R Yazdanparast

Summary

Affiliation: University of Tehran
Country: Iran

Publications

  1. ncbi request reprint Fluorimetric study of the artificial chaperone-assisted renaturation of carbonic anhydrase: a kinetic analysis
    Reza Khodarahmi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 36:191-7. 2005
  2. pmc Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress
    Alireza Rezazadeh
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    J Biomed Sci 19:26. 2012
  3. pmc Antioxidant and free radical scavenging potential of yakuchinone B derivatives in reduction of lipofuscin formation using H2O2-treated neuroblastoma cells
    Samaneh Bayati
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Iran Biomed J 15:134-42. 2011
  4. ncbi request reprint 3-Hydrogenkwadaphnin from Dendrostellera lessertii induces differentiation and apoptosis in HL-60 cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Planta Med 71:1112-7. 2005
  5. ncbi request reprint Induction of differentiation and apoptosis in three human leukemia cell lines by a new compound from Dendrostellera lessertii
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Acta Biochim Biophys Sin (Shanghai) 38:477-83. 2006
  6. ncbi request reprint Control of aggregation in protein refolding: cooperative effects of artificial chaperone and cold temperature
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 40:126-33. 2007
  7. ncbi request reprint Guanosine 5'-triphosphate induces differentiation-dependent apoptosis in human leukemia U937 and KG1 cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384 University of Tehran, Tehran, Iran
    Acta Pharmacol Sin 27:1175-84. 2006
  8. doi request reprint Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Chem Biol Interact 172:176-84. 2008
  9. ncbi request reprint In vitro antioxidant and free radical scavenging activity of Cyperus rotundus
    R Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    J Med Food 10:667-74. 2007
  10. ncbi request reprint Evaluation of artificial chaperoning behavior of an insoluble cyclodextrin-rich copolymer: solid-phase assisted refolding of carbonic anhydrase
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, PO Box 13145 1384, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 40:319-26. 2007

Collaborators

  • Effat Souri
  • Reza Khodarahmi
  • Fariba Khodagholi
  • Mohammad Ali Esmaeili
  • Young Tae Chang
  • Mohammad Amin Moosavi
  • Azadeh Meshkini
  • Amin Ardestani
  • Mohsen Mohammadi
  • Hamed Shaykhalishahi
  • Seifollah Bahramikia
  • Azin Nowrouzi
  • Safiyeh Aghazadeh
  • Narges Nosrati
  • Abbas Lotfi
  • Alireza Rezazadeh
  • Samaneh Bayati
  • Mahsa Molaei
  • Rahim Amini
  • A Ardestani
  • Leila Shahriyary
  • Mohammad Ali Esmaeili
  • Majid Mahdavi
  • Akram Sadeghirizi
  • Abdolfattah Sarraf Nejad
  • Mohammad Hasan Sanati
  • H Sadeghi
  • M Mianabadi
  • Heibatollah Sadeghi
  • Mohammad Taghizadeh
  • Hyung Ho Ha
  • Mojgan Haidari
  • Sh Jamshidi

Detail Information

Publications66

  1. ncbi request reprint Fluorimetric study of the artificial chaperone-assisted renaturation of carbonic anhydrase: a kinetic analysis
    Reza Khodarahmi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 36:191-7. 2005
    ..Based on these findings, appropriate refolding conditions could be designed to kinetically diminish the rate of off-pathway aggregation...
  2. pmc Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress
    Alireza Rezazadeh
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    J Biomed Sci 19:26. 2012
    ..The aim of present study was to determine whether antioxidant supplementations using EUK-8, EUK-134 and vitamin C could improve the biochemical and histological abnormalities associated with diet-induced NASH in rats...
  3. pmc Antioxidant and free radical scavenging potential of yakuchinone B derivatives in reduction of lipofuscin formation using H2O2-treated neuroblastoma cells
    Samaneh Bayati
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Iran Biomed J 15:134-42. 2011
    ..Yakuchinone B (1-[4'-hydroxy-3'-methoxyphenyl]-7-phenylhept-1-en-3-one) is a component of Alpinia oxyphylla seeds with established antioxidant activity...
  4. ncbi request reprint 3-Hydrogenkwadaphnin from Dendrostellera lessertii induces differentiation and apoptosis in HL-60 cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Planta Med 71:1112-7. 2005
    ..Therefore, GTP depletion, as a result of inhibition of inosine monophosphate dehydrogenase (IMPDH), is considered as one of the main reasons for differentiation and apoptotic cell death by this new drug...
