Maria Davoren

Summary

Affiliation: Dublin Institute of Technology
Country: Ireland

Publications

  1. pmc Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells
    Kunal Bhattacharya
    Institut für Hygiene und Arbeitsmedizin, Universitat Duisburg Essen, Germany
    Part Fibre Toxicol 6:17. 2009
  2. ncbi In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells
    Maria Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 21:438-48. 2007
  3. ncbi In vitro cytotoxicity assessment of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol using established fish cell lines
    Maria Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 20:1190-201. 2006
  4. ncbi A test battery approach for the ecotoxicological evaluation of estuarine sediments
    M Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Ireland
    Ecotoxicology 14:741-55. 2005
  5. ncbi Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates
    M Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 19:421-31. 2005
  6. ncbi Ecotoxicological evaluation of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol
    M Davoren
    Ecotoxicology Unit, School of Science, Athlone Institute of Technology, Dublin Rd, Athlone, Co Westmeath, Ireland
    Ecotoxicol Environ Saf 60:203-12. 2005
  7. doi A test battery approach to the ecotoxicological evaluation of cadmium and copper employing a battery of marine bioassays
    Ailbhe Macken
    Radiation and Environmental Science Centre, Focas Institute, DIT, Dublin, Ireland
    Ecotoxicology 18:470-80. 2009
  8. doi SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro
    Eva Herzog
    Radiation and Environmental Science Centre RESC, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol Appl Pharmacol 234:378-90. 2009
  9. ncbi An ecotoxicological study of poly(amidoamine) dendrimers-toward quantitative structure activity relationships
    Pratap C Naha
    Radiation and Environmental Science Centre, and NanoLab, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Environ Sci Technol 43:6864-9. 2009
  10. doi An integrated approach to the toxicity assessment of Irish marine sediments: validation of established marine bioassays for the monitoring of Irish marine sediments
    Ailbhe Macken
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
    Environ Int 34:1023-32. 2008

