Mohammad Sharifzadeh

Summary

Affiliation: Tehran University of Medical Sciences
Country: Iran

Publications

  1. ncbi request reprint Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice
    Mohammad Sharifzadeh
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Addict Biol 11:145-51. 2006
  2. doi request reprint Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats
    Ali Mahmoudi
    Department of Pharmacology and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
    J Nat Med 65:519-25. 2011
  3. pmc Effects of training in the Morris water maze on the spatial learning acquisition and VAChT expression in male rats
    A Hosseini-Sharifabad
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences and Medicinal Plant Research Centers, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
    Daru 19:166-72. 2011
  4. ncbi request reprint Evaluation of patient-related factors associated with causality, preventability, predictability and severity of hepatotoxicity during antituberculosis [correction of antituberclosis] treatment
    M Sharifzadeh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Iran
    Pharmacol Res 51:353-8. 2005
  5. ncbi request reprint Protective effects of chronic lithium treatment against spatial memory retention deficits induced by the protein kinase AII inhibitor H-89 in rats
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacology 80:158-65. 2007
  6. ncbi request reprint Intra-hippocampal inhibition of protein kinase AII attenuates morphine-induced conditioned place preference
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Medicinal Plants and Pharmaceutical Sciences Research Centers, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav 85:705-12. 2006
  7. ncbi request reprint A time course analysis of cyclooxygenase-2 suggests a role in spatial memory retrieval in rats
    Mohammad Sharifzadeh
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences and Medicinal Plants Research Centers, Tehran University of Medical Sciences, Tehran, Iran
    Neurosci Res 54:171-9. 2006
  8. doi request reprint The role of nitric oxide in the PKA inhibitor induced spatial memory deficits in rat: involvement of choline acetyltransferase
    Sheyda Najafi
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 714:478-85. 2013
  9. doi request reprint Interactive effects of a protein kinase AII inhibitor and testosterone on spatial learning in the Morris water maze
    Tina Khorshidahmad
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Behav Brain Res 228:432-9. 2012
  10. doi request reprint The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats
    Kian Azami
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155 6451, Tehran, Iran
    Eur J Pharmacol 636:102-7. 2010

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice
    Mohammad Sharifzadeh
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Addict Biol 11:145-51. 2006
    ..It is concluded that the extracts of V. officinalis L. could affect morphine withdrawal syndrome via possible interactions with inhibitory neurotransmitters in nervous system...
  2. doi request reprint Evaluation of systemic administration of Boswellia papyrifera extracts on spatial memory retention in male rats
    Ali Mahmoudi
    Department of Pharmacology and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
    J Nat Med 65:519-25. 2011
    ..These improving effects may be due to some extent to the interactions of these products with inflammatory mediators, neurotransmitter signaling cascades or protein kinase pathways in the brain...
  3. pmc Effects of training in the Morris water maze on the spatial learning acquisition and VAChT expression in male rats
    A Hosseini-Sharifabad
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences and Medicinal Plant Research Centers, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
    Daru 19:166-72. 2011
    ..The present study was designed to evaluate the effects of Morris water maze (MWM) training on spatial memory acquisition and expression of the vesicular acetylcholine transporter (VAChT) in male rats...
  4. ncbi request reprint Evaluation of patient-related factors associated with causality, preventability, predictability and severity of hepatotoxicity during antituberculosis [correction of antituberclosis] treatment
    M Sharifzadeh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Iran
    Pharmacol Res 51:353-8. 2005
    ..This study noted that the frequency of hepatotoxicity induced by antituberculosis drugs in Iranian patients is higher than other studied populations...
  5. ncbi request reprint Protective effects of chronic lithium treatment against spatial memory retention deficits induced by the protein kinase AII inhibitor H-89 in rats
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacology 80:158-65. 2007
    ..001) compared to H-89-treated animals. The data suggest that lithium treatment for 4 weeks improved spatial memory retention and that lithium pretreatment prevented or reversed the H-89-induced spatial memory deficits...
