Philip M Cummins

Summary

Affiliation: Dublin City University
Country: Ireland

Publications

  1. pmc Occludin: one protein, many forms
    Philip M Cummins
    School of Biotechnology and Centre for Preventive Medicine, Dublin City University, Dublin, Ireland
    Mol Cell Biol 32:242-50. 2012
  2. ncbi request reprint Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with
    Philip M Cummins
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City Univ, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 292:H28-42. 2007
  3. ncbi request reprint Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress
    Olga C Colgan
    Vascular Health Research Centre, Dublin City University, Glasnevin, Dublin 9, Ireland
    Am J Physiol Heart Circ Physiol 292:H3190-7. 2007
  4. ncbi request reprint Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation
    Nicholas Von Offenberg Sweeney
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    Biochem Biophys Res Commun 329:573-82. 2005
  5. doi request reprint Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction
    Nicholas P Tobin
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 295:H1403-13. 2008
  6. doi request reprint Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function
    Olga C Colgan
    Faculty of Science and Health, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Brain Res 1193:84-92. 2008
  7. ncbi request reprint Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro
    David Morrow
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    Am J Physiol Cell Physiol 289:C1188-96. 2005
  8. ncbi request reprint Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels
    Anthony F Guinan
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Cardiovasc Res 99:545-54. 2013
  9. ncbi request reprint Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro
    David Morrow
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin, Ireland
    Circ Res 96:567-75. 2005
  10. doi request reprint Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production
    Paul A Fitzpatrick
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Int J Biochem Cell Biol 41:2287-94. 2009

Collaborators

  • E M Redmond
  • Dermot Walls
  • Steven W Kerrigan
  • Ciarán O'Fágáin
  • Paul A Cahill
  • Yvonne A Birney
  • Ronan P Murphy
  • David Morrow
  • Anthony F Guinan
  • Nicholas Von Offenberg Sweeney
  • Keith D Rochfort
  • Olga C Colgan
  • Tony G Walsh
  • Paul A Fitzpatrick
  • Catherine Sweeney
  • Nora T Collins
  • Nicholas P Tobin
  • Gail Ferguson
  • Fiona A Martin
  • Eoin J Cotter
  • Adrian R Pierotti
  • Shaunta Guha
  • Ronan Murphy
  • Agnieszka Scheller
  • Laura E Collins
  • Susan Phelan
  • Paul Fitzpatrick
  • Andrew Murphy
  • Maria T Killeen
  • Dermot Cox
  • Gary T Henehan
  • John C Atherton
  • Gerardeane Meade
  • Nora Collins
  • Gerardene Meade
  • Colm Hennessy
  • James V Sitzmann
  • John P Cullen
  • Charles R Cappadona
  • Catherine H Sweeney
  • Marc J Glucksman
  • Paul M Coen
  • Seamus Coyle

