Norman Delanty

Summary

Affiliation: Cork University Hospital
Country: Ireland

Publications

  1. ncbi request reprint Examining the role of common genetic variation in the gamma2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs
    Peter Kinirons
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Division of Neurology, Beaumont Hospital, Dublin 9, Ireland
    Epilepsy Res 70:229-38. 2006
  2. ncbi request reprint Oxidative injury in epilepsy: potential for antioxidant therapy?
    Daniel J Costello
    Department of Clinical Neurological Sciences, Royal College of Surgeons of Ireland, Beaumont Hospital, Dublin, Ireland
    Expert Rev Neurother 4:541-53. 2004
  3. ncbi request reprint Audit of an inpatient neurology consultation service in a tertiary referral centre: value of the consulting neurologist
    D J Costello
    Department of Neurology, Mater Misericordiae Hospital and University College Dublin, Eccles Street, Dublin 7
    Ir Med J 98:134-7. 2005
  4. doi request reprint Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis
    Saud Alhusaini
    Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland
    Epilepsia 53:995-1003. 2012
  5. doi request reprint Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy
    Saud Alhusaini
    Brain Morphometry Laboratory, Epilepsy Programme, Beaumont Hospital, Dublin, Ireland
    Epilepsia 54:e138-41. 2013
  6. pmc Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy
    Saud Alhusaini
    Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 8:e61880. 2013
  7. doi request reprint MRI-based brain structure volumes in temporal lobe epilepsy patients and their unaffected siblings: a preliminary study
    Cathy Scanlon
    Brain Morphometry Laboratory, Epilepsy Programme, Beaumont Hospital, Dublin, Ireland
    J Neuroimaging 23:64-70. 2013
  8. pmc Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
    Eva M Jimenez-Mateos
    Department of Physiology and Medical Physics and Centre for Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland
    Nat Med 18:1087-94. 2012
  9. doi request reprint Opportunities and challenges for genome sequencing in the clinic
    Gianpiero L Cavalleri
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    Adv Protein Chem Struct Biol 89:65-83. 2012
  10. doi request reprint Widespread cortical morphologic changes in juvenile myoclonic epilepsy: evidence from structural MRI
    Lisa Ronan
    Brain Morphometry Laboratory, Neurophysics Department, Beaumont Hospital, Dublin, Ireland
    Epilepsia 53:651-8. 2012

