Mohammad Hossein Nasr-Esfahani

Summary

Affiliation: Isfahan University of Medical Sciences
Country: Iran

Publications

  1. ncbi request reprint Relationship between protamine deficiency with fertilization rate and incidence of sperm premature chromosomal condensation post-ICSI
    M H Nasr-Esfahani
    Royan Institute, Tehran, Iran
    Andrologia 36:95-100. 2004
  2. doi request reprint Improved bovine ICSI outcomes by sperm selected after combined heparin-glutathione treatment
    Mohammad Hadi Sekhavati
    Department of Animal Science, Ferdowsi University of Mashhad, Mashhad, Iran
    Cell Reprogram 14:295-304. 2012
  3. ncbi request reprint Sperm selection for ICSI using the hyaluronic acid binding assay
    Mohammad Hossein Nasr-Esfahani
    Department of Reproduction and Development, Reproductive Biomedicine Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Methods Mol Biol 927:263-8. 2013
  4. ncbi request reprint Varicocelectomy: semen parameters and protamine deficiency
    M H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Int J Androl 32:115-22. 2009
  5. doi request reprint Artificial oocyte activation in severe teratozoospermia undergoing intracytoplasmic sperm injection
    Mohammad H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Fertil Steril 90:2231-7. 2008
  6. ncbi request reprint Failed fertilization after ICSI and spermiogenic defects
    Mohammad H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Fertil Steril 89:892-8. 2008
  7. ncbi request reprint Effects of failed oocyte activation and sperm protamine deficiency on fertilization post-ICSI
    Mohammad Hossein Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Reprod Biomed Online 14:422-9. 2007
  8. ncbi request reprint Can sperm protamine deficiency induce sperm premature chromosomal condensation?
    M H Nasr-Esfahani
    Department of Embryology, Royan Institute, Tehran, Iran
    Andrologia 38:92-8. 2006
  9. doi request reprint Artificial oocyte activation and intracytoplasmic sperm injection
    Mohammad Hossein Nasr-Esfahani
    Isfahan Fertility and Infertility Center, Isfahan, Iran
    Fertil Steril 94:520-6. 2010
  10. pmc Evaluation of sperm selection procedure based on hyaluronic acid binding ability on ICSI outcome
    M H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, P O Box 19395 4644, Tehran, Iran
    J Assist Reprod Genet 25:197-203. 2008

Collaborators

  • Hossein Baharvand
  • Shahnaz Razavi
  • Molamma P Prabhakaran
  • Leila Hatami-Baroogh
  • Lorenzo Moroni
  • Salem S Al-Deyab
  • Armin Towhidi
  • Abolghasem Esmaeili
  • Mahdi Zhandi
  • Yousef Shafeghati
  • Mehrdad Hashemi
  • Hojjat Sadeghi-Aliabadi
  • H Mozdarani
  • K Steger
  • F Oreizi
  • Kamran Ghaedi
  • Khadijeh Karbalaie
  • Fereshteh Karamali
  • Abbas Kiani-Esfahani
  • Ahmad Salamian
  • Farzaneh Rabiee
  • Rokhsareh Meamar
  • Somayeh Tanhaei
  • Hossein Salehi
  • Maryam Peymani
  • Ali Niapour
  • Laleh Ghasemi-Mobarakeh
  • Marziyeh Tavalaee
  • Zahra Taghipour
  • Abbas Kiani
  • Mohammad Mardani
  • Parisa Mohamadynejad
  • Somayeh Tanhaie
  • Ali Ghoochani
  • Mohammad Reza Deemeh
  • Mohammad Morshed
  • Marzeyeh Tavalaee
  • Mohsen Sagha
  • Fatemeh Ahmadi Ghahrizjani
  • Amin Ziaei
  • Mohammad Jodeiri Farshbaf
  • Mohammad Hossein Beigi
  • Fatemeh Ejeian
  • Alireza Shoaraye Nejati
  • Afsoon Atrian Afiyani
  • Zahra Bateni
  • Tahere Seifi
  • Mehrnoosh Bahadorani
  • Hassan Abbasi
  • Leila Dehghani
