Leila Dargahi


Affiliation: Shaheed Beheshti University of Medical Sciences
Country: Iran


  1. Valian N, Heravi M, Ahmadiani A, Dargahi L. Effect of methamphetamine on rat primary midbrain cells; mitochondrial biogenesis as a compensatory response. Neuroscience. 2019;406:278-289 pubmed publisher
    ..Mitochondrial biogenesis activation, as a compensatory mechanism, did not prevent neuronal and glial cell death following high MA concentration. ..
  2. Pandamooz S, Salehi M, Safari A, Azarpira N, Heravi M, Ahmadiani A, et al. Enhancing the expression of neurotrophic factors in epidermal neural crest stem cells by valproic acid: A potential candidate for combinatorial treatment. Neurosci Lett. 2019;704:8-14 pubmed publisher
    ..Hence, these cells can be utilized to modulate destructive context of neurological disorders and injuries. ..
  3. Pandamooz S, Salehi M, Zibaii M, Safari A, Nabiuni M, Ahmadiani A, et al. Modeling traumatic injury in organotypic spinal cord slice culture obtained from adult rat. Tissue Cell. 2019;56:90-97 pubmed publisher
    ..Besides mimicking the disturbing features of human SCI, this model can response to VPA pharmacological treatment. ..
  4. Ronaghi A, Zibaii M, Pandamooz S, Nourzei N, Motamedi F, Ahmadiani A, et al. Entorhinal cortex stimulation induces dentate gyrus neurogenesis through insulin receptor signaling. Brain Res Bull. 2018;144:75-84 pubmed publisher
    ..Notably, GSK3β inhibition can play a major role in the downstream of insulin receptor signaling in DBS induced neurogenesis. ..
  5. Parsi S, Pandamooz S, Heidari S, Naji M, Morfini G, Ahmadiani A, et al. A novel rat model of Alzheimer's disease based on lentiviral-mediated expression of mutant APP. Neuroscience. 2015;284:99-106 pubmed publisher
    ..The relevance of this animal model to the study of sporadic AD is discussed. ..
  6. Nikseresht S, Khodagholi F, Nategh M, Dargahi L. RIP1 Inhibition Rescues from LPS-Induced RIP3-Mediated Programmed Cell Death, Distributed Energy Metabolism and Spatial Memory Impairment. J Mol Neurosci. 2015;57:219-30 pubmed publisher
    ..In conclusion, effects of RIP1 inhibition on RIP3 and cell death provide new approaches to ameliorate neuroinflammation and relative disorders. ..
  7. Pandamooz S, Nabiuni M, Miyan J, Ahmadiani A, Dargahi L. Organotypic Spinal Cord Culture: a Proper Platform for the Functional Screening. Mol Neurobiol. 2016;53:4659-74 pubmed publisher
  8. Khallaghi B, Safarian F, Nasoohi S, Ahmadiani A, Dargahi L. Metformin-induced protection against oxidative stress is associated with AKT/mTOR restoration in PC12 cells. Life Sci. 2016;148:286-92 pubmed publisher
    ..The present work while highlighting metformin anti-oxidant characteristics, concludes that Akt/mTOR signaling might be central to the drug's alleviating effects. ..
  9. Beirami E, Oryan S, Seyedhosseini Tamijani S, Ahmadiani A, Dargahi L. Intranasal insulin treatment alleviates methamphetamine induced anxiety-like behavior and neuroinflammation. Neurosci Lett. 2017;660:122-129 pubmed publisher
    ..These findings introduce insulin as a potential therapeutic approach for the treatment of MA aversive symptoms. ..

More Information


  1. Seyedhosseini Tamijani S, Beirami E, Ahmadiani A, Dargahi L. Effect of three different regimens of repeated methamphetamine on rats' cognitive performance. Cogn Process. 2018;19:107-115 pubmed publisher
    ..Though MA deleterious effect especially in recognition memory is somehow dose dependent, preconditioning effect of increasing doses may be ruled out at least in the case of parameters measured here. ..