Kamran Ghaedi


Affiliation: Royan Institute
Country: Iran


  1. Ebadi R, Kordi Tamandani D, Ghaedi K, Nasr Esfahani M. Comparison of two different media for maturation rate of neural progenitor cells to neuronal and glial cells emphasizing on expression of neurotrophins and their respective receptors. Mol Biol Rep. 2018;: pubmed publisher
    ..In conclusion, our results indicated that NB + 5%ES-FBS + N2B27 medium promoted neural differentiation process of mESCs and caused enhancement of neurotrophins protein expression in addition to their cognate receptors. ..
  2. Shirkhani S, Marandi S, Kazeminasab F, Esmaeili M, Ghaedi K, Esfarjani F, et al. Comparative studies on the effects of high-fat diet, endurance training and obesity on Ucp1 expression in male C57BL/6 mice. Gene. 2018;676:16-21 pubmed publisher
  3. Teimuri S, Hosseini A, Rezaenasab A, Ghaedi K, Ghoveud E, Etemadifar M, et al. Integrative Analysis of lncRNAs in Th17 Cell Lineage to Discover New Potential Biomarkers and Therapeutic Targets in Autoimmune Diseases. Mol Ther Nucleic Acids. 2018;12:393-404 pubmed publisher
    ..We propose that the recurrently deregulated lncRNAs identified in this report could provide a valuable resource for studies aimed at delineating the relationship between functional lncRNAs and autoimmune disorders. ..
  4. Pakravan G, Foroughmand A, Peymani M, Ghaedi K, Hashemi M, Hajjari M, et al. Downregulation of miR-130a, antagonized doxorubicin-induced cardiotoxicity via increasing the PPAR? expression in mESCs-derived cardiac cells. Cell Death Dis. 2018;9:758 pubmed publisher
    ..Our data strongly suggest that antagomiR-130a limits Dox-induced cellular toxicity via PPAR? upregulation and may have clinical relevance to limit in vivo Dox toxicity. ..
  5. Ziaei A, Ardakani M, Hashemi M, Peymani M, Ghaedi K, Baharvand H, et al. Acute course of deferoxamine promoted neuronal differentiation of neural progenitor cells through suppression of Wnt/β-catenin pathway: a novel efficient protocol for neuronal differentiation. Neurosci Lett. 2015;590:138-44 pubmed publisher
    ..We concluded that suppression of Wnt/β-catenin pathway was induced through chelating of intracellular Iron due to DFO treatment. These findings help to understand therapeutic benefit of DFO as a neuroprotective agent. ..
  6. Ghadiri N, Emamnia N, Ganjalikhani Hakemi M, Ghaedi K, Etemadifar M, Salehi M, et al. Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients. Gene. 2018;659:109-117 pubmed publisher
    ..Collectively, we showed a correlation between the four miRNAs with different phases of MS and their possible involvement in differentiation pathways of Th17 cells, as the most important players in MS. ..
  7. Rabiee F, Forouzanfar M, Ghazvini Zadegan F, Tanhaei S, Ghaedi K, Motovali Bashi M, et al. Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells. Gene. 2014;551:127-37 pubmed publisher
    ..These data suggest that Fndc5 may be involved in cardiomyocyte differentiation. Therefore, a new hope will be arisen for potential application of this myokine for regeneration of damaged cardiac tissues especially in cardiac failure. ..
  8. Ghahrizjani F, Ghaedi K, Salamian A, Tanhaei S, Nejati A, Salehi H, et al. Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues. Gene. 2015;557:123-9 pubmed publisher
    ..Additional research is necessary to determine the major function of FDNC5 in this process. ..
  9. Safaeinejad Z, Kazeminasab F, Kiani Esfahani A, Ghaedi K, Nasr Esfahani M. Multi-effects of Resveratrol on stem cell characteristics: Effective dose, time, cell culture conditions and cell type-specific responses of stem cells to Resveratrol. Eur J Med Chem. 2018;155:651-657 pubmed publisher
    ..Therefore, RSV could be accounted as an effective small molecule for a variety of cell therapies which should be implemented by a special care considering, effective concentration and duration of exposure. ..

