Research Topics
| Maria DavorenSummaryAffiliation: Dublin Institute of Technology Country: Ireland Publications
| Collaborators
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Detail Information
Publications
Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cellsKunal Bhattacharya
Institut für Hygiene und Arbeitsmedizin, Universitat Duisburg Essen, Germany
Part Fibre Toxicol 6:17. 2009....- In vitro toxicity evaluation of single walled carbon nanotubes on human A549 lung cellsMaria Davoren
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol In Vitro 21:438-48. 2007.... - In vitro cytotoxicity assessment of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenol using established fish cell linesMaria Davoren
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol In Vitro 20:1190-201. 2006..The EPC cells were found to be the most sensitive cell line tested based on Alamar Blue IC(50) data, and the Alamar Blue assay was consistently found to be the most sensitive endpoint of the three cytotoxicity assays employed... - A test battery approach for the ecotoxicological evaluation of estuarine sedimentsM Davoren
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Ireland
Ecotoxicology 14:741-55. 2005..The findings of this study highlight that salinity effects and geophysical properties need to be taken into account when interpreting the results of the bioassays... - Assessing the potential of fish cell lines as tools for the cytotoxicity testing of estuarine sediment aqueous elutriatesM Davoren
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol In Vitro 19:421-31. 2005..In order to fully evaluate the overall sensitivity of this cell line, further research is warranted using an extensive range of test sites incorporating more polluted sediments... - Ecotoxicological evaluation of the biocidal agents sodium o-phenylphenol, sodium o-benzyl-p-chlorophenol, and sodium p-tertiary amylphenolM Davoren
Ecotoxicology Unit, School of Science, Athlone Institute of Technology, Dublin Rd, Athlone, Co Westmeath, Ireland
Ecotoxicol Environ Saf 60:203-12. 2005..The majority of ecotoxicity data obtained in this research has not been previously reported and may therefore assist in the management and planning decisions regarding the application of pesticides and utilisation of SMC... - A test battery approach to the ecotoxicological evaluation of cadmium and copper employing a battery of marine bioassaysAilbhe Macken
Radiation and Environmental Science Centre, Focas Institute, DIT, Dublin, Ireland
Ecotoxicology 18:470-80. 2009..DNA damage was measured as percent number of comets and normal cells. There was no significant DNA damage observed at any concentration of CuCl(2) tested and no correlation with growth inhibition and genetic damage was found... - SWCNT suppress inflammatory mediator responses in human lung epithelium in vitroEva Herzog
Radiation and Environmental Science Centre RESC, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol Appl Pharmacol 234:378-90. 2009..This was also true for TNF-alpha stimulated cells. The use of DPPC improved the degree of SWCNT dispersion in A549 medium and in turn, leads to increased particle toxicity, however, it was not shown to modify NHBE cell responses... - An ecotoxicological study of poly(amidoamine) dendrimers-toward quantitative structure activity relationshipsPratap C Naha
Radiation and Environmental Science Centre, and NanoLab, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Environ Sci Technol 43:6864-9. 2009..The clear correlations of the observed toxicresponse with themeasured physicochemical properties pointtoward underlying structure activity relationships... - An integrated approach to the toxicity assessment of Irish marine sediments: validation of established marine bioassays for the monitoring of Irish marine sedimentsAilbhe Macken
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
Environ Int 34:1023-32. 2008..The results of this study have important implications for risk assessment in estuarine and coastal waters in Ireland, where, at present the monitoring of sediment and water quality is predominantly reliant on chemical analysis alone... - An integrated approach to the toxicity assessment of Irish marine sediments: application of porewater Toxicity Identification Evaluation (TIE) to Irish marine sedimentsAilbhe Macken
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin St, Dublin 8, Ireland
Environ Int 35:98-106. 2009..Results from these TIEs provide insight into the complexity of interpreting marine TIE data from porewater studies where mixtures of unknown substances are present... - A new approach to the toxicity testing of carbon-based nanomaterials--the clonogenic assayEva Herzog