  6. ncbi request reprint Intra-hippocampal inhibition of protein kinase AII attenuates morphine-induced conditioned place preference
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Medicinal Plants and Pharmaceutical Sciences Research Centers, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav 85:705-12. 2006
    ..It is concluded that the PKA II may play an active role in the consolidation of reward-related memory of morphine in CA1 region of the hippocampus...
  7. ncbi request reprint A time course analysis of cyclooxygenase-2 suggests a role in spatial memory retrieval in rats
    Mohammad Sharifzadeh
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences and Medicinal Plants Research Centers, Tehran University of Medical Sciences, Tehran, Iran
    Neurosci Res 54:171-9. 2006
    ..Moreover, the memory deficits induced by the infusions continuously persists for 3 days...
  8. doi request reprint The role of nitric oxide in the PKA inhibitor induced spatial memory deficits in rat: involvement of choline acetyltransferase
    Sheyda Najafi
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 714:478-85. 2013
    ..Moreover, the observed memory improvements caused by 1400 W infusions, might be due to interaction of iNOS with the cholinergic system...
  9. doi request reprint Interactive effects of a protein kinase AII inhibitor and testosterone on spatial learning in the Morris water maze
    Tina Khorshidahmad
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Behav Brain Res 228:432-9. 2012
    ..Overall, our data suggest that spatial acquisition was affected by PKAII inhibition or TE administration. Moreover, when co-administered, these drugs had a negative synergistic impact on acquisition...
  10. doi request reprint The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats
    Kian Azami
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155 6451, Tehran, Iran
    Eur J Pharmacol 636:102-7. 2010
    ....
  11. doi request reprint Nicotine attenuates spatial learning deficits induced by sodium metavanadate
    Kian Azami
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Neurotoxicology 33:44-52. 2012
    ..These findings might open a new avenue for the prevention of vanadium adverse effects on spatial learning and memory through activation of cholinergic signaling pathway...
  12. doi request reprint Role of nitric oxide in the anticonvulsive effect of progesterone
    Taha Gholipour
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Epilepsy Behav 13:579-84. 2008
    ..These findings suggest a potential role for NO signaling as an anticonvulsant target in females...
  13. ncbi request reprint Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences and Medicinal Plants Research Centers, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 562:212-20. 2007
    ..Taken together, our data suggest that intrahippocampal bucladesine infusions improve spatial memory retention in male rats and that bucladesine can interact synergistically with nicotine to improve spatial memory...
  14. doi request reprint Effects of protein kinase A and G inhibitors on hippocampal cholinergic markers expressions in rolipram- and sildenafil-induced spatial memory improvement
    Ali Hosseini-Sharifabad
    Department of Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
    Pharmacol Biochem Behav 101:311-9. 2012
    ..However, we did not find evidence for a chronic increase of cholinergic activity in the observed PDE inhibitor-induced memory improvement...
  15. doi request reprint Protective effect of magnesium-25 carrying porphyrin-fullerene nanoparticles on degeneration of dorsal root ganglion neurons and motor function in experimental diabetic neuropathy
    Asieh Hosseini
    Razi Institute for Drug Research, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Basic Clin Pharmacol Toxicol 109:381-6. 2011
    ..Moreover, our findings indicated that administration of (25)Mg-PMC16 as a magnetic form of Mg improved morphological abnormalities and motor dysfunctions significantly, whereas other forms of Mg were ineffective...
  16. doi request reprint Effects of pentoxifylline and H-89 on epileptogenic activity of bucladesine in pentylenetetrazol-treated mice
    Mahshid Sadat Hosseini-Zare
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 670:464-70. 2011
    ....
  17. ncbi request reprint Post-training intrahippocampal infusion of the COX-2 inhibitor celecoxib impaired spatial memory retention in rats
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 511:159-66. 2005
    ..06, or 0.1 M) on memory retention. Bilateral infusion of 0.1 M celecoxib significantly altered escape latency and traveled distance in rats. These results strongly suggest that cyclooxygenase-2 is involved in spatial memory retention...
