R Yazdanparast

..Based on these findings, appropriate refolding conditions could be designed to kinetically diminish the rate of off-pathway aggregation...

..The aim of present study was to determine whether antioxidant supplementations using EUK-8, EUK-134 and vitamin C could improve the biochemical and histological abnormalities associated with diet-induced NASH in rats...

..Yakuchinone B (1-[4'-hydroxy-3'-methoxyphenyl]-7-phenylhept-1-en-3-one) is a component of Alpinia oxyphylla seeds with established antioxidant activity...

..Therefore, GTP depletion, as a result of inhibition of inosine monophosphate dehydrogenase (IMPDH), is considered as one of the main reasons for differentiation and apoptotic cell death by this new drug...

..Based on the present data, the new compound seems a good candidate for further evaluation as an effective chemotherapeutic agent acting through induction of differentiation and apoptosis...

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..The differentiation capability of guanosine 5'-triphosphate (GTP) was studied using U937 and KG1 cells...

..Based on our data, it can be concluded that N. officinale has a high hypolipidaemic activity and this may be attributed to its antioxidative potential...

..These results clearly established the antioxidative potency of C. rotundus, which may account for some of the medical claims attributed to this plant...

..2 ml refolding solution containing 0.0286 mg/ml protein. Taking into account the recycling potential of the copolymer, the new resin, with significant cost-cutting capability, is a suitable candidate for industrial applications...

..However, further improvements in solid-phase artificial chaperone assisted technique are needed either through synthesizing better stripping agents or by optimizing and defining better refolding environments...

..Based on our data, it can be concluded that Achillea santolina have a high hypoglycaemic activity and this may be attributed to its antioxidative potential...

..These observations provide the basis for the traditional use of these herbs in treatments of cardiovascular diseases and thrombosis...

..This may be attributed to continuous structural rearrangements in the protein long after the return of enzyme activity. These observations are discussed in terms of kinetic and structural aspects of the refolding pathway...

..Based on the present data, these two active constituents of D. lessertii have the novelty of being further evaluated for pharmaceutical applications...

..Collectively it is expected that protein refolding process can be achieved easier, cheaper and more efficient, using the new technique reported here...

..These data strongly suggest that the purine biosynthetic pathway is significantly affected by gnidilatimonoein...

..These data clearly indicates that Dendrostellera lessertii is capable of mediating tumor metastasis through affecting the adhesion properties of the cells...

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..Collectively, the results of this investigation expand the range of procedural variations used to refold different denatured proteins through artificial chaperone-assisted method...

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..Thus, sequestration of this role by potential antioxidants such as AA3E2 might happen to be a suitable strategy for future treatments of AD...

..Based on these observations, it is concluded that T. polium may have protective effect(s) on pancreatic tissue in STZ-induced oxidative stress due to its high antioxidative potential...

..Based on these results, it can be concluded that different fractions of AGE especially EEF, besides its hypolipidaemic property, could protect the liver against the HFD-induced oxidative damage in rats...

..The aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using U937 cells...

..These findings may assist the activity recovery of recombinant proteins at relatively high concentrations...

..In this investigation an attempt was made to study the effect of Nasturtium officinale hydroalcoholic extract (NOE) on serum lipid profile which is closely associated with many cardiovascular diseases...

..Based on these results, 3-HK might become an ideal candidate for treatment of APL patients pending full exploration of its biological functions...

..Based on the present data, it seems that the new compound is a good candidate for further evaluation as an effective chemotherapeutic agent acting through induction of differentiation and apoptosis...

..Based on this newly developed method, it is expected that the protein refolding operation can be achieved easily, cheaply and efficiently...

..Overall, MetVO-salen appears to be an effective antioxidant and is quite suitable for further biological evaluation...

..The results demonstrate that dRib induces the generation of ROS leading to dRib-mediated apoptosis which can be attenuated by PLP through antioxidant mechanisms...

..Based on these results, the VO-salen complex might be considered as an effective antioxidant and hepatoprotective agent suitable for further biological evaluation...

