Hossein Hosseinzadeh

Summary

Affiliation: Mashhad University of Medical Sciences
Country: Iran

Publications

  1. ncbi Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    J Pharm Pharm Sci 8:387-93. 2005
  2. ncbi Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, I R Iran
    Phytomedicine 9:135-41. 2002
  3. pmc Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia L. Leaves in mice
    H Hosseinzadeh
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad, Iran
    Iran Red Crescent Med J 13:27-33. 2011
  4. ncbi Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments
    Soghra Mehri
    Pharmaceutical Research Center, Dept of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran Biomed J 18:101-6. 2014
  5. ncbi Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats
    Hossein Hosseinzadeh
    Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    J Acupunct Meridian Stud 6:18-23. 2013
  6. ncbi Anticonvulsant effect of Berberis integerrima L. root extracts in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    J Acupunct Meridian Stud 6:12-7. 2013
  7. ncbi Effect of linalool on morphine tolerance and dependence in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 26:1399-404. 2012
  8. doi Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice
    H Hosseinzadeh
    Department of Pharmacodynamics and Toxicology, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Arzneimittelforschung 62:324-9. 2012
  9. doi Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, 1365 91775, Mashhad, I R Iran
    Naunyn Schmiedebergs Arch Pharmacol 385:503-8. 2012
  10. doi Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. Aerial parts in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    J Acupunct Meridian Stud 4:242-7. 2011

Collaborators

Detail Information

Publications77

  1. ncbi Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    J Pharm Pharm Sci 8:387-93. 2005
    ..The aim of the present study was to assess the effect of aqueous saffron extract (Crocus sativus L.) and its active constituent, crocin, on oxidative stress following renal ischemia-reperfusion injury (IRI) in rats...
  2. ncbi Antinociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, I R Iran
    Phytomedicine 9:135-41. 2002
    ..The extracts also showed anti-inflammatory effects against acute and chronic inflammation...
  3. pmc Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia L. Leaves in mice
    H Hosseinzadeh
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad, Iran
    Iran Red Crescent Med J 13:27-33. 2011
    ..Juglans regia leaves have been used in folk medicine to alleviate inflammatory diseases. This study investigates the antinociceptive, anti-Inflammatory and acute toxicity effects of Juglans regia L. leaves in mice...
  4. ncbi Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments
    Soghra Mehri
    Pharmaceutical Research Center, Dept of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran Biomed J 18:101-6. 2014
    ..Chrysin is a natural, biologically active flavonoid compound, which is commonly found in many plants. The antioxidant and neuroprotective properties of chrysin have been demonstrated...
  5. ncbi Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats
    Hossein Hosseinzadeh
    Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    J Acupunct Meridian Stud 6:18-23. 2013
    ..5 g/kg, p < 0.01) and ethanolic extracts (1 g/kg, p < 0.05). It is concluded that aqueous and ethanolic extracts of N. sativa can stimulate milk production in rats...
  6. ncbi Anticonvulsant effect of Berberis integerrima L. root extracts in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Pharmacodynamics and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    J Acupunct Meridian Stud 6:12-7. 2013
    ..The present study, conducted in mice, indicated that B integerrima has anticonvulsant activity in PTZ-induced seizures. It is concluded that B integerrima may be useful in petit mal epilepsy...
  7. ncbi Effect of linalool on morphine tolerance and dependence in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 26:1399-404. 2012
    ..This study indicated that linalool has a significant effect on morphine tolerance and dependence. This effect may be mediated partially through the inhibition of NMDA receptors...
  8. doi Anti-nociceptive and anti-inflammatory effects of cyanocobalamin (vitamin B12) against acute and chronic pain and inflammation in mice
    H Hosseinzadeh
    Department of Pharmacodynamics and Toxicology, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Arzneimittelforschung 62:324-9. 2012
    ..Cyanocobalamin may have anti-inflammatory effect. It may reduce tolerance to anti-nociceptive effect of morphine as well...
  9. doi Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, 1365 91775, Mashhad, I R Iran
    Naunyn Schmiedebergs Arch Pharmacol 385:503-8. 2012
    ..The malondialdehyde (MDA) level was declined significantly in test groups. It is concluded that thymoquinone have some protective effects against the muscle tissue injury caused by lower limb ischemia-reperfusion...