  5. ncbi request reprint Induction of differentiation and apoptosis in three human leukemia cell lines by a new compound from Dendrostellera lessertii
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Acta Biochim Biophys Sin (Shanghai) 38:477-83. 2006
    ..Based on the present data, the new compound seems a good candidate for further evaluation as an effective chemotherapeutic agent acting through induction of differentiation and apoptosis...
  6. ncbi request reprint Control of aggregation in protein refolding: cooperative effects of artificial chaperone and cold temperature
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 40:126-33. 2007
    ....
  7. ncbi request reprint Guanosine 5'-triphosphate induces differentiation-dependent apoptosis in human leukemia U937 and KG1 cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384 University of Tehran, Tehran, Iran
    Acta Pharmacol Sin 27:1175-84. 2006
    ..The differentiation capability of guanosine 5'-triphosphate (GTP) was studied using U937 and KG1 cells...
  8. doi request reprint Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Chem Biol Interact 172:176-84. 2008
    ..Based on our data, it can be concluded that N. officinale has a high hypolipidaemic activity and this may be attributed to its antioxidative potential...
  9. ncbi request reprint In vitro antioxidant and free radical scavenging activity of Cyperus rotundus
    R Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    J Med Food 10:667-74. 2007
    ..These results clearly established the antioxidative potency of C. rotundus, which may account for some of the medical claims attributed to this plant...
  10. ncbi request reprint Evaluation of artificial chaperoning behavior of an insoluble cyclodextrin-rich copolymer: solid-phase assisted refolding of carbonic anhydrase
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, PO Box 13145 1384, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 40:319-26. 2007
    ..2 ml refolding solution containing 0.0286 mg/ml protein. Taking into account the recycling potential of the copolymer, the new resin, with significant cost-cutting capability, is a suitable candidate for industrial applications...
  11. ncbi request reprint Protein refolding assisted by molecular tube based alpha-cyclodextrin as an artificial chaperone
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    Biochemistry (Mosc) 71:1298-306. 2006
    ..However, further improvements in solid-phase artificial chaperone assisted technique are needed either through synthesizing better stripping agents or by optimizing and defining better refolding environments...
  12. ncbi request reprint Experimental diabetes treated with Achillea santolina: effect on pancreatic oxidative parameters
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    J Ethnopharmacol 112:13-8. 2007
    ..Based on our data, it can be concluded that Achillea santolina have a high hypoglycaemic activity and this may be attributed to its antioxidative potential...
  13. ncbi request reprint Comparative effects of Artemisia dracunculus, Satureja hortensis and Origanum majorana on inhibition of blood platelet adhesion, aggregation and secretion
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Vascul Pharmacol 48:32-7. 2008
    ..These observations provide the basis for the traditional use of these herbs in treatments of cardiovascular diseases and thrombosis...
  14. ncbi request reprint Kinetic aspects of alkaline phosphatase refolding in the presence of alpha-cyclodextrin
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, The University of Tehran, P O Box 13145 1384, Tehran, Iran
    Arch Biochem Biophys 446:11-9. 2006
    ..This may be attributed to continuous structural rearrangements in the protein long after the return of enzyme activity. These observations are discussed in terms of kinetic and structural aspects of the refolding pathway...
  15. doi request reprint 3-Hydrogenkwadaphnine, a novel diterpene ester from Dendrostellera lessertii, its role in differentiation and apoptosis of KG1 cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Phytomedicine 16:206-14. 2009
    ..Based on the present data, these two active constituents of D. lessertii have the novelty of being further evaluated for pharmaceutical applications...
  16. ncbi request reprint Alkaline phosphatase refolding assisted by sequential use of oppositely charged detergents: a new artificial chaperone system
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Int J Biol Macromol 42:195-202. 2008
    ..Collectively it is expected that protein refolding process can be achieved easier, cheaper and more efficient, using the new technique reported here...
  17. ncbi request reprint Nucleic acid synthesis in cancerous cells under the effect of gnidilatimonoein from Daphne mucronata
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Life Sci 74:1869-76. 2004
    ..These data strongly suggest that the purine biosynthetic pathway is significantly affected by gnidilatimonoein...
  18. ncbi request reprint The effect of the active component of Dendrostellera lessertii on the adhesive property of human platelets and HL-60 cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384 University of Tehran, Tehran, Iran
    Life Sci 75:733-9. 2004
    ..These data clearly indicates that Dendrostellera lessertii is capable of mediating tumor metastasis through affecting the adhesion properties of the cells...
