Abbas Mirshafiey

Summary

Affiliation: Tehran University of Medical Sciences
Country: Iran

Publications

  1. ncbi request reprint Autoantigens and autoantibodies in multiple sclerosis
    Abbas Mirshafiey
    Departmant of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 12:292-303. 2013
  2. pmc Natural killer cells and their role in rheumatoid arthritis: friend or foe?
    Hamid Shegarfi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, 0316 Oslo, Norway
    ScientificWorldJournal 2012:491974. 2012
  3. doi request reprint Prostaglandins in pathogenesis and treatment of multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Iran
    Immunopharmacol Immunotoxicol 32:543-54. 2010
  4. ncbi request reprint Novel promising therapeutic agents in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Recent Pat Inflamm Allergy Drug Discov 1:218-4. 2007
  5. doi request reprint The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:195-202. 2008
  6. doi request reprint Antioxidant therapy in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, Tehran University of Medical Sciences, Iran
    Immunopharmacol Immunotoxicol 31:13-29. 2009
  7. ncbi request reprint Venom therapy in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Medical Sciences, University of Tehran, Box 6446, Tehran 14155, Iran
    Neuropharmacology 53:353-61. 2007
  8. ncbi request reprint Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis
    A Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 29:49-61. 2007
  9. doi request reprint TGF-beta as a promising option in the treatment of multiple sclerosis
    Abbas Mirshafiey
    Departmant of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Box 6446, Iran
    Neuropharmacology 56:929-36. 2009
  10. doi request reprint Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 32:219-27. 2010

Collaborators

  • Farhad Jadidi-Niaragh
  • Mohammad Reza Khorramizadeh
  • Salvatore Cuzzocrea
  • Fatemeh Hajighasemi
  • Zahra Pourpak
  • Hassan Nikoueinejad
  • Behzad Einollahi
  • Mohsin Raza
  • Gholamreza Azizi
  • Farshid Saadat
  • Nargess Arandi
  • Alireza Razavi
  • Sima Sh Farid
  • Fatemeh Naddafi
  • Monireh Mohsenzadegan
  • Mohsen Hamedani
  • Bahman Yousefi
  • Hassan Abolhassani
  • Mahmood Jeddi-Tehrani
  • Bamdad Sadeghi
  • Asghar Aghamohammadi
  • Mohammadreza Shaghaghi
  • Parvin Forghani
  • Fariba Naderi Beni
  • Maryam Gol-Ara
  • Hamid Shegarfi
  • Laya Kafami
  • G Mosayebi
  • Azita Hekmatdoost
  • Hossein Vatanpour
  • Mohammad Saeid Rahiminejad
  • Ramazan Ali Sharifian
  • Babak Mirminachi
  • Jacques Galipeau
  • Edmund K Waller
  • Cynthia R Giver
  • Wayne Harris
  • Mostafa Moin
  • Masoud Movahedi
  • Mohammad Ansari
  • Reza Sadria
  • Fatemeh Fattahi
  • P Ekhtiari
  • D Haghmorad
  • A Ghazavi
  • Mansooreh Movahedian
  • S Namaki
  • Samira M Yeganeh
  • Mohammad M Feizabadi
  • Reza Sedaghat
  • Abolghasem Djazayery
  • Kevan Jacobson
  • Mohammad R Eshraghian
  • Hamid R Nouri
  • Farhad Mehrabian
  • Fatemeh Hadji-Ghasemi
  • Mohammad Reza Khorramizaheh
  • Mohammad Pezeshki
  • Rosanna Di Paola
  • Mohammad Sedaghat
  • Azar Berahmeh

