Nima Rezaei

Summary

Affiliation: Tehran University of Medical Sciences
Country: Iran

Publications

  1. ncbi Eponym: Johanson-Blizzard syndrome
    Nima Rezaei
    Research Group for Immunodeficiencies, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pediatr 170:179-83. 2011
  2. ncbi Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:231-4. 2008
  3. ncbi Serum bactericidal antibody response 1 year after meningococcal polysaccharide vaccination of patients with common variable immunodeficiency
    Nima Rezaei
    Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Vaccine Immunol 17:524-8. 2010
  4. ncbi B-cell-T-cell activation and interaction in common variable immunodeficiency
    Nima Rezaei
    Department of Infection and Immunity, The University of Sheffield, Sheffield, UK
    Hum Immunol 71:355-62. 2010
  5. ncbi T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome
    Elham Barkhordari
    Molecular Immunology Research Center and Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Inflammation 33:281-6. 2010
  6. ncbi Proinflammatory cytokine gene polymorphisms among Iranian patients with asthma
    Seyed Alireza Mahdaviani
    Department of Allergy and Clinical Immunology, Children s Medical Center Hospital, Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, 62 Gharib St, Keshavarz Blvd, P O Box 14185 863, Tehran, 14194, Iran
    J Clin Immunol 29:57-62. 2009
  7. ncbi IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma
    Masoud Movahedi
    Department of Allergy and Clinical Immunology of Children s Medical Center Hospital, Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    J Asthma 45:790-4. 2008
  8. ncbi Presence of Idiopathic Thrombocytopenic Purpura and autoimmune hemolytic anemia in the patients with common variable immunodeficiency
    Asghar Ramyar
    Department of Pediatrics, Division of Hematology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:169-75. 2008
  9. ncbi Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center Hospital, Tehran University of Medical Sciences, Iran
    Immunobiology 215:81-7. 2010
  10. ncbi Neutropenia associated with X-linked Agammaglobulinemia in an Iranian referral center
    Asghar Aghamohammadi
    Department of Pediatrics, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 8:43-7. 2009

Detail Information

Publications89

  1. ncbi Eponym: Johanson-Blizzard syndrome
    Nima Rezaei
    Research Group for Immunodeficiencies, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pediatr 170:179-83. 2011
    ..UBR1 gene defects are underlying the disease. Only symptomatic treatment is available. Exocrine pancreas insufficiency plus abnormal alae nasi is pathognomonic for Johanson-Blizzard syndrome...
  2. ncbi Response to polysaccharide vaccination amongst pediatric patients with common variable immunodeficiency correlates with clinical disease
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:231-4. 2008
    ..In contrast, low populations of memory B-cells do not correlate with these sequelae. The results of this study could help pediatricians plan strategies for prevention of sequelae in children presenting with CVID...
  3. ncbi Serum bactericidal antibody response 1 year after meningococcal polysaccharide vaccination of patients with common variable immunodeficiency
    Nima Rezaei
    Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Vaccine Immunol 17:524-8. 2010
    ....
  4. ncbi B-cell-T-cell activation and interaction in common variable immunodeficiency
    Nima Rezaei
    Department of Infection and Immunity, The University of Sheffield, Sheffield, UK
    Hum Immunol 71:355-62. 2010
    ..In conclusion, this sample of CVID patients exhibits a defect of T-cell "help" to B cells, and/or B-cell response to T-cell help...
  5. ncbi T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome
    Elham Barkhordari
    Molecular Immunology Research Center and Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Inflammation 33:281-6. 2010
    ..001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS...
  6. ncbi Proinflammatory cytokine gene polymorphisms among Iranian patients with asthma
    Seyed Alireza Mahdaviani
    Department of Allergy and Clinical Immunology, Children s Medical Center Hospital, Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, 62 Gharib St, Keshavarz Blvd, P O Box 14185 863, Tehran, 14194, Iran
    J Clin Immunol 29:57-62. 2009
    ..Proinflammatory cytokines could contribute to this inflammatory process. This study was performed in order to analyze the genetic profile of proinflammatory cytokines in Iranian asthmatic patients...
  7. ncbi IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma
    Masoud Movahedi
    Department of Allergy and Clinical Immunology of Children s Medical Center Hospital, Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    J Asthma 45:790-4. 2008
    ..Considering the high frequency of presence of IL-10 ATA haplotype and the IL-2 GT genotype, it seems that the production of IL-10 and IL-2 in the asthmatic patients could be lower than normal subjects...