  • Elahe Masaeli
  • Mahdi Hajian
  • Seeram Ramakrishna
  • Seyed Ali Mousavi
  • Mojtaba Tahmoorespur
  • Mohammad Reza Nasiri
  • Noushin Amirpour
  • Liana Lachinani
  • Mohammad Hadi Sekhavati
  • Nosrat Nourbakhsh
  • Farnoosh Jafarpour
  • Hamid Bahramian
  • Ebrahim Esfandiari
  • Maryam Soleimani
  • Somaieh Tanhaee
  • Zahra Babazadeh
  • M Kheirollahi-Kouhestani
  • Maryam Anjomshoa
  • Mahboubeh Farokhpour
  • Fariba Moulavi
  • Mohammad Nabiuni
  • Mohammad Reza Piri Ardakani
  • Mahboobeh Forouzanfar
  • Faezeh Ghazvini Zadegan
  • Borhan Shokrollahi
  • Mahsa Shirani
  • Mohammad Fazilati
  • Leila Azadi
  • Majid Motovali Bashi
  • Hamid Azadeh
  • Mazdak Razi
  • Sommayeh Tanhaei
  • Juergen Hescheler
  • Saeid Sadri
  • Amir Ashkan Mahjour
  • Clemens A van Blitterswijk
  • Janneke Hilderink
  • Solmaz Bahrami
  • Fatemeh Hadipour
  • Zahra Nasiri

Detail Information

Publications57

  1. ncbi request reprint Relationship between protamine deficiency with fertilization rate and incidence of sperm premature chromosomal condensation post-ICSI
    M H Nasr-Esfahani
    Royan Institute, Tehran, Iran
    Andrologia 36:95-100. 2004
    ..05). A significant correlation was observed between sperm protamine deficiency with fertilization rate. Hence sperm protamine deficiency affects fertilization rate and possibly prones sperm to PCC post-ICSI...
  2. doi request reprint Improved bovine ICSI outcomes by sperm selected after combined heparin-glutathione treatment
    Mohammad Hadi Sekhavati
    Department of Animal Science, Ferdowsi University of Mashhad, Mashhad, Iran
    Cell Reprogram 14:295-304. 2012
    ..05). The results of this study suggested that the degree of sperm decondensation derived from heparin-GSH pretreatment may affect ICSI efficiency in bovine...
  3. ncbi request reprint Sperm selection for ICSI using the hyaluronic acid binding assay
    Mohammad Hossein Nasr-Esfahani
    Department of Reproduction and Development, Reproductive Biomedicine Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Methods Mol Biol 927:263-8. 2013
    ..The methodology explained below describes the selection of sperm based on the ability of sperm to bind solid-state hyaluronic acid as its receptor, present on mature sperm with intact chromatin...
  4. ncbi request reprint Varicocelectomy: semen parameters and protamine deficiency
    M H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Int J Androl 32:115-22. 2009
    ..Thus, it can be suggested that patients with low initial sperm count may benefit more from assisted reproductive techniques or varicocelectomy followed by assisted reproduction...
  5. doi request reprint Artificial oocyte activation in severe teratozoospermia undergoing intracytoplasmic sperm injection
    Mohammad H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Fertil Steril 90:2231-7. 2008
    ..To evaluate efficiency of ionomycin on fertilization and cleavage rates, embryo development, and pregnancy rate after intracytoplasmic sperm injection (ICSI) in teratozoospermic patients...
  6. ncbi request reprint Failed fertilization after ICSI and spermiogenic defects
    Mohammad H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Fertil Steril 89:892-8. 2008
    ..To evaluate the relationship between late spermiogenic events, including histone-protamine replacement, acrosome integrity, and sperm morphology, with fertilization rate after intracytoplasmic sperm injection (ICSI)...
