Ameneh Rezayof


Affiliation: University of Tehran
Country: Iran


  1. Ghasemzadeh Z, Rezayof A. Medial Prefrontal Cortical Cannabinoid CB1 Receptors Mediate Morphine-Dextromethorphan Cross State-Dependent Memory: The Involvement of BDNF/cFOS Signaling Pathways. Neuroscience. 2018;393:295-304 pubmed publisher
    ..Taken together, it can be concluded that mPFC through CB1cannabinoid receptors has a critical role in morphine-DXM cross-SDM which may be associated with the PFC BDNF/cFOS signaling pathway. ..
  2. Keshavarzian E, Ghasemzadeh Z, Rezayof A. The basolateral amygdala dopaminergic system contributes to the improving effect of nicotine on stress-induced memory impairment in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2018;86:30-35 pubmed publisher
    ..Moreover, the dopaminergic neurotransmission in the BLA through D1 and D2 receptors mediates the improving effect of nicotine on stress-induced memory retrieval impairment. ..
  3. Rezayof A, Hosseini S, Zarrindast M. Effects of morphine on rat behaviour in the elevated plus maze: the role of central amygdala dopamine receptors. Behav Brain Res. 2009;202:171-8 pubmed publisher
    ..In conclusion, these findings suggest that the central amygdala dopaminergic mechanisms, probably via D(1)/D(2) receptors, may be involved in the modulation of morphine-induced anxiolytic-like behaviour in rat. ..
  4. Sardari M, Rezayof A, Zarrindast M. 5-HT1A receptor blockade targeting the basolateral amygdala improved stress-induced impairment of memory consolidation and retrieval in rats. Neuroscience. 2015;300:609-18 pubmed publisher
    ..The BLA 5-HT1A receptors have a critical role in learning and memory under stress. ..
  5. Alijanpour S, Rezayof A, Sepehri H, Delphi L. Alterations in the hippocampal phosphorylated CREB expression in drug state-dependent learning. Behav Brain Res. 2015;292:109-15 pubmed publisher
    ..It can be concluded that phosphorylation of CREB in the hippocampus is a critical event underlying the interaction of co-administration of drugs on memory retrieval in passive avoidance learning. ..
  6. Kosarmadar N, Ghasemzadeh Z, Rezayof A. Inhibition of microglia in the basolateral amygdala enhanced morphine-induced antinociception: Possible role of GABAA receptors. Eur J Pharmacol. 2015;765:157-63 pubmed publisher
    ..Moreover, basolateral amygdala GABAergic system may be involved in the minocycline-induced potentiation of morphine response via GABAA receptors. ..
  7. Rezayof A, Shirazi Zand Z, Zarrindast M, Nayer Nouri T. Nicotine improves ethanol-induced memory impairment: the role of dorsal hippocampal NMDA receptors. Life Sci. 2010;86:260-6 pubmed publisher
    ..The results suggest the importance of NMDA glutamate system(s) in the CA1 regions of dorsal hippocampus for improving the effect of nicotine on the ethanol-induced amnesia. ..
  8. Rezayof A, Sharifi K, Zarrindast M, Rassouli Y. Modulation of ethanol state-dependent learning by dorsal hippocampal NMDA receptors in mice. Alcohol. 2008;42:667-74 pubmed publisher
    ..25, 0.5, and 1 microg/mouse) alone did not affect memory retention. It may be concluded that dorsal hippocampal NMDA receptors are involved in mediating ethanol state-dependent learning. ..
  9. Sardari M, Rezayof A, Khodagholi F. Hippocampal signaling pathways are involved in stress-induced impairment of memory formation in rats. Brain Res. 2015;1625:54-63 pubmed publisher
    ..Overall, these findings suggest that down-regulation of CREB/PGC-1α signaling cascade and Nrf2 antioxidant pathways in the hippocampus may be associated with memory impairment induced by stress. ..

