Research Topics
| M IranshahiSummaryAffiliation: Mashhad University of Medical Sciences Country: Iran Publications
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Detail Information
Publications
Cytotoxic evaluation of alkaloids and isoflavonoids from the Australian tree Erythrina vespertilioMehrdad Iranshahi
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Vakilabad blvd, Mashhad, Iran
Planta Med 78:730-6. 2012..Among the tested compounds, phaseollidin showed cytotoxic activities against PC3 (IC (50) = 8.83 ± 1.87 µM) and NFF (0.64 ± 0.37 µM) cell lines...- Cancer chemopreventive activity of terpenoid coumarins from Ferula speciesMehrdad Iranshahi
Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Planta Med 74:147-50. 2008..Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids... - Diversolides A-G, guaianolides from the roots of Ferula diversivittataMehrdad Iranshahi
Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Vakilabad Boulevard, Mashhad, Iran
Phytochemistry 69:2753-7. 2008..Some of the tested compounds showed moderate antifungal and antibacterial activities with minimum inhibitory concentration (MIC) values from 40 to 80microg/ml... - Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivoMehrdad Iranshahi
Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Eur J Cancer Prev 18:412-5. 2009..In addition, the pattern of tumor promotion was slower in mice treated with umbelliprenin compared with the curcumin. Therefore, umbelliprenin might be valuable as a cancer chemopreventive agent... - Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivoM Iranshahi
Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, MUMS, P O Box 91775 1365, Mashhad, Iran
Phytomedicine 17:269-73. 2010.... - Persicasulphide C, a new sulphur-containing derivative from Ferula persicaMehrdad Iranshahi
Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Nat Prod Res 23:1584-8. 2009..In this article, the correct structures of persicasulphides A and B are also presented... - New sesquiterpene coumarins from the roots of Ferula flabellilobaMehrdad Iranshahi
Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Pharm Biol 48:217-20. 2010..f. & Aell. (Apiaceae). The structures of these compounds were elucidated by various 1- and 2-D NMR techniques as well as HREIMS... - Sesquiterpene coumarins from Ferula gumosaMehrdad Iranshahi
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
J Nat Prod 73:1958-62. 2010..The structures of 1-3 were elucidated by spectroscopic data interpretation. The cytotoxic activity of the sesquiterpene coumarin derivatives was evaluated against a small panel of cancer cell lines... - Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a reviewMilad Iranshahy
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
J Ethnopharmacol 134:1-10. 2011..Recent studies have shown new promising antiviral sesquiterpene coumarins from this old phytomedicine. The present review summarizes the information concerning the traditional uses, phytochemistry and biological activities of asafoetida... 
Polar secondary metabolites of Ferula persica rootsMehrdad Iranshahi
Department of Pharmacognosy and Biotechnology, Biotechnology Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Phytochemistry 69:473-8. 2008..The structures of these compounds were elucidated by extensive spectroscopic methods including 1D-((1)H and (13)C) and 2D NMR experiments (DQF-COSY, HSQC, HMBC, and ROESY) as well as ESIMS and TOFMS analyses...- Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell lineF Behnam Rassouli
Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
Phytomedicine 16:181-7. 2009..Results revealed that combination of 40 microg ml(-1) vincristine with 16 microg ml(-1) mogoltacin increased the cytotoxicity of vincristine after 48 h by 32.8%... - Two matrix metalloproteinases inhibitors from Ferula persica var. persicaA R Shahverdi
Department of Pharmaceutical Biotechnology and Medicinal Plant Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Phytomedicine 13:712-7. 2006..persica var. latisecta. Since inhibition of MMP activity has been employed in modality therapy in diseases such as cancer, this compound might be promising in the preparation of anti-MMP therapeutic derivatives... - Sulfur containing derivatives from Ferula persica var. latisectaMehrdad Iranshahi
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Phytochemistry 63:965-6. 2003..var. latisecta D. F. Chamberlain. Their structures were elucidated by spectral methods... - Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotesMehrdad Iranshahi
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad, Iran
Phytochemistry 68:554-61. 2007..Umbelliprenin and auraptene showed significant activity with IC(50) values of 4.9microg/ml (13.3microM) and 5.1microg/ml (17.1microM) after 48h incubation, respectively... - Galbanic acid from Ferula szowitsiana enhanced the antibacterial activity of penicillin G and cephalexin against Staphylococcus aureusAhmad Reza Shahverdi
