Research Topics
Species | Mehrbod KarimiSummaryAffiliation: Shiraz University of Medical Sciences Country: Iran Publications
| Collaborators
|
Detail Information
Publications
Iranian experience of deferasirox (Exjade(®)) in transfusion-dependent patients with iron overload: what is the most effective dose based on serum ferritin levels?Mehran Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Hematology 17:367-71. 2012..The aim of this study was to evaluate the efficacy and safety of deferasirox in patients from Iran...
Frequency and distribution of asymptomatic brain lesions in patients with β-thalassemia intermediaMehran Karimi
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Ann Hematol 91:1833-8. 2012..Larger prospective studies are suggested for the accurate evaluation of the correlation of these factors with developing asymptomatic brain lesions...
Sociocultural challenges of beta-thalassaemia major birth in carriers of beta-thalassaemia in IranSezaneh Haghpanah
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
J Med Screen 19:109-11. 2012..We examined the reasons for this decision, to evaluate the sociocultural challenges these couples face...
Comparative study of hypogonadism in beta-thalassemia intermedia patients with and without hydroxyureaMehran Karimi
Hematology Research Center, Shiraz University of Medical Science, Iran
Hematology 17:122-4. 2012..We aimed at evaluating the effect of long-term use of hydroxyurea (HU) on gonad function in patients with beta-thalassemia intermedia (beta-TI) in Iran...
Efficacy of prophylaxis and genotype-phenotype correlation in patients with severe Factor X deficiency in IranM Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Haemophilia 18:211-5. 2012..It seems that the dose of 20 IU kg(-1) could be probably the best choice for patients with severe FXD, who require regular prophylaxis...
Substance dependency in Iranian patients with hemophiliaMehran Karimi
Hemostasis and Thrombosis Unit, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Addict Behav 32:365-9. 2007..The prevalence and predisposing factors of substance dependency in 100 Iranian hemophilic patients were investigated...
Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia majorM Karimi
Iran Shiraz Namazee Hospital, Namazee Square, Hematology Research Center, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
Eur J Radiol 70:481-4. 2009..This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism...
Magnetic resonance imaging to determine the incidence of brain ischaemia in patients with beta-thalassaemia intermediaMehran Karimi
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Thromb Haemost 103:989-93. 2010..3) These results require confirmation in a larger group of similar patients with other types of thalassaemia who are multitransfused or have an intact spleen...
Adverse effects of hydroxyurea in beta-thalassemia intermedia patients: 10 years' experienceMehran Karimi
Hematology Research Center, Shiraze University of Medical Sciences, Shiraz, Iran
Pediatr Hematol Oncol 27:205-11. 2010..05). According to these results, it seems that most of adverse effects in low-dose HU therapy in patients with TI, at least in short and medium terms, are minor and can be tolerated without needs of discontinuation of treatment...
Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in IranMehran Karimi
Hemostasis and Thrombosis Unit, Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Eur J Radiol 69:120-2. 2009..The goal of this research was to study the frequency of these signs in the cases with beta thalassemia minor patients in Iran...
Epidemiology of tuberculosis among Afghan immigrants in Fars province, southern Islamic Republic of IranM R Kadivar
Research and Study Centre, Office of the Vice Chancellor for Public Health, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran
East Mediterr Health J 13:758-64. 2007..5%) were sputum smear-positive and 121 (43.5%) were sputum smear-negative. The incidence of tuberculosis per 100 000 Afghan population in Fars province was estimated at 96.2, 88.2 and 63.5 in 2000, 2001 and 2002 respectively...
Attitude toward prenatal diagnosis for beta-thalassemia major and medical abortion in Southern IranMehran Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Hemoglobin 34:49-54. 2010..The decision not to have a medical abortion correlated with religious beliefs only...
Successful control of central nervous system bleeding in two newborns with severe factor VII deficiency using rFVIIa administered via Port-a-CathMehran Karimi
Department of Pediatrics, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Semin Hematol 45:S74. 2008..She is now 36 months old and on a 3-year rFVIIa prophylactic regimen, which has provided good results to date...
The prevalence of signs and symptoms of childhood leukemia and lymphoma in Fars Province, Southern IranMehran Karimi
Hemostasis and Thrombosis Research Unit, Hematology Research Center, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Cancer Detect Prev 32:178-83. 2008..Leukemia and lymphomas are still the common childhood cancers in Iran. This study was undertaken to determine the prevalence of signs and symptoms of these malignancies in children of Fars Province, Southern Iran...