  18. ncbi request reprint Post-training intrahippocampal infusion of nicotine prevents spatial memory retention deficits induced by the cyclo-oxygenase-2-specific inhibitor celecoxib in rats
    Mohammad Sharifzadeh
    Department of Toxicology and Pharmacology, School of Pharmacy, Pharmaceutical Sciences and Medicinal Plant Research Centers, University of Medical Sciences, Tehran, Iran
    J Neurochem 95:1078-90. 2005
    ..These results suggest that nicotine prevented or reversed the adverse effects of celecoxib on spatial memory retention and protected or restored the immunostaining pattern of COX-2 neurons in the rat dorsal hippocampus...
  19. doi request reprint Inhibition of PKA attenuates memory deficits induced by β-amyloid (1-42), and decreases oxidative stress and NF-κB transcription factors
    Bahareh Eftekharzadeh
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Behav Brain Res 226:301-8. 2012
    ..Given the possible neuroprotective effects of H-89 on Aβ-induced memory impairment, our results may open a new avenue for the prevention of AD by PKAII signaling pathway inhibitor...
  20. ncbi request reprint Posttraining intrahippocampal infusion of a protein kinase AII inhibitor impairs spatial memory retention in rats
    Mohammad Sharifzadeh
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Neurosci Res 79:392-400. 2005
    ..Our results suggest that PKA II is involved in regulation of cholinergic gene expression and plays an important role in spatial memory retention in rats...
  21. doi request reprint Selective Inducible Nitric Oxide Synthase Inhibitor Reversed Zinc Chloride-Induced Spatial Memory Impairment via Increasing Cholinergic Marker Expression
    Kaveh Tabrizian
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
    Biol Trace Elem Res 173:443-51. 2016
    ..Taken together, these results emphasize the role of selective iNOS inhibitors in reversing zinc chloride-induced spatial memory deficits via modulation of cholinergic marker expression. ..
  22. doi request reprint How sodium arsenite improve amyloid β-induced memory deficit?
    Ehsan Nassireslami
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Physiol Behav 163:97-106. 2016
    ....
  23. doi request reprint Melatonin reverses H-89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function
    Rojin Sharif
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, P O Box 14155 6451, Tehran, Iran
    Behav Brain Res 316:115-124. 2017
    ..Collectively, these findings highlight a protective role for melatonin against H-89-induced memory impairment and indicate that melatonin may play a therapeutic role in the treatment of oxidative- related neurodegenerative disorders...
  24. doi request reprint A cAMP analog reverses contextual and tone memory deficits induced by a PKA inhibitor in Pavlovian fear conditioning
    Ehsan Nassireslami
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav 105:177-82. 2013
    ..Altogether, these results indicate that PKA inhibitor-induced memory deficit was attenuated by a cAMP analog and that the cAMP/PKA signaling pathway has an important role for memory consolidation in fear conditioning response model...
  25. doi request reprint A time course analysis of systemic administration of aqueous licorice extract on spatial memory retention in rats
    Mohammad Sharifzadeh
    Department of Toxicology Pharmacology and Center of Excellence of Toxicology, Pharmaceutical Sciences and Medicinal Plants Research Centers, Faculty of Pharmacy, Tehran University of Medicinal Sciences, Tehran, Iran
    Planta Med 74:485-90. 2008
    ..The maximum concentration was observed after four weeks of GE administration at 5 mg/mL of GL. These results showed that the enhancement effect of GE on spatial memory retention does not correlate with GA blood levels...
  26. ncbi request reprint Systemic and developmental exposure to lead causes spatial memory deficits and a reduction in COX-2 immunoreactivity in the hippocampus of male rats
    Maliheh Soodi
    Department of Toxicology and Pharmacology, School of Pharmacy, Pharmaceutical Sciences and Medicinal Plants Research Centers, Tehran University of Medical Sciences, Tehran, Iran
    J Neurosci Res 85:3183-92. 2007
    ..Taken together, these findings suggest that exposure to lead causes spatial memory deficits in male rats and a significant reduction in cyclooxygenase-2 immunoreactivity in the CA1 and dentate gyrus areas...
