M J Kerin

Summary

Affiliation: National University of Ireland
Country: Ireland

Publications

  1. pmc Advances in mesenchymal stem cell-mediated gene therapy for cancer
    Roisin M Dwyer
    Division of Surgery, School of Medicine, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
    Stem Cell Res Ther 1:25. 2010
  2. pmc Breast cancer research output, 1945-2008: a bibliometric and density-equalizing analysis
    Ronan W Glynn
    Department of Surgery, Clinical Science Institute, National University of Ireland Galway, Costello Road, Galway, Ireland
    Breast Cancer Res 12:R108. 2010
  3. pmc MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer
    Aoife J Lowery
    Department of Surgery, Clinical Science Institute, University Hospital National University of Ireland Galway, Galway, Ireland
    Breast Cancer Res 11:R27. 2009
  4. pmc Evolution of breast cancer management in Ireland: a decade of change
    Helen M Heneghan
    Department of Surgery, National University of Ireland Galway, Ireland
    BMC Surg 9:15. 2009
  5. pmc Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer
    Pamela A Davoren
    Department of Surgery, National University of Ireland, Galway, Ireland
    BMC Mol Biol 9:76. 2008
  6. pmc Evaluation and validation of candidate endogenous control genes for real-time quantitative PCR studies of breast cancer
    Roisin E McNeill
    Department of Surgery, Clinical Science Institute, National University of Ireland, Galway, Ireland
    BMC Mol Biol 8:107. 2007
  7. pmc Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer
    Elrasheid A H Kheirelseid
    Department of Surgery, National University of Ireland, Galway, Ireland
    BMC Mol Biol 11:12. 2010
  8. pmc The effect of breast cancer awareness month on internet search activity--a comparison with awareness campaigns for lung and prostate cancer
    Ronan W Glynn
    Department of Surgery, National University of Ireland Galway, Ireland
    BMC Cancer 11:442. 2011
  9. pmc Complementary and alternative medicine use in oncology: a questionnaire survey of patients and health care professionals
    Kah Hoong Chang
    Department of Surgery, University College Hospital Galway, National University of Ireland
    BMC Cancer 11:196. 2011
  10. pmc The effect of menopause and hysterectomy on systemic vascular endothelial growth factor in women undergoing surgery for breast cancer
    Aoife J Lowery
    Department of Surgery, Clinical Science Institute, University College Hospital Galway, Galway, Ireland
    BMC Cancer 8:279. 2008