Factor XI deficiency in Southern Iran: identification of a novel missense mutationMehran Karimi
Haemostasis and Thrombosis Unit, Hematology Research Center, Shiraz University of Medical Science, Shiraz, Iran
Ann Hematol 88:359-63. 2009..Screening a higher number of FXI-deficient patients will also be necessary to reveal the existence of a founder effect for these mutations in the Iranian population...
Hydroxyurea in the management of thalassemia intermediaMehran Karimi
Pediatric Department and Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Hemoglobin 33:S177-82. 2009..So HU therapy could be a useful alternative to blood transfusion in some TI patients...
Echocardiographic finding in beta-thalassemia intermedia and major: absence of pulmonary hypertension following hydroxyurea treatment in beta-thalassemia intermediaMehran Karimi
Haematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Eur J Haematol 82:213-8. 2009..The aim of this study was to investigate the echocardigraphic finding in beta-thalassemia intermedia (TI) and beta-thalassemia major (TM) and to compare this finding together and with healthy control subjects...
Termination of pregnancy due to Thalassemia major, Hemophilia, and Down's syndrome: the views of Iranian physiciansMehran Karimi
Thrombosis and Hemostasis Unit, Hematology Research Center, Dept, of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
BMC Med Ethics 9:19. 2008..This study was undertaken to determine physicians' opinions regarding the termination of pregnancy for three genetic diseases: thalassemia major, hemophilia, and Down's syndrome...
Malignancies in patients with beta-thalassemia major and beta-thalassemia intermedia: a multicenter study in IranMehran Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Pediatr Blood Cancer 53:1064-7. 2009..The aim of this study was to determine the frequency, characteristics, and pattern of malignancies in patients with beta thalassemia major (BTM) and beta thalassemia intermedia (BTI) in Iran...
Factor XIII DeficiencyMehran Karimi
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Semin Thromb Hemost 35:426-38. 2009..Analytical aspects of FXIII activity and antigen assays are discussed in this article. There are no hot-spot mutations in the F13A1 and F13B genes, and the majority of causative mutations are missense/nonsense point mutations...
RBC alloimmunization in blood transfusion-dependent beta-thalassemia patients in southern IranM Karimi
Thrombosis and Hemostasis Unit, Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Int J Lab Hematol 29:321-6. 2007..So for decreasing the rate of alloantibody synthesis, we should crossmatched the packed cells for minor blood groups especially for kell and Rh(E) in addition to major blood groups from the start of transfusion...
Is beta-thalassemia trait a protective factor against ischemic cerebrovascular accidents?Mehran Karimi
Hematology Research Center, Nemazee Hospital, Shiraz, Iran
J Stroke Cerebrovasc Dis 17:79-81. 2008..In this research, we sought to determine the association between beta-thalassemia trait and ischemic cerebrovascular accident (CVA)...
Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermediaMehran Karimi
Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Eur J Haematol 84:52-8. 2010..We assessed the effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia...
Evaluation of the incidence of sensorineural hearing loss in beta-thalassemia major patients under regular chelation therapy with desferrioxamineMehran Karimi
Department of Pediatrics, Division of Hematology, Shiraz Cooley s Medical Center, Nemazee Hospital, Shiraz, Iran
Acta Haematol 108:79-83. 2002..Thus we suggest periodical audiologic checkups and a low dosage of DFO (below 50 mg/kg/day) given on at least 5-6 days a week for the prevention and prompt diagnosis of audiologic complications...
Efficiency of premarital screening of beta-thalassemia trait using MCH rather than MCV in the population of Fars Province, IranM Karimi
Haematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Iran
Haematologia (Budap) 32:129-33. 2002..5% and 97.6% for the diagnosis of beta-thalassemia trait, respectively. A false negative value of MCH is about 1% lower than that of MCV. MCH is a more sensitive screening test for detecting beta-thalassemia minor before marriage...
How to deal with medical and social aspects of bleeding disorders--preparing women and the family in developing countriesM Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Haemophilia 17:42-4. 2011..Therefore it is recommended that women with coagulation disorders are provided with psychological and social support along with coagulation therapy...
Hematologic and clinical responses of thalassemia intermedia patients to hydroxyurea during 6 years of therapy in IranMehran Karimi
Hematology Research Center, Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
J Pediatr Hematol Oncol 27:380-5. 2005....
Is beta-thalassemia trait a protective factor against hypertension in young adults?Mehran Karimi
Hematology Research Center, Shiraz School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Ann Hematol 85:29-31. 2006..8 mmHg in the case group as compared with 130.7 mmHg in the control group). BTT has a protective effect on the development of hypertension in young male adults...