  27. ncbi request reprint Inhibition of the cyclooxygenase pathway attenuates morphine-induced conditioned place preference in mice
    Mohammad Hossein Ghahremani
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav 85:356-61. 2006
    ..These results indicate that the reward properties of morphine can be modulated by inhibiting COX activity in mice...
  28. doi request reprint Satureja bachtiarica ameliorate beta-amyloid induced memory impairment, oxidative stress and cholinergic deficit in animal model of Alzheimer's disease
    Maliheh Soodi
    Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Jalal al ahmad street, Tehran, Iran
    Metab Brain Dis 31:395-404. 2016
    ..In conclusion our study represent that S.bachtiarica methanolic extract can improve Aβ-induced memory impairment and cholinergic loss then we recommended this extract as a candidate for further investigation in treatment of AD...
  29. doi request reprint 5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide
    Borna Payandemehr
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Epilepsy Res 101:217-27. 2012
    ..This could propose a new approach toward finding the mechanism of citalopram activity, curtailing the adverse effects of citalopram and perhaps managing the convulsions as a vicious consequence of citalopram overdose...
  30. doi request reprint Anticonvulsant and antiepileptogenic effects of azolylchromanones on lithium-pilocarpine induced seizures and pentylenetetrazole-kindling model of epilepsy
    Abbas Kebriaeezadeh
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Biomed Pharmacother 62:208-11. 2008
    ....
  31. doi request reprint Protective effects of salicylate on PKA inhibitor (H-89)-induced spatial memory deficit via lessening autophagy and apoptosis in rats
    Leila Azimi
    Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav . 2016
    ..The antioxidant activity of salicylate might lead to increased pCREB via stimulation of signaling pathways, resulting in reduction of H-89-induced apoptosis and autophagy...
  32. doi request reprint The involvement of protein kinase G inhibitor in regulation of apoptosis and autophagy markers in spatial memory deficit induced by Aβ
    Marjan Shariatpanahi
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Fundam Clin Pharmacol 30:364-75. 2016
    ..As autophagy-related proteins lose their functions in neurodegenerative diseases, we can suggest that autophagy can be one of the therapeutic aims for remedy of Alzheimer's disease. ..
  33. doi request reprint The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination
    Gelareh Vakilzadeh
    Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran
    Mol Neurobiol 53:4675-84. 2016
    ..These findings may be important for the design of potential MLT therapy in demyelinating disorders, such as MS. ..
  34. doi request reprint Cationic albumin-conjugated chelating agent as a novel brain drug delivery system in neurodegeneration
    Golnaz Kamalinia
    Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
    Chem Biol Drug Des 86:1203-14. 2015
    ..The developed conjugated species were also able to attenuate amyloid beta-induced learning deficits when administered peripherally. ..
  35. doi request reprint Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: in vitro and in vivo studies
    Golnaz Kamalinia
    Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran
    Mol Pharm 10:4418-31. 2013
    ....
  36. doi request reprint The interaction of sildenafil with the anticonvulsant effect of diazepam
    Taha Gholipour
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol 617:79-83. 2009
    ..This suggests that the effects of facilitating GABA(A)-mediated inhibition and modulating NO pathways are additive and there might be a role for NO pathway in benzodiazepine effect against PTZ-induced seizures in mice...
  37. doi request reprint Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats
    Mahnaz Khanavi
    Department of Pharmacognosy, Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Nat Med 66:343-9. 2012
    ..The pharmacological and histological results of the present study proved that the aerial flowering parts of CBB possess preventive activity against peptic ulcer, supporting the traditional assertion in southern Iranian folk medicine...
