Michael Hutchinson

Summary

Affiliation: Beaumont Hospital
Country: Ireland

Publications

  1. pmc Natalizumab: A new treatment for relapsing remitting multiple sclerosis
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Dublin Ireland
    Ther Clin Risk Manag 3:259-68. 2007
  2. doi request reprint Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody
    M Hutchinson
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 71:1291-2. 2008
  3. doi request reprint The efficacy of natalizumab in patients with relapsing multiple sclerosis: subgroup analyses of AFFIRM and SENTINEL
    Michael Hutchinson
    Dept of Neurology, St Vincent s University Hospital, Dublin, Ireland
    J Neurol 256:405-15. 2009
  4. doi request reprint Natalizumab therapy of multiple sclerosis
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    J Interferon Cytokine Res 30:787-9. 2010
  5. doi request reprint Predicting and preventing the future: actively managing multiple sclerosis
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Pract Neurol 9:133-43, discussion 144. 2009
  6. ncbi request reprint Dementia in SPG4 hereditary spastic paraplegia: clinical, genetic, and neuropathologic evidence
    S Murphy
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 73:378-84. 2009
  7. ncbi request reprint Striatal morphology correlates with sensory abnormalities in unaffected relatives of cervical dystonia patients
    Richard A Walsh
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol 256:1307-13. 2009
  8. ncbi request reprint The endophenotype and the phenotype: temporal discrimination and adult-onset dystonia
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland University College Dublin, Dublin, Ireland
    Mov Disord 28:1766-74. 2013
  9. ncbi request reprint Temporal discrimination, a cervical dystonia endophenotype: penetrance and functional correlates
    Okka Kimmich
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    Mov Disord 29:804-11. 2014
  10. ncbi request reprint Outcome of beta-interferon treatment in relapsing-remitting multiple sclerosis: a Bayesian analysis
    Cathal Walsh
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    J Neurol 254:1547-54. 2007