  10. doi Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. Aerial parts in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    J Acupunct Meridian Stud 4:242-7. 2011
    ..015, and 0.03 g/kg) demonstrated anti-inflammatory effects against chronic inflammation. The aqueous and ethanolic extracts of the aerial parts of M communis L. showed antinociceptive effects and these may be mediated by opioid receptors...
  11. pmc Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, 1365 91775, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Evid Based Complement Alternat Med 6:343-50. 2009
    ..The MDA level was declined significantly in test groups. It is concluded that saffron extract and its constituents show a protective effect against lower limb I/R in rat...
  12. doi Effect of safranal on extracellular hippocampal levels of glutamate and aspartate during kainic Acid treatment in anesthetized rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Planta Med 74:1441-5. 2008
    ..P.; p < 0.001). The results of this study show that acute systemic injection of safranal reduces the extracellular concentrations of glutamate and aspartate in the rat hippocampus following KA administration...
  13. doi Protective effect of Crocus sativus stigma extract and crocin (trans-crocin 4) on methyl methanesulfonate-induced DNA damage in mice organs
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    DNA Cell Biol 27:657-64. 2008
    ..69-fold for liver and 6.55-fold for spleen, 400 mg/Kg), in a dose-dependent manner. These data indicate that there is a genoprotective property in CSE and crocin, as revealed by the comet assay, in vivo...
  14. ncbi Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, PO Box 1365 91775, Mashhad, IR Iran
    Phytomedicine 14:621-7. 2007
    ..001). Using a reversed-phase HPLC system, the amount of TQ in NSO was also quantified and was 0.58% w/w. These results suggest that TQ and NSO may have protective effects on lipid peroxidation process during IRI in rat hippocampus...
  15. ncbi Effect of safranal, a constituent of Crocus sativus (saffron), on methyl methanesulfonate (MMS)-induced DNA damage in mouse organs: an alkaline single-cell gel electrophoresis (comet) assay
    Hossein Hosseinzadeh
    Faculty of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, I R Iran
    DNA Cell Biol 26:841-6. 2007
    ....
  16. pmc Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle
    Hossein Hosseinzadeh
    Department of Pharmacology and Toxicology, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    BMC Complement Altern Med 7:23. 2007
    ..In this study, the effects of S. leriifolia aqueous and ethanolic extracts were evaluated on an animal model of I/R injury in the rat hind limb...
  17. ncbi Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashhad, Iran
    Fitoterapia 76:722-4. 2005
    ..Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice from death. Crocin (200 mg/kg, i.p.) did not show anticonvulsant activity...
  18. ncbi The effect of saffron, Crocus sativus stigma, extract and its constituents, safranal and crocin on sexual behaviors in normal male rats
    H Hosseinzadeh
    Pharmacology and Toxicology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, P O Box 1365 91775, Mashhad, IR Iran
    Phytomedicine 15:491-5. 2008
    ..increased MF, IF and EF behaviors and reduced EL, IL and ML parameters. Safranal did not show aphrodisiac effects. The present study reveals an aphrodisiac activity of saffron aqueous extract and its constituent crocin...
  19. ncbi The effects of carbenoxolone on spatial learning in the Morris water maze task in rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Med Sci Monit 11:BR88-94. 2005
    ..In this study we investigated the effects of carbenoxolone, as a gap-junction blocker, on spatial learning in the rat. Cognitive performance was assessed using the Morris water maze (MWM)...
  20. doi Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 24:726-30. 2010
    ..But crocin and the dose of 400 mg/kg ethanolic extract showed no effect on activity in this test. It is concluded that the extracts and crocin may have interaction with the opioid system to reduce withdrawal syndrome...
  21. ncbi Antiurolithiatic activity of Pinus eldarica medw: fruits aqueous extract in rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Urol J 7:232-7. 2010
    ..To evaluate the antiurolithiatic activity of Pinus eldarica fruit on induced calcium oxalate nephrolithiasis in rats...
