp
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Rd, Cork
    Ir Med J 103:262-4, 266. 2010
    ..Despite evidence suggesting most cancer patients would prefer to die at home, and developments in palliative care services, home deaths are declining and most lung cancer deaths occur in hospital...
  11. doi request reprint Social welfare and legal constraints associated with work among breast and prostate cancer survivors: experiences from Ireland
    Linda Sharp
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    J Cancer Surviv 5:382-94. 2011
    ..We investigated employment outcomes among survivors in Ireland where sick leave and sick pay are at the employers' discretion and the law affords no protection against dismissal following extended absence...
  12. ncbi request reprint Reasons for participation and non-participation in a randomized controlled trial: postal questionnaire surveys of women eligible for TOMBOLA (Trial Of Management of Borderline and Other Low-Grade Abnormal smears)
    L Sharp
    National Cancer Registry Ireland, Cork, Ireland
    Clin Trials 3:431-42. 2006
    ....
  13. ncbi request reprint The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR), maternal use of folic acid supplements, and risk of isolated clubfoot: A case-parent-triad analysis
    Linda Sharp
    National Cancer Registry Ireland, Cork, Ireland
    Am J Epidemiol 164:852-61. 2006
    ..However, clubfoot mechanisms are poorly understood, and the folate metabolism pathway is complex. Further research is needed to elucidate these relations...
  14. ncbi request reprint Enclosing a pen with a postal questionnaire can significantly increase the response rate
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
    J Clin Epidemiol 59:747-54. 2006
    ..It is important to maximize response rates to postal questionnaires. We compared the impact of three low-cost interventions on response rates...
  15. pmc Long-term psychosocial impact of alternative management policies in women with low-grade abnormal cervical cytology referred for colposcopy: a randomised controlled trial
    L Sharp
    National Cancer Registry, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Br J Cancer 104:255-64. 2011
    ..The debate continues regarding the best management for women with low-grade abnormal cervical cytology attending colposcopy. We compared psychosocial outcomes of alternative management policies in these women...
  16. ncbi request reprint Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
    Linda Sharp
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Nutr 99:379-89. 2008
    ..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways...
  17. ncbi request reprint CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors. a HuGE review
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom
    Am J Epidemiol 160:729-40. 2004
    ..Further investigation of relations between genotype and hormone levels, exogenous hormone use, and markers of hormonal status may advance understanding of hormonally mediated diseases...
  18. ncbi request reprint How much does it cost to care for survivors of colorectal cancer? Caregiver's time, travel and out-of-pocket costs
    Paul Hanly
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Support Care Cancer 21:2583-92. 2013
    ..This may entail a considerable economic burden for family members and friends who support patients/survivors. We estimated financial and time costs associated with informal care for colorectal cancer...
  19. doi request reprint Work-related productivity losses in an era of ageing populations: the case of colorectal cancer
    Paul Hanly
    National Cancer Registry Ireland, Cork Airport Business Park, Cork, Ireland
    J Occup Environ Med 55:128-34. 2013
    ..We investigated patterns and costs of lost productivity due to colorectal cancer in Ireland and examined how rising pension ages affect these costs...
  20. ncbi request reprint Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
    ..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other...
  21. ncbi request reprint Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design
    Seonaidh C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Contemp Clin Trials 27:449-71. 2006
    ..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial...
  22. ncbi request reprint Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    Sabrina Narayanan
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004
    ....
  23. doi request reprint Time costs associated with informal care for colorectal cancer: an investigation of the impact of alternative valuation methods
    Paul Hanly
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Appl Health Econ Health Policy 11:193-203. 2013
    ..A societal perspective in economic evaluation necessitates that all resources associated with a disease or intervention should be valued; however, informal care time costs are rarely considered...
  24. pmc After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trial
    Seonaidh Cotton
    Institute of Applied Health Sciences, University of Aberdeen, Scotland, UK
    Br J Gen Pract 61:e333-9. 2011
    ..Although it is recognised that some women experience pain or bleeding during a cervical cytology test, few studies have quantified physical after-effects of these tests...