  7. ncbi request reprint Effects of failed oocyte activation and sperm protamine deficiency on fertilization post-ICSI
    Mohammad Hossein Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Reprod Biomed Online 14:422-9. 2007
    ..Furthermore, the results of this study did not show any correlation between pronuclei size asynchrony and protamine deficiency...
  8. ncbi request reprint Can sperm protamine deficiency induce sperm premature chromosomal condensation?
    M H Nasr-Esfahani
    Department of Embryology, Royan Institute, Tehran, Iran
    Andrologia 38:92-8. 2006
    ..46, P = 0.004). Therefore, it can be suggested that oocytes injected with protamine deficient sperm have a higher chance of forming PCC sperm and may result in failed fertilization post-ICSI...
  9. doi request reprint Artificial oocyte activation and intracytoplasmic sperm injection
    Mohammad Hossein Nasr-Esfahani
    Isfahan Fertility and Infertility Center, Isfahan, Iran
    Fertil Steril 94:520-6. 2010
    ..To review different methods for artificial oocyte activation and its impact on intracytoplasmic sperm injection (ICSI)...
  10. pmc Evaluation of sperm selection procedure based on hyaluronic acid binding ability on ICSI outcome
    M H Nasr-Esfahani
    Department of Embryology and Andrology, Royan Institute, P O Box 19395 4644, Tehran, Iran
    J Assist Reprod Genet 25:197-203. 2008
    ....
  11. doi request reprint Dual effects of peroxisome proliferator-activated receptor γ on embryonic stem cell self-renewal in presence and absence of leukemia inhibitory factor
    Maryam Peymani
    Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Eur J Cell Biol 92:160-8. 2013
    ..These results suggest that the pivotal role of PPARγ on mESC self-renewal depends on the presence and absence of LIF...
  12. doi request reprint Differentiation of human ES cell-derived neural progenitors to neuronal cells with regional specific identity by co-culturing of notochord and somite
    Hossein Salehi
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, Esfahan, Iran
    Stem Cell Res 8:120-33. 2012
    ..These results indicate a very simple and efficient protocol to mimic in vivo events of human neural development in vitro which is important in the context of developmental neuroscience and cellular replacement therapies...
  13. doi request reprint Neuronal induction and regional identity by co-culture of adherent human embryonic stem cells with chicken notochords and somites
    Hossein Salehi
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, Esfahan, Iran
    Int J Dev Biol 55:321-6. 2011
    ..This study provides a model through which in vivo neuronal induction events may be imitated...
  14. ncbi request reprint Effect of sperm DNA damage and sperm protamine deficiency on fertilization and embryo development post-ICSI
    Mohammad Hossein Nasr-Esfahani
    Department of Clinical and Experimental Embryology and Andrology, Royan Institute, Tehran, Iran
    Reprod Biomed Online 11:198-205. 2005
    ..Unlike protamine deficiency, sperm DNA fragmentation does not preclude fertilization. Nonetheless, embryos derived from spermatozoa with high DNA damage have a lower potential to reach blastocyst stage...
  15. doi request reprint Cotransplantation of human embryonic stem cell-derived neural progenitors and schwann cells in a rat spinal cord contusion injury model elicits a distinct neurogenesis and functional recovery
    Ali Niapour
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Cell Transplant 21:827-43. 2012
    ..These findings have demonstrated that the cotransplantation of SCs with hESC-NPs could offer a synergistic effect, promoting neuronal differentiation and functional recovery...
  16. doi request reprint Transplantation of undifferentiated and induced human exfoliated deciduous teeth-derived stem cells promote functional recovery of rat spinal cord contusion injury model
    Zahra Taghipour
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Stem Cells Dev 21:1794-802. 2012
    ..These findings have demonstrated that transplantation of SHED or its derivatives could be a suitable candidate for the treatment of SCI as well as other neuronal degenerative diseases...