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol Lett 174:49-60. 2007..All three particle types were highly effective in inhibiting cell proliferation in all three cell lines, whereas only HaCaT and BEAS-2B cells also showed decreased cell viability... - Cellular responses in primary epidermal cultures from rainbow trout exposed to zinc chlorideSharon Ní Shúilleabháin
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Ecotoxicol Environ Saf 65:332-41. 2006..This model system may help to further elucidate the effects of ecotoxicants on the external innate immune system of fish... - In vitro mammalian cytotoxicological study of PAMAM dendrimers - towards quantitative structure activity relationshipsSourav Prasanna Mukherjee
Radiation and Environmental Science Centre, Focas Research Institute, Dublin Institute of Technology, Dublin 8, Ireland
Toxicol In Vitro 24:169-77. 2010..A trend of generation dependent toxic response and interaction of the dendrimers with the cell culture media was observed which may lay the basis of structure activity relationships... - Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cellsPratap C Naha
Radiation and Environmental Science Centre, Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol Appl Pharmacol 246:91-9. 2010..The intracellular ROS generation and cytokine production induced cytotoxicity point towards the mechanistic pathway of cell death upon exposure to PAMAM dendrimers... - Preparation, characterization of NIPAM and NIPAM/BAM copolymer nanoparticles and their acute toxicity testing using an aquatic test batteryPratap C Naha
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Aquat Toxicol 92:146-54. 2009..No correlation with particle size was observed. The sensitivity of the test species was seen to vary depending on copolymer composition. The relevance of the derived structure-activity relationships is discussed... - Aquatic ecotoxicity of the selective serotonin reuptake inhibitor sertraline hydrochloride in a battery of freshwater test speciesElaine Minagh
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Ecotoxicol Environ Saf 72:434-40. 2009.... - Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samplesEva Herzog
Radiation and Environmental Science Centre RESC, Focas Institute, Dublin Institute of Technology, Dublin, Ireland
Toxicol Appl Pharmacol 236:276-81. 2009..However, cell responses are strongly dependent on the vehicle used for dispersion. Whereas the presence of DPPC increased intracellular ROS formation, FCS seemed to protect the cells from oxidative insult... - Raman spectroscopy--a potential platform for the rapid measurement of carbon nanotube-induced cytotoxicityPeter Knief
School of Physics Focas Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Analyst 134:1182-91. 2009..This preliminary study demonstrates the potential of Raman spectroscopy as a probe of cytotoxicity to nanoparticle exposure... - A model compound study: the ecotoxicological evaluation of five organic contaminants employing a battery of marine bioassaysAilbhe Macken
Radiation and Environmental Science Centre, Focas Institute, DIT, Kevin Street, Dublin 8, Ireland
Environ Pollut 153:627-37. 2008..The results of this study have important implications for risk assessment in estuarine and coastal waters in Ireland, where, at present the monitoring of sediment and water quality is predominantly reliant on chemical analysis alone... - Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cellsSourav Prasanna Mukherjee
Radiation and Environmental Science Centre, Focas Research Institute, Dublin, Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol Appl Pharmacol 248:259-68. 2010..Overall, significant differences are observed between the responses of the dermal cell line, HaCaT, and the colon cell line, SW480, and it is suggested that these can be understood in terms of differing intrinsic antioxidant levels... - A test battery for the ecotoxicological evaluation of the agri-chemical EnvironM Davoren
Ecotoxicology Unit, School of Science, Athlone Institute of Technology, Dublin Road, Athlone, Co Westmeath, Ireland
Ecotoxicol Environ Saf 59:116-22. 2004..However, in vivo/in vitro comparisons in this instance we feel would be premature and imprecise owing to valid concerns regarding fish loading rates for the in vivo test, and exposure duration with the in vitro test... - Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung cellsA Casey
School of Physics, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Toxicol Lett 179:78-84. 2008.... - Identification of a multixenobiotic resistance mechanism in primary cultured epidermal cells from Oncorhynchus mykiss and the effects of environmental complex mixtures on its activitySharon Ní Shúilleabháin
Radiation and Environmental Science Centre, Focas Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland
Aquat Toxicol 73:115-27. 2005..The findings of the functional study also demonstrated that environmental pollutants, which interfere with P-gp function, could be identified using this model...