Mohammad Hossain Boskabady

Summary

Affiliation: Mashhad University of Medical Sciences
Country: Iran

Publications

  1. doi The impact of Zataria multiflora Boiss extract on in vitro and in vivo Th1/Th2 cytokine (IFN-γ/IL4) balance
    Mohammad Hossein Boskabady
    Neurogenic inflammation Research Centre, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Post code 9177948564, Mashhad, IR Iran Electronic address
    J Ethnopharmacol 150:1024-31. 2013
  2. doi Inhaled lead exposure affects tracheal responsiveness and lung inflammation in guinea pigs during sensitization
    Mohammad Hossein Boskabaddy
    Applied Physiology Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Biol Trace Elem Res 154:363-71. 2013
  3. pmc Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart
    Mohammad Hossein Boskabady
    Applied Physiology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
    Daru 21:38. 2013
  4. doi Effect of carvacrol on tracheal responsiveness, inflammatory mediators, total and differential WBC count in blood of sensitized guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, School of Medicine, and Applied Physiology Research Centre, Payam Noor University, 19395 4697 Tehran, I R Iran
    Exp Biol Med (Maywood) 238:200-8. 2013
  5. doi Pharmacologic bronchodilation response to salbutamol in COPD patients
    Morteza Boskabady
    Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Indian J Med Sci 64:363-72. 2010
  6. ncbi The effect of lead exposure on selected blood inflammatory biomarkers in guinea pigs
    Tahere Farkhondeh
    Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    Cardiovasc Hematol Disord Drug Targets 13:45-9. 2013
  7. doi Inhibitory effect of Zataria multiflora Boiss and carvacrol on histamine (H(1) ) receptors of guinea-pig tracheal chains
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Fundam Clin Pharmacol 26:609-20. 2012
  8. doi Anti-cholinergic effect of Zataria multiflora Boiss on guinea pig tracheal chains
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Nat Prod Res 26:1523-8. 2012
  9. doi Comparison of pulmonary function and respiratory symptoms in water pipe and cigarette smokers
    Mohammad Hossein Boskabady
    Department of Physiology and Applied Physiology Research Centre, School of Medicine, Mashhad, Iran
    Respirology 17:950-6. 2012
  10. doi The effect of vitamin E on pathological changes in kidney and liver of sulphur mustard-exposed guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    Toxicol Ind Health 28:216-21. 2012

Collaborators

  • Batool Shirmohammadi
  • Rana Keyhanmanesh
  • Zahra Jafari
  • Mohammad Naser Shafei
  • Tahere Farkhondeh
  • Mohammad Hossein Boskabaddy
  • Hamid Marefati
  • Nastran Hashemi
  • Boskabady Mohammad Hossein
  • Jalil Tavakkol Afshari
  • Goudarz Sadeghi-Hashjin
  • Mohammd Kazem Koohi
  • Mostafa Moin
  • Helimeh Nikbine
  • Ashraf Nazari
  • Vahedi Nasim
  • Amery Sediqa
  • Farhad Heydarian
  • Rasoul Khoshnavaz
  • Gholamreza Ghasemi
  • Ehsan Ghayoor Karimiani
  • Alireza Razavi
  • Sara Hosseini Farahabadi
  • Reza Farid Hosseini