  19. ncbi request reprint The combined effects of two anti-aggregatory agents, alpha-cyclodextrin and Ca2+, on the refolding process of denatured alpha-amylase
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Biotechnol Appl Biochem 41:157-62. 2005
    ....
  20. ncbi request reprint Artificial chaperone-assisted refolding of chemically denatured alpha-amylase
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, The University of Tehran, Tehran, Iran
    Int J Biol Macromol 35:257-63. 2005
    ..Collectively, the results of this investigation expand the range of procedural variations used to refold different denatured proteins through artificial chaperone-assisted method...
  21. ncbi request reprint Comparative studies of the artificial chaperone-assisted refolding of thermally denatured bovine carbonic anhydrase using different capturing ionic detergents and beta-cyclodextrin
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Arch Biochem Biophys 437:178-85. 2005
    ....
  22. doi request reprint Protective effect of a triazine-derivative (AA3E2) on beta-amyloid-induced damages in SK-N-MC cells
    Razieh Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Toxicol In Vitro 23:1277-83. 2009
    ..Thus, sequestration of this role by potential antioxidants such as AA3E2 might happen to be a suitable strategy for future treatments of AD...
  23. doi request reprint Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induced diabetic rats
    A Ardestani
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    J Med Food 11:525-32. 2008
    ..Based on these observations, it is concluded that T. polium may have protective effect(s) on pancreatic tissue in STZ-induced oxidative stress due to its high antioxidative potential...
  24. ncbi request reprint Efficacy of different fractions of Anethum graveolens leaves on serum lipoproteins and serum and liver oxidative status in experimentally induced hypercholesterolaemic rat models
    Seifollah Bahramikia
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Am J Chin Med 37:685-99. 2009
    ..Based on these results, it can be concluded that different fractions of AGE especially EEF, besides its hypolipidaemic property, could protect the liver against the HFD-induced oxidative damage in rats...
  25. ncbi request reprint Differentiation and apoptosis of U-937 leukemia cells by an active compound from Dendrostellera lessertii
    Azadeh Meshkini
    Institute of Biochemistry and Biophysic, University of Tehran, Tehran, Iran
    Iran Biomed J 13:35-42. 2009
    ..The aim of this study was to determine whether the anti-proliferative effect observed for this compound, is differentiation-dependent among the drug-treated cells, using U937 cells...
  26. ncbi request reprint Artificial chaperone-assisted refolding of GuHCl-denatured alpha-amylase at low temperature: refolding versus aggregation
    Fariba Khodagholi
    Institute of Biochemistry and Biophysics, The University of Tehran, P O Box 13145 1384, Tehran, Iran
    Protein J 24:303-13. 2005
    ..These findings may assist the activity recovery of recombinant proteins at relatively high concentrations...
  27. ncbi request reprint Effect of hydroalcoholic extracts of Nasturtium officinale leaves on lipid profile in high-fat diet rats
    Seifollah Bahramikia
    Institute of Biochemistry and Biophysics, PO Box 13145 1384, University of Tehran, Tehran, Iran
    J Ethnopharmacol 115:116-21. 2008
    ..In this investigation an attempt was made to study the effect of Nasturtium officinale hydroalcoholic extract (NOE) on serum lipid profile which is closely associated with many cardiovascular diseases...
  28. ncbi request reprint 3-Hydrogenkwadaphnin induces monocytic differentiation and enhances retinoic acid-mediated granulocytic differentiation in NB4 cell line
    Mohammad Amin Moosavi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384 University of Tehran, Tehran, Iran
    J Biochem Mol Biol 39:722-9. 2006
    ..Based on these results, 3-HK might become an ideal candidate for treatment of APL patients pending full exploration of its biological functions...
  29. ncbi request reprint Gnidilatimonoein from Daphne mucronata induces differentiation and apoptosis in leukemia cell lines
    Majid Mahdavi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Arch Pharm Res 30:177-81. 2007
    ..Based on the present data, it seems that the new compound is a good candidate for further evaluation as an effective chemotherapeutic agent acting through induction of differentiation and apoptosis...
  30. ncbi request reprint A new artificial chaperone for protein refolding: sequential use of detergent and alginate
    Fariba Khodagholi
    Institute of Biochemistry and Biophysics, The University of Tehran, P O Box 13145 1384, Tehran, Iran
    Protein J 27:123-9. 2008
    ..Based on this newly developed method, it is expected that the protein refolding operation can be achieved easily, cheaply and efficiently...
