Seyed Abdolrahim Rezaee


Affiliation: Mashhad University of Medical Sciences
Country: Iran


  1. Zandhaghighi M, Hadizadeh F, Soleimanpour S, Meshkat Z, Rezaee S, Derakhshan M, et al. In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis. J Infect Dev Ctries. 2017;11:453-458 pubmed publisher
  2. Karbalaei Zadeh Babaki M, Taghiabadi M, Soleimanpour S, Saleh Moghadam M, Mosavat A, Amini A, et al. Mycobacterium tuberculosis Ag85b:hfcγ1 recombinant fusion protein as a selective receptor-dependent delivery system for antigen presentation. Microb Pathog. 2019;129:68-73 pubmed publisher
  3. Tarokhian H, Rahimi H, Mosavat A, Shirdel A, Rafatpanah H, Akbarin M, et al. HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions. BMC Cancer. 2018;18:1287 pubmed publisher
    ..However, high level of RORγt may inhibit Th1 response and complicated in ATLL progressions. ..
  4. Amini A, Solovyova A, Sadeghian H, Blackbourn D, Rezaee S. Structural properties of a viral orthologue of cellular CD200 protein: KSHV vOX2. Virology. 2015;474:94-104 pubmed publisher
    ..0-33.6 kDa, much less than 50 kDa. Thus, the structural similarity to PD-L1 verifies its immunomodulatory potential and the RGD motif suggests an adhesive capacity. ..
  5. Boostani R, Vakili R, Hosseiny S, Shoeibi A, Fazeli B, Etemadi M, et al. Triple Therapy with Prednisolone, Pegylated Interferon and Sodium Valproate Improves Clinical Outcome and Reduces Human T-Cell Leukemia Virus Type 1 (HTLV-1) Proviral Load, Tax and HBZ mRNA Expression in Patients with HTLV-1-Associated Myelopathy/Tro. Neurotherapeutics. 2015;12:887-95 pubmed publisher
    ..The results provide new insight into the complicated conditions underlying HTLV-1-associated diseases. ..
  6. Soleimanpour S, Farsiani H, Mosavat A, Ghazvini K, Eydgahi M, Sankian M, et al. APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice. Appl Microbiol Biotechnol. 2015;99:10467-80 pubmed publisher
  7. Mahmoudabady M, Kazemi N, Niazmand S, Rezaee S, Soukhtanloo M, Hosseini M. The effect of angiotensin-converting enzyme inhibition on inflammatory and angiogenic factors in hypercholesterolemia. Pharmacol Rep. 2015;67:837-41 pubmed publisher
    ..01 and p<0.05, respectively). Captopril, an ACE inhibitor, improves hyperlipidemia and prevents from overexpression of genes for VEGF and VCAM-1, that are implicated in the inflammation and angiogenesis. ..
  8. Soleimanpour S, Mohammadi A, Ghazvini K, Jamehdar S, Sadeghian H, Taghiabadi M, et al. Construction of Mycobacterium tuberculosis ESAT-6 fused to human Fcγ of IgG1: To target FcγR as a delivery system for enhancement of immunogenicity. Gene. 2016;580:111-117 pubmed publisher
    ..Since, ESAT6:Fcγ1 protein dimerizes and bind to FcγRs, therefore, Fc-tagged protein could target APCs for inducing appropriate immune response or using in interferon-based assays. ..
  9. Mosavat A, Soleimanpour S, Farsiani H, Sadeghian H, Ghazvini K, Sankian M, et al. Fused Mycobacterium tuberculosis multi-stage immunogens with an Fc-delivery system as a promising approach for the development of a tuberculosis vaccine. Infect Genet Evol. 2016;39:163-172 pubmed publisher

More Information


  1. Farsiani H, Mosavat A, Soleimanpour S, Sadeghian H, Akbari Eydgahi M, Ghazvini K, et al. Fc-based delivery system enhances immunogenicity of a tuberculosis subunit vaccine candidate consisting of the ESAT-6:CFP-10 complex. Mol Biosyst. 2016;12:2189-201 pubmed publisher
    ..Therefore, additional investigations are necessary for the development of appropriate Fc-based tuberculosis vaccines. ..
  2. Amirnasr M, Fallah Tafti T, Sankian M, Rezaei A, Tafaghodi M. Immunization against HTLV-I with chitosan and tri-methylchitosan nanoparticles loaded with recombinant env23 and env13 antigens of envelope protein gp46. Microb Pathog. 2016;97:38-44 pubmed publisher
    ..001). Both nanoparticles showed good immunoadjuvant potential. Env23 antigen was a better candidate for vaccination against HTLV-I, as it induced higher cellular immune responses, compared with env13. ..
  3. Tarokhian H, Taghadosi M, Rafatpanah H, Rajaei T, Azarpazhooh M, Valizadeh N, et al. The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis. Virus Res. 2017;228:1-6 pubmed publisher
    ..In addition, Tax and neopterin are more helpful than PVL for the monitoring of HTLV-1-infected patients. ..
  4. Ghezeldasht S, Sadeghian H, Azarpazhooh M, Shamsian S, Rafatpanah H, Mahmoodi M, et al. Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients. Appl Biochem Biotechnol. 2017;182:1403-1414 pubmed publisher
    ..These findings suggest that HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR, which may lead to immune response deterioration of Tregs and consequently HAM/TSP manifestation. ..
  5. Ramezani S, Shirdel A, Rafatpanah H, Akbarin M, Tarokhian H, Rahimi H, et al. Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma. Med Microbiol Immunol. 2017;206:327-335 pubmed publisher
    ..Furthermore, the overexpression of RAD51 which has been induced in HTLV-1 infected cells as a consequence of virus replication is not able to overcome the DNA damage toward cell transformation. ..
  6. Karbalaei Zadeh Babaki M, Soleimanpour S, Rezaee S. Antigen 85 complex as a powerful Mycobacterium tuberculosis immunogene: Biology, immune-pathogenicity, applications in diagnosis, and vaccine design. Microb Pathog. 2017;112:20-29 pubmed publisher
    ..This paper represents a comprehensive review of studies on Mtb molecules examining pathogenicity, biochemistry, immunology, and the role of Mtb in therapeutic or vaccine research. ..
  7. Rajaei T, Farajifard H, Rafatpanah H, Bustani R, Valizadeh N, Rajaei B, et al. Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Med Microbiol Immunol. 2017;206:195-201 pubmed publisher