Detail Information

Publications42

  1. ncbi request reprint Autoantigens and autoantibodies in multiple sclerosis
    Abbas Mirshafiey
    Departmant of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 12:292-303. 2013
    ..In this review, we try to introduce the autoantigens and autoantibodies and explain their roles in pathogenesis of MS. ..
  2. pmc Natural killer cells and their role in rheumatoid arthritis: friend or foe?
    Hamid Shegarfi
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, 0316 Oslo, Norway
    ScientificWorldJournal 2012:491974. 2012
    ..We have decided in this paper to focus on the NK cell biology, and attempt to bring the interested readership of this Journal up to date on the NK cell, specifically its possible relation to RA...
  3. doi request reprint Prostaglandins in pathogenesis and treatment of multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Iran
    Immunopharmacol Immunotoxicol 32:543-54. 2010
    ..Thus use of agonists or antagonists of PG receptors may be considered as a new therapeutic protocol in MS. In this review, we try to clarify the role of PGs in immunopathology and treatment of MS...
  4. ncbi request reprint Novel promising therapeutic agents in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Recent Pat Inflamm Allergy Drug Discov 1:218-4. 2007
    ..This review provides a compilation of the more thoroughly studied of these novel immunotherapeutic agents and new aspects of designed molecular targets and patents which have recently evolved...
  5. doi request reprint The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 7:195-202. 2008
    ..In this review article, our aim is to clarify the role of ROS in immunopathogenesis of Rheumatoid arthritis...
  6. doi request reprint Antioxidant therapy in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, Tehran University of Medical Sciences, Iran
    Immunopharmacol Immunotoxicol 31:13-29. 2009
    ..In this review, our aim is to clarify the therapeutic efficacy of antioxidants in MS disease...
  7. ncbi request reprint Venom therapy in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Medical Sciences, University of Tehran, Box 6446, Tehran 14155, Iran
    Neuropharmacology 53:353-61. 2007
    ..The aim of this review is to describe the recent findings regarding the role of venoms and their components in treatment of MS disease and that whether venom therapy could be recommended as a complementary treatment or not...
  8. ncbi request reprint Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis
    A Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 29:49-61. 2007
    ..Moreover, the toxicological study revealed that M2000 had no influence on serum (BUN, creatinine, triglyceride and cholesterol) determinants, urinary protein excretion and glomerular histology in healthy group receiving drug...
  9. doi request reprint TGF-beta as a promising option in the treatment of multiple sclerosis
    Abbas Mirshafiey
    Departmant of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Box 6446, Iran
    Neuropharmacology 56:929-36. 2009
    ..In this review, we will describe the regulatory and therapeutic effects of TGF-beta in multiple sclerosis...
  10. doi request reprint Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 32:219-27. 2010
    ..Moreover, we suggest that blockage of LT receptors by potent specific antagonists and/or agonists can be as a novel useful method in treatment of MS...
  11. ncbi request reprint M2000: a revolution in pharmacology
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Med Sci Monit 11:PI53-63. 2005
    ..The tolerability and the anti-inflammatory and immunosuppressive properties of a novel designed non-steroidal anti-inflammatory drug, M2000 (beta-D-mannuronic acid), were investigated in various experimental models...
  12. ncbi request reprint Treatment of experimental immune complex glomerulonephritis by sodium alginate
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P O Box 6446, 14155 Tehran, Iran
    Vascul Pharmacol 43:30-5. 2005
    ....
  13. ncbi request reprint Novel immunosuppressive therapy by M2000 in experimental multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 27:255-65. 2005
    ..Collectively, our data suggest that M2000 may provide a novel therapeutic option for T-cell-mediated autoimmune diseases in animal models and possibly in humans...
  14. ncbi request reprint Chemoprevention by pyrimethamine
    Farshid Saadat
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 27:233-40. 2005
    ..1, 1, and 10 microg/ml) was 3.30%, 9.42%, and 11.32%, respectively. Our data suggest that pyrimethamine enables suppression of MMP-2 activity and induces apoptosis that could be assumed for chemoprevention therapy...
  15. ncbi request reprint Alteration in Frequency and Function of CD4+CD25+FOXP3+ Regulatory T cells in Patients with Immune Thrombocytopenic Purpura
    Nargess Arandi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 13:85-92. 2014
    ..It could be concluded that alteration in Treg frequency and functional characteristics might be responsible for loss of self-tolerance and subsequently destructive immune responses observed in ITP patients. ..
  16. ncbi request reprint Effect of pyrimethamine in experimental rheumatoid arthritis
    Farshid Saadat