  22. ncbi Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems
    H Hosseinzadeh
    Faculty of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Phytomedicine 14:256-62. 2007
    ..c.v. and 2mg/kg body wt., i.p.). Results of this study demonstrated that safranal could exert anticonvulsant activity in the PTZ model and this effect may be mediated, at least partly, through GABA(A)-benzodiazepine receptor complex...
  23. doi Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 23:768-74. 2009
    ..05 and 0.15 mL/kg) decreased some locomotion activity parameters. Safranal demonstrated no effects on motor coordination. The results showed that saffron aqueous extract and safranal have anxiolytic and hypnotic effects...
  24. ncbi Anticonvulsant effect of Hypericum perforatum: role of nitric oxide
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, P O Box 1365 91775, Mashhad, I R Iran
    J Ethnopharmacol 98:207-8. 2005
    ..The results of this study indicate that the extracts of Hypericum perforatum aerial parts could contribute to the control of petit mal seizure and this effect may be partially mediated by nitric oxide pathway...
  25. ncbi Antinociceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth seed extract in mice and rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences MUMS, PO Box 91775 1365, Mashhad, IR Iran
    Phytother Res 17:422-5. 2003
    ..The aqueous seed extract of S. leriifolia may therefore have supraspinal antinociceptive effects which may be mediated by opioid receptors, and showed considerable effects against acute and chronic inflammation...
  26. ncbi Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats
    Hossein Hosseinzadeh
    Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Med Sci Monit 11:BR106-10. 2005
    ..In this study, we evaluated the effect and mechanism(s) of the action of thymoquinone more precisely via intracerebroventricular (i.c.v.) injection...
  27. doi Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure
    Bibi Marjan Razavi
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Chem Biol Interact 203:547-55. 2013
    ..This study was designed to evaluate the effectiveness of crocin, main component of Crocus sativus L. (Saffron) against subchronic diazinon (DZN) induced cardiotoxicity in rats...
  28. doi The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats
    Alireza Timcheh Hariri
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Islamic Republic of Iran
    Phytomedicine 18:499-504. 2011
    ..This study showed that vitamin E, safranal and crocin (without effects on cholinesterase) reduced diazinon hematological toxicity, but they did not prevent the genotoxicity induced by diazinon...
  29. doi Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats
    Mohsen Imenshahidi
    School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Phytother Res 24:990-4. 2010
    ..It seems that safranal is more important than crocin for lowering down blood pressure of rats...
  30. doi Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 26:381-6. 2012
    ..This study suggests that saffron extract and crocin improve spatial cognitive abilities following chronic cerebral hypoperfusion and that these effects may be related to the antioxidant effects of these compounds...
  31. ncbi Evaluation of the gastric antiulcerogenic effects of Portulaca oleracea L. extracts in mice
    Gholamreza Karimi
    Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashad, Iran
    Phytother Res 18:484-7. 2004
    ..These results suggest that Portulaca oleracea has gastroprotective action and validates its use in folk medicine for gastrointestinal diseases...
  32. ncbi Crocetin attenuates spatial learning dysfunction and hippocampal injury in a model of vascular dementia
    Faezeh Tashakori-Sabzevar
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Curr Neurovasc Res 10:325-34. 2013
    ..In conclusion, treatment with crocetin could effectively prevent neuropathological alterations in hippocampus thereby resulting in improvement of spatial learning memory in rats after chronic cerebral hypoperfusion. ..
  33. ncbi Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs
    Hossein Hosseinzadeh
    Pharmacology and Toxicology Department, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR, Iran
    Fitoterapia 77:446-8. 2006
    ..The ethanolic extract of C. sativus (100-800 mg/kg) and safranal (0.25-0.75 ml/kg) reduced the number of cough. The ethanolic and aqueous extracts of petal and crocin did not show antitussive activity...
  34. ncbi Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, P O Box 91775 1365, and Center of Pharmaceutical Sciences Research, Mashhad, I R Iran
    Phytother Res 17:938-41. 2003
    ..Phytochemical study indicated that only the aqueous extract of R. officinalis has an alkaloid component. It is concluded that the aqueous and ethanol extracts of R. officinalis aerial parts could diminish morphine withdrawal syndrome...