Collaborators

Detail Information

Publications25

  1. pmc Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells
    Kunal Bhattacharya
    Institut für Hygiene und Arbeitsmedizin, Universitat Duisburg Essen, Germany
    Part Fibre Toxicol 6:17. 2009
    ....
  2. ncbi In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cells
    Maria Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 21:438-48. 2007
    ....
  3. ncbi In vitro cytotoxicity assessment of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol using established fish cell lines
    Maria Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 20:1190-201. 2006
    ..The EPC cells were found to be the most sensitive cell line tested based on Alamar Blue IC(50) data, and the Alamar Blue assay was consistently found to be the most sensitive endpoint of the three cytotoxicity assays employed...
  4. ncbi A test battery approach for the ecotoxicological evaluation of estuarine sediments
    M Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Ireland
    Ecotoxicology 14:741-55. 2005
    ..The findings of this study highlight that salinity effects and geophysical properties need to be taken into account when interpreting the results of the bioassays...
  5. ncbi Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriates
    M Davoren
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 19:421-31. 2005
    ..In order to fully evaluate the overall sensitivity of this cell line, further research is warranted using an extensive range of test sites incorporating more polluted sediments...
  6. ncbi Ecotoxicological evaluation of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol
    M Davoren
    Ecotoxicology Unit, School of Science, Athlone Institute of Technology, Dublin Rd, Athlone, Co Westmeath, Ireland
    Ecotoxicol Environ Saf 60:203-12. 2005
    ..The majority of ecotoxicity data obtained in this research has not been previously reported and may therefore assist in the management and planning decisions regarding the application of pesticides and utilisation of SMC...
  7. doi A test battery approach to the ecotoxicological evaluation of cadmium and copper employing a battery of marine bioassays
    Ailbhe Macken
    Radiation and Environmental Science Centre, Focas Institute, DIT, Dublin, Ireland
    Ecotoxicology 18:470-80. 2009
    ..DNA damage was measured as percent number of comets and normal cells. There was no significant DNA damage observed at any concentration of CuCl(2) tested and no correlation with growth inhibition and genetic damage was found...
  8. doi SWCNT suppress inflammatory mediator responses in human lung epithelium in vitro
    Eva Herzog
    Radiation and Environmental Science Centre RESC, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol Appl Pharmacol 234:378-90. 2009
    ..This was also true for TNF-alpha stimulated cells. The use of DPPC improved the degree of SWCNT dispersion in A549 medium and in turn, leads to increased particle toxicity, however, it was not shown to modify NHBE cell responses...
  9. ncbi An ecotoxicological study of poly(amidoamine) dendrimers-toward quantitative structure activity relationships
    Pratap C Naha
    Radiation and Environmental Science Centre, and NanoLab, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Environ Sci Technol 43:6864-9. 2009
    ..The clear correlations of the observed toxicresponse with themeasured physicochemical properties pointtoward underlying structure activity relationships...
  10. doi An integrated approach to the toxicity assessment of Irish marine sediments: validation of established marine bioassays for the monitoring of Irish marine sediments
    Ailbhe Macken
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
    Environ Int 34:1023-32. 2008
    ..The results of this study have important implications for risk assessment in estuarine and coastal waters in Ireland, where, at present the monitoring of sediment and water quality is predominantly reliant on chemical analysis alone...
  11. doi An integrated approach to the toxicity assessment of Irish marine sediments: application of porewater Toxicity Identification Evaluation (TIE) to Irish marine sediments
    Ailbhe Macken
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
    Environ Int 35:98-106. 2009
    ..Results from these TIEs provide insight into the complexity of interpreting marine TIE data from porewater studies where mixtures of unknown substances are present...
  12. ncbi A new approach to the toxicity testing of carbon-based nanomaterials--the clonogenic assay
    Eva Herzog
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol Lett 174:49-60. 2007
    ..All three particle types were highly effective in inhibiting cell proliferation in all three cell lines, whereas only HaCaT and BEAS-2B cells also showed decreased cell viability...
  13. ncbi Cellular responses in primary epidermal cultures from rainbow trout exposed to zinc chloride
    Sharon Ní Shúilleabháin
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Ecotoxicol Environ Saf 65:332-41. 2006
    ..This model system may help to further elucidate the effects of ecotoxicants on the external innate immune system of fish...
  14. doi In vitro mammalian cytotoxicological study of PAMAM dendrimers - towards quantitative structure activity relationships
    Sourav Prasanna Mukherjee
    Radiation and Environmental Science Centre, Focas Research Institute, Dublin Institute of Technology, Dublin 8, Ireland
    Toxicol In Vitro 24:169-77. 2010
    ..A trend of generation dependent toxic response and interaction of the dendrimers with the cell culture media was observed which may lay the basis of structure activity relationships...
  15. ncbi Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells
    Pratap C Naha
    Radiation and Environmental Science Centre, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol Appl Pharmacol 246:91-9. 2010
    ..The intracellular ROS generation and cytokine production induced cytotoxicity point towards the mechanistic pathway of cell death upon exposure to PAMAM dendrimers...
  16. doi Preparation, characterization of NIPAM and NIPAM/BAM copolymer nanoparticles and their acute toxicity testing using an aquatic test battery
    Pratap C Naha
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Aquat Toxicol 92:146-54. 2009
    ..No correlation with particle size was observed. The sensitivity of the test species was seen to vary depending on copolymer composition. The relevance of the derived structure-activity relationships is discussed...
  17. doi Aquatic ecotoxicity of the selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of freshwater test species
    Elaine Minagh
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Ecotoxicol Environ Saf 72:434-40. 2009
    ....
  18. doi Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples
    Eva Herzog
    Radiation and Environmental Science Centre RESC, Focas Institute, Dublin Institute of Technology, Dublin, Ireland
    Toxicol Appl Pharmacol 236:276-81. 2009
    ..However, cell responses are strongly dependent on the vehicle used for dispersion. Whereas the presence of DPPC increased intracellular ROS formation, FCS seemed to protect the cells from oxidative insult...
  19. doi Raman spectroscopy--a potential platform for the rapid measurement of carbon nanotube-induced cytotoxicity
    Peter Knief
    School of Physics Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Analyst 134:1182-91. 2009
    ..This preliminary study demonstrates the potential of Raman spectroscopy as a probe of cytotoxicity to nanoparticle exposure...
  20. ncbi A model compound study: the ecotoxicological evaluation of five organic contaminants employing a battery of marine bioassays
    Ailbhe Macken
    Radiation and Environmental Science Centre, Focas Institute, DIT, Kevin Street, Dublin 8, Ireland
    Environ Pollut 153:627-37. 2008
    ..The results of this study have important implications for risk assessment in estuarine and coastal waters in Ireland, where, at present the monitoring of sediment and water quality is predominantly reliant on chemical analysis alone...
  21. doi Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells
    Sourav Prasanna Mukherjee
    Radiation and Environmental Science Centre, Focas Research Institute, Dublin, Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol Appl Pharmacol 248:259-68. 2010
    ..Overall, significant differences are observed between the responses of the dermal cell line, HaCaT, and the colon cell line, SW480, and it is suggested that these can be understood in terms of differing intrinsic antioxidant levels...
  22. ncbi In vitro cytotoxicity testing of three zinc metal salts using established fish cell lines
    S Ní Shúilleabháin
    Radiation and Environmental Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol In Vitro 18:365-76. 2004
    ..In conclusion, careful consideration should be given to study design and statistics applied and use of a battery style approach is recommended for toxicological screening studies...
  23. ncbi A test battery for the ecotoxicological evaluation of the agri-chemical Environ
    M Davoren
    Ecotoxicology Unit, School of Science, Athlone Institute of Technology, Dublin Road, Athlone, Co Westmeath, Ireland
    Ecotoxicol Environ Saf 59:116-22. 2004
    ..However, in vivo/in vitro comparisons in this instance we feel would be premature and imprecise owing to valid concerns regarding fish loading rates for the in vivo test, and exposure duration with the in vitro test...
  24. doi Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung cells
    A Casey
    School of Physics, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Toxicol Lett 179:78-84. 2008
    ....
  25. ncbi Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activity
    Sharon Ní Shúilleabháin
    Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
    Aquat Toxicol 73:115-27. 2005
    ..The findings of the functional study also demonstrated that environmental pollutants, which interfere with P-gp function, could be identified using this model...