Collaborators

Detail Information

Publications46

  1. pmc Natalizumab: A new treatment for relapsing remitting multiple sclerosis
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Dublin Ireland
    Ther Clin Risk Manag 3:259-68. 2007
    ..The benefits and risks of natalizumab support its use as monotherapy for RRMS with high disease activity despite treatment with IFNbeta, and for patients with rapidly evolving severe RRMS...
  2. doi request reprint Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody
    M Hutchinson
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 71:1291-2. 2008
  3. doi request reprint The efficacy of natalizumab in patients with relapsing multiple sclerosis: subgroup analyses of AFFIRM and SENTINEL
    Michael Hutchinson
    Dept of Neurology, St Vincent s University Hospital, Dublin, Ireland
    J Neurol 256:405-15. 2009
    ..These results indicate that natalizumab is effective in reducing disability progression and relapses in patients with relapsing MS, particularly in patients with highly active disease...
  4. doi request reprint Natalizumab therapy of multiple sclerosis
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    J Interferon Cytokine Res 30:787-9. 2010
    ..With time and accumulated lesion load, secondary degeneration of denuded axons results in the phase of secondary progressive MS usually 15-20 years after onset...
  5. doi request reprint Predicting and preventing the future: actively managing multiple sclerosis
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Pract Neurol 9:133-43, discussion 144. 2009
    ....
  6. ncbi request reprint Dementia in SPG4 hereditary spastic paraplegia: clinical, genetic, and neuropathologic evidence
    S Murphy
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 73:378-84. 2009
    ..There has only been one postmortem examination described; not all accept that progressive cognitive decline is a feature of this disorder...
  7. ncbi request reprint Striatal morphology correlates with sensory abnormalities in unaffected relatives of cervical dystonia patients
    Richard A Walsh
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol 256:1307-13. 2009
    ..Further investigation of grey matter changes as a candidate endophenotype may assist future genetic studies of dystonia...
  8. ncbi request reprint The endophenotype and the phenotype: temporal discrimination and adult-onset dystonia
    Michael Hutchinson
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland University College Dublin, Dublin, Ireland
    Mov Disord 28:1766-74. 2013
    ..The mechanisms of dysfunction in this pathway should be a focus for future research in the pathogenesis of adult-onset primary torsion dystonia...
  9. ncbi request reprint Temporal discrimination, a cervical dystonia endophenotype: penetrance and functional correlates
    Okka Kimmich
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland
    Mov Disord 29:804-11. 2014
    ..These findings further support abnormal temporal discrimination as an endophenotype of cervical dystonia involving disordered basal ganglia circuits...
  10. ncbi request reprint Outcome of beta-interferon treatment in relapsing-remitting multiple sclerosis: a Bayesian analysis
    Cathal Walsh
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    J Neurol 254:1547-54. 2007
    ..52, 0.94. It is concluded that two years of IFNbeta therapy for RRMS reduces accumulation of fixed disability in clinical practice...
  11. doi request reprint Discontinuing disease-modifying therapy in progressive multiple sclerosis: can we stop what we have started?
    Roisin Lonergan
    St Vincent s University Hospital, Neurology, Dublin, Republic of Ireland
    Mult Scler 15:1528-31. 2009
    ..The costs of disease-modifying therapies in this group (>170,000 euro yearly) could be re-directed towards development of neurology services to optimize their management...
  12. doi request reprint Sporadic adult onset primary torsion dystonia is a genetic disorder by the temporal discrimination test
    Okka Kimmich
    St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Brain 134:2656-63. 2011
    ....
  13. ncbi request reprint Sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO) in a sibling pair with a homozygous p.A467T POLG mutation
    John C McHugh
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    Muscle Nerve 41:265-9. 2010
    ..The enlarging spectrum of sensory ataxic neuropathies associated with mitochondrial DNA (mtDNA) instability and POLG mutations should be recognized and considered in the differential diagnosis of this unusual presentation...
  14. doi request reprint Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the CONFIRM study
    Michael Hutchinson
    St Vincent s University Hospital, Elm Park, Donnybrook, Dublin 4, Ireland
    J Neurol 260:2286-96. 2013
    ..The results of these analyses indicate that treatment with BG-12 is effective on relapses across a broad range of patients with relapsing-remitting multiple sclerosis with varied demographic and disease characteristics...
  15. doi request reprint Using atypical symptoms and red flags to identify non-demyelinating disease
    Siobhan B Kelly
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol Neurosurg Psychiatry 83:44-8. 2012
    ..The aim of this study was to establish the predictive value of red flags and the typicality/atypicality of symptoms at presentation in relation to the final diagnosis of patients referred with suspected MS...
  16. doi request reprint Comparing endophenotypes in adult-onset primary torsion dystonia
    David Bradley
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    Mov Disord 25:84-90. 2010
    ..The SDT is an unreliable AOPTD endophenotype; TDT testing fulfils criteria for a reliable endophenotype with a high sensitivity...
  17. ncbi request reprint Age-related cognitive decline in hereditary spastic paraparesis linked to chromosome 2p