  8. ncbi Presence of Idiopathic Thrombocytopenic Purpura and autoimmune hemolytic anemia in the patients with common variable immunodeficiency
    Asghar Ramyar
    Department of Pediatrics, Division of Hematology, Children Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:169-75. 2008
    ..Chronic and recurrent ITP, especially in the presence of propensity to respiratory and gastrointestinal infections mandate the evaluation for an underlying immune dysregulation such as CVID...
  9. ncbi Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center Hospital, Tehran University of Medical Sciences, Iran
    Immunobiology 215:81-7. 2010
    ..High production of IL-4 could also be expected based on haplotypes frequencies of this cytokine gene polymorphisms...
  10. ncbi Neutropenia associated with X-linked Agammaglobulinemia in an Iranian referral center
    Asghar Aghamohammadi
    Department of Pediatrics, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 8:43-7. 2009
    ..Neutropenia in XLA is mainly associated with infection and is resolved with intravenous immunoglobulin replacement and antibiotics therapy...
  11. ncbi Proinflammatory cytokine gene polymorphisms in irritable bowel syndrome
    Elham Barkhordari
    Department of Gastroenterology and Hepatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 30:74-9. 2010
    ..Proinflammatory cytokines can play an important role in intestinal inflammation, while their production is under genetic control...
  12. ncbi Analysis of switched memory B cells in patients with IgA deficiency
    Asghar Aghamohammadi
    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, 62 Gharib Street, Tehran, Iran
    Int Arch Allergy Immunol 156:462-8. 2011
    ..Despite several investigations into the nature of the disease, the exact pathophysiology of SIGAD is still unknown...
  13. ncbi Immunologic evaluation of patients with recurrent ear, nose, and throat infections
    Asghar Aghamohammadi
    Department of Pediatrics, Children s Medical Center Hospital, Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    Am J Otolaryngol 29:385-92. 2008
    ..In this study, we aimed to study the frequency of possible underlying immunodeficiency responsible for susceptibility to ear, nose, and throat (ENT) infection...
  14. ncbi IgA deficiency: correlation between clinical and immunological phenotypes
    Asghar Aghamohammadi
    Department of Pediatrics, Division of Immunology and Allergy, Children Medical Center Hospital, Tehran University of Medical Sciences, 62 Gharib St, Keshavarz Blvd, 14194, Tehran, Iran
    J Clin Immunol 29:130-6. 2009
    ..We aimed to investigate the clinical features in relation to immune function of Iranian patients with symptomatic IGAD...
  15. ncbi Comparison of pulmonary diseases in common variable immunodeficiency and X-linked agammaglobulinaemia
    Asghar Aghamohammadi
    Department of Pediatrics, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Respirology 15:289-95. 2010
    ..Early diagnosis and appropriate treatment reduces the incidence of pulmonary infections in both groups of patients. However, CVID patients are prone to progressive lung disease despite optimal immunoglobulin therapy...
  16. ncbi Serum bactericidal antibody responses to meningococcal polysaccharide vaccination as a basis for clinical classification of common variable immunodeficiency
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran 14194, Iran
    Clin Vaccine Immunol 15:607-11. 2008
    ..Vaccination response may define subgroups of patients with CVID, enabling more effective monitoring and therapeutic strategies...
  17. ncbi Gastrointestinal manifestations in patients with common variable immunodeficiency
    Ahmad Khodadad
    Department of Pediatrics, Division of Gastroenterology, Children s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Dig Dis Sci 52:2977-83. 2007
    ..CVID patients are at increased risk of infectious and inflammatory conditions in the GI tract. Early diagnosis of these complications improves the quality of life and well-being of patients...
  18. ncbi Novel UBR1 gene mutation in a patient with typical phenotype of Johanson-Blizzard syndrome
    Gholam Hossein Fallahi
    Department of Pediatrics, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Eur J Pediatr 170:233-5. 2011
    ..Prompt diagnosis and exact monitoring of the patients with JBS are required to avoid further complications...
  19. ncbi Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease
    Farhad Shahram
    Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Rheumatol 29:S28-31. 2011
    ..Cytokine single nucleotide polymorphisms could play a role in the pathophysiology of BD. The results of this study could suggest a tendency towards higher production of IL-2 and lower production of IL-4 in the patients with BD...
  20. ncbi X-linked agammaglobulinemia: a survey of 33 Iranian patients
    Mostafa Moin
    Department of Allergy and Clinical Immunology of Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Immunol Invest 33:81-93. 2004
    ..9%, 75.8%, 33.3%, and 21.2% of XLA patients, respectively. The most common complications of these patients were chronic infections in 75.8% of them, including: chronic otitis media, chronic sinusitis, chronic diarrhea, and bronchiectasis...
