Affiliation: Dublin City University
Taupin P. Apigenin and related compounds stimulate adult neurogenesis. Mars, Inc., the Salk Institute for Biological Studies: WO2008147483. Expert Opin Ther Pat. 2009;19:523-7 pubmed publisher
Taupin P. Neurogenic drugs and compounds. Recent Pat CNS Drug Discov. 2010;5:253-7 pubmed
..Here, we reviewed and discussed recent patents on neurogenic drugs and compounds, particularly nootropic agents and apigenin and related compounds. ..
Taupin P. Adult neurogenesis, neural stem cells and Alzheimer's disease: developments, limitations, problems and promises. Curr Alzheimer Res. 2009;6:461-70 pubmed
..Limitations in protocols to establish homogeneous populations of neural progenitor and stem cells and niches for neurogenesis need to be resolved and unlocked, for the full potential of adult NSCs to be realized for therapy. ..
Taupin P. A dual activity of ROS and oxidative stress on adult neurogenesis and Alzheimer's disease. Cent Nerv Syst Agents Med Chem. 2010;10:16-21 pubmed
..Antioxidant may be used to reduce the deleterious activity of ROS, particularly on newly generated neuronal cells of the adult brain, potentially delaying the development of AD and promoting the regenerative capacity of the adult brain. ..
Taupin P. Neurogenic drugs and compounds to treat CNS diseases and disorders. Cent Nerv Syst Agents Med Chem. 2011;11:35-7 pubmed
Taupin P. A simple and direct pre-embedding technique for ultrastructure of scarce biological specimens. Biotech Histochem. 2008;83:253-7 pubmed publisher
..The ability to pre-embed scarce biological specimens efficiently and reproducibly provides a valuable way to study and characterize cytological tissues such as biopsies or cystic and amniotic fluid cells...
Taupin P. Nootropic agents stimulate neurogenesis. Brain Cells, Inc.: WO2007104035. Expert Opin Ther Pat. 2009;19:727-30 pubmed publisher
..The application claims the use of nootropic agents for their neurogenic activity and for the treatment of neurological diseases, disorders and injuries, by stimulating or increasing the generation of neuronal cells in the adult brain. ..
Taupin P. Transplantation of two populations of stem cells to improve engraftment: WO2008060932. Expert Opin Ther Pat. 2010;20:1259-63 pubmed publisher
..The procedure may be extended to other types of stem cells for treating a broad range of diseases and injuries. ..