  35. pmc Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, I R Iran
    BMC Pharmacol 3:3. 2003
    ..Thus, we considered the possible anticonvulsant effects of carbenoxolone in animal seizure models...
  36. pmc Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775 1365, Mashhad, Iran
    BMC Pharmacol 2:7. 2002
    ..Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-inflammatory activity of saffron extracts in mice...
  37. ncbi Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice
    Hossein Hosseinzadeh
    Department of Pharmacodynamy and Toxicology, Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775 1365, Mashhad IR, Iran
    J Ethnopharmacol 84:275-8. 2003
    ..fractions did not show activity. Preliminary phytochemical tests showed that the extract contains flavonoid. The results suggested that E. angustifolia fruit seeds exerted muscle relaxant activity via flavonoid component(s)...
  38. doi Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study
    Ali Shamsa
    Urology Department, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytomedicine 16:690-3. 2009
    ..15+/-1.44; after treatment 39.20+/-1.90, p<0.001). Saffron showed a positive effect on sexual function with increased number and duration of erectile events seen in patients with ED even only after taking it for ten days...
  39. doi Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal
    Alireza Timcheh Hariri
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    Food Chem Toxicol 48:2803-8. 2010
    ..This study showed that vitamin E, safranal and crocin could prevent diazinon induced enzymes elevation and augmentation of some specific biomarkers...
  40. ncbi Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    J Pharm Pharm Sci 8:394-9. 2005
    ..31 vs. 159.70 nmol/g, p<0.001; 727.5 mg/kg). It is concluded that safranal have some protective effects on different markers of oxidative damage in hippocampal tissue from ischemic rats...
  41. doi Avicenna's (Ibn Sina) the Canon of Medicine and saffron (Crocus sativus): a review
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Pharmacodynamics and Toxicological Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR, Iran
    Phytother Res 27:475-83. 2013
    ..This review indicates that the evaluation of plants based on ethnobotanical information and ancient books may be a valuable approach to finding new biological activities and compounds...
  42. ncbi The pharmacological effects of Salvia species on the central nervous system
    Mohsen Imanshahidi
    Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Phytother Res 20:427-37. 2006
    ....
  43. ncbi Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography
    Hamid R Sadeghnia
    Department of Pharmacology, Mashhad University of Medical Sciences, Mashhad, Iran
    J Pharm Pharm Sci 11:1-14. 2008
    ..We examined the effect of safranal, a constituent of Crocus sativus, in acute experimental animal models of generalized absence seizures...
  44. ncbi A study of acute and chronic anti-nociceptive and anti-inflammatory effects of thiamine in mice
    Seyed Adel Moallem
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran Biomed J 12:173-8. 2008
    ..However, there has been little experimental investigation on this effect. In this study, anti-nociceptive and anti-inflammatory effects of thiamine were investigated in mice...
  45. ncbi Antinociceptive effects of Zataria multiflora Boiss fractions in mice
    Mohammad Ramezani
    Pharmaceutical Research Center, Bu Ali Research Institute and School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775 1365, Mashhad, Iran
    J Ethnopharmacol 91:167-70. 2004
    ..Further fractionation of the hydroalcoholic fraction on silica gel gave six fractions. Three fractions at 100 mg/kg showed activity comparable to those of morphine...
  46. ncbi Evaluating the effects and safety of intravenous lipid emulsion on haloperidol-induced neurotoxicity in rabbit
    Mohammad Moshiri
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Biomed Res Int 2014:949262. 2014
    ..ILE reversed sings of HA neurotoxicity; however, synergistic effect of high dose of ILE and HA increased complications and mortality. ..
  47. doi Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity
    Marzieh Rashedinia
    Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Toxicol Appl Pharmacol 272:199-207. 2013
    ..These findings suggested that acrolein induces the oxidative stress and lipid peroxidation in the brain, and so that may contribute to the pathophysiology of neurological disorders. ..
  48. doi Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine
    Mohsen Imanshahidi
    Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran
    Phytother Res 22:999-1012. 2008
    ..This article reviews the traditional uses and pharmacological effects of total extract and the most active ingredient of B. vulgaris (berberine)...