More Information


  1. Amiri M, Yousefnia S, Seyed Forootan F, Peymani M, Ghaedi K, Nasr Esfahani M. Diverse roles of fatty acid binding proteins (FABPs) in development and pathogenesis of cancers. Gene. 2018;676:171-183 pubmed publisher
    ..This review introduces several isoforms of FABPs (FABP1-12) and summarizes their function and their possible roles in cancer development through some proposed mechanisms. ..
  2. Darehgazani R, Peymani M, Hashemi M, Omrani M, Movafagh A, Ghaedi K, et al. PPARγ ameliorated LPS induced inflammation of HEK cell line expressing both human Toll-like receptor 4 (TLR4) and MD2. Cytotechnology. 2016;68:1337-48 pubmed publisher
    ..PPARγ was shown to negatively regulate TLR4 activity and therefore exerts its anti-inflammatory action against LPS induced inflammation. ..
  3. Zadegan F, Ghaedi K, Kalantar S, Peymani M, Hashemi M, Baharvand H, et al. Cardiac differentiation of mouse embryonic stem cells is influenced by a PPAR γ/PGC-1α-FNDC5 pathway during the stage of cardiac precursor cell formation. Eur J Cell Biol. 2015;94:257-66 pubmed publisher
    ..We concluded that PPARγ agonist and antagonist induced up and down-regulation of PGC-1α and subsequently modulated the process of CPCs formation through an alteration in FNDC5 and mitochondrial markers expression. ..
  4. Hosseini Farahabadi S, Ghaedi K, Ghazvini Zadegan F, Karbalaie K, Rabiee F, Nematollahi M, et al. ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs. Neuroscience. 2015;297:252-61 pubmed publisher
    ..This led us to conclude that RA enhances Fndc5 expression through a non-genomic pathway via the ERK signaling pathway. ..
  5. Esmaeili M, Ghaedi K, Shoaraye Nejati A, Nematollahi M, Shiralyian H, Nasr Esfahani M. Pioglitazone significantly prevented decreased rate of neural differentiation of mouse embryonic stem cells which was reduced by Pex11β knock-down. Neuroscience. 2016;312:35-47 pubmed publisher
  6. Jodeiri Farshbaf M, Ghaedi K, Megraw T, Curtiss J, Shirani Faradonbeh M, Vaziri P, et al. Does PGC1?/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?. Neuromolecular Med. 2016;18:1-15 pubmed publisher
    ..This review presents recent findings on the PGC1?/FNDC5/BDNF pathway and its role in neuroprotection, and discusses the controversial promise of irisin as a mediator of the positive benefits of exercise. ..
  7. Taheri M, Salamian A, Ghaedi K, Peymani M, Izadi T, Nejati A, et al. A ground state of PPARγ activity and expression is required for appropriate neural differentiation of hESCs. Pharmacol Rep. 2015;67:1103-14 pubmed publisher
    ..However, high expression and activity of PPARγ could not enhance the required neural differentiation, whereas the PPARγ inactivation could negatively influence NP formation from hESCs by antagonist. ..
  8. Kajabadi N, Ghoochani A, Peymani M, Ghaedi K, Kiani Esfahani A, Hashemi M, et al. The Synergistic Enhancement of Cloning Efficiency in Individualized Human Pluripotent Stem Cells by Peroxisome Proliferative-activated Receptor-γ (PPARγ) Activation and Rho-associated Kinase (ROCK) Inhibition. J Biol Chem. 2015;290:26303-13 pubmed publisher
    ..These effects were reversed by GW-9662, an irreversible peroxisome proliferative-activated receptor-γ antagonist. This novel setting provided a step toward hPSC manipulation and its biomedical applications. ..
  9. Ahmadian Elmi M, Bidmeshki Pour A, Naghavian R, Ghaedi K, Tanhaei S, Izadi T, et al. miR-27a and miR-214 exert opposite regulatory roles in Th17 differentiation via mediating different signaling pathways in peripheral blood CD4+ T lymphocytes of patients with relapsing-remitting multiple sclerosis. Immunogenetics. 2016;68:43-54 pubmed publisher
    ..Our data suggest that miR-27a may probably inhibit negative regulators of Th17 cell differentiation, thus promoting its differentiation while miR-214 has an adverse effect. ..
  10. Jodeiri Farshbaf M, Forouzanfar M, Ghaedi K, Kiani Esfahani A, Peymani M, Shoaraye Nejati A, et al. Nurr1 and PPAR? protect PC12 cells against MPP(+) toxicity: involvement of selective genes, anti-inflammatory, ROS generation, and antimitochondrial impairment. Mol Cell Biochem. 2016;420:29-42 pubmed publisher
    ..Moreover, production of intracellular ROS and MMP modulated by MPP(+) was decreased by PPAR? and Nurr1 agonists' treatment alone and in the combined form. ..
  11. Peymani M, Ghaedi K, Hashemi M, Ghoochani A, Kiani Esfahani A, Nasr Esfahani M, et al. Ameliorating the Effect of Pioglitazone on LPS-Induced Inflammation of Human Oligodendrocyte Progenitor Cells. Cell Mol Neurobiol. 2018;38:517-527 pubmed publisher
    ..Taken together, therapy with Pioglitazone represents a novel potential drug in alleviating the loss of OPCs in neurodegenerative conditions. ..
  12. Safaeinejad Z, Nabiuni M, Peymani M, Ghaedi K, Nasr Esfahani M, Baharvand H. Resveratrol promotes human embryonic stem cells self-renewal by targeting SIRT1-ERK signaling pathway. Eur J Cell Biol. 2017;96:665-672 pubmed publisher
    ..These findings provide a novel application of RSV for developing a defined medium for hESCs culture which could help to better understanding of the signaling events that govern self-renewal of hESCs. ..
  13. Mazaheri N, Peymani M, Galehdari H, Ghaedi K, Ghoochani A, Kiani Esfahani A, et al. Ameliorating Effect of Osteopontin on H2O2-Induced Apoptosis of Human Oligodendrocyte Progenitor Cells. Cell Mol Neurobiol. 2018;38:891-899 pubmed publisher
    ..In conclusion, OPN may act via ?V integrin signaling and trigger suppression of P53-dependent apoptotic cascades. Therefore OPN therapy may be considered as a feasible process to prevent progress of neurodegenerative diseases in human. ..