  31. doi request reprint Methoxy VO-salen complex: in vitro antioxidant activity, cytotoxicity evaluation and protective effect on CCl4-induced oxidative stress in rats
    Mohsen Mohammadi
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Food Chem Toxicol 47:716-21. 2009
    ..Overall, MetVO-salen appears to be an effective antioxidant and is quite suitable for further biological evaluation...
  32. doi request reprint 2-Deoxy-D-ribose-induced oxidative stress causes apoptosis in human monocytic cells: prevention by pyridoxal-5'-phosphate
    Amin Ardestani
    Institute of Biochemistry and Biophysics, PO Box 13145 1384, University of Tehran, Tehran, Iran
    Toxicol In Vitro 22:968-79. 2008
    ..The results demonstrate that dRib induces the generation of ROS leading to dRib-mediated apoptosis which can be attenuated by PLP through antioxidant mechanisms...
  33. doi request reprint Radical scavenging abilities and hepatoprotective effect of [N, N'-Bis (salicylidene) ethane-1, 2-diaminato] oxovanadium (IV) complex in CCl4-treated rats
    Mohsen Mohammadi
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Exp Toxicol Pathol 62:533-8. 2010
    ..Based on these results, the VO-salen complex might be considered as an effective antioxidant and hepatoprotective agent suitable for further biological evaluation...
  34. ncbi request reprint Induction of megakaryocytic differentiation in chronic myelogenous leukemia cell K562 by 3-hydrogenkwadaphnin
    Azadeh Meshkini
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    J Biochem Mol Biol 40:944-51. 2007
    ..These interesting results necessitate further investigation regarding the mechanism of action of this unique anti-leukemic agent...
  35. ncbi request reprint Plasma membrane homing of tissue nonspecific alkaline phosphatase under the influence of 3-hydrogenkwadaphnin, an antiproliferative agent from Dendrostellera lessertii
    Akram Sadeghirizi
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Acta Biochim Pol 54:323-9. 2007
    ....
  36. ncbi request reprint Isolation and structure elucidation of a new potent anti-neoplastic diterpene from Dendrostellera lessertii
    H Sadeghi
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Am J Chin Med 33:831-7. 2005
    ..Using flow cytometry technique, it was found that treatment of the most responsive cells (K562) with compound I inhibited the progression of cells through G1 phase by almost 20% compared to the untreated cells...
  37. ncbi request reprint Antihyperlipidaemic and antihypercholesterolaemic effects of Anethum graveolens leaves after the removal of furocoumarins
    R Yazdanparast
    Institute of Biochemistry and Biophysics, University of Tehran, Iran
    Cytobios 105:185-91. 2001
    ..Oral administration of the essential oil of A. graveolens seeds, at two different doses, also reduced the triacylglyceride levels by almost 42%. The total cholesterol level was not reduced by the same doses of the essential oil...
  38. ncbi request reprint The cytotoxic and anti-proliferative effects of 3-hydrogenkwadaphnin in K562 and jurkat cells is reduced by guanosine
    Mohammad Amin Moosavi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    J Biochem Mol Biol 38:391-8. 2005
    ..However, the drug effects on K562 cells were potentiated by hypoxanthine. Based on these observations, perturbation of GTP metabolism is considered as one of the main reasons for apoptotic cell death by 3-HK...
  39. doi request reprint Inhibition of H2O2-induced neuroblastoma cell cytotoxicity by a triazine derivative, AA3E2
    Hamed Shaykhalishahi
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Eur J Pharmacol 622:1-6. 2009
    ..Based on these data, an antioxidant mode of action is proposed for AA3E2 besides its previously beta-amyloid-breaking activity...
  40. ncbi request reprint GTP induces S-phase cell-cycle arrest and inhibits DNA synthesis in K562 cells but not in normal human peripheral lymphocytes
    Mohammad Amin Moosavi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    J Biochem Mol Biol 39:492-501. 2006
    ..In conclusion, our data will hopefully have important impact on pharmaceutical evaluation of guanine nucleotides for leukemia treatments...
  41. doi request reprint Solid-phase assisted refolding of carbonic anhydrase using beta-cyclodextrin-polyurethane polymer
    Mohammad Ali Esmaeili
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Protein J 27:334-42. 2008
    ..However, further-improvements in solid-phase artificial chaperone assisted technique are demanded either through synthesizing better stripping agents or by optimizing and defining better refolding environments...