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Examining the role of common genetic variation in the gamma2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs
    Peter Kinirons
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Division of Neurology, Beaumont Hospital, Dublin 9, Ireland
    Epilepsy Res 70:229-38. 2006
    ..Here we set out to examine whether common variation in GABRG2 predisposes to the development of common, complex forms of epilepsy in two large independent cohorts...
  2. ncbi request reprint Oxidative injury in epilepsy: potential for antioxidant therapy?
    Daniel J Costello
    Department of Clinical Neurological Sciences, Royal College of Surgeons of Ireland, Beaumont Hospital, Dublin, Ireland
    Expert Rev Neurother 4:541-53. 2004
    ..This review examines the evidence for the role of oxidative injury in epilepsy, the rationale for use of antioxidant therapy in epilepsy and appraises the current clinical performance of the studies of antioxidant therapies...
  3. ncbi request reprint Audit of an inpatient neurology consultation service in a tertiary referral centre: value of the consulting neurologist
    D J Costello
    Department of Neurology, Mater Misericordiae Hospital and University College Dublin, Eccles Street, Dublin 7
    Ir Med J 98:134-7. 2005
    ..3%)), acute headache (28 case (4.8%)) and functional neurological syndromes (26 cases (4.5%)). This audit highlights the value of a consulting neurology service in a multidisciplinary tertiary referral setting...
  4. doi request reprint Asymmetric cortical surface area and morphology changes in mesial temporal lobe epilepsy with hippocampal sclerosis
    Saud Alhusaini
    Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland
    Epilepsia 53:995-1003. 2012
    ..The goal of this study was to investigate cerebral cortex (1) surface area, (2) surface geometric distortion, and (3) thickness in MTLE with hippocampal sclerosis (HS)...
  5. doi request reprint Regional increase of cerebral cortex thickness in juvenile myoclonic epilepsy
    Saud Alhusaini
    Brain Morphometry Laboratory, Epilepsy Programme, Beaumont Hospital, Dublin, Ireland
    Epilepsia 54:e138-41. 2013
    ..These findings confirm that the underlying mechanisms in JME are related to aberrant corticothalamic structure and indicate that frontal cortex abnormalities are possibly linked to regional increase in cerebral cortical thickness...
  6. pmc Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy
    Saud Alhusaini
    Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 8:e61880. 2013
    ..We aimed to 1) determine if subcortical volume deficits are common to mesial temporal lobe epilepsy (MTLE) patients and their unaffected siblings 2) assess the suitability of subcortical volumetric traits as endophenotypes for MTLE...
  7. doi request reprint MRI-based brain structure volumes in temporal lobe epilepsy patients and their unaffected siblings: a preliminary study
    Cathy Scanlon
    Brain Morphometry Laboratory, Epilepsy Programme, Beaumont Hospital, Dublin, Ireland
    J Neuroimaging 23:64-70. 2013
    ..A preliminary study is presented to determine if volume deficits of candidate brain structures present at a higher rate in unaffected siblings than controls subjects...
  8. pmc Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
    Eva M Jimenez-Mateos
    Department of Physiology and Medical Physics and Centre for Study of Neurological Disorders, Royal College of Surgeons in Ireland, Dublin, Ireland
    Nat Med 18:1087-94. 2012
    ..Thus, silencing miR-134 exerts prolonged seizure-suppressant and neuroprotective actions; determining whether these are anticonvulsant effects or are truly antiepileptogenic effects requires additional experimentation...
  9. doi request reprint Opportunities and challenges for genome sequencing in the clinic
    Gianpiero L Cavalleri
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    Adv Protein Chem Struct Biol 89:65-83. 2012
    ..Finally, the authors discuss the practical challenges of actual implementation of whole-genome sequencing to the clinic...
  10. doi request reprint Widespread cortical morphologic changes in juvenile myoclonic epilepsy: evidence from structural MRI
    Lisa Ronan
    Brain Morphometry Laboratory, Neurophysics Department, Beaumont Hospital, Dublin, Ireland
    Epilepsia 53:651-8. 2012
    ..Using magnetic resonance imaging (MRI)-based analysis, we examined cortical morphology in patients with juvenile myoclonic epilepsy (JME)...
  11. doi request reprint The Irish epilepsy surgery experience: Long-term follow-up
    Orla Dunlea
    Department of Neurology, Beaumont Hospital, Dublin 9, Ireland
    Seizure 19:247-52. 2010
    ..We also wished to determine the impact of pathology and surgical technique (with particular reference to neocorticectomy) on seizure outcome...
  12. doi request reprint Assessing the quality of epilepsy care with an electronic patient record
    Mary Fitzsimons
    Epilepsy Programme, Beaumont Hospital, Dublin 9, Ireland
    Seizure 22:604-10. 2013
    ..This study aimed to demonstrate the use of an epilepsy-specific EPR in applying the AAN measures to objectively monitor clinical performance...
  13. doi request reprint Evidence-based models of care for people with epilepsy
    Mary Fitzsimons
    Epilepsy Programme, Beaumont Hospital, Dublin, Ireland
    Epilepsy Behav 23:1-6. 2012
    ..Evidence of the effectiveness of CDM models in epilepsy care is presented in this review article...
  14. doi request reprint Adjunctive levetiracetam in children, adolescents, and adults with primary generalized seizures: open-label, noncomparative, multicenter, long-term follow-up study
    Norman Delanty
    Division of Neurology, Beaumont Hospital, Dublin, Ireland
    Epilepsia 53:111-9. 2012
    ..To evaluate the long-term efficacy and tolerability of adjunctive levetiracetam (LEV) in patients with uncontrolled idiopathic generalized epilepsy (IGE)...
  15. doi request reprint Diagnostic exome sequencing: a new paradigm in neurology
    Norman Delanty
    Department of Neurology, Beaumont Hospital, Royal College of Surgeons, Dublin 9, Ireland Electronic address
    Neuron 80:841-3. 2013
    ..Now, consistent clinical applications have finally arrived and bring with them the promise of identifying the underlying causes of complex neurological disorders in a patient-specific manner. ..
  16. pmc Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis
    Ross C McKiernan
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    PLoS ONE 7:e35921. 2012