  17. doi request reprint Differentiation of human embryonic stem cell-derived retinal progenitors into retinal cells by Sonic hedgehog and/or retinal pigmented epithelium and transplantation into the subretinal space of sodium iodate-injected rabbits
    Noushin Amirpour
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, Isfahan, Iran
    Stem Cells Dev 21:42-53. 2012
    ..Our results indicate that putative hESC-derived retinal cells express related genes and proteins. Further, our results show that retinal-like cells can be useful replacements for photoreceptors in retinal diseases...
  18. doi request reprint Neural induction in mouse embryonic stem cells by co-culturing with chicken somites
    Mohsen Sagha
    Department of Stem Cells, Cell Science Research Center, Royan Institute, Esfahan Campus, Iranian Academic Center for Education, Culture, and Research ACECR, Esfahan, Iran
    Stem Cells Dev 18:1351-60. 2009
    ..However, no effective influence of somitic co-culture on rostrocaudal or dorsoventral patterning is seen. Therefore, like amphibians, somites have a modest neural-inducing activity in amniotes...
  19. doi request reprint Influence of sperm chromatin anomalies on assisted reproductive technology outcome
    Marzeyeh Tavalaee
    Department of Embryology and Andrology, Royan Institute, Tehran, Iran
    Fertil Steril 91:1119-26. 2009
    ..To evaluate the influence of DNA fragmentation, DNA methylation, and protamine deficiency as indicators of chromatin status on assisted reproductive technology outcome, and also to assess the relation between these parameters...
  20. doi request reprint Sperm DNA damage and its relation with leukocyte DNA damage
    Zahra Babazadeh
    Department of Anatomy, Isfahan Medical University, Isfahan, Iran
    Reprod Toxicol 29:120-4. 2010
    ..The results showed that leukocyte DNA integrity could be used to identify individuals at high risk in order to reduce the extent of DNA damage in patients before ICSI in order to improve the subsequent outcome of this procedure...
  21. pmc Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering
    Elahe Masaeli
    Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
    PLoS ONE 8:e57157. 2013
    ....
  22. doi request reprint Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues
    Fatemeh Ahmadi Ghahrizjani
    Biology Department, Science and Research Branch, Islamic Azad University, Tehran, Iran
    Gene 557:123-9. 2015
    ..Additional research is necessary to determine the major function of FDNC5 in this process. ..
  23. doi request reprint The influence of dexamethasone administration on the protection against doxorubicin-induced cardiotoxicity in purified embryonic stem cell-derived cardiomyocytes
    Leila Dehghani
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Tissue Cell 45:101-6. 2013
    ....
  24. doi request reprint Identification of a novel missense mutation of PEX7 gene in an Iranian patient with rhizomelic chondrodysplasia punctata type 1
    Parisa Mohamadynejad
    Biology Department, Science and Research Branch, Islamic Azad University, Tehran, Iran
    Gene 518:461-6. 2013
    ....
  25. pmc Characterization and Functional Assessment of Mouse PPARγ1 Promoter
    Liana Lachinani
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Avicenna J Med Biotechnol 4:160-9. 2012
    ..During neural differentiation, PPARγ1 isoform expression reaches to maximal level at neural precursor cell formation...
  26. doi request reprint The influence of peroxisome proliferator-activated receptor γ(1) during differentiation of mouse embryonic stem cells to neural cells
    Ali Ghoochani
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Differentiation 83:60-7. 2012
    ..Here, we have demonstrated the stage dependent role of PPARγ modulation on neural differentiation of mESCs by retinoic acid treatment for the first time...
  27. doi request reprint Novel method to obtain highly enriched cultures of adult rat Schwann cells
    Ali Niapour
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, ACECR, P O Box 815896 8433, Isfahan, Iran
    Biotechnol Lett 32:781-6. 2010
    ..This method has the advantage of being technically easier, faster, and more efficient than other previously described methods. An SC culture that was about 99% homogenous was achieved...
  28. doi request reprint Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells
    Farzaneh Rabiee
    Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Gene 551:127-37. 2014
    ..These data suggest that Fndc5 may be involved in cardiomyocyte differentiation. Therefore, a new hope will be arisen for potential application of this myokine for regeneration of damaged cardiac tissues especially in cardiac failure. ..