Detail Information

Publications24

  1. pmc Occludin: one protein, many forms
    Philip M Cummins
    School of Biotechnology and Centre for Preventive Medicine, Dublin City University, Dublin, Ireland
    Mol Cell Biol 32:242-50. 2012
    ..Mechanistic concepts such as splice variance and alternate promoter usage, proteolysis, phosphorylation, dimerization, and ubiquitination are comprehensively examined, and possible avenues for future investigation highlighted...
  2. ncbi request reprint Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with
    Philip M Cummins
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City Univ, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 292:H28-42. 2007
    ..Possible relevance of these phenomena to vascular endothelial dysfunction and pathological remodeling are also addressed...
  3. ncbi request reprint Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress
    Olga C Colgan
    Vascular Health Research Centre, Dublin City University, Glasnevin, Dublin 9, Ireland
    Am J Physiol Heart Circ Physiol 292:H3190-7. 2007
    ..Shear stress upregulates BBMvEC barrier function at the molecular level via modulation of expression, association, and localization of occludin and ZO-1. The pulsatile shear model appeared to give the most profound biochemical responses...
  4. ncbi request reprint Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation
    Nicholas Von Offenberg Sweeney
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    Biochem Biophys Res Commun 329:573-82. 2005
    ..7+/-31%, respectively. Finally, integrin blockade with cRGD peptide and siRNA-directed attenuation of uPA expression reduced strain-induced tube formation by 85.7+/-15% and 84.7+/-31%, respectively, whilst having no effect on migration...
  5. doi request reprint Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction
    Nicholas P Tobin
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 295:H1403-13. 2008
    ..Specifically, the VacA-dependent reduction in endothelial NO is indicated in these events. The atheroprotective impact of laminar shear stress in this context is also evident...
  6. doi request reprint Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function
    Olga C Colgan
    Faculty of Science and Health, School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Brain Res 1193:84-92. 2008
    ....
  7. ncbi request reprint Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro
    David Morrow
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    Am J Physiol Cell Physiol 289:C1188-96. 2005
    ....
  8. ncbi request reprint Shear stress is a positive regulator of thimet oligopeptidase (EC3.4.24.15) in vascular endothelial cells: consequences for MHC1 levels
    Anthony F Guinan
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Cardiovasc Res 99:545-54. 2013
    ..We examine for the first time the relationship between TOP expression and laminar shear stress, a haemodynamic force associated with endothelium-mediated vascular homeostasis...
  9. ncbi request reprint Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro
    David Morrow
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin, Ireland
    Circ Res 96:567-75. 2005
    ..These findings suggest that cyclic strain inhibits SMC growth while enhancing SMC apoptosis, in part, through regulation of Notch receptor and downstream target gene expression...
  10. doi request reprint Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production
    Paul A Fitzpatrick
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Int J Biochem Cell Biol 41:2287-94. 2009
    ..In conclusion, we confirm for the first time that NEP expression is down-regulated in vascular endothelial cells by physiological laminar shear, possibly via a mechanotransduction mechanism involving NADPH oxidase-induced ROS production...
  11. ncbi request reprint Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo
    David Morrow
    Faculty of Science and Health, Vascular Health Research Centre, Dublin City University, Glasnevin, Dublin 9, Ireland
    Am J Physiol Cell Physiol 292:C488-96. 2007
    ..These data suggest that Hh expression is diminished by biomechanical stimulation in vitro and in vivo and thus may play a fundamental role in arterial remodeling and atherogenesis in vivo...
  12. ncbi request reprint Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and function
    Nora T Collins
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland
    Arterioscler Thromb Vasc Biol 26:62-8. 2006
    ..We, therefore, examined the effects of cyclic strain on the expression, modification, and function of 2 pivotal endothelial tight junction components, occludin and ZO-1...
  13. doi request reprint Stabilization of brain microvascular endothelial barrier function by shear stress involves VE-cadherin signaling leading to modulation of pTyr-occludin levels
    Tony G Walsh
    School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Cell Physiol 226:3053-63. 2011
    ..A downstream role is also strongly indicated for a protein tyrosine phosphatase in pTyr-occludin modulation. Importantly, these findings suggest an important route of inter-junctional signaling cross-talk during BBB response to flow...
  14. ncbi request reprint Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity
    Nicholas Von Offenberg Sweeney
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland
    Cardiovasc Res 63:625-34. 2004
    ..To investigate the role of cyclic strain in controlling matrix metalloproteinase-2 (MMP-2) expression and activity in endothelial cells (ECs) in vitro...
  15. ncbi request reprint Pulse pressure-induced transmural fluid flux increases bovine aortic smooth muscle cell apoptosis in a mitogen activated protein kinase dependent manner
    Yvonne A Birney
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin, Ireland
    J Vasc Res 41:364-74. 2004
    ..We investigated the effect of pulse pressure on VSMC apoptosis...
  16. ncbi request reprint Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration
    Nicholas Von Offenberg Sweeney
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biochem Biophys Res Commun 320:325-33. 2004
    ..These findings reveal a potentially novel role for strain-induced endothelial MMP-2 in regulating vascular SMC migration...
  17. ncbi request reprint Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway
    Catherine Sweeney
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin 9, Ireland
    FASEB J 18:1421-3. 2004
    ..Notch signaling, therefore, represents a novel therapeutic target for disease states in which changes in vascular cell fate occur in vivo...
  18. doi request reprint Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects
    Fiona A Martin
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Am J Physiol Heart Circ Physiol 304:H1585-97. 2013
    ....
  19. doi request reprint Hydrophobic interaction chromatography
    Philip M Cummins
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Methods Mol Biol 681:431-7. 2011
    ..For these reasons, this technique has a widespread use for the purification of proteins and large polypeptides...
  20. ncbi request reprint Regulation of endopeptidases EC3.4.24.15 and EC3.4.24.16 in vascular endothelial cells by cyclic strain: role of Gi protein signaling
    Eoin J Cotter
    Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin, Ireland
    Arterioscler Thromb Vasc Biol 24:457-63. 2004
    ..The objective of this study, therefore, was to investigate the putative role of cyclic strain in regulating the expression and enzymatic activity of EP24.15 and EP24.16 in bovine aortic endothelial cells (BAECs)...
  21. ncbi request reprint Hemodynamic regulation of metallopeptidases within the vasculature
    Philip M Cummins
    Vascular Health Research Centre, Dublin City University, Glasnevin, Dublin 9, Ireland
    Protein Pept Lett 11:433-42. 2004
    ..This review examines the relationship between hemodynamic forces such as shear stress and cyclic strain, and an important group of peptide-degrading enzymes within the endothelium, the thermolysin-like zinc metallopeptidases...
  22. pmc Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions
    Keith D Rochfort
    School of Biotechnology, Dublin City University, Dublin, Ireland
    PLoS ONE 9:e101815. 2014
    ....
  23. doi request reprint Ion-exchange chromatography: basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase
    Philip M Cummins
    School of Biotechnology, Dublin City University, Dublin, Ireland
    Methods Mol Biol 681:215-28. 2011
    ..g. thyroliberin, gonadotropin-releasing hormone)...
  24. doi request reprint Gel-filtration chromatography
    Ciarán O'Fágáin
    School of Biotechnology and National Centre for Sensor Research, Dublin City University, Dublin, Ireland
    Methods Mol Biol 681:25-33. 2011
    ..Here, the basis of the method is described and typical matrix types are contrasted. The selection of suitable operating conditions and applications of the method are also discussed...