  25. doi request reprint Cost comparisons and methodological heterogeneity in cost-of-illness studies: the example of colorectal cancer
    Alan J O Céilleachair
    National Cancer Registry Ireland, Cork, Ireland
    Med Care 51:339-50. 2013
    ..Cost-of-illness (COI) studies are key building blocks in economic evaluations of interventions and comparative effectiveness research. We systematically reviewed and critiqued the COI literature on CRC...
  26. ncbi request reprint Length and somatic mosaicism of CAG and GGN repeats in the androgen receptor gene and the risk of prostate cancer in men with benign prostatic hyperplasia
    Mohammed T Tayeb
    Departments of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Ann Saudi Med 24:21-6. 2004
    ..We analysed the polymorphic CAG and GGN repeats sequence in exon 1 of the AR gene to determine if the number of repeats might be an indicator of PRCa risk in patients with BPH...
  27. pmc A population-based study of hospital length of stay and emergency readmission following surgery for non-small-cell lung cancer
    Joseph McDevitt
    National Cancer Registry Ireland, Cork, Ireland
    Eur J Cardiothorac Surg 44:e253-9. 2013
    ..We conducted a population-based analysis of time trends in length of stay (LOS), predictors of prolonged LOS and emergency readmission following resection for non-small-cell lung cancer (NSCLC)...
  28. doi request reprint The multidimensional nature of the financial and economic burden of a cancer diagnosis on patients and their families: qualitative findings from a country with a mixed public-private healthcare system
    Aileen Timmons
    National Cancer Registry, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Support Care Cancer 21:107-17. 2013
    ..To elucidate these issues, we used qualitative methods to explore the financial impact of a cancer diagnosis in Ireland, which has a mixed public-private healthcare system and where sick leave and sick pay are at employers' discretion...
  29. ncbi request reprint Dietary flavonoid intake and colorectal cancer: a case-control study
    Janet A M Kyle
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Br J Nutr 103:429-36. 2010
    ..5; 95 % CI 0.3, 0.8; P(trend) < 0.01). We concluded that flavonols, specifically quercetin, obtained from non-tea components of the diet may be linked with reduced risk of developing colon cancer...
  30. pmc "It's at a time in your life when you are most vulnerable": a qualitative exploration of the financial impact of a cancer diagnosis and implications for financial protection in health
    Aileen Timmons
    National Cancer Registry, Cork, Ireland
    PLoS ONE 8:e77549. 2013
    ..In the interim, cancer patients require financial information and advice intermittently post diagnosis. ..
  31. pmc Using resource modelling to inform decision making and service planning: the case of colorectal cancer screening in Ireland
    Linda Sharp
    National Cancer Registry Ireland, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    BMC Health Serv Res 13:105. 2013
    ..As an illustration of such an approach, we estimated annual health service resource requirements and health outcomes over the first decade of a population-based colorectal cancer screening programme in Ireland...
  32. pmc Inter-relationships between the economic and emotional consequences of colorectal cancer for patients and their families: a qualitative study
    Alan Ó Céilleachair
    National Cancer Registry Ireland, Cork, Ireland
    BMC Gastroenterol 12:62. 2012
    ..We investigated the economic costs of cancer in the context of patients' emotions and how these both shaped the patient and family burden...
  33. pmc Factors predicting hospital length-of-stay and readmission after colorectal resection: a population-based study of elective and emergency admissions
    Maria Kelly
    National Cancer Registry, Building 6800, Cork Airport Business Park, Cork, Ireland
    BMC Health Serv Res 12:77. 2012
    ..In a population-based analysis, we investigated predictors of LOS and emergency readmission after the initial surgery episode...