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Med Sci Monit 11:BR293-9. 2005
    ..Recent evidence has shown that the antimalarials are useful drugs in the treatment of various rheumatic diseases. The present study was designed to test the therapeutic effect of pyrimethamine (PYR) in collagen-induced arthritis (CIA)...
  17. ncbi request reprint Treatment of experimental nephrotic syndrome with artesunate
    Alireza Razavi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Int J Toxicol 26:373-80. 2007
    ..These data suggest that artesunate therapy can ameliorate proteinuria, and suppress the progression of glomerular lesions in experimental model of nephrotic syndrome; it may also be recommended as a lipid-lowering drug...
  18. doi request reprint The immunopathogenic role of reactive oxygen species in Alzheimer disease
    Monireh Mohsenzadegan
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 11:203-16. 2012
    ..In this review, our aim was to clarify the role of ROS in pathogenesis of AD and will discuss therapeutic efficacy of some antioxidants studies in recent years in this disease...
  19. ncbi request reprint In vitro assessment of bee venom effects on matrix metalloproteinase activity and interferon production
    Mohsen Hamedani
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Iran J Allergy Asthma Immunol 4:9-14. 2005
    ..In contrast, its inhibitory effect was seen at high concentrations.It is concluded that, honeybee venom affects on MMP-2 activity and interferon beta production as well as cell proliferation in a time and dose-dependent manner...
  20. doi request reprint The neglected role of histamine in Alzheimer's disease
    Fatemeh Naddafi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Am J Alzheimers Dis Other Demen 28:327-36. 2013
    ..In this review, we focus on the role of histamine and its receptors in the treatment of AD, and we hope that histamine could be an effective therapeutic factor in the treatment of AD. ..
  21. doi request reprint Increased production of nitric oxide by neutrophils from patients with chronic granulomatous disease on interferon-gamma treatment
    Fariba Naderi Beni
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Int Immunopharmacol 12:689-93. 2012
    ..This could be an explanation for the therapeutic effect of IFN-γ in patients with CGD as NO acts as a bactericidal agent and plays a role in host defense mechanism instead of O(2)(-)...
  22. doi request reprint Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 33:545-67. 2011
    ..In this review, we intend to submit the comprehensive information about the immunobiology of various subsets of Tregs and their roles and function in immunopathophysiology of MS and its animal model, EAE...
  23. doi request reprint Therapeutic effect of EDTA in experimental model of multiple sclerosis
    G Mosayebi
    Department of Immunology, Arak University of Medical Sciences, Arak, Iran
    Immunopharmacol Immunotoxicol 32:321-6. 2010
    ..p. at a dose 75 mg/kg/day. The mice were sacrificed 21 days after EAE induction and blood samples were taken from their hearts. The brains of mice were removed for histological analysis and their isolated splenocytes were cultured...
  24. doi request reprint Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Box 6446, Tehran 14155, Iran
    Neuropharmacology 59:180-9. 2010
    ..In this review, we try to clarify the role of histamine in pathogenesis of MS, as well as we evaluate the efficacy of histamine receptors agonists and antagonists in treatment of this disease...
  25. doi request reprint The role of leukotrienes in immunopathogenesis of rheumatoid arthritis
    Bahman Yousefi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Mod Rheumatol 24:225-35. 2014
    ..A number of studies have reported that pharmacological modulation in this field can significantly attenuate clinical manifestations associated with different inflammatory pathologies. ..
  26. pmc Properties of immature myeloid progenitors with nitric-oxide-dependent immunosuppressive activity isolated from bone marrow of tumor-free mice
    Parvin Forghani
    Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    PLoS ONE 8:e64837. 2013
    ..These results indicate that IMCs have a role in regulating T-cell activation and proliferation in the BM microenvironment. ..
  27. doi request reprint Anti-citrullinated protein antibodies and their clinical utility in rheumatoid arthritis
    Sima Sh Farid
    Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Int J Rheum Dis 16:379-86. 2013
    ..Anti-CCP can predict erosive disease, therefore could be a good serological marker for RA diagnosis. ..
  28. ncbi request reprint Conversion of calcineurin inhibitors with mammalian target of rapamycin inhibitors after kidney transplant
    Hassan Nikoueinejad
    Tehran University of Medical Sciences, Tehran, IR Iran
    Exp Clin Transplant 11:12-6. 2013
    ..This review considers the conversion effects of calcineurin inhibitors with mammalian target of rapamycin inhibitors from the view point of kidney function during different periods after a kidney transplant...
  29. pmc The role of different subsets of regulatory T cells in immunopathogenesis of rheumatoid arthritis
    Maryam Gol-Ara
