P Meleady

Summary

Affiliation: Dublin City University
Country: Ireland

Publications

  1. ncbi Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 160:251-62. 2012
  2. ncbi Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Biotechnol Bioeng 109:1386-94. 2012
  3. ncbi Differential protein expression following low temperature culture of suspension CHO-K1 cells
    Niraj Kumar
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    BMC Biotechnol 8:42. 2008
  4. ncbi Bromodeoxyuridine increases keratin 19 protein expression at a posttranscriptional level in two human lung tumor cell lines
    P Meleady
    National Cell and Tissue Culture Centre, Dublin City University, Glasnevin, Dublin, Ireland
    In Vitro Cell Dev Biol Anim 37:536-42. 2001
  5. ncbi 2D gel electrophoresis and mass spectrometry identification and analysis of proteins
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Ireland
    Methods Mol Biol 784:123-37. 2011
  6. ncbi Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    BMC Biotechnol 11:78. 2011
  7. ncbi Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Cytotechnology 53:23-31. 2007
  8. ncbi Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Proteomics 8:2611-24. 2008
  9. ncbi MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines
    M K Muniyappa
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Eur J Cancer 45:3104-18. 2009
  10. ncbi Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness
    Y Liang
    National Cell and Tissue Culture Center/National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland
    Eur J Cancer 37:1041-52. 2001

Collaborators

Detail Information

Publications24

  1. ncbi Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 160:251-62. 2012
    ..This is the first report investigating the impact of a miRNA on the proteome of CHO cells...
  2. ncbi Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Biotechnol Bioeng 109:1386-94. 2012
    ..The new sequence information offers improved interpretation of proteomic analyses and will, in the years to come, prove vital to unraveling the CHO proteome...
  3. ncbi Differential protein expression following low temperature culture of suspension CHO-K1 cells
    Niraj Kumar
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    BMC Biotechnol 8:42. 2008
    ....
  4. ncbi Bromodeoxyuridine increases keratin 19 protein expression at a posttranscriptional level in two human lung tumor cell lines
    P Meleady
    National Cell and Tissue Culture Centre, Dublin City University, Glasnevin, Dublin, Ireland
    In Vitro Cell Dev Biol Anim 37:536-42. 2001
    ....
  5. ncbi 2D gel electrophoresis and mass spectrometry identification and analysis of proteins
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Ireland
    Methods Mol Biol 784:123-37. 2011
    ..e. lc-ms/ms...
  6. ncbi Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    BMC Biotechnol 11:78. 2011
    ....
  7. ncbi Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Cytotechnology 53:23-31. 2007
    ..In this review I will focus on the contribution of proteomic technologies to a greater understanding of the biology of Chinese hamster ovary cells and other producing cell lines such as NS0 mouse cells...
  8. ncbi Proteomic profiling of CHO cells with enhanced rhBMP-2 productivity following co-expression of PACEsol
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Proteomics 8:2611-24. 2008
    ..These results support the use of proteomic profiling as a valuable tool towards understanding the biology of bioprocess cultures...
  9. ncbi MiRNA-29a regulates the expression of numerous proteins and reduces the invasiveness and proliferation of human carcinoma cell lines
    M K Muniyappa
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Eur J Cancer 45:3104-18. 2009
    ..This function is likely mediated through the post-transcriptional fine tuning of the cellular levels of several proteins, both directly and indirectly, and in particular we provide some evidence that RAN represents one of these...
  10. ncbi Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness
    Y Liang
    National Cell and Tissue Culture Center/National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland
    Eur J Cancer 37:1041-52. 2001
    ....
  11. ncbi Proteomic investigation of taxol and taxotere resistance and invasiveness in a squamous lung carcinoma cell line
    L Murphy
    National Institute of Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biochim Biophys Acta 1784:1184-91. 2008
    ..A large number of differentially regulated proteins were identified in the resistant and invasive variants affecting cellular processes including stress response, protein turnover and cytoskeleton proteins...
  12. ncbi Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7
    N Barron
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    J Biotechnol 151:204-11. 2011
    ..Finally, we report the cloning and sequencing of the hamster-specific cgr-miR-7...
  13. ncbi Bromodeoxyuridine induces keratin protein synthesis at a posttranscriptional level in human lung tumour cell lines
    S McBride
    National Cell and Tissue Culture Centre, BioResearch Ireland, Dublin City University, Glasnevin, Ireland
    Differentiation 64:185-93. 1999
    ..This may represent a regulatory step in early lung development or a mechanism whereby tumour cells downregulate expression of a differentiated phenotype...
  14. ncbi Bromodeoxyuridine induces integrin expression at transcriptional (alpha2 subunit) and post-transcriptional (beta1 subunit) levels, and alters the adhesive properties of two human lung tumour cell lines
    P Meleady
    National Cell and Tissue Culture Centre, Dublin City University, Glasnevin, Dublin, Ireland
    Cell Commun Adhes 8:45-59. 2001
    ..The results presented here suggest that DLKP (and A549) may be useful cellular models to investigate the role of the alpha2beta1 integrin in lung epithelial cell differentiation...
  15. ncbi Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells
    P Dowling
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Anticancer Res 27:1309-17. 2007
    ..Selection of the human drug sensitive and invasive cell line (MDA-MB-435S-F) with the chemotherapeutic agent paclitaxel, resulted in the development of drug resistant cell lines displaying enhanced invasion-related characteristics...
  16. ncbi Proteomic profiling of secreted proteins from CHO cells using Surface-Enhanced Laser desorption ionization time-of-flight mass spectrometry
    Niraj Kumar
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biotechnol Prog 24:273-8. 2008
    ..From this study, 24 proteins were found to be differentially regulated at different phases of the growth cycle in CHO-K1 cells, when profiled on two chromatographic surfaces, Q10 (anionic) and IMAC30 (metal affinity) ProteinChip arrays...
  17. ncbi Proteomic analysis of isolated membrane fractions from superinvasive cancer cells
    Paul Dowling
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biochim Biophys Acta 1774:93-101. 2007
    ..These results suggest a correlation between the increased abundance of these proteins with the superinvasive phenotype of the paclitaxel-selected MDA-MB-435S-F/Taxol-10p4p population...
  18. ncbi Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress
    Paul Dowling
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Proteomics 6:6578-87. 2006
    ..These results suggest that non-GSIS MIN-6 cells do not have the same ability/capacity of glucose-responsive MIN-6 cells to successfully fold, modify or secrete proteins and counteract the problems associated with oxidative stress...
  19. ncbi Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis
    Paul Dowling
    The National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    J Proteomics 71:168-75. 2008
    ....
  20. ncbi 2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins
    Paul Dowling
    The National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Electrophoresis 28:4302-10. 2007
    ..The identification of lung cancer-specific biomarkers is crucial to early detection, which in turn could lead to a dramatic increase in survival rates...
  21. ncbi Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2
    Padraig Doolan
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Mol Biotechnol 39:187-99. 2008
    ..The results presented here support the use of large-scale microarray expression profiling as a viable and valuable route towards understanding the behaviour of bioprocess cultures in vitro...
  22. ncbi Proteomic approaches for serum biomarker discovery in cancer
    Priyanka Maurya
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Anticancer Res 27:1247-55. 2007
    ....
  23. ncbi Challenges in molecular analysis for individualized cancer therapy
    Martin Clynes
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Ireland
    Drug Discov Today 8:531. 2003
  24. ncbi Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines
    Derek Walsh
    National Cell and Tissue Culture Centre/National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Ireland
    Differentiation 71:126-34. 2003
    ....