  29. doi request reprint In vivo integration of poly(ε-caprolactone)/gelatin nanofibrous nerve guide seeded with teeth derived stem cells for peripheral nerve regeneration
    Mohammad Hossein Beigi
    Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Materials Engineering Department, Najafabad Branch, Islamic Azad University, Najafabad, Iran
    J Biomed Mater Res A 102:4554-67. 2014
    ....
  30. doi request reprint Cytosolic and mitochondrial ROS: which one is associated with poor chromatin remodeling?
    Abbas Kiani-Esfahani
    Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Syst Biol Reprod Med 59:352-9. 2013
    ..Rather, it is likely that apoptosis is induced by ROS production. Considering that these conclusions are derived from correlative analyses, additional studies including an interventive approach are required. ..
  31. doi request reprint Identification, cloning, and functional analysis of the TATA-less mouse FNDC5 promoter during neural differentiation
    Tahere Seifi
    Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran
    Cell Mol Neurobiol 34:715-25. 2014
    ..However, Noggin induction induced up regulation of FNDC5 expression at final stage of neural differentiation. In conclusion, stage dependent expression of FNDC5 is affected by neural induction method used for neural differentiation...
  32. ncbi request reprint C86Y: as a destructive homozygous mutation deteriorating Pex7p function causing rhizomelic chondrodysplasia punctata type I
    Ahmad Salamian
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Ann Clin Lab Sci 43:76-80. 2013
    ..Back-transfection of vector encoding mutant Pex7p did not restore the normal peroxisomal function in RCDP patient's fibroblast cells dissimilar to the native type of PEX7...
  33. ncbi request reprint The thickness of electrospun poly (epsilon-caprolactone) nanofibrous scaffolds influences cell proliferation
    Laleh Ghasemi-Mobarakeh
    Department of Stem Cells, Cell Science Research Center, Royan Institute, Esfahan Campus, ACECR, Esfahan Iran
    Int J Artif Organs 32:150-8. 2009
    ..Therefore, regardless of cell origin, thicker scaffolds provide a better substrate for cell proliferation, possibly due to the higher dimensional stability and tightness of thicker scaffolds...
  34. doi request reprint Induced in vitro differentiation of neural-like cells from human exfoliated deciduous teeth-derived stem cells
    Nosrat Nourbakhsh
    Pediatric Department, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
    Int J Dev Biol 55:189-95. 2011
    ..SHED cells might be considered as new candidates for the autologous transplantation of a wide variety of neurological diseases and neurotraumatic injuries...
  35. pmc Evaluation of the leptin receptor in human spermatozoa
    Leila Hatami-Baroogh
    Department of Reproduction and Development, Royan Institute for Animal Biotechnology, ACER, Isfahan, Iran
    Reprod Biol Endocrinol 8:17. 2010
    ..In this study, we have attempted to assess leptin receptor expression in the spermatozoa of fertile males and those diagnosed with male factor infertility; both at the mRNA or protein levels...
  36. pmc Evaluation of Fas positive sperm and complement mediated lysis in subfertile individuals
    Maryam Soleimani
    Department of Anatomy, Isfahan Medical University, Isfahan, Iran
    J Assist Reprod Genet 27:477-82. 2010
    ..Evaluation of Fas receptor on surface of sperm, as an apoptotic marker, using flow cytometry and confirming the results using an antibody-antigen complex through the classic complement pathway...
  37. doi request reprint Embryonic stem cell-derived cardiomyocytes as a model system to study cardioprotective effects of dexamethasone in doxorubicin cardiotoxicity
    Mahboubeh Farokhpour
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, Esfahan, Iran
    Toxicol In Vitro 23:1422-8. 2009
    ..This model provides us with a clinical suggestion which proposes that the beneficial effect of DEX is obtained when DEX was added before DOX administration...