  49. ncbi The protective effect of Allium sativum L. clove aqueous and methanolic extracts against hypoxia-induced lethality in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775 1365, Mashhad, I R Iran
    Phytother Res 17:279-81. 2003
    ..8 g/kg) extracts increased survival time up to 73.17 +/- 4.9 and 68.41 +/- 3.7, respectively. These results indicated that the extracts of A. sativum cloves have a protective effect against hypoxia-induced lethality in mice...
  50. ncbi Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice
    H Hosseinzadeh
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, P O Box 91775 1365, Mashhad, I R Iran
    Phytother Res 16:745-7. 2002
    ..The results indicate that S. securidaca seed extracts significantly reduce blood glucose in alloxan-induced diabetic mice by a mechanism different from that of sulfonylurea agents...
  51. ncbi Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice
    H Hosseinzadeh
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Phytomedicine 11:56-64. 2004
    ..These results indicate that thymoquinone may have anticonvulsant activity in the petit mal epilepsy probably through an opioid receptor-mediated increase in GABAergic tone...
  52. ncbi Isolation, characterization and study of enhancing effects on nasal absorption of insulin in rat of the total saponin from Acanthophyllum squarrosum
    S A Sajadi Tabassi
    Pharmaceutical Research Center, Mashhad University of Medical Sciences, P O Box 1365 91775, Mashhad, Iran
    Curr Drug Deliv 3:399-404. 2006
    ..e. Quillaja total saponin (QTS) and sodium cholate (SC)...
  53. ncbi Alteration of protein profile in rat liver of animals exposed to subacute diazinon: a proteomic approach
    Parisa Lari
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Electrophoresis 35:1419-27. 2014
    ..Our results suggested that diazinon may induce hepatotoxicity through oxidative stress, apoptosis, and metabolic disorders in rat liver. ..
  54. doi Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats
    Seyed Adel Moallem
    1Medical Toxicology Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Islamic Republic of Iran
    Toxicol Ind Health 30:141-6. 2014
    ..This study showed that the aqueous extract of saffron prevents DZN-induced rise of several specific inflammation, oxidative stress and neuronal damage biomarkers...
  55. doi Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells
    Soghra Mehri
    Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Cell Mol Neurobiol 32:227-35. 2012
    ..Also, crocin inhibited ROS generation in cells exposed to ACR. In conclusion, our results indicated that pretreatment with crocin protected cells from ACR-induced apoptosis partly by inhibition of intracellular ROS production...
  56. pmc Affinity-based target deconvolution of safranal
    Hossein Hosseinzadeh
    Pharmaceutical Research Center, Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Daru 21:25. 2013
    ..These interactions may explain part of safranal's pharmacological effects. However, phenotypic and/or biological relevance of these interactions remains to be elucidated by future pharmacological studies...
  57. pmc Cardioprotective effect of saffron extract and safranal in isoproterenol-induced myocardial infarction in wistar rats
    Roya Mehdizadeh
    Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Basic Med Sci 16:56-63. 2013
    ..Conclusion: Saffron and safranal may have cardioprotective effect in ISO-induced myocardial infarction through modulation of oxidative stress in such a way that they maintain the redox status of the cell...
  58. pmc Crocin restores hypotensive effect of subchronic administration of diazinon in rats
    Marjan Razavi
    School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Basic Med Sci 16:64-72. 2013
    ..Crocin alone did not have any effect on SBP and HR. Conclusion: This study showed that concurrent administration of crocin and DZN could restore the effects of subchronic DZN administration on SBP and HR in rats...
  59. doi Extraction of crocin from saffron (Crocus sativus) using molecularly imprinted polymer solid-phase extraction
    Seyed Ahmad Mohajeri
    Department of Pharmacodynamics and Toxicology, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    J Sep Sci 33:2302-9. 2010
    ..The results demonstrated the possibility of using a part of a big molecule in preparing a molecularly imprinted polymer with a good selectivity for the main structure...
  60. pmc Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice
    Hossein Hosseinzadeh
    Pharmaceutical Research Center and Department of Pharmacodynamy and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences MUMS, Mashhad, Iran
    BMC Pharmacol 2:21. 2002
    ..As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice...