  34. pmc Variation in WNT7A is unlikely to be a cause of familial congenital talipes equinovarus
    Guoqing Liu
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, UK
    BMC Med Genet 9:50. 2008
    ..WNT7A is a plausible candidate gene for CTEV as it provides a signal for pattern formation during limb development, and mutation in WNT7A has been reported in a number of limb malformation syndromes...
  35. pmc Factors prompting PSA-testing of asymptomatic men in a country with no guidelines: a national survey of general practitioners
    Frances J Drummond
    National Cancer Registry, Ireland, Building 6800, Airport Business Park, Kinsale Rd, Cork, Ireland
    BMC Fam Pract 10:3. 2009
    ..GPs have a pivotal role in influencing PSA testing, therefore, our aim was to describe GP testing practices and to identify factors influencing these...
  36. ncbi request reprint Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested...
  37. ncbi request reprint The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  38. ncbi request reprint Postcolposcopy management of women with histologically proven CIN 1: results from TOMBOLA
    Mahalakshmi Gurumurthy
    1Gynaecological Oncology, University Hospital of Llandough, Wales and 2University of Aberdeen, Aberdeen, United Kingdom 3National Cancer Registry Ireland, Cork, Ireland 4Aberdeen Royal Infirmary, Aberdeen, United Kingdom 5Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada and 6Warwick Medical School, Coventry, United Kingdom
    J Low Genit Tract Dis 18:203-9. 2014
    ....
  39. ncbi request reprint The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance
    Linda Sharp
    1National Cancer Registry Ireland, Cork Airport Business Park, Cork, Ireland 2Obstetrics and Gynaecology and 3Centre of Academic Primary Care, University of Aberdeen, Foresterhill, Aberdeen, Scotland 4Medical Statistics Team, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, Scotland 5Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, Scotland 6University of Hull, Hull, England and 7Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Low Genit Tract Dis 18:142-50. 2014
    ..Less is known about the impact of follow-up by repeat cytology tests. We quantified prevalence, and identified predictors, of distress after repeat cytologic testing in women with a single low-grade test...
  40. doi request reprint Cost effectiveness of fecal DNA screening for colorectal cancer: a systematic review and quality appraisal of the literature
    Mairead Skally
    National Cancer Registry Ireland, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Appl Health Econ Health Policy 11:181-92. 2013
    ..Fecal DNA (fDNA) testing is a noninvasive potential alternative to current colorectal cancer screening tests...
  41. ncbi request reprint Persistent infection with human papillomavirus following the successful treatment of high grade cervical intraepithelial neoplasia
    Margaret E Cruickshank
    Wellbeing Centre for the Prevention of Cervical Cancer, University of Aberdeen, UK
    BJOG 109:579-81. 2002
    ..0 (95% CI 2.13-30.37). The persistence of HPV 16/18 infection following the confirmed eradication of CIN is a highly significant risk factor for recurrence...
  42. doi request reprint Questionnaire order significantly increased response to a postal survey sent to primary care physicians
    Frances J Drummond
    National Cancer Registry, Ireland, Elm Court, Boreenmanna Road, Cork, Ireland
    J Clin Epidemiol 61:177-85. 2008
    ..Difficulties in achieving adequate response rates among physicians have been reported. We investigated the effect of two low-cost interventions on response to a primary care physician postal questionnaire...
  43. ncbi request reprint CYP3A4 promoter variant is associated with prostate cancer risk in men with benign prostate hyperplasia
    Mohammed T Tayeb
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, UK
    Oncol Rep 9:653-5. 2002
    ..The CYP3A4 variant allele identified men with BPH who are at increased risk of progressing to PRCa (odds ratio 6.3, 95% CI 2.3-17.3), providing a potential tool to assist prediction strategies for this disease...
  44. doi request reprint Breast and prostate cancer productivity costs: a comparison of the human capital approach and the friction cost approach
    Paul Hanly
    National Cancer Registry Ireland, Cork, Ireland
    Value Health 15:429-36. 2012
    ....
