Gary W Jones

Summary

Affiliation: National University of Ireland
Country: Ireland

Publications

  1. ncbi Chaperoning prions: the cellular machinery for propagating an infectious protein?
    Gary W Jones
    Department of Biology, National University of Ireland, Maynooth, Co Kildare Ireland
    Bioessays 27:823-32. 2005
  2. pmc Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo
    Ciara Moran
    Yeast Genetics Laboratory, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    G3 (Bethesda) 3:1409-18. 2013
  3. ncbi Influence of Hsp70 chaperone machinery on yeast prion propagation
    Emma Guinan
    Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    Protein Pept Lett 16:583-6. 2009
  4. pmc Importance of the Hsp70 ATPase domain in yeast prion propagation
    Harriet M Loovers
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Genetics 175:621-30. 2007
  5. pmc Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes
    David A Fitzpatrick
    Genome Evolution Laboratory, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    PLoS ONE 6:e28684. 2011
  6. pmc Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity
    Naushaba Hasin
    Yeast Genetics Laboratory, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    BMC Genomics 15:194. 2014
  7. pmc Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus
    Karen A O'Hanlon
    Biotechnology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Nucleic Acids Res 40:7806-20. 2012
  8. doi Insights into the mechanism of prion propagation
    Sarah Perrett
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Curr Opin Struct Biol 18:52-9. 2008
  9. ncbi Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils
    Hui Yong Lian
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    J Biol Chem 282:11931-40. 2007
  10. ncbi The yeast prion protein Ure2: structure, function and folding
    Hui Yong Lian
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Biochim Biophys Acta 1764:535-45. 2006

Collaborators

Detail Information

Publications12

  1. ncbi Chaperoning prions: the cellular machinery for propagating an infectious protein?
    Gary W Jones
    Department of Biology, National University of Ireland, Maynooth, Co Kildare Ireland
    Bioessays 27:823-32. 2005
    ....
  2. pmc Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo
    Ciara Moran
    Yeast Genetics Laboratory, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    G3 (Bethesda) 3:1409-18. 2013
    ..Our results suggest that Sse1 can influence prion propagation through a variety of different mechanisms. ..
  3. ncbi Influence of Hsp70 chaperone machinery on yeast prion propagation
    Emma Guinan
    Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    Protein Pept Lett 16:583-6. 2009
    ..The following minireview focuses on the Hsp70 chaperone family and it's involvement in the propagation of yeast prions...
  4. pmc Importance of the Hsp70 ATPase domain in yeast prion propagation
    Harriet M Loovers
    Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Genetics 175:621-30. 2007
    ..Analysis of the effects of Hsp70 mutants upon propagation of a second yeast prion [URE3] further classifies these mutants as having general or prion-specific inhibitory properties...
  5. pmc Assessment of inactivating stop codon mutations in forty Saccharomyces cerevisiae strains: implications for [PSI] prion- mediated phenotypes
    David A Fitzpatrick
    Genome Evolution Laboratory, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    PLoS ONE 6:e28684. 2011
    ....
  6. pmc Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity
    Naushaba Hasin
    Yeast Genetics Laboratory, Department of Biology, National University of Ireland Maynooth, Maynooth, County Kildare, Ireland
    BMC Genomics 15:194. 2014
    ..Additionally we also analysed the global gene expression patterns in yeast strains expressing individual Ssa proteins, using microarray and RT-qPCR analysis...
  7. pmc Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus
    Karen A O'Hanlon
    Biotechnology Laboratory, Department of Biology, National University of Ireland, Maynooth, County Kildare, Ireland
    Nucleic Acids Res 40:7806-20. 2012
    ..Our data constitute the first detailed characterization of the molecular mechanism of the adaptive response in a lower eukaryote and has applications for development of novel fungal therapeutics targeting this DNA repair system...
  8. doi Insights into the mechanism of prion propagation
    Sarah Perrett
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Curr Opin Struct Biol 18:52-9. 2008
    ..Whether aspects of the mechanisms of formation, maintenance and clearance of prions are conserved between fungi and mammals remains to be seen...
  9. ncbi Hsp40 interacts directly with the native state of the yeast prion protein Ure2 and inhibits formation of amyloid-like fibrils
    Hui Yong Lian
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    J Biol Chem 282:11931-40. 2007
    ..In contrast, Hdj2, which did not suppress fibril formation, did not show this interaction. The results suggest that Ydj1 inhibits Ure2 fibril formation by binding to the native state of Ure2, thus delaying the onset of oligomerization...
  10. ncbi The yeast prion protein Ure2: structure, function and folding
    Hui Yong Lian
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Biochim Biophys Acta 1764:535-45. 2006
    ..The relationship between structure, function and folding for the yeast prion Ure2 are discussed...
  11. pmc Saccharomyces cerevisiae Hsp70 mutations affect [PSI+] prion propagation and cell growth differently and implicate Hsp40 and tetratricopeptide repeat cochaperones in impairment of [PSI+]
    Gary W Jones
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 163:495-506. 2003
    ..Other suppressing mutations are in residues important for interactions with Hsp40 or TPR-containing cochaperones, suggesting that such interactions are necessary for the impairment of [PSI(+)] propagation caused by mutant Ssa1p...
  12. ncbi The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells
    Peter W Piper
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Aging Cell 1:149-57. 2002
    ..They often arrest growth with their last bud strongly attached and with the mitochondria adjacent to the septum between the mother and the daughter cell...