More Information


  1. Ghasemzadeh Z, Rezayof A. Ventral hippocampal nicotinic acetylcholine receptors mediate stress-induced analgesia in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2015;56:235-42 pubmed publisher
    ..Taken together, it can be concluded that exposure to acute stress induces SIA in a time-dependent manner and the ventral hippocampal cholinergic system may be involved in SIA via nAChRs. ..
  2. Ofogh S, Rezayof A, Sardari M, Ghasemzadeh Z. Basolateral amygdala CB1 cannabinoid receptors are involved in cross state-dependent memory retrieval between morphine and ethanol. Pharmacol Biochem Behav. 2016;148:92-8 pubmed publisher
    ..In addition, the BLA endocannabinoid system mediates via CB1 receptors the functional interaction of morphine and ethanol state-dependent memory retrieval which may depend on the rewarding effects of the drugs. ..
  3. Ghasemzadeh Z, Rezayof A. Neuromodulatory effects of the dorsal hippocampal endocannabinoid system in dextromethorphan/morphine-induced amnesia. Eur J Pharmacol. 2017;794:100-105 pubmed publisher
    ..Thus, it can be concluded that the dorsal hippocampal endocannabinoid system, via CB1 receptor-dependent mechanism, may be involved in morphine/dextromethorphan -induced amnesia. ..
  4. Nazarinia E, Rezayof A, Sardari M, Yazdanbakhsh N. Contribution of the basolateral amygdala NMDA and muscarinic receptors in rat's memory retrieval. Neurobiol Learn Mem. 2017;139:28-36 pubmed publisher
    ..Our results also suggest that a cooperative interaction between the BLA NMDA and muscarinic acetylcholine receptors modulates memory formation of inhibitory avoidance task in rats. ..
  5. Ghasemzadeh Z, Rezayof A. Role of hippocampal and prefrontal cortical signaling pathways in dextromethorphan effect on morphine-induced memory impairment in rats. Neurobiol Learn Mem. 2016;128:23-32 pubmed publisher
    ..Moreover, a cross SDL can be induced between the co-administration of DM and morphine. Interestingly, CAMKII-CREB signaling pathways also mediate the drugs-induced SDL. ..
  6. Tajik A, Rezayof A, Ghasemzadeh Z, Sardari M. Activation of the dorsal hippocampal nicotinic acetylcholine receptors improves tamoxifen-induced memory retrieval impairment in adult female rats. Neuroscience. 2016;327:1-9 pubmed publisher
    ..Taken together, it can be concluded that the impairing effect of TAM on memory formation may be modulated by nAChRs of the CA1 regions. It seems that memory impairment may be considered as an important side effect of TAM. ..
  7. Mohammadmirzaei N, Rezayof A, Ghasemzadeh Z. Activation of cannabinoid CB1 receptors in the ventral hippocampus improved stress-induced amnesia in rat. Brain Res. 2016;1646:219-226 pubmed publisher
    ..Taken together, it can be concluded that exposure to post-training inescapable stress impaired memory consolidation. The impairing effects of stress on memory retrieval may be mediated by the VH cannabinoid CB1 receptors. ..
  8. Rostami M, Rezayof A, Alijanpour S, Sharifi K. Hippocampal nicotinic receptors have a modulatory role for ethanol and MDMA interaction in memory retrieval. Brain Res. 2017;1669:11-17 pubmed publisher
    ..Thus, it can be concluded that there may be functional interactions among ethanol, MDMA and nicotine via the dorsal hippocampal nicotinic acetylcholine receptor mechanism in memory retrieval and drug state-dependent learning. ..
  9. Tirgar F, Rezayof A, Alijanpour S, Yazdanbakhsh N. Interactive effects of morphine and nicotine on memory function depend on the central amygdala cannabinoid CB1 receptor function in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:62-68 pubmed publisher
    ..Confirmed by the cubic interpolation planes, the dose-response data revealed a cross-state-dependent learning between morphine and nicotine which may be mediated by the CeA endocannabinoid system via CB1 receptors. ..
  10. request reprint
    Rezayof A, Nazari Serenjeh F, Zarrindast M, Sepehri H, Delphi L. Morphine-induced place preference: involvement of cholinergic receptors of the ventral tegmental area. Eur J Pharmacol. 2007;562:92-102 pubmed
    ..We conclude that muscarinic and nicotinic acetylcholine receptors in the ventral tegmental area may critically mediate the rewarding effects of morphine. ..