  21. ncbi Ataxia-telangiectasia in Iran: clinical and laboratory features of 104 patients
    Mostafa Moin
    Department of Allergy and Clinical Immunology, Children s Medical Center, and Immunology, Asthma and Allergy Research Institute, Tehran, Iran
    Pediatr Neurol 37:21-8. 2007
    ..Average serum alpha-fetoprotein level was 149 +/- 137 ng/dL. The incidence of ataxia-telangiectasia in Iran is high, possibly due to familial marriages. Treatment should be focused on supportive management to prolong survival...
  22. ncbi Frequency and clinical manifestations of patients with primary immunodeficiency disorders in Iran: update from the Iranian Primary Immunodeficiency Registry
    Nima Rezaei
    Department of Allergy and Clinical Immunology of Children Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 26:519-32. 2006
    ..Construction of such registry is not only important for its epidemiological aspect but also for its role in increasing the physician's knowledge about such disorders...
  23. ncbi The clinical, immunohematological, and molecular study of Iranian patients with severe congenital neutropenia
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Department of Allergy and Clinical Immunology of Children Medical Center, Medical Sciences University of Tehran, Tehran 14194, Iran
    J Clin Immunol 27:525-33. 2007
    ..Three patients died because of a severe infection. Although SCN is a rare disorder, early onset of severe and recurrent infections should always raise a suspicion, which deserves further evaluation for detecting such disorder...
  24. ncbi Clinical and laboratory findings in hyper-IgM syndrome with novel CD40L and AICDA mutations
    Asghar Aghamohammadi
    Center of Excellence for Pediatrics, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 29:769-76. 2009
    ..These patients have immunoglobulin class switch recombination defects, caused by mutations in several genes...
  25. ncbi Mannose-binding lectin polymorphisms in common variable immunodeficiency
    Asghar Aghamohammadi
    Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Exp Med 9:285-90. 2009
    ..Mutant and low-producing MBL alleles and haplotypes might reflect as an associated genetic factor in CVID patients, which could play as a susceptibility factor in CVID...
  26. ncbi Cytokine gene polymorphisms in common variable immunodeficiency
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center Hospital, Tehran University of Medical Sciences 62 Qarib St, Keshavarz Blvd, PO Box 14185 863, Tehran 14194, Iran
    Int Arch Allergy Immunol 150:1-7. 2009
    ..Considering the significantly lower frequency of the high production haplotype (TG) and the higher frequency of the low production halplotype (TC) of TGF-beta, low production of this cytokine is expected in some CVID patients...
  27. ncbi Consanguinity in primary immunodeficiency disorders; the report from Iranian Primary Immunodeficiency Registry
    Nima Rezaei
    Department of Allergy and Clinical Immunology, Children Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Iran
    Am J Reprod Immunol 56:145-51. 2006
    ..This study was accomplished in order to determine the frequency of consanguineous marriages in the families of patients with PiD...
  28. ncbi Cutaneous granulomas in common variable immunodeficiency: case report and review of literature
    Asghar Aghamohammadi
    Department of Allergy and Clinical Immunology Children s Medical Center, No 62 Dr Gharib St, Keshavarz Blvd, Tehran, Iran
    Acta Dermatovenerol Croat 18:107-13. 2010
    ..In conclusion, taking history of recurrent infections and measuring immunoglobulin levels can be suggested in patients with granulomatous lesions instead of other expensive tests...
  29. ncbi Health-related quality of life in primary antibody deficiency
    Asghar Aghamohammadi
    Research Center for Immunodeficiency, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 10:47-51. 2011
    ..However, the patients with severe phenotypes and long delay in diagnosis showed lower QoL, even in medical management...
  30. ncbi IL-2, IFN-gamma, and IL-12 gene polymorphisms and susceptibility to multiple sclerosis
    Mohammad Ali Shokrgozar
    National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
    J Clin Immunol 29:747-51. 2009
    ..In order to investigate the role of some proinflammatory cytokines (interleukin (IL)-2, IL-12, and interferon-gamma (IFN-gamma)) as a risk factor for MS, this study was performed...
  31. ncbi Cytokine single nucleotide polymorphisms in Iranian populations
    Ali Akbar Amirzargar
    Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Iran
    Eur Cytokine Netw 19:104-12. 2008
    ..Although some significant differences were observed for some cytokines, it seems that the cytokine gene polymorphism profile of the Iranian population is similar to that of Caucasians, particularly the Italian population...