  42. ncbi request reprint The glycophosphatidylinositol anchor oppositely affects unfolding and refolding of alkaline phosphatase
    Fariba Khodagholi
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    J Biomol Struct Dyn 25:189-94. 2007
    ..e., cyclodextrins). This situation will lead to higher intermolecular hydrophobic interactions among the refolding protein intermediates leading to their higher misfolding and aggregation...
  43. ncbi request reprint Comparative evaluation of alpha-amylase refolding through two different artificial chaperone systems
    Fariba Khodagholi
    Institute of Biochemistry and Biophysics, The University of Tehran, Tehran, Iran
    Protein J 26:293-301. 2007
    ..However, the high activity recovery in the presence of detergents, as the stripping agent, suggests that they can constitute suitable replacement for the more expensive and common stripping agent of cyclodextrins...
  44. ncbi request reprint Inhibition of blood platelet adhesion, aggregation and secretion by Artemisia dracunculus leaves extracts
    Leila Shahriyary
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    J Ethnopharmacol 114:194-8. 2007
    ..Platelet hyperactivity plays an important role in atherosclerosis and arterial thrombosis. Artemisia dracunculus L. (tarragon) is a common table vegetable all over Iran and known for its anticoagulant activity in Iranian folk medicine...
  45. ncbi request reprint Inhibition of substrate-tumor cell adhesion under the effect of gnidilatimonoein purified from Daphne mucronata
    M Mianabadi
    Institute of Biochemistry and Biophysics, University of Tehran P O Box 13145 1384, Tehran, Iran
    Am J Chin Med 32:369-76. 2004
    ..While the untreated cells have polygonal shapes, the treated cells had spherical shapes...
  46. ncbi request reprint 3-Hydrogenkwadaphnin targets inosine 5'-monophosphate dehydrogenase and triggers post-G1 arrest apoptosis in human leukemia cell lines
    Mohammad Amin Moosavi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Int J Biochem Cell Biol 37:2366-79. 2005
    ..These results suggest that 3-HK may be a powerful candidate for treatment of leukemia...
  47. doi request reprint Chemosensitization of human leukemia K562 cells to taxol by a Vanadium-salen complex
    Azadeh Meshkini
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Exp Mol Pathol 89:334-42. 2010
    ..These findings support that combination of VO-salen, as a chemosensitizer, and taxol might constitute an affective new strategy for leukemia therapy...
  48. ncbi request reprint Refolding of chemically denatured alpha-amylase in dilution additive mode
    Reza Khodarahmi
    Institute of Biochemistry and Biophysics, The University of Tehran, PO Box 13145 1384, Enghelab Street, Tehran 13145 1384, Iran
    Biochim Biophys Acta 1674:175-81. 2004
    ..As a result, more aggregates were formed in the presence of alpha-CD compared to the corresponding control samples...
  49. doi request reprint Anti-amyloidogenic effect of AA3E2 attenuates beta-amyloid induced toxicity in SK-N-MC cells
    Hamed Shaykhalishahi
    Institute of Biochemistry and Biophysics, University of Tehran, Enghelab Ave, Tehran, Iran
    Chem Biol Interact 186:16-23. 2010
    ..These observations provide the background for future design of more elegant beta-breaking agents for dissolution of Abeta fibrillar aggregates...
  50. doi request reprint Effects of Teucrium polium on Insulin Resistance in Nonalcoholic Steatohepatitis
    Narges Nosrati
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    J Acupunct Meridian Stud 3:104-10. 2010
    ..Moreover, both extracts significantly decreased plasma glucose and insulin levels along with insulin resistance. In conclusion, both extracts of T. polium could reverse the adverse effects of an MCD diet...
  51. doi request reprint Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats
    Safiyeh Aghazadeh
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Clin Nutr 29:381-5. 2010
    ....
  52. ncbi request reprint Designing a highly efficient refolding system for alkaline phosphatase using combination of cyclodextrin and Mg2+ ion
    Fariba Khodagholi
    Institute of Biochemistry and Biophysics, The University of Tehran, P O Box 13145 1384, Tehran, Iran
    Protein J 27:1-6. 2008
    ..Replacement of Mg2+ ion with other type of ions which interact with alpha-cyclodextrin interfere with the function of cyclodextrin resulting in low refolding yields...
  53. ncbi request reprint Effect of Dendrostellera lessertii on the intracellular alkaline phosphatase activity of four human cancer cell lines
    Heibatollah Sadeghi
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    J Ethnopharmacol 86:11-4. 2003
    ..5 x 10(-9)M, were capable of enhancing the intracellular protein content of each of the cell lines by almost 160% while the intracellular alkaline phosphatase activity was increased up to 450%...