Detail Information

Publications41

  1. doi The impact of Zataria multiflora Boiss extract on in vitro and in vivo Th1/Th2 cytokine (IFN-γ/IL4) balance
    Mohammad Hossein Boskabady
    Neurogenic inflammation Research Centre, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Post code 9177948564, Mashhad, IR Iran Electronic address
    J Ethnopharmacol 150:1024-31. 2013
    ..To evaluate the immune modulatory effects of Zataria multiflora on Th1/Th2 balance, which may be implicated in inflammatory disorders, in vitro and in vivo studies were carried out...
  2. doi Inhaled lead exposure affects tracheal responsiveness and lung inflammation in guinea pigs during sensitization
    Mohammad Hossein Boskabaddy
    Applied Physiology Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Biol Trace Elem Res 154:363-71. 2013
    ..It can also cause a decrease in lymphocyte count, IFNγ level, and IFNγ/IL-4 ratio especially in its high concentration. Therefore inhaled lead exposure may cause increased severity of asthma during development of the disease...
  3. pmc Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart
    Mohammad Hossein Boskabady
    Applied Physiology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
    Daru 21:38. 2013
    ..The possible mechanism(s) of inotropic and chronotropic effects of the extract from Rosa damascena (R. damascena) on heart was examined...
  4. doi Effect of carvacrol on tracheal responsiveness, inflammatory mediators, total and differential WBC count in blood of sensitized guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, School of Medicine, and Applied Physiology Research Centre, Payam Noor University, 19395 4697 Tehran, I R Iran
    Exp Biol Med (Maywood) 238:200-8. 2013
    ....
  5. doi Pharmacologic bronchodilation response to salbutamol in COPD patients
    Morteza Boskabady
    Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Indian J Med Sci 64:363-72. 2010
    ..However, there is no report regarding AHR to ί-agonist drugs in COPD patients. Therefore, in this study pharmacologic bronchodilation response to salbutamol in COPD patients was examined...
  6. ncbi The effect of lead exposure on selected blood inflammatory biomarkers in guinea pigs
    Tahere Farkhondeh
    Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    Cardiovasc Hematol Disord Drug Targets 13:45-9. 2013
    ..The findings of the present study indicated that exposure to inhaled lead acetate may lead to asthma-like disease...
  7. doi Inhibitory effect of Zataria multiflora Boiss and carvacrol on histamine (H(1) ) receptors of guinea-pig tracheal chains
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Fundam Clin Pharmacol 26:609-20. 2012
    ..These results indicated an inhibitory effect of Z. multiflora and its constituent carvacrol on histamine H(1) receptors...
  8. doi Anti-cholinergic effect of Zataria multiflora Boiss on guinea pig tracheal chains
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Nat Prod Res 26:1523-8. 2012
    ..05) and group 2 (p < 0.001). These results indicate an anti-cholinergic effect of Zataria multiflora Boiss on the tracheal chains of guinea pigs. A β-adrenoceptor stimulatory effect for the plant was also suggested...
  9. doi Comparison of pulmonary function and respiratory symptoms in water pipe and cigarette smokers
    Mohammad Hossein Boskabady
    Department of Physiology and Applied Physiology Research Centre, School of Medicine, Mashhad, Iran
    Respirology 17:950-6. 2012
    ..In the present study, pulmonary function tests (PFT) and respiratory symptoms (RS) were compared in WP smokers and deep inspiration (S-DI) or normal inspiration (S-NI) cigarette smokers...
  10. doi The effect of vitamin E on pathological changes in kidney and liver of sulphur mustard-exposed guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
    Toxicol Ind Health 28:216-21. 2012
    ..05 to p < 0.001). These results showed a preventive effect of vitamin E on pathological changes in the liver and more prominently in the kidneys of SME guinea pigs...
  11. ncbi Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran Mehrdad Iranshahi
    Indian J Exp Biol 49:679-83. 2011
    ..There were parallel right ward shift in concentration response curves obtained in presence of all concentrations of the extract in both the groups. These results indicated an inhibitory effect of Z. multiflora at histamine H1 receptors...
  12. doi Prevalence of exercise induced asthma in female school students
    Hamid Marefati
    Department of Physiology and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Allergy Asthma Immunol 10:273-9. 2011
    ..05 to p<0.001) and there was not any significant difference between two groups.The results showed that although higher number of symptomatic students showed EIA, some asymptomatic students also sowed EIA...
  13. pmc The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs
    Mohammad Hossein Boskabady
    Dept of Physiology and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
    Clinics (Sao Paulo) 66:879-87. 2011
    ..To examine the preventive effect of a hydro-ethanolic extract of Nigella sativa on the tracheal responsiveness and white blood cell count in the lung lavage fluid of sensitized guinea pigs...
  14. doi Pulmonary function tests and respiratory symptoms among smokers in the city of Mashhad (north east of Iran)
    M H Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Rev Port Pneumol 17:199-204. 2011