  61. ncbi Effect of Crocus sativus L. (saffron) on coagulation and anticoagulation systems in healthy volunteers
    Hossein Ayatollahi
    Cancer Molecular Pathology Research Center, Department of Hematopathology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 28:539-43. 2014
    ..Statistical analysis showed no difference between groups for any of evaluated factors. This study rejected any effect of saffron with dose of 200 and 400 mg for 1 week on coagulant and anticoagulant system...
  62. doi Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma
    Marziyeh Rastgoo
    Biotechnology Research Center, Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Science, Mashhad, Iran
    Planta Med 79:447-51. 2013
    ..The results of this study indicated that liposomal encapsulation of crocin could increase its antitumorigenic activity. Thus, to obtain an optimal dose for use in humans, the formulation merits further investigation...
  63. doi Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers
    Mohammad Hadi Modaghegh
    Mashhad Vascular Surgery Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad MUMS, Islamic Republic of Iran
    Phytomedicine 15:1032-7. 2008
    ..This study showed that saffron tablets may change some hematological and biochemical parameters. However, these alterations were in normal ranges and they were not important clinically...
  64. ncbi Promising effects of intravenous lipid emulsion as an antidote in acute tramadol poisoning
    Maryam Vahabzadeh
    Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR, Iran
    Reg Anesth Pain Med 38:425-30. 2013
    ..The aim of this study was to investigate the possible antidotal effect of ILE on acute tramadol poisoning...
  65. pmc Development and Validation of HPLC Method for Determination of Crocetin, a constituent of Saffron, in Human Serum Samples
    Amir Hooshang Mohammadpour
    Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Basic Med Sci 16:47-55. 2013
    ..Conclusion: The validated direct precipitation method for HPLC satisfied all of the criteria that were necessary for a bioanalytical method and could reliably quantitate crocetin in human serum for future clinical pharmacokinetic study...
  66. pmc Safety Evaluation of Crocin (a constituent of saffron) Tablets in Healthy Volunteers
    Amir Houshang Mohamadpour
    Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Basic Med Sci 16:39-46. 2013
    ..Conclusion: This clinical safety evaluation showed a relatively safe and normal profile for crocin in healthy volunteers at the given doses within the trial period...
  67. pmc Synthesis of Novel 4-[1-(4-fluorobenzyl)-5-imidazolyl] Dihydropyridines and Studying their Effects on Rat Blood Pressure
    Seyed Ahmad Mohajeri
    Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Basic Med Sci 14:451-7. 2011
    ..Derivatives of 1, 4-dihydropyridine are one of the most potent calcium antagonists. In this study four novel 1, 4-dihydropyridine calcium channel blockers were synthesized and their hypotensive properties were investigated in male rats...
  68. ncbi Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice
    M Ramezani
    Department of Pharmacognosy and Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, P O Box 91775 1365, Mashhad, Iran
    J Ethnopharmacol 77:71-5. 2001
    ..The results of this study indicated that the plant extract contained component(s) that could be useful for the alleviation of morphine withdrawal syndrome...
  69. ncbi The effects of carbenoxolone, a semisynthetic derivative of glycyrrhizinic acid, on peripheral and central ischemia-reperfusion injuries in the skeletal muscle and hippocampus of rats
    H Hosseinzadeh
    Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Phytomedicine 12:632-7. 2005
    ..These results suggest that carbenoxolone can salvage the skeletal muscle and hippocampus from acute ischemia-reperfusion injury...
  70. ncbi Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats
    H Hosseinzadeh
    Faculty of Pharmacy, Mashhad University of Medical Sciences, P O Box 91775 1365, Mashhad, Iran
    J Ethnopharmacol 73:379-85. 2000
    ..multiflora Boiss have antinociceptive effect and this may be mediated by opioid receptors. The extracts showed also anti-inflammatory effect against acute and chronic inflammation...
  71. ncbi Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice
    M Ramezani
    Faculty of Pharmacy, Mashhad University of Medical Sciences, P O Box 91775 1365, I R, Mashhad, Iran
    Fitoterapia 72:255-62. 2001
    ....
  72. doi Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    Marjan Nassiri Asl
    Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
    Phytother Res 22:709-24. 2008
    ..This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components...