Collaborators

Detail Information

Publications44

  1. pmc Advances in mesenchymal stem cell-mediated gene therapy for cancer
    Roisin M Dwyer
    Division of Surgery, School of Medicine, Clinical Science Institute, National University of Ireland Galway, Galway, Ireland
    Stem Cell Res Ther 1:25. 2010
    ....
  2. pmc Breast cancer research output, 1945-2008: a bibliometric and density-equalizing analysis
    Ronan W Glynn
    Department of Surgery, Clinical Science Institute, National University of Ireland Galway, Costello Road, Galway, Ireland
    Breast Cancer Res 12:R108. 2010
    ....
  3. pmc MicroRNA signatures predict oestrogen receptor, progesterone receptor and HER2/neu receptor status in breast cancer
    Aoife J Lowery
    Department of Surgery, Clinical Science Institute, University Hospital National University of Ireland Galway, Galway, Ireland
    Breast Cancer Res 11:R27. 2009
    ....
  4. pmc Evolution of breast cancer management in Ireland: a decade of change
    Helen M Heneghan
    Department of Surgery, National University of Ireland Galway, Ireland
    BMC Surg 9:15. 2009
    ..We aimed to assess the changing practices of breast cancer management over the last decade within a specialist tertiary referral Breast Cancer Centre...
  5. pmc Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer
    Pamela A Davoren
    Department of Surgery, National University of Ireland, Galway, Ireland
    BMC Mol Biol 9:76. 2008
    ..This is the first study to identify reliable ECs for analysis of miRNA by RQ-PCR in human breast tissue...
  6. pmc Evaluation and validation of candidate endogenous control genes for real-time quantitative PCR studies of breast cancer
    Roisin E McNeill
    Department of Surgery, Clinical Science Institute, National University of Ireland, Galway, Ireland
    BMC Mol Biol 8:107. 2007
    ..Oestrogen receptor alpha (ESR1) was used a target gene to compare the effect of choice of EC on the estimate of gene quantity...
  7. pmc Identification of endogenous control genes for normalisation of real-time quantitative PCR data in colorectal cancer
    Elrasheid A H Kheirelseid
    Department of Surgery, National University of Ireland, Galway, Ireland
    BMC Mol Biol 11:12. 2010
    ..The purpose of this study was to evaluate a panel of candidate EC genes from which to identify the most stably expressed gene(s) to normalise RQ-PCR data derived from primary colorectal cancer tissue...
  8. pmc The effect of breast cancer awareness month on internet search activity--a comparison with awareness campaigns for lung and prostate cancer
    Ronan W Glynn
    Department of Surgery, National University of Ireland Galway, Ireland
    BMC Cancer 11:442. 2011
    ..We further aimed to assess overall levels of online activity relating to all three neoplasms between 2004 and 2009...
  9. pmc Complementary and alternative medicine use in oncology: a questionnaire survey of patients and health care professionals
    Kah Hoong Chang
    Department of Surgery, University College Hospital Galway, National University of Ireland
    BMC Cancer 11:196. 2011
    ....
  10. pmc The effect of menopause and hysterectomy on systemic vascular endothelial growth factor in women undergoing surgery for breast cancer
    Aoife J Lowery
    Department of Surgery, Clinical Science Institute, University College Hospital Galway, Galway, Ireland
    BMC Cancer 8:279. 2008
    ..The aims of this study were to investigate circulating VEGF levels in breast cancer patients and assess the effect of menopause or hysterectomy on systemic VEGF...
  11. pmc Dysregulated miR-183 inhibits migration in breast cancer cells
    Aoife J Lowery
    Department of Surgery, National University of Ireland, Galway, Ireland
    BMC Cancer 10:502. 2010
    ..MiR-183 is located on chromosome 7q32 and is part of a miRNA family which are dysregulated in numerous cancers. The aims of this study were to further examine the expression and functional role of miR-183 in breast cancer...
  12. pmc MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer
    Kah Hoong Chang
    Department of Surgery, National University of Ireland, Galway, Republic of Ireland
    BMC Cancer 10:173. 2010
    ..However, few reports detailed a robust identification and validation strategy for suitable reference genes for normalisation in miRNA RT-qPCR studies...
  13. doi request reprint General paediatric surgery in Ireland: a crisis in evolution
    M J Kerin
    Department of Surgery, Clinical Science Institute, University College Hospital, Galway, Ireland
    Ir J Med Sci 177:9-10. 2008
  14. pmc Younger age as a prognostic indicator in breast cancer: a cohort study
    Elrasheid H A Kheirelseid
    Department of Surgery, National University of Ireland, Galway, Ireland
    BMC Cancer 11:383. 2011
    ..The objectives of this study were to determine the incidence of breast cancer in women under 40 years old and to analyse the clinicopathological characteristics and outcome compared to an older patient cohort...
  15. doi request reprint Quality of life after immediate breast reconstruction and skin-sparing mastectomy - a comparison with patients undergoing breast conserving surgery
    H M Heneghan
    Department of Surgery, National University of Ireland, Clinical Science Institute, Galway, Ireland
    Eur J Surg Oncol 37:937-43. 2011
    ..Our primary aim was to assess patient's quality of life after IBR, compared to a matched group undergoing breast conservation. We also investigated the oncological safety and morbidity associated with immediate reconstruction...
  16. doi request reprint Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)
    F T Martin
    Department of Surgery, National University of Ireland Galway, Galway, Ireland
    Breast Cancer Res Treat 124:317-26. 2010