    ..05-p<0.001). In this study the prevalence of smoking in population of Mashhad city was shown. The prevalence of smoking was higher among male than females. Smoking leads to increased respiratory symptoms and reduction of PFTs values...
  15. pmc Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs
    Mohammad Hossein Boskabady
    Pharmaceutical Research Centre, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    J Zhejiang Univ Sci B 12:201-9. 2011
    ..001), except for the oedema in the sensitized group treated with low concentration of the extract, but an increased IFN-γ. These results confirm a preventive effect of N. sativa extract on lung inflammation of sensitized guinea pigs...
  16. ncbi The prevalence of smoking among the population in the city of Mashhad (north east of Iran) and pulmonary function tests among smokers
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Pneumonol Alergol Pol 79:21-5. 2011
    ..Smoking is known as a major cause of chronic obstructive pulmonary disease (COPD). In this study the prevalence of smoking in the population of Mashhad city was evaluated as well as pulmonary function tests (PFTs) of smokers...
  17. pmc Work-related respiratory symptoms and pulmonary function tests in northeast iranian (the city of Mashhad) carpenters
    Mohammad Hossain Boskabady
    Pharmaceutical Research Centre Department of Physiology, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Clinics (Sao Paulo) 65:1003-7. 2010
    ..To assess the respiratory symptoms and pulmonary function of carpenters from the city of Mashhad (northeast Iran)...
  18. doi The effect of carvacrol on muscarinic receptors of guinea-pig tracheal chains
    M H Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran
    Phytother Res 25:530-5. 2011
    ..These results indicated an inhibitory effect of carvacrol on muscarinic receptors. A β-adrenoceptor stimulatory effect was also suggested for carvacrol...
  19. doi The effect of safranal on histamine (H(1)) receptors of guinea pig tracheal chains
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran
    Fitoterapia 82:162-7. 2011
    ..05 to p < 0.001). The EC(50) obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 μg/mL) in group 2 were greater than in group 1 (p < 0.05 to p < 0.001)...
  20. doi The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed Guinea pigs
    Boskabady Mohammad Hossein
    Department of Physiology and Pharmacological Research Center of Medicinal Plants, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Exp Lung Res 34:183-94. 2008
    ..05). These results showed a preventive effect of Nigella sativa on TR of SM-exposed guinea pigs...
  21. ncbi Inhibitory effect of Crocus sativus (saffron) on histamine (H1) receptors of guinea pig tracheal chains
    M H Boskabady
    Departement of Physiology and Pharmacological Research Centre of Medicinal Plants, Medical School Mashhad University of Medical Sciences, Mashhad, Iran
    Pharmazie 65:300-5. 2010
    ..These results indicated an inhibitory effect of Crocus sativus at histamine H1 receptors...
  22. doi Antiasthmatic effect of Nigella sativa in airways of asthmatic patients
    M H Boskabady
    Department of Physiology, Medical School and Pharmacology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Phytomedicine 17:707-13. 2010
    ..However, the effects of boiled extract of this plant on most measured PFTs was less than those of theophylline at concentrations used...
  23. ncbi Work-related respiratory symptoms and pulmonary function tests in Iranian printers
    Mohammad H Boskabady
    Department of Physiology and Pharmacological Research Centre of Medical Plants, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
    Saudi Med J 30:1170-5. 2009
    ..To assess lung function tests and self-reported frequency of work related respiratory and allergic symptoms among subjects working as printers...
  24. doi The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
    Inhal Toxicol 23:157-65. 2011
    ..01) and SME + D (P < 0.05) groups. The results showed a preventive effect of vitamin E, dexamethasone and their combination on TR and lung inflammation in SME guinea pigs...
  25. doi Pulmonary function tests and work-related respiratory and allergic symptoms in Iranian bakers
    Mohammad Hosein Boskabady
    Department of Physiology and Pharmacological, Research Centre of Medical Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Iran J Allergy Asthma Immunol 8:107-10. 2009
    ..001). These results showed that bakers have a higher frequency of work related respiratory symptoms and to a lesser extend allergic symptoms particularly during the work period. PFT values were also significantly reduced among bakers...
  26. ncbi Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s)
    Mohammad Hossein Boskabady
    Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    Indian J Exp Biol 46:805-10. 2008
    ..The results showed relaxant effect of most fractions from N. sativa on tracheal chains of guinea pigs which was more potent for methanol and dichloromethane fractions...
  27. doi The effect of Crocus sativus extract on human lymphocytes' cytokines and T helper 2/T helper 1 balance
    Mohammad Hossein Boskabady
    Department of Physiology and Pharmaceutical Research Center, BuALI Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    J Med Food 14:1538-45. 2011
