R Anwyl

Summary

Country: Ireland

Publications

  1. ncbi Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
    R Anwyl
    Department of Physiology, Trinity College, Dublin, Ireland
    Brain Res Brain Res Rev 29:83-120. 1999
  2. ncbi Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
    J H Kim
    Departments of Pharmacology, Trinity College, Dublin 2, Ireland
    J Neurosci 21:1327-33. 2001
  3. ncbi Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro
    J Kilbride
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurophysiol 85:2509-15. 2001
  4. ncbi Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neurosci Lett 298:175-8. 2001
  5. ncbi NMDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro
    J Wu
    Department of Physiology, Trinity College, University of Dublin, Dublin 2, Ireland
    J Physiol 533:745-55. 2001
  6. ncbi A role for protein kinase A and protein kinase M zeta in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo
    J Hayes
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Neuroscience 151:604-12. 2008
  7. ncbi Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo
    C Holscher
    Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland
    Eur J Pharmacol 322:155-63. 1997
  8. ncbi Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neuroscience 105:335-41. 2001
  9. ncbi Metabotropic glutamate receptor-dependent long-term potentiation
    R Anwyl
    Department of Physiology, Faculty of Health Sciences, Trinity College, Dublin 2, Ireland
    Neuropharmacology 56:735-40. 2009
  10. ncbi Developmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus
    Q Wang
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuroscience 144:110-8. 2007

Collaborators

Detail Information

Publications12

  1. ncbi Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
    R Anwyl
    Department of Physiology, Trinity College, Dublin, Ireland
    Brain Res Brain Res Rev 29:83-120. 1999
    ....
  2. ncbi Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo
    J H Kim
    Departments of Pharmacology, Trinity College, Dublin 2, Ireland
    J Neurosci 21:1327-33. 2001
    ..This will result in a profound disruption of information processing dependent on hippocampal synaptic plasticity...
  3. ncbi Presynaptic group II mGluR inhibition of short-term depression in the medial perforant path of the dentate gyrus in vitro
    J Kilbride
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurophysiol 85:2509-15. 2001
    ..Activation of presynaptically located group II mGluR increased the frequency at which the EPSP per unit time plateaued up to 30-50 Hz...
  4. ncbi Application of N-methyl-D-aspartate induces long-term potentiation in the medial perforant path and long-term depression in the lateral perforant path of the rat dentate gyrus in vitro
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neurosci Lett 298:175-8. 2001
    ..Bath perfusion of NMDA (10 microM, 5 min) resulted in induction of long-term potentiation in the medial perforant path, and induction of long-term depression in the lateral perforant path...
  5. ncbi NMDA receptor- and metabotropic glutamate receptor-dependent synaptic plasticity induced by high frequency stimulation in the rat dentate gyrus in vitro
    J Wu
    Department of Physiology, Trinity College, University of Dublin, Dublin 2, Ireland
    J Physiol 533:745-55. 2001
    ..6. Quantal analysis involving minimal stimulation demonstrated that the mGluR-dependent LTD induction was associated with a decrease in potency and an increase in failure rate...
  6. ncbi A role for protein kinase A and protein kinase M zeta in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo
    J Hayes
    Department of Pharmacology and Therapeutics, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Neuroscience 151:604-12. 2008
    ..These findings are strong evidence that antagonism of M2 muscarinic ACh receptors in vivo induces an NMDA receptor-independent persistent synaptic enhancement that requires activation of both PKA and PKM zeta...
  7. ncbi Activation of group-II metabotropic glutamate receptors blocks induction of long-term potentiation and depotentiation in area CA1 of the rat in vivo
    C Holscher
    Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland
    Eur J Pharmacol 322:155-63. 1997
    ..It is concluded that activation of group-II metabotropic glutamate receptors can block both high-frequency stimulation-induced long term potentiation and low-frequency stimulation-induced depotentiation in the CA1 area in vivo...
  8. ncbi Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus
    A M Rush
    Department of Physiology, Trinity College, Dublin, Ireland
    Neuroscience 105:335-41. 2001
    ....
  9. ncbi Metabotropic glutamate receptor-dependent long-term potentiation
    R Anwyl
    Department of Physiology, Faculty of Health Sciences, Trinity College, Dublin 2, Ireland
    Neuropharmacology 56:735-40. 2009
    ..mGluR-dependent LTP can be expressed presynaptically or postsynaptically, and can involve a range of intracellular mediators including protein kinase C (PKC) and protein kinase A (PKA), tyrosine kinase Src and nitric oxide (NO)...
  10. ncbi Developmental dependence, the role of the kinases p38 MAPK and PKC, and the involvement of tumor necrosis factor-R1 in the induction of mGlu-5 LTD in the dentate gyrus
    Q Wang
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Neuroscience 144:110-8. 2007
    ..Evidence for the involvement of tumor necrosis factor-receptor 1 (TNF-R1) in the induction of mGluR-LTD was presented in the present study, with both HFS-mGluR-LTD and DHPG-LTD being absent in mutant mice null for TNF-R1...
  11. ncbi Muscarinic acetylcholine receptor-dependent induction of persistent synaptic enhancement in rat hippocampus in vivo
    S Li
    Department of Pharmacology and Therapeutics, Biotechnology Building, Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Neuroscience 144:754-61. 2007
    ..The present studies provide evidence for the rapid induction of a persistent potentiation at hippocampal glutamatergic synapses by endogenous ACh in vivo following disinhibition of inhibitory M2 muscarinic autoreceptors...
  12. ncbi Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction
    M J Rowan
    Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland
    Biochem Soc Trans 35:1219-23. 2007
    ..Taken together, this research lends support to therapeutic trials of drugs antagonizing synaptic plasticity-disrupting actions of Abeta oligomers in preclinical AD...