  32. ncbi Autosomal recessive chronic granulomatous disease, IgA deficiency and refractory autoimmune thrombocytopenia responding to Anti-CD20 monoclonal antibody
    Bibi Shahin Shamsian
    Department of Pediatric Hematology Oncology, Immunology, Pathology, Mofid Children s Hospital, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:181-4. 2008
    ..Patients with primary immunodeficiencies may have variable autoimmune manifestations. So for early detection and appropriate treatment, autoimmune diseases should always be suspected in such patients...
  33. ncbi Serum bactericidal antibody response to serogroup C polysaccharide meningococcal vaccination in children with primary antibody deficiencies
    Nima Rezaei
    Department of Allergy and Clinical Immunology of Children Medical Center, Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    Vaccine 25:5308-14. 2007
    ..This supports the use of polysaccharide-containing vaccines in these patients...
  34. ncbi Congenital neutropenia and primary immunodeficiency disorders: a survey of 26 Iranian patients
    Nima Rezaei
    From Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    J Pediatr Hematol Oncol 27:351-6. 2005
    ..Although inherited neutropenias are rare, recurrent infections always deserves further evaluation for detecting such disorders...
  35. ncbi Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency
    Asghar Aghamohammadi
    Department of Clinical Immunology of Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Clin Diagn Lab Immunol 12:825-32. 2005
    ..CVID should be considered in any patient with a history of recurrent infections and decreased levels of all serum immunoglobulin isotypes...
  36. ncbi Chronic granulomatous disease: a clinical survey of 41 patients from the Iranian primary immunodeficiency registry
    Masoud Movahedi
    Immunology, Asthma and Allergy Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Int Arch Allergy Immunol 134:253-9. 2004
    ..CONCLUSIONS: Early diagnosis of the disease is crucial. In view of the possibility of timely treatment, i.e. prophylactic treatment of infection, CGD should be excluded in any patient with unexplained infections or granulomas...
  37. ncbi The clinical and laboratory survey of Iranian patients with hyper-IgE syndrome
    Mostafa Moin
    Department of Allergy and Clinical Immunology of Children Medical Centre, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Scand J Infect Dis 38:898-903. 2006
    ..Although HIES is a rare condition, the recurrent infections should always raise a suspicion, which deserves further evaluation for detecting the syndrome...
  38. ncbi The approach to children with recurrent infections
    Asghar Aghamohammadi
    Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 11:89-109. 2012
    ..If indicated, appropriate laboratory studies including simple screening and advanced tests must be performed...
  39. ncbi Study of programmed cell death 1 (PDCD1) gene polymorphims in Iranian patients with ankylosing spondylitis
    Narjes Soleimanifar
    Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Inflammation 34:707-12. 2011
    ..There was no evidence of association for PDCD1 SNPs with AS in our study, but CT genotype (PD-1.9) seems to be associated with HLA-B27 positivity in the patients with AS...
  40. ncbi BAK, BAX, and NBK/BIK proapoptotic gene alterations in Iranian patients with ataxia telangiectasia
    Anna Isaian
    National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
    J Clin Immunol 30:132-7. 2010
    ..This study was designed to study the role of proapoptotic BAK, BAX, and NBK/BIK genes in a group of patients with AT to elucidate the possible role of these genes in progression of malignancies in this disease...
  41. ncbi Antibody response to pneumococcal capsular polysaccharide vaccination in patients with chronic kidney disease
    Majid Mahmoodi
    Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
    Eur Cytokine Netw 20:69-74. 2009
    ..Nevertheless, this vaccination policy should be administered as it could prevent infection in responder patients...
  42. ncbi Evaluation of liver diseases in Iranian patients with primary antibody deficiencies
    Farzaneh Motamed
    Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Ann Hepatol 8:196-202. 2009
    ..Patients with primary antibody deficiency (PAD) can complicate with liver disease. This study was performed in order to study the prevalence and causes of hepatobiliary diseases in Iranian patients with PAD...
  43. ncbi Behavior abnormality following intravenous immunoglobulin treatment in patients with primary antibody deficiencies
    Sepide Saroukhani
    Research Center for Immunodeficiencies, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Hum Psychopharmacol 25:419-22. 2010
    ..Meantime behavioral disorders reactions have not been reported yet. In this study, we describe for the first time a group of patients with PADs, who were under IVIG therapy and experienced some behavioral disorders...