    ..These findings suggest loss of Dicer and failure of mature miRNA expression may be a feature of the pathophysiology of HS in patients with TLE...
  17. doi request reprint Complex single gene disorders and epilepsy
    Aine Merwick
    Epilepsy Programme, Department of Neurology, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland
    Epilepsia 53:81-91. 2012
    ..These disorders are important in informing genetic testing to confirm a diagnosis and to permit better understanding of the variability in phenotype-genotype correlation...
  18. pmc Formative evaluation of a telemedicine model for delivering clinical neurophysiology services part I: utility, technical performance and service provider perspective
    Patricia Breen
    Epilepsy Programme, Beaumont Hospital, Dublin 9, Ireland
    BMC Med Inform Decis Mak 10:48. 2010
    ..A formative evaluation of a teleneurophysiology service was conducted to examine its technical and sociological dimensions...
  19. doi request reprint Pharmacogenomics and epilepsy: the road ahead
    Gianpiero L Cavalleri
    Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland
    Pharmacogenomics 12:1429-47. 2011
    ..Here, we review the pharmacogenomic work to date in the context of these issues and comment on key aspects of study design that are required to speed up the identification of clinically relevant genetic factors...
  20. doi request reprint Epidemiology and classification of epilepsy: gender comparisons
    John C McHugh
    Department of Neurology, Beaumont Hospital, Dublin 9, Ireland
    Int Rev Neurobiol 83:11-26. 2008
    ..These include the incidence of status epilepticus (more common in men), incidence of sudden unexpected death in epilepsy (SUDEP), prognosis, and mortality...
  21. ncbi request reprint Outcome measurement after vagal nerve stimulation therapy: proposal of a new classification
    John C McHugh
    Department of Neurology, Beaumount Hospital, Dublin, Ireland
    Epilepsia 48:375-8. 2007
    ..No accepted standard exists for outcome measurement after VNS treatment. We present a novel classification for outcome, which includes assessment of both seizure frequency and severity in VNS-treated patients...
  22. ncbi request reprint A pharmacogenetic exploration of vigabatrin-induced visual field constriction
    Peter Kinirons
    Department of Clinical Neurological Sciences, Royal College of Surgeons, Division of Neurology, Beaumont Hospital, Dublin, Ireland
    Epilepsy Res 70:144-52. 2006
    ..Given the evidence suggesting an idiosyncratic drug response, we set out to detect genetic variation of strong, clinically relevant effect that might guide clinicians in the safe, controlled prescribing of this otherwise usefuldrug...
  23. ncbi request reprint Vigabatrin retinopathy in an Irish cohort: lack of correlation with dose
    Peter Kinirons
    Department of Clinical Neuroscience, Beaumont Hospital, Dublin 9, Ireland
    Epilepsia 47:311-7. 2006
    ..We conducted a retrospective analysis of patients receiving long-term VGB to examine whether toxicity is related to the daily dose, duration of therapy, or cumulative dose...
  24. ncbi request reprint The controversial association of ABCB1 polymorphisms in refractory epilepsy: an analysis of multiple SNPs in an Irish population
    Amre Shahwan
    Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
    Epilepsy Res 73:192-8. 2007
    ..Variability in phenotypic descriptions in genetic association studies may partly explain the inconsistency of attempted replications...
  25. doi request reprint Epilepsy in Ireland: towards the primary-tertiary care continuum
    Jarlath Varley
    Epilepsy Programme, Beaumont Hospital, Dublin 9, Ireland
    Seizure 19:47-52. 2010
    ..The diagnosis and optimal management relies on contribution from a number of healthcare disciplines in a variety of healthcare settings...
  26. ncbi request reprint Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study
    Gianpiero L Cavalleri
    Department of Clinical Neurological Sciences and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland Research Institute, and Division of Neurology, Beaumont Hospital, Dublin, Ireland
    Lancet Neurol 6:970-80. 2007
    ..The Epilepsy Genetics (EPIGEN) Consortium was established to undertake genetic mapping analyses with augmented statistical power to detect variants that influence the development and treatment of common forms of epilepsy...
  27. ncbi request reprint Integrating clinical theory and practice in an epilepsy-specific electronic patient record
    Patricia Breen
    Epilepsy Programme, Department of Neurology, Beaumont Hospital, Dublin, Ireland
    Stud Health Technol Inform 150:145. 2009
    ..Results indicated that the module was useable but the design did not work as well in practice as anticipated by theory. The next iteration of the module included identified enhancements; this iteration is currently in use...
  28. doi request reprint Socio-technical considerations in epilepsy electronic patient record implementation
    Louise Mc Quaid
    Epilepsy Programme, Department of Neurology, Beaumont Hospital, Dublin 9, Ireland
    Int J Med Inform 79:349-60. 2010
    ..The objective was to introduce the module to a live clinical setting within strictly controlled conditions to evaluate its usability and usefulness...
  29. ncbi request reprint Herbal remedies, dietary supplements, and seizures
    Alok Tyagi
    Department of Neurology and Clinical Neurological Sciences, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland
    Epilepsia 44:228-35. 2003
    ....
  30. ncbi request reprint Genetics of epilepsy: epilepsy research foundation workshop report
    Sanjay Sisodiya
    Epilepsy Research Foundation, United Kingdom
    Epileptic Disord 9:194-236. 2007
    ..Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy...
  31. ncbi request reprint Use of complementary and alternative medicine in epilepsy
    Valeria Ricotti
    Curr Neurol Neurosci Rep 6:347-53. 2006
    ..More effort needs to be put into future trials, with the assistance of qualified CAM professionals to ensure conformation to their therapeutic principles...
  32. ncbi request reprint An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases
    Colm T O'Dushlaine
    Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Ireland
    Eur J Hum Genet 16:176-83. 2008
    ..This analysis therefore confirms that the genetic architecture of the Irish population is well suited to the study of complex traits and that tSNPs selected using the HapMap data can be confidently applied to the Irish population...