  38. doi request reprint Sedative effects of Iranian Artemisia annua in mice: possible benzodiazepine receptors involvement
    Fatemeh Emadi
    Department of Pharmacognosy and Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Pharm Biol 49:784-8. 2011
    ..The plant grows broadly in Caspian Sea shores in North of Iran. In China, the aerial parts of this plant are source of artemisinin, which is an antimalarial compound...
  39. doi request reprint Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain
    Akram Ranjbar
    Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Hum Exp Toxicol 29:851-64. 2010
    ..The objective of this study was to investigate the possible protective effects of pentoxifylline as a phosphodiesterase-5 inhibitor on malathion-induced oxidative damage to rat brain mitochondria...
  40. doi request reprint Molecular and biochemical evidence on the protection of cardiomyocytes from phosphine-induced oxidative stress, mitochondrial dysfunction and apoptosis by acetyl-L-carnitine
    Amir Baghaei
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center and Poisoning and Toxicology Research Center and Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran 1417614411, Iran
    Environ Toxicol Pharmacol 42:30-7. 2016
    ..ALCAR also increased the activity of cytochrome oxidase, which in turn amplified ATP production. Furthermore, flow cytometric assays and caspase activity indicated that ALCAR prohibited AlP-induced apoptosis in cardiomyocytes...
  41. doi request reprint Design and synthesis of novel anti-Alzheimer's agents: Acridine-chromenone and quinoline-chromenone hybrids
    Zahra Najafi
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Bioorg Chem 67:84-94. 2016
    ..It should be noted that both kinetic study on the inhibition of AChE and molecular modeling revealed that compound 8e interacted simultaneously with both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. ..
  42. pmc The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat
    Hamid Reza Rahimi
    Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran PharmaceuticsResearch Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
    Iran J Pharm Res 14:1123-35. 2015
    ....
  43. doi request reprint Protective Effect of a cAMP Analogue on Behavioral Deficits and Neuropathological Changes in Cuprizone Model of Demyelination
    Gelareh Vakilzadeh
    School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Mol Neurobiol 52:130-41. 2015
    ..This suggests the modulation of intracellular cAMP as a potential target for treatment of MS...
  44. doi request reprint Synthesis and dopaminergic activity of some E-3-(piperidin-1-yl)-1-(4-substituted phenyl)prop-2-en-1-one derivatives
    Amirhossein Sakhteman
    Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran
    Bioorg Med Chem 17:6908-13. 2009
    ..It was demonstrated that most of the synthesized compounds showed moderate activity in inhibition of lickings, among which 6a, was the most active compound at 30 mg/kg...
  45. ncbi request reprint Solid lipid nanoparticles surface modified with anti-Contactin2 or anti-Neurofascin for brain targeted delivery of medicines
    Nargess Gandomi
    a Dept of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran
    Pharm Dev Technol . 2016
    ..Brain uptake results demonstrated higher uptake of surface modified SLNs in the brain tissue compared with the pegylated SLNs. The results of this report will help scientist to design more efficient nanocarriers for treatment of MS...
  46. doi request reprint Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers
    Farideh Asadi
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav 139:47-58. 2015
    ..Our results further confirm the neuroprotective properties of crocin as a potential pharmaceutical agent for management of Alzheimer's disease. ..
  47. doi request reprint Paradoxical role of PKA inhibitor on amyloidβ-induced memory deficit
    Elham Amini
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Physiol Behav 149:76-85. 2015
    ..In conclusion, our data suggest that H89 as a PKA inhibitor influences memory process through a dose and time dependent manner...
  48. doi request reprint Protective effects of lithium chloride on seizure susceptibility: Involvement of α2-adrenoceptor
    Borna Payandemehr
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Pharmacol Biochem Behav 133:37-42. 2015
    ..In summary, our findings demonstrated that α2-adrenoceptor pathway could be involved in the anticonvulsant properties of lithium chloride in the model of chemically induced clonic seizure. ..