  45. ncbi request reprint Trends in incidence of, and mortality from, cervical lesions in Ireland: baseline data for future evaluation of the national cervical screening programme
    Katie M O'Brien
    National Cancer Registry, Building 6800, Airport Business Park, Kinsale Road, Cork, Ireland Electronic address
    Cancer Epidemiol 37:830-5. 2013
    ..To investigate incidence and mortality trends for cervical lesions in Ireland in the period 1994-2008...
  46. ncbi request reprint Treatment and survival for non-Hodgkin's lymphoma: influence of histological subtype, age, and other factors in a population-based study (1999-2001)
    Deirdre P Cronin-Fenton
    National Cancer Registry of Ireland, Elm Court, Boreenmanna Road, Cork, Ireland
    Eur J Cancer 42:2786-93. 2006
    ....
  47. doi request reprint "Bird in the hand" cash was more effective than prize draws in increasing physician questionnaire response
    Frances J Drummond
    National Cancer Registry, Building 6800, Airport Business Park, Kinsale Road, Cork, Ireland Electronic address
    J Clin Epidemiol 67:228-31. 2014
    ..To investigate the effects of two monetary incentives on response rates to postal questionnaires from primary care physicians (PCPs)...
  48. doi request reprint Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis
    Linda Sharp
    National Cancer Registry Ireland, Cork, Ireland
    J Nutr 143:1966-73. 2013
    ..15; 95% CI: 3.61, 18.40). The same group had increased BE risk (OR: 2.93; 95% CI: 1.24, 6.92; P-interaction = 0.12). Folate and other dietary methyl-group factors are implicated in the etiology of EAC and its precursors...
  49. doi request reprint Cost-effectiveness of computed tomography colonography in colorectal cancer screening: a systematic review
    Paul Hanly
    Health Economist, National Cancer Registry Ireland, Cork, Ireland
    Int J Technol Assess Health Care 28:415-23. 2012
    ..CT-colonography (CTC) is one of several screening tests available. We systematically reviewed evidence on, and identified key factors influencing, cost-effectiveness of CTC screening...
  50. pmc Is there evidence for aetiologically distinct subgroups of idiopathic congenital talipes equinovarus? A case-only study and pedigree analysis
    Amanda H Cardy
    Clubfoot Research Group, University of Aberdeen, Aberdeen, Scotland
    PLoS ONE 6:e17895. 2011
    ..Previous studies consider CTEV as a homogenous entity which may conceal risk factors in particular subgroups. We investigate evidence for aetiologically distinct subgroups of CTEV...
  51. ncbi request reprint Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review
    L F Masson
    Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 161:901-15. 2005
    ....
  52. doi request reprint Major inter-laboratory variations in PSA testing practices: results from national surveys in Ireland in 2006 and 2007
    F J Drummond
    National Cancer Registry Ireland, Building 6800, Airport Business Park, Kinsale Rd, Cork, Ireland
    Ir J Med Sci 177:317-23. 2008
    ..Ireland had the highest prostate cancer incidence in Europe in 2006. In that year, the National Cancer Forum (NCF) recommended against prostate specific antigen (PSA) testing for population-based screening...
  53. doi request reprint Trends in prostate specific antigen testing in Ireland: lessons from a country without guidelines
    F J Drummond
    National Cancer Registry, Building 6800, Airport Business Park, Kinsale Rd, Cork, Ireland
    Ir J Med Sci 179:43-9. 2010
    ..Prostate specific antigen (PSA) testing is associated with increased prostate cancer (PCa) incidence. Ireland has no national guidelines on PCa screening and had the highest PCa incidence in Europe, 2006...
  54. pmc 'It's a can of worms': understanding primary care practitioners' behaviours in relation to HPV using the Theoretical Domains Framework
    Lisa A McSherry
    National Cancer Registry, Building 6800 Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Implement Sci 7:73. 2012
    ..A secondary objective was to informally assess the utility of the Theoretical Domains Framework (TDF) in understanding clinical behaviours in an area with an evolving evidence-base...