    P C Byrne
    Department of Pathology, University College Dublin and St Vincent s University Hospital, St Vincent s University Hospital, Dublin, Ireland
    Neurology 54:1510-7. 2000
    ..To investigate whether cognitive decline is part of the phenotype of SPG4-linked hereditary spastic paraparesis (HSP) and to determine whether cognitive changes are present in haplotype carriers before the onset of paraparesis...
  18. pmc The patient knows best: significant change in the physical component of the Multiple Sclerosis Impact Scale (MSIS-29 physical)
    Lisa Costelloe
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    J Neurol Neurosurg Psychiatry 78:841-4. 2007
    ..The aims of this study were to determine the reliability, responsiveness and minimally important change score of the Multiple Sclerosis Impact Scale (MSIS)-29 physical using the Expanded Disability Status Scale (EDSS) as an anchor measure...
  19. ncbi request reprint Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland
    Christopher McGuigan
    Dept of Neurology, St Vincent s University Hospital, Dublin, Ireland
    J Neurol 252:1245-8. 2005
    ..6/100,000 vs. 120.7/ 100,000). The aim of this paper is to examine whether the MS prevalence difference between the two counties is due to population differences in the genetic predisposition to MS...
  20. pmc Sporadic adult onset dystonia: sensory abnormalities as an endophenotype in unaffected relatives
    Richard Walsh
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    J Neurol Neurosurg Psychiatry 78:980-3. 2007
    ..Our hypothesis was that abnormal SDTs might be found in unaffected relatives of patients with sporadic AOPTD...
  21. ncbi request reprint Inherited myoclonus-dystonia and epilepsy: further evidence of an association?
    Sean O'Riordan
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    Mov Disord 19:1456-9. 2004
    ..A nonsense mutation in exon 3 (289C-->T) of SGCE resulting in the insertion of a premature stop codon (R97X) was detected in affected members of this family...
  22. ncbi request reprint Familial adolescent-onset scoliosis and later segmental dystonia in an Irish family
    Sean O'Riordan
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol 251:845-8. 2004
    ..Four other individuals have isolated childhood- or adolescent-onset scoliosis. Adolescent-onset scoliosis may represent part of the dystonia phenotype in this family...
  23. ncbi request reprint Molding the sensory cortex: spatial acuity improves after botulinum toxin treatment for cervical dystonia
    Richard Walsh
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    Mov Disord 22:2443-6. 2007
    ..The presumed mechanism of SDT improvement is a modulation of afferent cortical inputs from muscle spindles. Society...
  24. doi request reprint Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing-remitting multiple sclerosis: a systematic review and mixed treatment comparison
    Michael Hutchinson
    Newman Clinical Research Professor, St Vincent s University Hospital, University College Dublin, Ireland
    Curr Med Res Opin 30:613-27. 2014
    ..This study is a systematic review and data synthesis of published randomized clinical trials comparing the efficacy and safety of existing DMTs to BG-12 for relapsing-remitting multiple sclerosis (RRMS)...
  25. pmc Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial
    Karen O'Connell
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Trials 14:272. 2013
    ....
  26. ncbi request reprint Age at onset as a factor in determining the phenotype of primary torsion dystonia
    S O'Riordan
    Department of Neurology, St Vincent s University Hospital and University College Dublin, Ireland
    Neurology 63:1423-6. 2004
    ..Intrafamilial, age-related, phenotypic heterogeneity was noted in 14 PTD families. The authors hypothesized that the clinical presentation of PTD was modulated by the age at onset of the dystonia, irrespective of the genotype...
  27. ncbi request reprint SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q
    C A Hughes
    Department of Pathology, University College Dublin and St Vincent s University Hospital, Dublin, Ireland
    Neurology 56:1230-3. 2001
    ..20 at zero recombination). Haplotype construction of nearby markers confirms the existence of this novel HSP locus (SPG15) and narrows it to a 19-cM interval flanked by D14S1038 and D14S61...
  28. doi request reprint Phenotypic diversity associated with the mitochondrial m.8313G>A point mutation
    Killian O'Rourke
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    Muscle Nerve 40:648-51. 2009
    ..This report of a second case, together with single muscle fiber mutation analysis that shows clear segregation of mutation load with cytochrome c oxidase deficiency, confirms that the mutation is pathologic...
  29. pmc The prevalence of "pure" autosomal dominant hereditary spastic paraparesis in the island of Ireland
    P McMonagle
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    J Neurol Neurosurg Psychiatry 72:43-6. 2002
    ..Previous studies have included autosomal recessive and sporadic cases in prevalence calculations. This study aimed to determine the prevalence and features of pure ADHSP in the island of Ireland...
  30. ncbi request reprint OAS1: a multiple sclerosis susceptibility gene that influences disease severity
    M O'BRIEN
    Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Neurology 75:411-8. 2010
    ....
  31. ncbi request reprint Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: a high-density EEG study
    R Whelan
    Department of Neurology, St Vincent s University Hospital, University College Dublin, Dublin, Ireland
    J Neurol Sci 293:45-50. 2010
    ....
  32. ncbi request reprint Primary torsion dystonia due to the Tor1A GAG deletion in an Irish family
    S O'Riordan