  49. ncbi request reprint Lithium attenuates cannabinoid-induced dependence in the animal model: involvement of phosphorylated ERK1/2 and GSK-3β signaling pathways
    Hamid Reza Rahimi
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Acta Med Iran 52:656-63. 2014
    ..In conclusion, Li neuroprotectionwith regard to cannabinoid abstinence may occur through the regulation of the p-ERK1/2 cascade inconsequent of p-GSK-3β signaling pathways in rats. ..
  50. doi request reprint A novel traumatic brain injury model for induction of mild brain injury in rats
    Tahereh Ghadiri
    School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Shefa Neuroscience Research Center, Tehran, Iran
    J Neurosci Methods 233:18-27. 2014
    ..This study was designed to develop a modified TBI weight drop model for induction of focal mild cerebral injury...
  51. doi request reprint Lithium attenuates peripheral neuropathy induced by paclitaxel in rats
    Nasir Pourmohammadi
    Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Basic Clin Pharmacol Toxicol 110:231-7. 2012
    ..Thus, lithium at these doses, as an inexpensive and relatively safe salt, may be useful clinically in preventing the neuropathy induced by paclitaxel treatment...
  52. ncbi request reprint Phytochemical investigation and anti-inflammatory activity of aerial parts of Stachys byzanthina C. Koch
    Mahnaz Khanavi
    Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Ethnopharmacol 97:463-8. 2005
    ..In conclusion, the present data provide further evidence for an important role of extracts of Stachys byzanthina C. Koch. in the inhibition of pain and inflammatory processes...
  53. doi request reprint Protective effects of physical exercise on MDMA-induced cognitive and mitochondrial impairment
    Ghorban Taghizadeh
    Department of Neuroscience, School of Advanced Science and Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Free Radic Biol Med 99:11-19. 2016
    ..However, physical exercise could reduce these deleterious effects of MDMA through protective effects on brain mitochondrial function...
  54. doi request reprint The effect of arsenite on spatial learning: involvement of autophagy and apoptosis
    Behnoosh BonakdarYazdi
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Toxicology and poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pharmacol . 2016
    ..This facilitation could be attributed to neuronal autophagy induced by low concentrations of sodium arsenite. These findings may help to clarify the regulatory pathways for apoptosis and autophagy balance due to sodium arsenite...
  55. pmc Curcumin as a double-edged sword for stem cells: dose, time and cell type-specific responses to curcumin
    Fatemeh Attari
    Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Daru 23:33. 2015
    ..Little information is available regarding the optimal dose and treatment periods of curcumin on the proliferation rate of different sources of stem cells...
  56. ncbi request reprint The neuroprotective effect of a triazine derivative in an Alzheimer's rat model
    Fatemeh Alipour
    Shafa Neuroscience Research Center, Tehran, Iran AND Department of Animal Physiology, Faculty of Biological Sciences, Tehran University of Medical Sciences, Tehran, Iran
    Acta Med Iran 53:8-16. 2015
    ..This study was aimed to investigate the effect of a triazine derivative, C16H12Cl2N3S, on learning in an Alzheimer's rat model. Animals were divided into seven groups; each group contained seven animals...
  57. doi request reprint Dual effect of cAMP agonist on ameliorative function of PKA inhibitor in morphine-dependent mice
    Seyedeh Y Seyedi
    Department of Pharmacology and Toxicology, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14155 6451, Tehran, Iran
    Fundam Clin Pharmacol 28:445-54. 2014
    ..It is concluded that H-89 and bucladesine could affect morphine withdrawal syndrome via possible interaction with cyclic nucleotide messengering systems, protein kinase A signaling pathways, and modified related neurotransmitters. ..
  58. doi request reprint Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents
    Hamid Irannejad
    Department of Medicinal Chemistry, Faculty of Pharmacy, and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Bioorg Med Chem 18:4224-30. 2010
    ..Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases...
  59. ncbi request reprint Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice
    Shervin Gholizadeh
    Department of Pharmacology, School of Medicine, Medical Sciences, University of Tehran, P O Box 13145 784, Tehran, Iran
    Neuropharmacology 53:763-70. 2007
    ..The present data suggest that ultra-low doses of cannabinoid receptor antagonists may provide a potent strategy to modulate seizure susceptibility, especially in conjunction with very low doses of cannabinoids...