  44. ncbi The clinical and laboratory manifestations of Iranian patients with cystic fibrosis
    Gholamhossein Fallahi
    Department of Pediatrics, Pediatrics Center of Excellence, Children s Medical Center, Tehran, Iran
    Turk J Pediatr 52:132-8. 2010
    ....
  45. ncbi Association of CTLA4 gene polymorphism in Iranian patients with ankylosing spondylitis
    Esfandiar Azizi
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 30:268-71. 2010
    ..This study was performed to investigate the allele and genotype frequencies of CTLA4 gene polymorphisms in Iranian patients with ankylosing spondylitis (AS)...
  46. ncbi Adverse reactions of prophylactic intravenous immunoglobulin infusions in Iranian patients with primary immunodeficiency
    Asghar Aghamohammadi
    Department of Allergy and Clinical Immunology of Children's Medical Center, Immunology Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Ann Allergy Asthma Immunol 92:60-4. 2004
    ..However, to prevent occurrence of immediate adverse reactions during infusion in these patients, physicians should perform a detailed history and proper physical examination and check the titer of anti-IgA...
  47. ncbi HLA-B27 subtypes and tumor necrosis factor alpha promoter region polymorphism in Iranian patients with ankylosing spondylitis
    Mohammad Hossein Nicknam
    Molecular Immunology Research Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran, Rheumatology Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Eur Cytokine Netw 20:17-20. 2009
    ..This study was performed to determine HLA-B27 subtypes among Iranian patients with AS, and to investigate TNF-alpha gene polymorphisms in the patient groups...
  48. ncbi Severe combined immunodeficiency: a cohort of 40 patients
    Mehdi Yeganeh
    Immunology, Asthma and Allergy Research Institute, Division of Allergy and Clinical Immunology, Children s Medical Centre, Medical Sciences University of Tehran, Tehran, Iran
    Pediatr Allergy Immunol 19:303-6. 2008
    ..A complete blood count of cord blood could reveal lymphocytopenia at birth; this helps early diagnosis. Genetic consultation would help the families with affected members preventing new SCID offspring...
  49. ncbi Gastrointestinal manifestations of patients with chronic granulomatous disease
    Masoud Movahedi
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 3:83-7. 2004
    ..Also, failure to thrive was detected in 6 patients (10.5%). Four patients died (7%). CGD should be excluded in any patient with gastrointestinal manifestations especially chronic diarrhea, hepatic abscess, and gastric outlet obstruction...
  50. ncbi Co-administration of chenopodium album allergens and CpG oligodeoxynucleotides effects on peripheral blood mononuclear cells of patients with Allergic Rhinitis treated with intranasal corticosteroids and antihistamines
    Shokrollah Farrokhi
    Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 10:101-10. 2011
    ..a or CpG/rCh.a that showed intracellular assay could be more sensitive than ELISA. Also, treatment with intranasal corticosteroids and antihistamines could enhance this CpG effect, in vitro...
  51. ncbi Novel mutation of the activation-induced cytidine deaminase gene in a Tajik family: special review on hyper-immunoglobulin M syndrome
    Seyed Alireza Mahdaviani
    Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Expert Rev Clin Immunol 8:539-46. 2012
    ..Mutations in this gene are responsible for an autosomal recessive form of HIGM. We have also reviewed and summarized all published cases with HIGM due to defects in AICDA...
  52. ncbi Lack of Association between Interleukin 12 C(-1188)A Polymorphism and Irritable Bowel Syndrome
    Elham Barkhordari
    Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Avicenna J Med Biotechnol 3:45-8. 2011
    ..7% vs. 11.5%, respectively, p = 0.16). Considering the lack of association between IL-12 C(-1188)A polymorphism and IBS, this cytokine gene polymorphism may not have significant role in the pathophysiology of disease...
  53. ncbi Primary hemophagocytic lymphohistiocytosis in Iran: report from a single referral center
    Bibi Shahin Shamsian
    Department of Pediatric Hematology Oncology, Mofid Children s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Pediatr Hematol Oncol 29:215-9. 2012
    ..Herein the authors report 6 Iranian patients with primary HLH and their outcome from a single tertiary-care center...
  54. ncbi HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris
    Sheida Shams
    Department of Dermatology, Razi Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 29:175-9. 2009
    ..Pemphigus vulgaris (PV), an autoimmune disease affecting the skin and mucous membranes, is associated with some human leukocyte antigen (HLA) class II alleles and haplotypes...