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, P O Box 6446, Tehran 14155, Iran
    Arthritis 2012:805875. 2012
    ..In this paper, we intend to submit the comprehensive information about the immunobiology of various subsets of Tregs and their roles and function in immunopathophysiology of RA and its animal model, CIA...
  30. pmc Intermittent feeding attenuates clinical course of experimental autoimmune encephalomyelitis in C57BL/6 mice
    Laya Kafami
    Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Avicenna J Med Biotechnol 2:47-52. 2010
    ..The results of this study suggest possible role of intermittent feeding in the treatment of Multiple Sclerosis patients...
  31. ncbi request reprint The effect of dietary oils on cecal microflora in experimental colitis in mice
    Azita Hekmatdoost
    Department of Human Nutrition, School of Health, Tehran University of Medical Sciences, Tehran, Iran
    Indian J Gastroenterol 27:186-9. 2008
    ..This study aimed to examine the effects of different dietary oils on intestinal microflora in an experimental model of colitis...
  32. ncbi request reprint Apoptotic efficacy and inhibitory effect of dexamethasone on matrix metalloproteinase
    Farshid Saadat
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Med Sci Monit 11:BR253-7. 2005
    ..This study was undertaken to determine the effect of dexamethasone on apoptosis and matrix metalloproteinase 2 (MMP-2) activity compared with two nonsteroidal anti-inflammatory drugs (NSAIDs), piroxicam and diclofenac...
  33. ncbi request reprint Therapeutic approach to multiple sclerosis by novel oral drug
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Box 6446, Iran
    Recent Pat Inflamm Allergy Drug Discov 5:66-80. 2011
    ..In this review, we will discuss about relevant patents and novel designed immunosuppressive and anti-inflammatory oral drugs promising for treatment of multiple sclerosis...
  34. ncbi request reprint Bee venom, immunostimulant or immunosuppressor? Insight into the effect on matrix metalloproteinases and interferons
    Mohsen Hamedani
    Department of Toxicology and Pharmacology, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 27:671-81. 2005
    ..We conclude that time- and dose-dependent response as well as the type of treated cell line could determine the immunosuppressive and/or immunostimulant property of bee venom that could be effective in future therapeutic strategies...
  35. ncbi request reprint Imatinib mesylate: an innovation in treatment of autoimmune diseases
    Gholamreza Azizi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Box 6446, Iran
    Recent Pat Inflamm Allergy Drug Discov 7:259-67. 2013
    ....
  36. doi request reprint The potential role of proinflammatory and antiinflammatory cytokines in Alzheimer disease pathogenesis
    Gholamreza Azizi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 34:881-95. 2012
    ..However, their effects in disease progression and neurodegeneration remain an area of investigation. This review article provides an overview of pro- and anti-inflammatory cytokine activity in AD...
  37. doi request reprint Evaluation of CD4+CD25+FOXP3+ regulatory T cells function in patients with common variable immunodeficiency
    Nargess Arandi
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Cell Immunol 281:129-33. 2013
    ..007). Our findings suggest that disturbed Tregs frequency and their functional characteristics might account for aberrant immune responses observed in CVID patients...
  38. doi request reprint Siglec-8 and Siglec-F, the new therapeutic targets in asthma
    Sima Sh Farid
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 34:721-6. 2012
    ..Eosinophil apoptosis is an important therapeutic target for the development of novel anti-asthma treatments that specifically target the eosinophil...
  39. doi request reprint The deviated balance between regulatory T cell and Th17 in autoimmunity
    Farhad Jadidi-Niaragh
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 34:727-39. 2012
    ..In this review, we try to clarify the factors, which can affect on this balance in various autoimmune diseases, as new targets in treatment of these diseases...
  40. ncbi request reprint M-2000, as a new anti-inflammatory molecule in treatment of experimental nephrosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Immunopharmacol Immunotoxicol 26:611-9. 2004
    ..These data suggest that M-2000 therapy can ameliorate proteinuria, and suppress the progression of glomerular lesions in experimental model of nephrosis...
  41. ncbi request reprint Treatment of experimental nephrosis by culture filtrate of Cryptococcus neoformans var. gattii (CneF)
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Iran
    Immunopharmacol Immunotoxicol 24:349-64. 2002
    ..These data suggest that CneF therapy can ameliorate proteinuria, hypercholesterolemia and suppress the progression of glomerular lesions in experimental model of nephrosis...
  42. ncbi request reprint Chemopreventive effect of M2000, a new anti-inflammatory agent
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
    Med Sci Monit 10:PI105-9. 2004
    ..This study was undertaken to explore the role of a newly designed NSAID, M2000 (C6H10O7), as an anti-inflammatory drug in chemoprevention therapy under in vitro conditions...