  60. ncbi request reprint Recent updates in imperative natural compounds for healthy brain and nerve function: A systematic review of implications for multiple sclerosis
    Nima Sanadgol
    Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran
    Curr Drug Targets . 2016
    ..The evolution of the 'Green' movement in western society has changed attitudes in the general population who now perceive natural compounds as being inherently harmless and more desirable than artificial chemical products...
  61. doi request reprint Molecular evidence on the protective effect of ellagic acid on phosalone-induced senescence in rat embryonic fibroblast cells
    Maryam Baeeri
    Toxicology and Diseases Group, Pharmaceutical Sciences Research Group, Tehran University of Medical Sciences, Tehran, Iran
    Food Chem Toxicol 100:8-23. 2016
    ..Analysis of cell cycle showed that the percentage of G0/G1 arrest, in REF cells treated by EA was elevated as compared to control and PLN treated cells...
  62. doi request reprint Zinc Chloride and Lead Acetate-Induced Passive Avoidance Memory Retention Deficits Reversed by Nicotine and Bucladesine in Mice
    Kaveh Tabrizian
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
    Biol Trace Elem Res 169:106-13. 2016
    ..Taken together, these results showed the probable role of cholinergic system and protein kinase A pathways in zinc chloride- and lead acetate-induced avoidance memory alterations. ..
  63. ncbi request reprint Nitric oxide agents and apomorphine-induced rat behaviors
    Mohammad Reza Zarrindast
    Department of Pharmacology, Tehran University of Medical Sciences, Institute of Studies of Mathematics and Physics, Tehran University, Tehran, Iran
    Pharmacology 71:169-73. 2004
    ..We have investigated the modulatory actions of the precursor of NO synthesis (L-arginine) and the broad-spectrum NO synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) on apomorphine-induced behaviors in the rat...
  64. pmc Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy
    Asieh Hosseini
    Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Int J Nanomedicine 5:517-23. 2010
    ..It is concluded that in DN, oxidative stress initiates injuries to DRG neurons that finally results in death of neurons whereas administration of (25)Mg-PMC(16) by release of Mg and increasing ATP acts protectively...
  65. doi request reprint Elevated level of nitric oxide mediates the anti-depressant effect of rubidium chloride in mice
    Nastaran Kordjazy
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Eur J Pharmacol 762:411-8. 2015
    ..Our data for the first time reveal the role of NO pathway in the antidepressant-like activity of RbCl, concluding that this effect results from elevation of NO through involvement of iNOS in mice. ..
  66. pmc Antinociceptive effect of some extracts from Ajuga chamaecistus Ging. ssp. tomentella (Boiss.) Rech. f. aerial parts
    Mahnaz Khanavi
    Department of Traditional Pharmacy, School of Traditional Iranian Medicine and Traditional Iranian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Daru 22:56. 2014
    ..tomentella is an exclusive subspecies of Ajuga chamaecistus in the flora of Iran. The aim of this study was to evaluate antinociceptive properties of some extracts from aerial parts of A. chamaecistus ssp. tomentella...
  67. ncbi request reprint Role of nitric oxide in systemic effect of theophylline on mouse body temperature
    Mohammad Reza Zarrindast
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145 784, Tehran, Iran
    Eur J Pharmacol 451:63-8. 2002
    ..Both L-NAME and L-NA by themselves reduced body temperature. It is concluded that nitric oxide (NO) may be involved in the effects of theophylline on body temperature in mice...
  68. ncbi request reprint Anti-infectives-induced adverse drug reactions in hospitalized patients
    K Gholami
    Department of Clinical Pharmacy, College of Pharmacy, Tehran Medical Sciences University, Tehran, Iran
    Pharmacoepidemiol Drug Saf 14:501-6. 2005
    ....