  38. doi request reprint THY1 as a reliable marker for enrichment of undifferentiated spermatogonia in the goat
    Hassan Abbasi
    Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Theriogenology 80:923-32. 2013
    ..In conclusion, the results provide indications that THY1 surface marker can be reliably used for enrichment of undifferentiated spermatogonial in the goats. ..
  39. doi request reprint Stem cell therapy in amyotrophic lateral sclerosis
    Rokhsareh Meamar
    Department of Medical Science, Najafabad Branch, Islamic Azad University, Isfahan, Iran
    J Clin Neurosci 20:1659-63. 2013
    ..We present a brief review of different methods of stem cell therapy in ALS patients and discuss the results with different cell types and routes of administration...
  40. doi request reprint Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    Islamic Azad University, Najafabad Branch, Isfahan, Iran
    J Tissue Eng Regen Med 5:e17-35. 2011
    ..Different procedures of electrical stimulation which have been used in tissue engineering, with examples on their specific applications in tissue engineering, are also discussed...
  41. pmc Sperm MTT viability assay: a new method for evaluation of human sperm viability
    Mohammad Hossein Nasr-Esfahani
    Department of Clinical and Experimental Embryology and Andrology, Royan Institute, Tehran, Iran
    J Assist Reprod Genet 19:477-82. 2002
    ..The objective of this study was to evaluate the capability of MTT assay to discriminate between viable and nonviable sperms and compare it sefficiency with E&N (eosin and nigrosin) and HOST (hypo-osmotic swelling test)...
  42. ncbi request reprint Effect of human sperm chromatin anomalies on fertilization outcome post-ICSI
    S Razavi
    Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran
    Andrologia 35:238-43. 2003
    ..In conclusion, that sperm protamine deficiency has profound effect on fertilization failure in ICSI...
  43. doi request reprint Selection of sperm based on combined density gradient and Zeta method may improve ICSI outcome
    M Kheirollahi-Kouhestani
    Department of Biology, Isfahan University, Isfahan, Iran
    Hum Reprod 24:2409-16. 2009
    ..The aim of this study was to evaluate the efficiency of density gradient centrifugation (DGC) and Zeta methods to recover sperm with intact chromatin, and to evaluate whether the combined DGC/Zeta procedure improved ICSI outcome...
  44. ncbi request reprint Effect of protamine-2 deficiency on ICSI outcome
    M H Nasr-Esfahani
    Royan Institute, Tehran, Iran
    Reprod Biomed Online 9:652-8. 2004
    ..Therefore, it can be concluded that altered P1/P2 ratio effects fertilization rate and embryo quality which subsequently may affect implantation and pregnancy outcome...
  45. doi request reprint Acute course of deferoxamine promoted neuronal differentiation of neural progenitor cells through suppression of Wnt/β-catenin pathway: A novel efficient protocol for neuronal differentiation
    Amin Ziaei
    Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Neurosci Lett 590:138-44. 2015
    ..We concluded that suppression of Wnt/β-catenin pathway was induced through chelating of intracellular Iron due to DFO treatment. These findings help to understand therapeutic benefit of DFO as a neuroprotective agent. ..
  46. doi request reprint Evaluation of heat-shock protein A2 (HSPA2) in male rats before and after varicocele induction
    Afsoon Atrian Afiyani
    Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran Department of Biochemistry, Science and Research Branch, Islamic Azad University, Kurdistan, Iran
    Mol Reprod Dev 81:766-76. 2014
    ..Levels of ubiquitination were also remarkably lower in the left testis of the varicocele group. Therefore, varicocele impacts expression of HSPA2 and ubiquitination...
  47. pmc Unexpected detrimental effect of Insulin like growth factor-1 on bovine oocyte developmental competence under heat stress
    Mahdi Zhandi
    Department of Animal Science, University College of Agriculture and Natural Resources, University of Tehran, POBox 4111, Karaj, Iran
    J Assist Reprod Genet 26:605-11. 2009
    ..To investigate the effects of Insulin like growth factor-1 (IGF-1) on bovine oocyte developmental competence under heat stress...