Investigation of Helicobacter pylori infection in beta-thalassaemia major patients with recurrent abdominal painMehran Karimi
Haemostasis and Thrombosis Unit, Haematology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, Iran
Eur J Gastroenterol Hepatol 17:1363-7. 2005..Recurrent abdominal pain (RAP) affects many children, especially those affected by beta-thalassaemia major. The role of Helicobacter pylori is still unclear in children with RAP...
Reduced insulin growth factor I concentrations in iron-overloaded beta thalassaemic patients with normal growth hormone secretion and liver functionHamdollah Karamifar
Endocrine Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Pediatr Endocrinol Rev 2:256-8. 2004..The possibility of GHIS in beta-Th patients with short stature indicates that higher doses of rechGH may be required to obtain an improvement in growth velocity in beta-Th patients...
Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea: a 13-year experience in IranMehran Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Int J Hematol 95:51-6. 2012..Hydroxyurea may thus represent a safe alternative to blood transfusion in transfusion-dependent β-thalassemia patients, or help to increase Hb level in untransfused βTI patients...
Analysis of intelligence quotient in patients with homozygous beta-thalassemiaMehran Karimi
Hematology Research Center, Pediatric Department, Namazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Saudi Med J 27:982-5. 2006..To compare the intelligence quotient (IQ) of patients with thalassemia major (TM) to that of normal children...
Unusual lymphoblastic leukemia/lymphoma in Eastern IranMehrbod Karimi
Department of Pathology, Ali Asghar Hospital, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Indian J Pediatr 73:619-22. 2006..After appropriate treatment, the symptoms of the patient relieved significantly and he is in complete remission for about one year...
Clinical response of patients with sickle cell anemia to cromolyn sodium nasal sprayMehran Karimi
Department of Pediatrics, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Am J Hematol 81:809-16. 2006..Every combination used in this survey had positive effects on decreasing the pain. cromolyn sodium nasal spray is significantly efficient in decreasing sickle cell crisis as well as pain intensity in patients with sickle cell anemia...
Clinical and laboratory patterns of the haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura in southern IranMehran Karimi
Haemostasis and Thrombosis Unit, Haematology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Intern Emerg Med 1:35-9. 2006....
Bone mineral density in beta-thalassemia major and intermediaMehran Karimi
Hemostasis and Thrombosis Unit, Hematology Research Center, Internal Medicine Division, Endocrinology Research Center and Immunology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Indian Pediatr 44:29-32. 2007..This study was conducted to assess bone mineral density (BMD) and bone mineral content (BMC) in patients with thalassemia major and intermedia, and to correlate them with biochemical and hematological profile...
Magnetic resonance imaging (MRI) findings of joints in young beta-thalassemia major patients: fluid surrounding the scaphoid bone: a novel finding, as the possible effect of secondary hemochromatosisMehran Karimi
Hematology Research Center, Department of Radiology, Nemazee Hospital, Shiraz University of Medical Science, Shiraz, Iran
J Pediatr Hematol Oncol 29:393-8. 2007..Beta-thalassemia major is a hereditary disease with developing hemochromatosis as a consequence of repeated blood transfusions. Degenerative arthropathy may be the first manifestation of primary hemochromatosis...
Premarital screening for beta-thalassaemia in Southern Iran: options for improving the programmeMehran Karimi
Department of Pediatrics, Hematology Research Center, Shiraz University of Medical Science Shiraz, Iran
J Med Screen 14:62-6. 2007..beta-thalassaemia is a preventable disease. Iran has about 20,000 homozygote beta-thalassaemia patients and 3,750,000 carriers...
Spectrum of inherited bleeding disorders in southern Iran, before and after the establishment of comprehensive coagulation laboratoryMehran Karimi
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Blood Coagul Fibrinolysis 20:642-5. 2009....
Seroprevalence of hepatitis B, hepatitis C and human immunodeficiency virus antibodies among multitransfused thalassaemic children in Shiraz, IranM Karimi
Department of Pediatrics, School of Medicine and Center for Research Consultation, Shiraz University of Medical Sciences, Shiraz, Iran
J Paediatr Child Health 37:564-6. 2001..To evaluate the rate of seropositivity to hepatitis B and C and human immunodeficiency virus (HIV) infections among children with beta-thalassaemia major receiving multiple transfusions in Shiraz, Iran, compared with healthy controls...