    Neurology Department, St Vincent s University Hospital, Dublin, Ireland
    Ir J Med Sci 171:31-2. 2002
    ..The majority of carriers of this mutation conform to a characteristic phenotype that is similar in different ethnic populations...
  33. ncbi request reprint Long-term clinical relevance of criteria for designating multiple sclerosis as benign after 10 years of disease
    L Costelloe
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 79:1245-8. 2008
    ..To determine the long-term outcome of a cohort of 436 patients with multiple sclerosis (MS) seen in 1985 and long-term predictors of benign MS...
  34. ncbi request reprint The Face-Symbol Test and the Symbol-Digit Test are not reliable surrogates for the Paced Auditory Serial Addition Test in multiple sclerosis
    J Williams
    St Vincent s University Hospital, Elm Park, Dublin 4, Republic of Ireland
    Mult Scler 12:599-604. 2006
    ..80, 95% CI 0.66-0.88), R(2) 65%, with moderate inter-test agreement (k =0.52). In contrast, SDT and FST scores were less predictive of PASAT scores. We concluded that neither the FST nor SDT are reliable surrogates for the PASAT...
  35. ncbi request reprint Hereditary spastic paraparesis and psychosis
    P McMonagle
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin, Ireland
    Eur J Neurol 13:874-9. 2006
    ..We found a higher than expected rate of psychosis in the Irish HSP population. Two groups of HSP patients may have increased risk of developing psychosis: those with Kjellin's syndrome and those with SPG4-HSP...
  36. ncbi request reprint Predicting beta-interferon failure in relapsing-remitting multiple sclerosis
    C Walsh
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    Mult Scler 13:336-42. 2007
    ..Higher baseline EDSS and failure of complete relapse suppression were associated with a significantly greater likelihood of accumulation of fixed disability...
  37. ncbi request reprint Sensory abnormalities in unaffected relatives in familial adult-onset dystonia
    J P O'Dwyer
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    Neurology 65:938-40. 2005
    ..5 SD), abnormal SDTs were found in four of five affected with adult-onset PTD and in 12 of 49 unaffected relatives. Sensory abnormalities may be an endophenotype, possibly expressed later as adult-onset PTD...
  38. ncbi request reprint The longitudinal relationship between the patient-reported Multiple Sclerosis Impact Scale and the clinician-assessed Multiple Sclerosis Functional Composite
    L Costelloe
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    Mult Scler 14:255-8. 2008
    ..To examine the longitudinal relationship between the patient-rated Multiple Sclerosis Impact Scale (MSIS-29) and the doctor-reported Multiple Sclerosis Functional Composite (MSFC)...
  39. ncbi request reprint Variant Creutzfeldt-Jakob disease: first two indigenous cases in Republic of Ireland. Case report and perspective
    J C McHugh
    Department of Neurology, St Vincent s University Hospital, Elm Park, Dublin, Ireland
    Eur J Neurol 14:467-9. 2007
    ..We discuss some of the clinical aspects of vCJD and the significance of these cases in the Irish context...
  40. ncbi request reprint Phenotype of AD-HSP due to mutations in the SPAST gene: comparison with AD-HSP without mutations
    P McMonagle
    Department of Neurology, St Vincent s University Hospital and Department of Pathology, University College Dublin and St Vincent s University Hospital, Dublin, Ireland
    Neurology 55:1794-800. 2000
    ..There are at least seven genetic loci with varying ages at onset and disability. The SPAST gene at the SPG4 locus on chromosome 2p is the major disease gene for AD-HSP...
  41. pmc Latitudinal variation in the prevalence of multiple sclerosis in Ireland, an effect of genetic diversity
    C McGuigan
    St Vincent s University Hospital, Elm Park, Dublin 4, Republic of Ireland
    J Neurol Neurosurg Psychiatry 75:572-6. 2004
    ..7/100 000. Recorded prevalence rates for the south of Ireland, including County Wexford, have been markedly lower and seemed to suggest the existence of a prevalence gradient within the island...
  42. ncbi request reprint Fragile X-associated tremor/ataxia syndrome presenting in a woman after chemotherapy
    J P O'Dwyer
    Department of Neurology, St Vincent s University Hospital, Dublin 4, Ireland
    Neurology 65:331-2. 2005
  43. ncbi request reprint Presenilin-1 mutation (E280G), spastic paraparesis, and cranial MRI white-matter abnormalities
    S O'Riordan
    St Vincent s University Hospital, Dublin, Ireland
    Neurology 59:1108-10. 2002
    ..Another affected sibling also had MRI white matter abnormalities. The MRI findings may reflect an ischemic leukoencephalopathy due to amyloid angiopathy affecting meningocortical vessels...
  44. ncbi request reprint Temporal discrimination threshold: VBM evidence for an endophenotype in adult onset primary torsion dystonia
    D Bradley
    Department of Neurology, St Vincent s University Hospital, Dublin, Ireland
    Brain 132:2327-35. 2009
    ..Voxel-based morphometry findings indicate that putaminal enlargement in AOPTD is a primary phenomenon. TDTs may be an effective tool in AOPTD research with particular relevance to genetic studies of the disorder...
  45. pmc The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure
    C McGuigan
    Department of Neurology, University College Dublin and St Vincent s University Hospital, Dublin, Ireland
    J Neurol Neurosurg Psychiatry 75:266-9. 2004
    ..The aim of this study was to assess the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) for patients in the community and in a hospital setting...
  46. ncbi request reprint A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls
    R Whelan
    Department of Neurology, St Vincent s University Hospital University College Dublin, Ireland
    Clin Neurophysiol 121:1420-6. 2010
    ....