  55. pmc "If you can't treat HPV, why test for it?" Women's attitudes to the changing face of cervical cancer prevention: a focus group study
    Judith McRae
    National Cancer Registry, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    BMC Womens Health 14:64. 2014
    ..Women's views on the transformation of cervical cancer prevention have been relatively little investigated...
  56. doi request reprint Hospital and surgeon caseload are associated with risk of re-operation following breast-conserving surgery
    Marianna de Camargo Cancela
    National Cancer Registry, Building 6800, Airport Business Park, Kinsale Road, Cork, Ireland
    Breast Cancer Res Treat 140:535-44. 2013
    ..Our results may inform the development of information strategies to help ensure that women are aware of risks of re-operation following BCS and hence, make appropriate treatment choices. ..
  57. ncbi request reprint Colon cancer and genetic variation in folate metabolism: the clinical bottom line
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
    J Nutr 133:3758S-3766S. 2003
    ....
  58. pmc Lifestyle and socio-demographic factors associated with high-risk HPV infection in UK women
    S C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland
    Br J Cancer 97:133-9. 2007
    ..In stratified analyses, current smear status and age remained associated with hrHPV infection. Data of this type are relevant to the debate on human papillomavirus (HPV) testing in screening and development of HPV vaccination programmes...
  59. ncbi request reprint N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review
    N Brockton
    Department of Medicine and Therapeutics, University of Aberdeen, Scotland, United Kingdom
    Am J Epidemiol 151:846-61. 2000
    ....
  60. ncbi request reprint Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review
    S C Cotton
    Department of Medicine and Therapeutics, Faculty of Medicine and Medical Sciences, University of Aberdeen, Scotland
    Am J Epidemiol 151:7-32. 2000
    ..These finding require confirmation. Methods for determining GSTM1 and GSTT1 genotype are well established. Population testing is not currently justified...
  61. pmc CYP3A4 and VDR gene polymorphisms and the risk of prostate cancer in men with benign prostate hyperplasia
    M T Tayeb
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresthill, UK
    Br J Cancer 88:928-32. 2003
    ..43; 95% CI=0.99-11.77). While independent confirmation is required in further studies, these results provide a potential tool to assist prediction strategies for this important disease...
  62. ncbi request reprint Developing a questionnaire to measure the psychosocial impact of an abnormal cervical smear result and its subsequent management: the TOMBOLA (Trial of Management of Borderline and Other Low-grade Abnormal Smears) trial
    N M Gray
    Department of Public Health, University of Aberdeen, Foresterhill, Aberdeen, UK
    Qual Life Res 14:1553-62. 2005
    ..The POSM will enable comparison of the alternative management policies for low-grade cervical smears in terms of the benefits (or otherwise) perceived by the women managed by these policies...
  63. ncbi request reprint Motivators for women to attend cervical screening: the influential role of GPs
    Mairead O'Connor
    National Cancer Registry, Building 6800, Cork Airport Business Park, Kinsale Road, Cork and
    Fam Pract 31:475-82. 2014
    ..Moreover, little is known about health care provider/practitioner-level barriers and facilitators to participation. Better understanding of these issues could help inform strategies to improve participation...
  64. pmc Increasing late stage colorectal cancer and rectal cancer mortality demonstrates the need for screening: a population based study in Ireland, 1994-2010
    Nicholas Clarke
    National Cancer Registry, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    BMC Gastroenterol 14:92. 2014
    ..This paper describes trends in colorectal cancer incidence, survival and mortality from 1994 to 2010 in Ireland prior to the introduction of population-based screening...
  65. doi request reprint Is there under-treatment of pancreatic cancer? Evidence from a population-based study in Ireland
    L Sharp
    National Cancer Registry, Building 6800, Cork Airport Business Park, Kinsale Road, Cork, Ireland
    Eur J Cancer 45:1450-9. 2009
    ....