  48. doi request reprint Generation of motor neurons by coculture of retinoic acid-pretreated embryonic stem cells with chicken notochords
    Maryam Anjomshoa
    Department of Stem Cells, Cell Science Research Center, Royan Institute, ACECR, Esfahan Campus, Esfahan, Iran
    Stem Cells Dev 18:259-67. 2009
    ....
  49. doi request reprint Toxicity of ecstasy (MDMA) towards embryonic stem cell-derived cardiac and neural cells
    Rokhsareh Meamar
    Department of Cell and Molecular Biology, Royan Institute for Animal Biotechnology, P O Box 815896 8433, Esfahan, Iran
    Toxicol In Vitro 24:1133-8. 2010
    ..In conclusion, MDMA causes a marked reduction in beating cardiomyocytes and neurons in ESC cultures, and this drug has a more potent toxicity on neural rather than cardiac cell differentiation...
  50. doi request reprint Addition of Tempol in semen cryopreservation medium improves the post-thaw sperm function
    Zahra Bateni
    Department of Reproductive Biotechnology at Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Syst Biol Reprod Med 60:245-50. 2014
    ..These effects of Tempol can be attributed to cell permeability characteristic and ability to reduce superoxide production both at intra- and extra-cellular levels. Tempol may hold the potential for clinical applications...
  51. pmc Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?
    Rokhsareh Meamar
    1 Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran 2 Isfahan Neurosciences research center, Isfahan University of Medical Sciences, Isfahan, Iran 3 Islamic Azad University, Najafabad Branch, Isfahan, Iran
    Cell J 14:185-92. 2012
    ..This study aims to investigate whether MDMA could influence self-renewal via the mGlu5 receptor in mESCs...
  52. ncbi request reprint Can Vero cell co-culture improve in-vitro maturation of bovine oocytes?
    Fariba Moulavi
    Royan Institute, Tehran, Iran
    Reprod Biomed Online 13:404-11. 2006
    ..5, 245.5 and 51.3, 265, 316.3 respectively). Results confirm that co-culture of bovine COC during in-vitro maturation, enhances their ability for cleavage and for producing blastocysts with higher quality...
  53. pmc Somatic cell-induced hyperacetylation, but not hypomethylation, positively and reversibly affects the efficiency of in vitro cloned blastocyst production in cattle
    Farnoosh Jafarpour
    Department of Reproduction and Development, Reproductive Biomedicine Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Cell Reprogram 13:483-93. 2011
    ..Moreover, H3K9 hyperacetylation (induced with TSA and NaB), but not DNA hypomethylation (induced with AzC), favors cloning efficiency...
  54. doi request reprint Hedgehog signalling is dispensable in the proliferation of stem cells from human exfoliated deciduous teeth
    Fatemeh Ejeian
    Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Cell Biol Int 38:480-7. 2014
    ..Our findings have suggested the possibility that SHEDs demonstrate a different potential from human bone marrow mesenchymal stem cells (h-BMSCs) and dorsal neural progenitor in response to growth factors such as SHH. ..
  55. doi request reprint Peroxisome proliferator activated receptor gamma (PPARγ) as a therapeutic target for improvement of cognitive performance in Fragile-X
    Mohammad Jodeiri Farshbaf
    Department of Biology, School of Sciences, University of Isfahan, Isfahan, Iran Department of Cellular Biotechnology at Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
    Med Hypotheses 82:291-4. 2014
    ..The present hypothesis consists of enhancing synaptic plasticity that may then rescue the learning and memory in FXS. This will open many new therapeutic avenues for a variety of human diseases. ..
  56. ncbi request reprint Relation between different human sperm nuclear maturity tests and in vitro fertilization
    M H Nasr-Esfahani
    Isfahan Fertility and Infertility Center, Isfahan, Iran
    J Assist Reprod Genet 18:219-25. 2001
    ..To consider the relationship between different sperm nuclear maturity tests and in vitro fertilization (IVF) rate, in order to select the most sensitive, specific, and independent factor(s) for prediction of in vitro fertilization...