  54. ncbi request reprint Cyperus rotundus suppresses AGE formation and protein oxidation in a model of fructose-mediated protein glycoxidation
    Amin Ardestani
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Int J Biol Macromol 41:572-8. 2007
    ..rotundus. These results might lead to the possibility of using the plant extract or its purified active components for targeting diabetic complications...
  55. ncbi request reprint ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5'-triphosphate-mediated terminal erythroid differentiation of K562 cells
    Mohammad Amin Moosavi
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Int J Biochem Cell Biol 39:1685-97. 2007
    ....
  56. ncbi request reprint Molecularly imprinted poly beta-cyclodextrin polymer: application in protein refolding
    Mohammad Ali Esmaeili
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    Biochim Biophys Acta 1770:943-50. 2007
    ..Based on these results, it seems that the new stripping strategy can constitute an ideal approach for refolding of proteins at much lower industrial costs compared to stripping with soluble beta-cyclodextrin...
  57. ncbi request reprint Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets
    Mohammad Ali Esmaeili
    Institute of Biochemistry and Biophysics, P O Box 13145 1384, University of Tehran, Tehran, Iran
    J Ethnopharmacol 95:27-30. 2004
    ..These data clearly show that the plant extract, probably without metabolic transformation, is able to reduce high blood glucose levels through enhancing insulin secretion by the pancreas...
  58. doi request reprint Teucrium polium in prevention of steatohepatitis in rats
    Rahim Amini
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Liver Int 29:1216-21. 2009
    ..In this study, we tried to evaluate whether the ethyl acetate (EtOAc) extract of Teucrium polium, with a high antioxidant activity, is able to prevent the incidence of nonalcoholic steatohepatitis...
  59. doi request reprint Distinct MAPK signaling pathways, p21 up-regulation and caspase-mediated p21 cleavage establishes the fate of U937 cells exposed to 3-hydrogenkwadaphnin: differentiation versus apoptosis
    Mohammad Amin Moosavi
    Institute of Biochemistry and Biophysics, P O Box 13145 1384 University of Tehran, Tehran, Iran
    Toxicol Appl Pharmacol 230:86-96. 2008
    ..Taken together, these results suggest that distinct signaling pathways play a pivotal role in fates of drug-treated leukemia cells, thus this may pave some novel therapeutical utilities...
  60. doi request reprint Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin
    Azadeh Meshkini
    Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
    Toxicol In Vitro 22:1503-10. 2008
    ..Consequently, it is concluded that up-regulation of cyclin D1, accompanied by the persistent activation of ERK/MAPK, is involved in the megakaryocytic differentiation of K562 cells under the influence of 3-HK...
  61. ncbi request reprint G1 phase arrest and apoptosis induction in human thyroid cancer cell line Thr.C1.PI33 by 3-hydrogenkwadaphnin isolated from Dendrostellera lessertii
    Azin Nowrouzi
    Institute of Biochemistry and Biophysics, Department of Clinical Biochemistry, School of Medicine, University of Tehran, Tehran, Iran
    Iran Biomed J 11:215-21. 2007
    ..The anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-HK), have been established using several cancer cell lines...
  62. ncbi request reprint Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation
    Amin Ardestani
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Food Chem Toxicol 45:2402-11. 2007
    ..These results clearly demonstrate that, the EtOAc fraction, owning to its antioxidant content, is capable of suppressing the formation of AGEs and protein oxidation in vitro...
  63. ncbi request reprint Alkaline phosphatase retained in HepG2 hepatocarcinoma cells vs. alkaline phosphatase released to culture medium: difference of aberrant glycosylation
    Azin Nowrouzi
    Institute of Biochemistry and Biophysics, University of Tehran, P O Box 13145 1384, Tehran, Iran
    Biochem Biophys Res Commun 330:400-9. 2005
    ..In addition, the differences between the cell-pellet AP and the culture medium AP seemed to stem from different sugar moieties in their structures...
  64. ncbi request reprint Differentiation therapy as an effective strategy for the treatment of chronic myelogenous leukemia
    Mohammad Amin Moosavi
    Med Hypotheses 67:1470-1. 2006
  65. ncbi request reprint Daphnane-type diterpene esters as powerful agents for the treatment of leukemia
    Razieh Yazdanparast
    Med Hypotheses 67:1472-3. 2006
  66. ncbi request reprint Flavonoids as potential therapeutic agents for type 1 diabetes
    Amin Ardestani
    Med Hypotheses 69:955. 2007