    ..05 to P<.01). These results indicated that the extract of saffron leads to increased ratio of IFN-γ to IL-4...
  28. doi The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs
    Rana Keyhanmanesh
    Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
    Planta Med 76:218-22. 2010
    ..sativa, on tracheal responsiveness and inflammatory cells of lung lavage of sensitized guinea pigs which was comparable or even greater than that of the inhaled steroid...
  29. ncbi Tracheal responsiveness to both isoprenaline and beta2-adrenoreceptor blockade by propranolol in cigarette smoke exposed and sensitized guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
    Respirology 11:572-8. 2006
    ..In this study, tracheal responsiveness to isoprenaline and beta-adrenergic receptor blockade was investigated in animals exposed to cigarette smoke (AECS) with or without sensitization by ovalbumin (OA)...
  30. ncbi Influence of epithelium on beta-adrenoceptor desensitization of guinea pig tracheal smooth muscle
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Post Code 91735, Iran
    Respir Physiol Neurobiol 156:69-78. 2007
    ..05). These results indicate decrease in both tracheal response to beta-agonist (tolerance) and CR-1 (due to incubation of tissues with isoprenaline), which were greater in denuded epithelium groups...
  31. ncbi Bronchodilatory effect of Carum copticum in airways of asthmatic patients
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Therapie 62:23-9. 2007
    ..In the present study, the bronchodilatory effect of boiled extract from Carum copticum in the airways of asthmatic patients was examined...
  32. ncbi Effect of ascorbic acid on airway responsiveness in ovalbumin sensitized guinea pigs
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Respirology 8:473-8. 2003
    ..The aim of this study was to evaluate the effects of both acute exposure and a 30-day administration of ascorbic acid (AA), which has an antioxidant effect, on airway responsiveness in sensitized guinea pigs...
  33. ncbi Respiratory symptoms and pulmonary function changes among carpet weavers in Iran
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Hospital, Mashad University of Medical Sciences MUMS, Mashad, Iran
    Int J Occup Environ Health 13:369-75. 2007
    ..01 - p<0.001). Pulmonary function test results of the carpet weavers showed significant impairment compared with controls (p<0.05 - p<0.001)...
  34. ncbi Relation of airway responsiveness to salbutamol and to methacholine in smokers
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Med Sci Monit 11:CR344-50. 2005
    ..After our previous studies had shown AHR to b-agonists in asthmatic patients, we examined airway responsiveness to salbutamol and its relationship to responsiveness to methachline in smokers...
  35. ncbi Airway responsiveness to beta-adrenergic agonist (salbutamol) in asthma
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    J Asthma 40:917-25. 2003
    ..The increased sensitivity of asthmatics to inhaled salbutamol suggests that they also may be more sensitive to their endogenous adrenaline, which may thus dilate and stabilize their airways...
  36. ncbi The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
    Fundam Clin Pharmacol 21:559-66. 2007
    ..The results of phase I study generally suggest a prophylactic effect of N. sativa on asthma disease and warrant further research regarding this effect...
  37. ncbi Effect of aqueous extract from Nigella sativa L. on guinea pig isolated heart
    Mohammad Naser Shafei
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, 91735, Iran
    Indian J Exp Biol 43:635-9. 2005
    ..sativa on calcium channel of guinea pig heart was found comparable and even greater than that of diltazem. The results may also indicate an opening effect for the plant on potassium channel of isolated heart...
  38. ncbi Occupational exposures and obstructive lung disease: a case-control study in hairdressers
    Nastran Hashemi
    Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran, 177948564
    Respir Care 55:895-900. 2010
    ..Hairdressers are exposed to various irritating chemicals during work...
  39. ncbi Prediction equations for pulmonary function values in healthy young Iranians aged 8-18 years
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Respirology 9:535-42. 2004
    ..In addition, there is evidence of PFT variation in different ethnic groups. Prediction equations for PFT from a healthy, non-smoking, urban young population in the city of Mashhad (north-east Iran) have been derived...
  40. ncbi Prevalence of asthma symptoms among the adult population in the city of Mashhad (north-east of Iran)
    Mohammad Hossein Boskabady
    Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
    Respirology 7:267-72. 2002
    ..Although there is evidence of worldwide variation in the prevalence of asthma, the prevalence of asthma in adult populations in Iran is not known...
  41. ncbi Association of the expression of IL-4 and IL-13 genes, IL-4 and IgE serum levels with allergic asthma
    Jalil Tavakkol Afshari
    Department of Immunogenetics, Immunology Research Centre, Bu Ali Research Institute, Mashhad, Iran
    Iran J Allergy Asthma Immunol 6:67-72. 2007
    ..The results showed that there was a correlation between the expression of IL-4 gene and the level of serum IL-4. Levels of serum IgE and IL-4 were considerably higher in asthmatics than non-asthmatic controls...