    ..Breast cancer cell morphology and growth pattern also altered in response to MSCs. MSCs may promote breast cancer metastasis through facilitation of EMT...
  17. doi request reprint Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers
    H M Heneghan
    Department of Surgery, National University of Ireland, Galway, Galway, Ireland
    J Clin Endocrinol Metab 96:E846-50. 2011
    ..This study sought to characterize the miRNA expression in omentum, sc fat and in the circulation of obese and nonobese individuals. Their potential as noninvasive metabolic biomarkers was also explored...
  18. doi request reprint MicroRNA-21 and PDCD4 expression in colorectal cancer
    K H Chang
    Department of Surgery, National University of Ireland, Galway, Ireland
    Eur J Surg Oncol 37:597-603. 2011
    ..The purpose of this study was to delineate the interaction between PDCD4 and its oncogenic modulator miR-21 in colorectal cancer...
  19. doi request reprint Evaluation of variants in the CHEK2, BRIP1 and PALB2 genes in an Irish breast cancer cohort
    N M McInerney
    Department of Surgery, Clinical Science Institute, University College Hospital, Galway, Ireland
    Breast Cancer Res Treat 121:203-10. 2010
    ..We found no evidence to suggest that PALB2 mutation is an important breast cancer predisposition gene in this population...
  20. doi request reprint Systemic mirnas as potential biomarkers for malignancy
    N A Healy
    Discipline of Surgery, National University of Ireland, Galway, Republic of Ireland
    Int J Cancer 131:2215-22. 2012
    ..In addition, this review questions the source of these small molecules in the bloodstream and how they may possibly play a role in the future detection of cancer as either prognostic or predictive markers...
  21. doi request reprint Circulating miR-34a levels are reduced in colorectal cancer
    M Nugent
    Department of Surgery, National University of Ireland, Galway, Ireland
    J Surg Oncol 106:947-52. 2012
    ..Most work has focused on tissue and cell expression with few reports of circulating miRNAs in colorectal cancer. Available biomarkers for colorectal cancer have limited sensitivity and specificity, thus there is a need for new markers...
  22. doi request reprint A study of pre-operative type and screen in breast surgery: improved efficiency and cost saving
    R S Prichard
    Surgical Professorial Unit, Department of Surgery, University College Hospital Galway, Galway, Ireland
    Ir J Med Sci 180:513-6. 2011
    ..The aim of this study was to ascertain whether pre-operative blood typing is justified in patients undergoing surgical procedures with an intermediate transfusion probability...
  23. doi request reprint Mesenchymal stem cells and cancer: tumor-specific delivery vehicles or therapeutic targets?
    R M Dwyer
    Division of Surgery, School of Medicine, National University of Ireland, Galway, Ireland
    Hum Gene Ther 21:1506-12. 2010
    ..Elucidation of any potential negative effect of MSCs in the tumor setting will support development of protocols to minimize these effects while taking full advantage of the remarkable tumor-homing capacity of these cells...
  24. doi request reprint The h index and the identification of global benchmarks for breast cancer research output
    N A Healy
    Department of Surgery, National University of Ireland, Galway, Clinical Science Institute, Costello Road, Galway, Republic of Ireland
    Breast Cancer Res Treat 127:845-51. 2011
    ..Our findings suggest that there is need for wider involvement of surgeons in the research process and raises questions regarding the future of scientific breast surgery...
  25. ncbi request reprint Pregnancy associated breast cancer
    M Makgasa
    Department of Surgery, University College Hospital Galway, Galway
    Ir Med J 102:314-7. 2009
    ..3%) of the PABC patients. At median follow up of 36 months, there was a single mortality and two patients (17%) had developed recurrent disease. All children are healthy with no deformity or learning disability...
  26. doi request reprint Prospective matched-pair comparison of outcome after treatment for lobular and ductal breast carcinoma
    J Ní Mhuircheartaigh
    Department of Surgery, University College Hospital, Galway, Ireland
    Br J Surg 95:827-33. 2008
    ..The aim of this study was to compare the outcome in age- and stage-matched patients with lobular carcinoma and those with invasive breast cancer, and in particular to compare predictors of outcome...
  27. doi request reprint Role of microRNAs in obesity and the metabolic syndrome
    H M Heneghan
    Department of Surgery, National University of Ireland, Galway, Ireland
    Obes Rev 11:354-61. 2010
    ..This review discusses the role of miRNAs in obesity and related components of the metabolic syndrome, and highlights the potential of using miRNAs as novel biomarkers and therapeutic targets for these diseases...
  28. pmc An evaluation of preoperative CA 15-3 measurement in primary breast carcinoma
    M J Kerin
    Department of Surgery, University College Hospital, Galway, Ireland
    Br J Cancer 71:1288-91. 1995
    ..We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma...
  29. doi request reprint 17q12-21 - the pursuit of targeted therapy in breast cancer
    R W Glynn
    Department of Surgery, Clinical Science Institute, National University of Ireland, Costello Road, Galway, Ireland
    Cancer Treat Rev 36:224-9. 2010
    ....
  30. ncbi request reprint A comparative study of risk factors and prognostic features between symptomatic and screen detected breast cancer
    J P Burke
    Department of Surgery, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland
    Eur J Surg Oncol 34:149-53. 2008
    ..To compare prognostic factors in screen detected breast cancer (SDBC) and symptomatically presenting breast cancer (SBC)...