Department of Pharmaceutical Biotechnology and Medicinal Plant Research Center, Faculty of Pharmacy, Medical Sciences University of Tehran, Tehran 1417614411, Iran
Biol Pharm Bull 30:1805-7. 2007..aureus... - Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stressFatemeh Soltani
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Cell Biol Toxicol 25:291-6. 2009..However, no significant difference (p > 0.05) in the protective activity was found between UMB and AA at concentrations of approximately higher than 50 microM... - Cytotoxicity of vincristine on the 5637 cell line is enhanced by combination with conferoneVajiheh Neshati
Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
Z Naturforsch C 64:317-22. 2009..The results of the MTT assay confirmed the morphological observations. After 48 h of combined treatment with 40 microg/ml vincristine and 16 microg/ml conferone, the cytotoxicity of vincristine was increased by 23.6%... - The enhancement of vincristine cytotoxicity by combination with feselolSamaneh Mollazadeh
Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
J Asian Nat Prod Res 12:569-75. 2010..Results showed that the combination of 40 microg/ml VCR with 16 microg/ml feselol increased the cytotoxicity of VCR by 28.32% after 48 h. This effect might be due to inhibition of P-glycoprotein in TCC cells by feselol... - Kopetdaghins A-E, sesquiterpene derivatives from the aerial parts and the roots of Dorema kopetdaghenseMehrdad Iranshahi
Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
J Nat Prod 70:1240-3. 2007..The structures of these compounds were elucidated by various 1D and 2D NMR techniques as well as high-resolution positive-ion ESIMS... - Auraptene from Ferula szowitsiana protects human peripheral lymphocytes against oxidative stressFatemeh Soltani
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Phytother Res 24:85-9. 2010..This study suggests that the antigenotoxic property of auraptene is of great pharmacological importance and might be beneficial for cancer prevention... - Evaluation of cytotoxicity and anticonvulsant activity of some Iranian medicinal Ferula speciesSeyyed Majid Bagheri
Department of Pharmacognosy, Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences MUMS, Mashhad, Iran
Pharm Biol 48:242-6. 2010..badrakema fruits and lowest in F. badrakema roots. Our findings also revealed that the methanol extracts and F. assafoetida oleo-gum resin do not possess anticonvulsant activity... - Bleaching of Serratia marcescens by some coumarins: a spectrophotometric studyAhmad Reza Shahverdi
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
J Basic Microbiol 45:470-4. 2005..Comparing the structures of the different coumarins showed that the linear sesquiterpene part of the umbelliprenin structure may be essential for the bleaching effect of S. marcescens ... - Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin testHamid Reza Monsef
Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
J Pharm Pharm Sci 7:65-9. 2004..To evaluate the effect of Peganum harmala (Syrian rue) a wild-growing flowering plant belonging to the family Zygophylaceae and found abundantly in Iran on formalin-induced pain response in mice... - Antigenotoxic effects of the disulfide compound persicasulfide A (PSA) on rat lymphocytes exposed to oxidative stressSaeid Noroozi
Biotechnology Research Center, Department of Pharmacognosy and Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Planta Med 75:32-6. 2009..47+/-67.46 microM). Compared to the EC50 for ascorbic acid (1399.23+/-205.21 microM), it was deduced that PSA was more effective than ascorbic acid in the prevention of oxidative damage to DNA... - Antigenotoxic effects of Satureja hortensis L. on rat lymphocytes exposed to oxidative stressFatemeh Mosaffa
Biotechnology Laboratory, Biotechnology Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Arch Pharm Res 29:159-64. 2006..01) on H2O2 induced chromosomal damage. In conclusion both the ethanolic extract and the essential oil of the plant reversed the oxidative damage to rat lymphocytes induced by hydrogen peroxide... - Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosisChantal Barthomeuf
University Clermont1, Laboratoire de Pharmacognosie Biotechnologies, INSERM, U484, Groupe de Recherche Clinique, UFR Pharmacie, Clermont Fd F 63001, France
Phytomedicine 15:103-11. 2008..In vivo investigations are needed to test these hypotheses... - Umbelliprenin from Ferula persica roots inhibits the red pigment production in Serratia marcescensMehrdad Iranshahi
Department of Pharmacognosy Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Z Naturforsch [C] 59:506-8. 2004..Neither the chloroform extract nor the isolated umbelliprenin fraction showed any antibacterial activity against the test strain at a certain concentration. In contrast, they exhibited depigmentation zones on culture plates...