  66. ncbi request reprint Impact of PSA testing and prostatic biopsy on cancer incidence and mortality: comparative study between the Republic of Ireland and Northern Ireland
    A E Carsin
    National Cancer Registry Ireland, Cork, Ireland
    Cancer Causes Control 21:1523-31. 2010
    ..To investigate the impact of different PSA testing policies and health-care systems on prostate cancer incidence and mortality in two countries with similar populations, the Republic of Ireland (RoI) and Northern Ireland (NI)...
  67. ncbi request reprint Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR)
    L Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill House Annex, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Cancer Lett 181:65-71. 2002
    ..Patterns in risk with regard to genotype and folate combinations are broadly similar those reported for colorectal neoplasia. The roles of MTHFR and folate in breast cancer aetiology are likely to be complex...
  68. pmc Psychological effects of a low-grade abnormal cervical smear test result: anxiety and associated factors
    N M Gray
    Department of General Practice and Primary Care, Foresterhill Health Centre, University of Aberdeen and Grampian University Hospitals, Aberdeen, UK
    Br J Cancer 94:1253-62. 2006
    ....
  69. ncbi request reprint The role of human papillomavirus testing in the management of women with low-grade abnormalities: multicentre randomised controlled trial
    S Cotton
    Department of Public Health, University of Aberdeen, Aberdeen, UK
    BJOG 117:645-59. 2010
    ....
  70. ncbi request reprint Colorectal neoplasia and genetic polymorphisms associated with folate metabolism
    J Little
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Polwarth Building, Foresterhill, Aberdeen, Scotland, AB25 2ZD, UK
    Eur J Cancer Prev 11:105-10. 2002
  71. ncbi request reprint Patterns of care and effects on mortality for cancers of the oesophagus and gastric cardia: a population-based study
    D P Cronin-Fenton
    National Cancer Registry, Ireland, Elm Court, Boreenmanna Road, Cork, Ireland
    Eur J Cancer 43:565-75. 2007
    ..We investigated temporal trends in treatment, and factors influencing treatment receipt and survival, for upper gastrointestinal cancers in routine community-based clinical practice...
  72. ncbi request reprint Vitamin D receptor, HER-2 polymorphisms and risk of prostate cancer in men with benign prostate hyperplasia
    Mohammed T Tayeb
    Department of Medical Sciences, Faculty of Medicine and Medical Sciences, Umm Al Qura University, Makkah, Kingdom of Saudi Arabia
    Saudi Med J 25:447-51. 2004
    ..This study used a case-control design to assess the predictive value of 3 polymorphisms in VDR (TaqI and FokI) and HER-2 (Val655Ile) to determine the risk of developing PRCa in patients with BPH...
  73. ncbi request reprint Folate, DNA stability and colo-rectal neoplasia
    Susan J Duthie
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 63:571-8. 2004
    ..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...
  74. ncbi request reprint Evidence for an age-related influence of microsatellite instability on colorectal cancer survival
    Susan M Farrington
    Colon Cancer Genetics Group, University of Edinburgh, Edinburgh, United Kingdom
    Int J Cancer 98:844-50. 2002
    ..These findings underscore the rationale for surveillance and early identification of tumours in MMR gene carriers as well as refining understanding of the influence of MSI on cancer progression...
  75. ncbi request reprint United Kingdom cervical cancer screening and the costs of time and travel
    Claire Woolley
    University of Nottingham, UK
    Int J Technol Assess Health Care 23:232-9. 2007
    ....
  76. ncbi request reprint Functional analysis of mouse hepatocytes differing in DNA content: volume, receptor expression, and effect of IFNgamma
    Nicola C Martin
    Department of Pathology, University of Edinburgh, Medical School, United Kingdom
    J Cell Physiol 191:138-44. 2002
    ..Although the function of polyploidy remains unanswered, we have described some of the characteristics of polyploidy in isolated hepatocytes and in vitro...