  55. ncbi Evaluation of immunoglobulin levels and infection rate in patients with common variable immunodeficiency after immunoglobulin replacement therapy
    Mahin Salehzadeh
    Department of Pediatrics, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Microbiol Immunol Infect 43:11-7. 2010
    ..Common variable immunodeficiency (CVID) is characterized by decreased serum levels of IgG and increased susceptibility to recurrent infections. The aim of this study was to evaluate the IgG subclass levels of CVID patients...
  56. ncbi Efficacy of intravenous immunoglobulin on the prevention of pneumonia in patients with agammaglobulinemia
    Asghar Aghamohammadi
    Department of Allergy of Children's Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    FEMS Immunol Med Microbiol 40:113-8. 2004
    ..001). Treatment of agammaglobulinemia with IVIG significantly reduced the incidence of pneumonia and hospital admission. Intensive management and regular monitoring is required in order to fully prevent severe respiratory complications...
  57. ncbi Effect of regular intravenous immunoglobulin therapy on prevention of pneumonia in patients with common variable immunodeficiency
    Zahra Pourpak
    Department of Allergy and Clinical Immunology, Children Medical Center, Tehran University of Medical Sciences, Tehran, IR Iran
    J Microbiol Immunol Infect 39:114-20. 2006
    ..The aim of this study was to evaluate the effectiveness of IVIG treatment in reducing the incidence of pneumonia in patients with CVID...
  58. ncbi Impact of delayed diagnosis in children with primary antibody deficiencies
    Asghar Aghamohammadi
    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Microbiol Immunol Infect 44:229-34. 2011
    ..To evaluate the diagnostic delay in Iranian PADs in association with their infections, we scored such manifestations to find an association between such delay and the scoring system...
  59. ncbi Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene
    Nima Parvaneh
    Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 30:756-60. 2010
    ..Severe recurrent infections, impaired wound healing, and periodontal diseases are the main features of disease...
  60. ncbi CD40 ligand expression on stimulated T-helper lymphocytes in patients with common variable immunodeficiency
    Masoud Ravanbakhsh
    Department of Immunology, School of Public Health and Institute of Public Health Research, Medical Sciences, University of Tehran, Tehran, Iran
    Iran J Allergy Asthma Immunol 6:129-35. 2007
    ..The results of this study are in agreement with some other studies, indicating that CD40 ligand expression on stimulated T-helper lymphocytes of Common variable immunodeficiency patients is similar to normal controls...
  61. ncbi Screening of the Bruton Tyrosine Kinase (BTK) Gene Mutations in 13 Iranian Patients with Presumed X-Linked Agammaglobulinemia
    Asghar Aghamohammadi
    Department of Clinical Pediatric Immunology of Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 3:175-9. 2004
    ..The results of this study further support the notion that molecular genetic testing represents an important tool for definitive and early diagnosis of XLA and may allow accurate carrier detection and prenatal diagnosis...
  62. ncbi Prophylactic and therapeutic implications of toll-like receptor ligands
    Mona Hedayat
    Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Med Res Rev 32:294-325. 2012
    ....
  63. ncbi Chromosomal radiosensitivity in patients with common variable immunodeficiency
    Asghar Aghamohammadi
    Department of Allergy and Clinical Immunology of Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    Immunobiology 213:447-54. 2008
    ..05). CVID patients appear to be susceptible to in vitro irradiation. These patients should be protected from unnecessary radiographic diagnostic and therapeutic procedures. Also, radiosensitivity may help classifying CVID patients...
  64. ncbi Mortality in primary immunodeficient patients, registered in Iranian primary immunodeficiency registry
    Bahram Mir Saeid Ghazi
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 3:31-6. 2004
    ..6%) and salmonella in 1 (3.1%).Based on our study, delay in diagnosis in patients with PID results in tissue and organ damage and several complications. Mortality and morbidity are increased in undiagnosed patients...
  65. ncbi A 10-year single center survey of pediatric patients with histiocytic disorders in Iran
    Bibi Shahin Shamsian
    Department of Pediatric Hematology Oncology, Mofid Children s Hospital, Shahid Beheshti Medical University, Tehran, Iran
    Turk J Pediatr 53:34-42. 2011
    ....
  66. ncbi Progression of selective IgA deficiency to common variable immunodeficiency
    Asghar Aghamohammadi
    Department of Allergy and Clinical Immunology, Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Int Arch Allergy Immunol 147:87-92. 2008
    ..Early diagnosis of this conversion and institution of immunoglobulin therapy is effective in preventing severe bacterial infections and pulmonary insufficiency...
