M Iranshahi

Summary

Affiliation: Mashhad University of Medical Sciences
Country: Iran

Publications

  1. pmc Cytotoxic activities of phytochemicals from Ferula species
    Seied Mojtaba Valiahdi
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, 91775 1365, Mashhad, Iran
    Daru 21:39. 2013
  2. doi Cytotoxic evaluation of alkaloids and isoflavonoids from the Australian tree Erythrina vespertilio
    Mehrdad Iranshahi
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Vakilabad blvd, Mashhad, Iran
    Planta Med 78:730-6. 2012
  3. doi Diversolides A-G, guaianolides from the roots of Ferula diversivittata
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Vakilabad Boulevard, Mashhad, Iran
    Phytochemistry 69:2753-7. 2008
  4. doi Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo
    Mehrdad Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Eur J Cancer Prev 18:412-5. 2009
  5. doi Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo
    M Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, MUMS, P O Box 91775 1365, Mashhad, Iran
    Phytomedicine 17:269-73. 2010
  6. doi Persicasulphide C, a new sulphur-containing derivative from Ferula persica
    Mehrdad Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Nat Prod Res 23:1584-8. 2009
  7. doi New sesquiterpene coumarins from the roots of Ferula flabelliloba
    Mehrdad Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Pharm Biol 48:217-20. 2010
  8. doi Sesquiterpene coumarins from Ferula gumosa
    Mehrdad Iranshahi
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    J Nat Prod 73:1958-62. 2010
  9. doi Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a review
    Milad Iranshahy
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    J Ethnopharmacol 134:1-10. 2011
  10. doi Cancer chemopreventive activity of terpenoid coumarins from Ferula species
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Planta Med 74:147-50. 2008

