Colin Clarke

Summary

Affiliation: Dublin City University
Country: Ireland

Publications

  1. pmc Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    BMC Genomics 13:656. 2012
  2. doi request reprint CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biotechnol Bioeng 109:1368-70. 2012
  3. doi request reprint Predicting cell-specific productivity from CHO gene expression
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 151:159-65. 2011
  4. doi request reprint Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 155:350-9. 2011
  5. doi request reprint Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines
    Padraig Doolan
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Biotechnol J 7:516-26. 2012
  6. pmc Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    BMC Biotechnol 11:78. 2011
  7. doi request reprint Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 160:251-62. 2012
  8. doi request reprint Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Biotechnol Bioeng 109:1386-94. 2012
  9. doi request reprint Transcriptomic analysis of clonal growth rate variation during CHO cell line development
    Padraig Doolan
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    J Biotechnol 166:105-13. 2013
  10. doi request reprint Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib
    Paula Kinsella
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Exp Cell Res 318:641-52. 2012

Collaborators

Detail Information

Publications11

  1. pmc Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    BMC Genomics 13:656. 2012
    ....
  2. doi request reprint CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    Biotechnol Bioeng 109:1368-70. 2012
    ..It is hoped that this resource will allow researchers to prioritize cell line engineering and/or biomarker candidates to enhance CHO-based cell culture for the production of biotherapeutics. Availability: www.cgcdb.org...
  3. doi request reprint Predicting cell-specific productivity from CHO gene expression
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 151:159-65. 2011
    ..Several of the genes constituting the model are linked with biological processes relevant to protein metabolism...
  4. doi request reprint Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity
    Colin Clarke
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 155:350-9. 2011
    ..In summary, the approach presented in this study provides a novel perspective on the CHO cell transcriptome...
  5. doi request reprint Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines
    Padraig Doolan
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    Biotechnol J 7:516-26. 2012
    ....
  6. pmc Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    BMC Biotechnol 11:78. 2011
    ....
  7. doi request reprint Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland
    J Biotechnol 160:251-62. 2012
    ..This is the first report investigating the impact of a miRNA on the proteome of CHO cells...
  8. doi request reprint Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics
    Paula Meleady
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Biotechnol Bioeng 109:1386-94. 2012
    ..The new sequence information offers improved interpretation of proteomic analyses and will, in the years to come, prove vital to unraveling the CHO proteome...
  9. doi request reprint Transcriptomic analysis of clonal growth rate variation during CHO cell line development
    Padraig Doolan
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    J Biotechnol 166:105-13. 2013
    ..Finally, we demonstrate the enrichment of predicted mRNA targets of miR17-92, a microRNA (miRNA) cluster known to be upregulated during rapid proliferation, within downregulated transcripts...
  10. doi request reprint Characterization and response of newly developed high-grade glioma cultures to the tyrosine kinase inhibitors, erlotinib, gefitinib and imatinib
    Paula Kinsella
    National Institute for Cellular Biotechnology, Dublin City University, Dublin 9, Ireland
    Exp Cell Res 318:641-52. 2012
    ..The results of this in vitro study suggest gefitinib and imatinib may have therapeutic potential in HGG tumours with a corresponding growth factor receptor expression profile...
  11. pmc MiR-7 triggers cell cycle arrest at the G1/S transition by targeting multiple genes including Skp2 and Psme3
    Noelia Sanchez
    National Institute for Cellular Biotechnology, Dublin City University, Dublin, Ireland
    PLoS ONE 8:e65671. 2013
    ..This work provides further mechanistic insight into the role of miR-7 as a regulator of cell growth in times of cellular stress...