  67. ncbi Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies
    Nima Rezaei
    Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Allergy Clin Immunol 127:1329-41.e2; quiz 1342-3. 2011
    ..It is of importance that we gain in-depth insights into the fundamental molecular nature of these unique PIDs to better understand the pathogenesis of virus-associated malignancies and to develop innovative therapeutic strategies...
  68. ncbi Indications and safety of intravenous and subcutaneous immunoglobulin therapy
    Nima Rezaei
    Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Expert Rev Clin Immunol 7:301-16. 2011
    ..This article presents current information on indications, mechanisms of action, efficacy and practical aspects of intravenous and subcutaneous Ig replacement/immunomodulatory therapy as well as associated adverse reactions...
  69. ncbi Defective T-cell Proliferation and IL-2 Production in a Subgroup of Patients with Coronary Artery Disease
    Maryam Mahmoudi
    Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 9:133-40. 2010
    ..Considering the autoimmune nature of atherosclerosis, decreased IL-2 production may potentially enhance the atherogenic process, leading to spontaneous activation of autoreactive T lymphocytes...
  70. ncbi Lymphocyte cytotoxicity of oxLDL in patients with atherosclerosis
    Mohammad Jafar Mahmoudi
    Division of Cardiology, Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Immunol 8:27-33. 2011
    ..Oxidized low-density lipoprotein (oxLDL) is considered as an important determining factor in the pathogenesis of atherosclerosis...
  71. ncbi Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis
    Ali Akbar Amirzargar
    Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Eur Cytokine Netw 17:84-9. 2006
    ..Several genes coding for different cytokines may affect host susceptibility to tuberculosis...
  72. ncbi Hodgkin lymphoma in two siblings with common variable immunodeficiency
    Asghar Aghamohammadi
    Department of Allergy and Clinical Immunology of Children s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Pediatr Hematol Oncol 24:337-42. 2007
    ..Their father and 1 uncle were also affected by the same cancer with no immunodeficiency state. The presence of lymphoma should be considered in the patients with CVID, especially in those with family history of malignancies...
  73. ncbi Gastrointestinal complications in two patients with common variable immunodeficiency
    Nasser Ebrahimi Daryani
    Department of Gastroenterology and Hepatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 3:149-52. 2004
    ..Diagnostic delay results in more morbidity and complications in untreated patients....
  74. ncbi Cytokine response following transthoracic and transhiatal esophagectomy in patients with esophageal cancer
    Majid Mahmoodi
    Cancer Research Center, Medical Sciences University of Tehran, Tehran, Iran
    Eur Cytokine Netw 19:92-8. 2008
    ..Post-operatively, a significantly reduced production of Th1 and Th2 cytokines, except for IFN-gamma, was observed only in patients who had undergone surgical esophageal resection using the TT method...
  75. ncbi Mortality and morbidity in common variable immunodeficiency
    Asghar Aghamohammadi
    Children s Medical Center, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran
    J Trop Pediatr 53:32-8. 2007
    ..Based on our observation, it can be highlighted that all patients with CVID, even under regular immunoglobulin replacement, need close monitoring for early detection of complications and introduction of appropriate management...
  76. ncbi The effect of omeprazole on asthmatic adolescents with gastroesophageal reflux disease
    Enayatollah Nemat Khorasani
    Department of Pediatric Gastroenterology, Children s Medical Center Hospital, Tehran University of Medical Sciences corrected Tehran, Iran
    Allergy Asthma Proc 29:517-20. 2008
    ..0001). Treatment by omeprazole is effective for treatment of asthmatic patients with GERD...
  77. ncbi Corneal neovascularization: molecular events and therapeutic options
    Yadollah Shakiba
    Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Recent Pat Inflamm Allergy Drug Discov 3:221-31. 2009
    ..Understanding the role of growth factors, proteinases and inflammatory cytokines in corneal NV can help the investigators to design therapeutic options for controlling this debilitating condition...
  78. ncbi Screening for celiac disease in diabetic children from Iran
    Gholam Hossein Fallahi
    Department of Pediatric Gastroenterology and Growth, Pediatrics Center of Excellence, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Indian Pediatr 47:268-70. 2010
    ..Ninety-six patients with type 1 diabetes mellitus were tested for anti-tissue transglutaminase antibodies. Six patients (6.25%) were seropositive, and histopathological changes were compatible with celiac disease in intestinal biopsy...
  79. ncbi Clinical characteristics of Iranian pediatric patients with inflammatory bowel disease
    Gholam Hossein Fallahi
    Department of Pediatric Gastroenterology of Children s Medical Center Hospital, Tehran, Iran
    Acta Gastroenterol Belg 72:230-4. 2009
    ..Inflammatory bowel disease (IBD) is a group of disorders, including Crohn's disease (CD), ulcerative colitis (UC) and indeterminate colitis (IC). Small intestine and colon are primarily affected in this group of disorders...