Collaborators

Detail Information

Publications29

  1. pmc Cytotoxic activities of phytochemicals from Ferula species
    Seied Mojtaba Valiahdi
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, 91775 1365, Mashhad, Iran
    Daru 21:39. 2013
    ....
  2. doi Cytotoxic evaluation of alkaloids and isoflavonoids from the Australian tree Erythrina vespertilio
    Mehrdad Iranshahi
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Vakilabad blvd, Mashhad, Iran
    Planta Med 78:730-6. 2012
    ..Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC (50) = 8.83 ± 1.87 µM) and NFF (0.64 ± 0.37 µM) cell lines...
  3. doi Diversolides A-G, guaianolides from the roots of Ferula diversivittata
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Vakilabad Boulevard, Mashhad, Iran
    Phytochemistry 69:2753-7. 2008
    ..Some of the tested compounds showed moderate antifungal and antibacterial activities with minimum inhibitory concentration (MIC) values from 40 to 80microg/ml...
  4. doi Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo
    Mehrdad Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Eur J Cancer Prev 18:412-5. 2009
    ..In addition, the pattern of tumor promotion was slower in mice treated with umbelliprenin compared with the curcumin. Therefore, umbelliprenin might be valuable as a cancer chemopreventive agent...
  5. doi Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo
    M Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, MUMS, P O Box 91775 1365, Mashhad, Iran
    Phytomedicine 17:269-73. 2010
    ....
  6. doi Persicasulphide C, a new sulphur-containing derivative from Ferula persica
    Mehrdad Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Nat Prod Res 23:1584-8. 2009
    ..In this article, the correct structures of persicasulphides A and B are also presented...
  7. doi New sesquiterpene coumarins from the roots of Ferula flabelliloba
    Mehrdad Iranshahi
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Pharm Biol 48:217-20. 2010
    ..f. & Aell. (Apiaceae). The structures of these compounds were elucidated by various 1- and 2-D NMR techniques as well as HREIMS...
  8. doi Sesquiterpene coumarins from Ferula gumosa
    Mehrdad Iranshahi
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    J Nat Prod 73:1958-62. 2010
    ..The structures of 1-3 were elucidated by spectroscopic data interpretation. The cytotoxic activity of the sesquiterpene coumarin derivatives was evaluated against a small panel of cancer cell lines...
  9. doi Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a review
    Milad Iranshahy
    Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    J Ethnopharmacol 134:1-10. 2011
    ..Recent studies have shown new promising antiviral sesquiterpene coumarins from this old phytomedicine. The present review summarizes the information concerning the traditional uses, phytochemistry and biological activities of asafoetida...
  10. doi Cancer chemopreventive activity of terpenoid coumarins from Ferula species
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Planta Med 74:147-50. 2008
    ..Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids...
  11. ncbi Polar secondary metabolites of Ferula persica roots
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytochemistry 69:473-8. 2008
    ..The structures of these compounds were elucidated by extensive spectroscopic methods including 1D-((1)H and (13)C) and 2D NMR experiments (DQF-COSY, HSQC, HMBC, and ROESY) as well as ESIMS and TOFMS analyses...
  12. doi Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell line
    F Behnam Rassouli
    Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
    Phytomedicine 16:181-7. 2009
    ..Results revealed that combination of 40 microg ml(-1) vincristine with 16 microg ml(-1) mogoltacin increased the cytotoxicity of vincristine after 48 h by 32.8%...
  13. ncbi Two matrix metalloproteinases inhibitors from Ferula persica var. persica
    A R Shahverdi
    Department of Pharmaceutical Biotechnology and Medicinal Plant Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Phytomedicine 13:712-7. 2006
    ..persica var. latisecta. Since inhibition of MMP activity has been employed in modality therapy in diseases such as cancer, this compound might be promising in the preparation of anti-MMP therapeutic derivatives...
  14. ncbi Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad, Iran
    Phytochemistry 68:554-61. 2007
    ..Umbelliprenin and auraptene showed significant activity with IC(50) values of 4.9microg/ml (13.3microM) and 5.1microg/ml (17.1microM) after 48h incubation, respectively...
  15. ncbi Sulfur containing derivatives from Ferula persica var. latisecta
    Mehrdad Iranshahi
    Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Phytochemistry 63:965-6. 2003
    ..var. latisecta D. F. Chamberlain. Their structures were elucidated by spectral methods...
  16. ncbi Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureus
    Ahmad Reza Shahverdi
    Department of Pharmaceutical Biotechnology and Medicinal Plant Research Center, Faculty of Pharmacy, Medical Sciences University of Tehran, Tehran 1417614411, Iran
    Biol Pharm Bull 30:1805-7. 2007
    ..aureus...
  17. doi Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress
    Fatemeh Soltani
    Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Cell Biol Toxicol 25:291-6. 2009
    ..However, no significant difference (p > 0.05) in the protective activity was found between UMB and AA at concentrations of approximately higher than 50 microM...
  18. doi Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stress
    Fatemeh Soltani
    Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 24:85-9. 2010
    ..This study suggests that the antigenotoxic property of auraptene is of great pharmacological importance and might be beneficial for cancer prevention...
  19. ncbi Kopetdaghins A-E, sesquiterpene derivatives from the aerial parts and the roots of Dorema kopetdaghense
    Mehrdad Iranshahi
    Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    J Nat Prod 70:1240-3. 2007
    ..The structures of these compounds were elucidated by various 1D and 2D NMR techniques as well as high-resolution positive-ion ESIMS...
  20. ncbi Cytotoxicity of vincristine on the 5637 cell line is enhanced by combination with conferone
    Vajiheh Neshati
    Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
    Z Naturforsch C 64:317-22. 2009
    ..The results of the MTT assay confirmed the morphological observations. After 48 h of combined treatment with 40 microg/ml vincristine and 16 microg/ml conferone, the cytotoxicity of vincristine was increased by 23.6%...
  21. doi The enhancement of vincristine cytotoxicity by combination with feselol
    Samaneh Mollazadeh
    Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
    J Asian Nat Prod Res 12:569-75. 2010
    ..Results showed that the combination of 40 microg/ml VCR with 16 microg/ml feselol increased the cytotoxicity of VCR by 28.32% after 48 h. This effect might be due to inhibition of P-glycoprotein in TCC cells by feselol...
  22. ncbi Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test
    Hamid Reza Monsef
    Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Pharm Pharm Sci 7:65-9. 2004
    ..To evaluate the effect of Peganum harmala (Syrian rue) a wild-growing flowering plant belonging to the family Zygophylaceae and found abundantly in Iran on formalin-induced pain response in mice...
  23. ncbi Bleaching of Serratia marcescens by some coumarins: a spectrophotometric study
    Ahmad Reza Shahverdi
    Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Basic Microbiol 45:470-4. 2005
    ..Comparing the structures of the different coumarins showed that the linear sesquiterpene part of the umbelliprenin structure may be essential for the bleaching effect of S. marcescens ...
  24. doi Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula species
    Seyyed Majid Bagheri
    Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences MUMS, Mashhad, Iran
    Pharm Biol 48:242-6. 2010
    ..badrakema fruits and lowest in F. badrakema roots. Our findings also revealed that the methanol extracts and F. assafoetida oleo-gum resin do not possess anticonvulsant activity...
  25. doi Antigenotoxic effects of the disulfide compound persicasulfide A (PSA) on rat lymphocytes exposed to oxidative stress
    Saeid Noroozi
    Biotechnology Research Center, Department of Pharmacognosy and Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Planta Med 75:32-6. 2009
    ..47+/-67.46 microM). Compared to the EC50 for ascorbic acid (1399.23+/-205.21 microM), it was deduced that PSA was more effective than ascorbic acid in the prevention of oxidative damage to DNA...
  26. ncbi Antigenotoxic effects of Satureja hortensis L. on rat lymphocytes exposed to oxidative stress
    Fatemeh Mosaffa
    Biotechnology Laboratory, Biotechnology Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Arch Pharm Res 29:159-64. 2006
    ..01) on H2O2 induced chromosomal damage. In conclusion both the ethanolic extract and the essential oil of the plant reversed the oxidative damage to rat lymphocytes induced by hydrogen peroxide...
  27. ncbi Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis
    Chantal Barthomeuf
    University Clermont1, Laboratoire de Pharmacognosie Biotechnologies, INSERM, U484, Groupe de Recherche Clinique, UFR Pharmacie, Clermont Fd F 63001, France
    Phytomedicine 15:103-11. 2008
    ..In vivo investigations are needed to test these hypotheses...
  28. ncbi Umbelliprenin from Ferula persica roots inhibits the red pigment production in Serratia marcescens
    Mehrdad Iranshahi
    Department of Pharmacognosy Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    Z Naturforsch C 59:506-8. 2004
    ..Neither the chloroform extract nor the isolated umbelliprenin fraction showed any antibacterial activity against the test strain at a certain concentration. In contrast, they exhibited depigmentation zones on culture plates...