..These interesting results necessitate further investigation regarding the mechanism of action of this unique anti-leukemic agent...

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..Using flow cytometry technique, it was found that treatment of the most responsive cells (K562) with compound I inhibited the progression of cells through G1 phase by almost 20% compared to the untreated cells...

..Oral administration of the essential oil of A. graveolens seeds, at two different doses, also reduced the triacylglyceride levels by almost 42%. The total cholesterol level was not reduced by the same doses of the essential oil...

..However, the drug effects on K562 cells were potentiated by hypoxanthine. Based on these observations, perturbation of GTP metabolism is considered as one of the main reasons for apoptotic cell death by 3-HK...

..Based on these data, an antioxidant mode of action is proposed for AA3E2 besides its previously beta-amyloid-breaking activity...

..In conclusion, our data will hopefully have important impact on pharmaceutical evaluation of guanine nucleotides for leukemia treatments...

..However, further-improvements in solid-phase artificial chaperone assisted technique are demanded either through synthesizing better stripping agents or by optimizing and defining better refolding environments...

..e., cyclodextrins). This situation will lead to higher intermolecular hydrophobic interactions among the refolding protein intermediates leading to their higher misfolding and aggregation...

..However, the high activity recovery in the presence of detergents, as the stripping agent, suggests that they can constitute suitable replacement for the more expensive and common stripping agent of cyclodextrins...

..Platelet hyperactivity plays an important role in atherosclerosis and arterial thrombosis. Artemisia dracunculus L. (tarragon) is a common table vegetable all over Iran and known for its anticoagulant activity in Iranian folk medicine...

..While the untreated cells have polygonal shapes, the treated cells had spherical shapes...

..These results suggest that 3-HK may be a powerful candidate for treatment of leukemia...

..These findings support that combination of VO-salen, as a chemosensitizer, and taxol might constitute an affective new strategy for leukemia therapy...

..As a result, more aggregates were formed in the presence of alpha-CD compared to the corresponding control samples...

..These observations provide the background for future design of more elegant beta-breaking agents for dissolution of Abeta fibrillar aggregates...

..Moreover, both extracts significantly decreased plasma glucose and insulin levels along with insulin resistance. In conclusion, both extracts of T. polium could reverse the adverse effects of an MCD diet...

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..Replacement of Mg2+ ion with other type of ions which interact with alpha-cyclodextrin interfere with the function of cyclodextrin resulting in low refolding yields...

..5 x 10(-9)M, were capable of enhancing the intracellular protein content of each of the cell lines by almost 160% while the intracellular alkaline phosphatase activity was increased up to 450%...

..rotundus. These results might lead to the possibility of using the plant extract or its purified active components for targeting diabetic complications...

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..Based on these results, it seems that the new stripping strategy can constitute an ideal approach for refolding of proteins at much lower industrial costs compared to stripping with soluble beta-cyclodextrin...

..These data clearly show that the plant extract, probably without metabolic transformation, is able to reduce high blood glucose levels through enhancing insulin secretion by the pancreas...

..In this study, we tried to evaluate whether the ethyl acetate (EtOAc) extract of Teucrium polium, with a high antioxidant activity, is able to prevent the incidence of nonalcoholic steatohepatitis...

..Taken together, these results suggest that distinct signaling pathways play a pivotal role in fates of drug-treated leukemia cells, thus this may pave some novel therapeutical utilities...

..Consequently, it is concluded that up-regulation of cyclin D1, accompanied by the persistent activation of ERK/MAPK, is involved in the megakaryocytic differentiation of K562 cells under the influence of 3-HK...

..The anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-HK), have been established using several cancer cell lines...

..These results clearly demonstrate that, the EtOAc fraction, owning to its antioxidant content, is capable of suppressing the formation of AGEs and protein oxidation in vitro...

..In addition, the differences between the cell-pellet AP and the culture medium AP seemed to stem from different sugar moieties in their structures...