  80. ncbi Clinical, immunological and molecular characteristics of 37 Iranian patients with X-linked agammaglobulinemia
    Asghar Aghamohammadi
    Division of Clinical Pediatric Immunology, Children s Medical Center, Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
    Int Arch Allergy Immunol 141:408-14. 2006
    ..Eighty-five percent of the patients with this phenotype have mutations in Bruton's tyrosine kinase (BTK) gene...
  81. ncbi Chronic mucocutaneous candidiasis; report of three cases with different phenotypes
    Mohammad Reza Fazlollahi
    Department of Immunology and Allergy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Allergy Asthma Immunol 4:39-42. 2005
    ..We report three cases of CMCC. These patients show different phenotypes and highlight the need for complete evaluation and long term follow-up for accompanying disorders...
  82. ncbi X-linked lymphoproliferative syndrome: a genetic condition typified by the triad of infection, immunodeficiency and lymphoma
    Nima Rezaei
    Molecular Immunology Research Center, Department of Immunology, and School of Medicine, and Research Group for Immunodeficiencies, Children s Medical Center, Tehran University of Medical Sciences, Dr Qarib Street, Keshavarz Boulevard, Tehran, Iran
    Br J Haematol 152:13-30. 2011
    ..These studies are also highlighting critical signalling pathways that might be amenable to pharmacological targeting to improve the treatment of XLP and other disorders associated with impaired antiviral and antitumour immunity...
  83. ncbi Successful management of neutropenia in a patient with CD40 ligand deficiency by immunoglobulin replacement therapy
    Lida Atarod
    Department of Allergy and Clinical Immunology, Immunology, Asthma and Allergy Research Institute Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 6:37-40. 2007
    ..It seems that regular administration of sufficient doses of IVIG can be useful in the management of neutropenia in CD40 ligand deficiency, which results in better quality of life with decreasing occurrence of infection...
  84. ncbi Increased serum levels of soluble CD30 in patients with common variable immunodeficiency and its clinical implications
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center, Medical Sciences University of Tehran, No 62, Dr Gharib st, Keshavarz Blvd, P O Box 14185 863 Tehran, 14194, Iran
    J Clin Immunol 28:78-84. 2008
    ..010). High levels of sCD30 in the CVID patients with splenomegaly and the presence of lymphoma in a patient with the highest level of sCD30 may suggest a soluble form of this marker as a prognostic tool in such diseases...
  85. ncbi High production of IL-18 by dendritic cells induced by sera from patients with primary antibody deficiency
    Maryam Nourizadeh
    Immunology, Asthma and Allergy Research Institute, Medical Sciences Tehran University, Tehran, Iran
    Iran J Allergy Asthma Immunol 6:59-65. 2007
    ..55+/-0.68) ng/ml. These results suggest that the sera of patients with predominantly antibody deficiencies may contain soluble factor(s) that can induce a significant increase in IL-18 production by DCs...
  86. ncbi Study of alpha1-antitrypsin phenotypes frequencies in patients with primary antibody deficiency
    Mohammad Reza Fazlollahi
    Department of Allergy and Clinical Immunology, Children Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 5:69-74. 2006
    ..Larger studies will be required to clarify the relationship between alpha-1-antitrypsin genotype and susceptibility to bronchiectasis in patients with antibody deficiency...
  87. ncbi Severe congenital neutropenia or hyper-IgM syndrome? A novel mutation of CD40 ligand in a patient with severe neutropenia
    Nima Rezaei
    Immunology, Asthma and Allergy Research Institute, Children s Medical Center, Tehran, Iran
    Int Arch Allergy Immunol 147:255-9. 2008
    ....
  88. ncbi Echocardiographic abnormalities and their correlation with bronchiectasis score in primary antibody deficiencies
    Ali Akbar Zeinaloo
    Growth and Development Research Center, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Cardiovasc Med (Hagerstown) 11:244-9. 2010
    ..Our aim was to assess noninvasively the cardiac complications due to pulmonary disease in patients with primary antibody deficiency...
  89. ncbi Primary immunodeficiency in Iran: first report of the National Registry of PID in Children and Adults
    Asghar Aghamohammadi
    Department of Clinical Pediatric Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
    J Clin Immunol 22:375-80. 2002
    ..A comparative study shows some differences between our results and other registries...