Inherited coagulation disorders in southern IranM Karimi
Hematology Research Center, Department of Pediatric Hematology, Shiraz University of Medical Sciences, Shiraz, Iran
Haemophilia 8:740-4. 2002..7%) were hepatitis B positive, so that the rate of transfusion-transmitted infections was lower compared with other populations...
Seroprevalence of HBsAg, anti-HCV, and anti-HIV among haemophiliac patients in Shiraz, IranM Karimi
Department of Paediatrics, School of Medicine, Shiraz University of Medical Sciences, Iran
Haematologia (Budap) 31:251-5. 2001..0008). It is concluded that HCV is the current major problem in multi-transfused haemophiliac patients and more careful pre-transfusion screening of blood for anti-HCV must be introduced in all blood banks...
Antiphospholipid antibodies and hepatitis C virus infection in Iranian thalassemia major patientsS Kashef
Allergy Research Center, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
Int J Lab Hematol 30:11-6. 2008..A high prevalence of aCLAbs, the majority in low titers, was detected in Iranian thalassemic patients irrespective of previous history of thrombosis and presence of HCV infection...
Prevalence of pyruvate kinase deficiency among the south Iranian population: quantitative assay and molecular analysisM Yavarian
Hematology Research Center, School of Medicine, Shiraz University of Medical Science, Shiraz, Iran
Blood Cells Mol Dis 40:308-11. 2008..The polymorphism at nt 1705 was in linkage disequilibrium with the A and C polymorphism, which indicated a multi-centric origin of the mutation. Further study of the promoter region and intron/exon boundary is under investigation...
Glanzmann thrombasthenia and Bernard-Soulier syndrome in south IranA Afrasiabi
Haemostasis and Thrombosis Unit, Hematology Research Center, Shiraz University of Medical Science, Shiraz, Iran
Clin Lab Haematol 27:324-7. 2005..Patients affected by GT and BSS suffer mainly from mucocutaneous bleedings causing anemia and transfusion requirements...
Quality of life in thalassemia major: reliability and validity of the Persian version of the SF-36 questionnaireH Jafari
Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
J Postgrad Med 54:273-5. 2008..The objective of this study was to determine the reliability and validity of the eight-item Short Form Health Survey (SF-36) questionnaire translated into Persian for use in Iranian patients with thalassemia major...
Prevalence of celiac disease among blood donors in Sistan and Balouchestan Province, Southeastern IranAli Bahari
Department of Gastroenterology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Arch Iran Med 13:301-5. 2010..The prevalence of celiac disease is common in Iran. The aim of the present study was to determine the prevalence of celiac disease in apparently healthy blood donors of Sistan and Balouchestan Province, southeastern Iran...
Comparison of attitudes towards prenatal diagnosis and termination of pregnancy for haemophilia in Iran and ItalyM Karimi
Hemostasis and Thrombosis Unit, Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Haemophilia 10:367-9. 2004..2% of the Iranian and 16.7% of the Italian participants (P < 0.001). The greater rate of acceptability of abortion in Iranians may be due to differences in the quality of patient care in the two countries...
Renal tubular function in patients with beta-thalassaemia major in Zahedan, southeast IranS Sadeghi-Bojd
Department of Paediatrics and Research Center for Children and Adolescent Health, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Singapore Med J 49:410-2. 2008..The aim of this study is to investigate renal tubular and glomerular functions in patients with beta-thalassaemia major...
Radiofrequency ablation of the spleen in patients with thalassemia intermedia: a pilot studyA R Rasekhi
Department of Radiology, Imaging Research Center, School of Medicine, Shiraz University of Medical Sciences, Namazee Sq, Shiraz, Fars, Iran
AJR Am J Roentgenol 192:1425-9. 2009..We investigated the efficacy and safety of radiofrequency ablation on the hematologic parameters in patients with thalassemia intermedia (TI)...
Beta-globin gene cluster haplotypes in sickle cell patients from southwest IranZ Rahimi
Department of Biochemistry, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Am J Hematol 74:156-60. 2003..More haplotype investigations of a normal population can clarify the high incidence of Bantu A2 haplotype in our population...
Genetic characterization of patients with Bernard-Soulier syndrome and their relatives from Southern IranA Afrasiabi
Haemostasis and Thrombosis Unit, Haematology Research Center, Shiraz Medical University of Science, Shiraz, Iran
Platelets 18:409-13. 2007..Among the family members studied several heterozygotes were identified. None of them, with one exception, had macrothrombocytopenia. In one family a slight reduction of GpIb/IX/V expression was observed...