  31. pmc MicroRNAs as Novel Biomarkers for Breast Cancer
    H M Heneghan
    Department of Surgery, Clinical Science Institute, National University of Ireland, Galway, Ireland
    J Oncol 2009:950201. 2009
    ..Finally, we comment on the potential role of miRNAs in breast cancer management, particularly in improving current prognostic tools and achieving the goal of individualized cancer treatment...
  32. doi request reprint MicroRNAs in colorectal cancer: function, dysregulation and potential as novel biomarkers
    M Nugent
    National University of Ireland, Galway, Ireland
    Eur J Surg Oncol 37:649-54. 2011
    ..These altered expression patterns may serve as novel biomarkers for colorectal cancer. This review explores recent developments in this rapidly evolving field...
  33. doi request reprint Authorship trends in the surgical literature
    R W Glynn
    Department of Surgery, National University of Ireland, Galway, Clinical Science Institute, Costello Road, Galway, Ireland
    Br J Surg 97:1304-8. 2010
    ..This study aimed to examine authorship trends in surgical titles between 1998 and 2008, and to compare these trends with those in general medicine publications...
  34. ncbi request reprint Preparing new doctors for clinical practice: an evaluation of pre-internship training
    D Byrne
    Department of Surgery, Galway University Hospitals, Newcastle Road, Galway
    Ir Med J 105:328-30. 2012
    ..Nevertheless, it is suggested that this course serve as a model to address the unsatisfactory levels of preparedness for the work of a junior reported by medical students from many countries...
  35. doi request reprint Changing practices in the surgical management of hyperparathyroidism - A 10-year review
    T McVeigh
    Department of Surgery, Galway University Hospital, Galway, Ireland Electronic address
    Surgeon 10:314-20. 2012
    ..We aimed to assess changing surgical practices and their impact on the management of parathyroid disease in a tertiary referral centre in the West of Ireland...
  36. ncbi request reprint A pilot project of European Working Time Directive compliant rosters in a university teaching hospital
    J T Garvin
    Department of Surgery, University Hospital Galway, Ireland
    Surgeon 6:88-93. 2008
    ..As part of this process, a pilot EWTD compliant rota was run for six weeks amongst general surgical SHOs in University Hospital Galway...
  37. doi request reprint Factors influencing medical students and junior doctors in choosing a career in surgery
    R W Glynn
    Department of Surgery, University College Hospital, Galway, Ireland
    Surgeon 8:187-91. 2010
    ..We aimed to determine the views of medical students and junior doctors regarding influences on their career aspirations, such that potential disincentives to a career in surgery could be identified...
  38. ncbi request reprint Justifying adjuvant chemotherapy in breast cancer: a survey of women and healthcare professionals
    K J Sweeney
    Department of Surgery, Clinical Science Institute, University College Hospital, Galway, Ireland
    Eur J Surg Oncol 33:838-42. 2007
    ..The absolute survival gains required to make adjuvant chemotherapy acceptable to women are unknown. We questioned women and healthcare professionals on the absolute survival benefits required to make adjuvant chemotherapy acceptable...
  39. ncbi request reprint Graves' ophthalmopathy: the case for thyroid surgery
    A J Lowery
    Clinical Science Institute, University College Hospital Galway, National University of Ireland Galway, Galway, Ireland
    Surgeon 7:290-6. 2009
    ..This review discusses the indications for surgical intervention in Graves' disease, with specific focus on the extent of resection and the relative merits of subtotal and total thyroidectomy in patients with GO...
  40. ncbi request reprint Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells
    R M Dwyer
    Department of Surgery, National University of Ireland, Galway, Ireland
    Clin Cancer Res 13:5020-7. 2007
    ..This study is aimed at investigating factors mediating homing of human MSCs to breast cancer primary cultures and cell lines in vitro and in vivo...
  41. doi request reprint Cyclical ischaemic preconditioning modulates the adaptive immune response in human limb ischaemia-reperfusion injury
    P J Sullivan
    Department of Surgery, Galway University Hospitals National University of Ireland, Galway, Ireland
    Br J Surg 96:381-90. 2009
    ..Ischaemic preconditioning (IPC) modulates RI and the innate immune response. This study examined whether IPC attenuates RI-mediated changes in lymphocyte populations and function following elective surgery...
  42. ncbi request reprint A comparison of surgical impression, histological findings and microbiological results at open appendicectomy
    G Colleran
    Department of Surgery, Clinical Science Institute, University College Hospital, Galway
    Ir Med J 100:593-6. 2007
    ....
  43. ncbi request reprint Breast reconstruction in the United Kingdom and Ireland
    C J Callaghan
    Cambridge Breast Unit, Addenbrooke s Hospital and Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Br J Surg 89:335-40. 2002
    ..The aims of this study were to define current practice of breast reconstruction in the UK and Ireland, and to identify the characteristics of surgeons who use immediate breast reconstruction...
  44. ncbi request reprint The clinical and pathological differences in prevalent round screen-detected and symptomatic invasive breast cancer
    K J Sweeney
    Department of Surgery, Mater Misericordiae Hospital, Eccles Street, Dublin 7
    Ir Med J 100:550-2. 2007
    ..This study suggests that tumours detected by screening during the prevalent round of a screening programme are of a more prognostically favourable type than symptomatic breast cancers in the same age group...