Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological featuresE Ioachim
Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
Int J Clin Pract 62:1736-43. 2008
..In addition, the interrelationships, probably means their contribution to the regulation of cell growth, through different pathways in colorectal carcinogenesis...
Immunohistochemical study of angiogenesis and proliferative activity in epiretinal membranesE Tsanou
Department of Pathology-Cytology, Medical School, University of Ioannina, Ioannina, Greece
Int J Clin Pract 59:1157-61. 2005
..Our study confirms the presence of vascularisation in PDR membranes, as well as the presence of VEGF even in avascular PVR membranes, suggesting that immunoreactivity for VEGF may not be accompanied by angiogenesis...
- Glycoprotein CD44 expression in normal, hyperplasic and neoplastic endometrium. An immunohistochemical study including correlations with p53, steroid receptor status and proliferative indices (PCNA, MIB1)
N Zagorianakou
Department of Pathology, Medical School, University of Ioannina, Greece
Eur J Gynaecol Oncol 24:500-4. 2003
....
- Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas. correlation with extracellular matrix components
E Tsanou
Dept of Pathology, Medical School, University of Ioannina, Ioannina, Greece
J Exp Clin Cancer Res 23:641-50. 2004
..0067). The results of the present study show the implication of this protein in the remodeling of breast cancer tissue, through the interaction with other extracellular matrix components, probably influences the tumour progression...
- Expression patterns of cyclins D1, E in laryngeal epithelial lesions: correlation with other cell cycle regulators (p53, pRb, Ki-67 and PCNA) and clinicopathological features
E Ioachim
Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
J Exp Clin Cancer Res 23:277-83. 2004
..In addition, their expression may be involved in the development of laryngeal lesions, implicated in cell proliferation, with other cell cycle related proteins, probably by different molecular pathways...
- Expression of the cell-cycle regulatory proteins (cyclins D1 and E) in endometrial carcinomas: correlations with hormone receptor status, proliferating indices, tumor suppressor gene products (p53, pRb), and clinicopathological parameters
A Mitselou
Department of Forensic Pathology, Medical School, University of Ioannina, Greece
Eur J Gynaecol Oncol 25:719-24. 2004
..Immunoexpression of cyclin D1 does not appear to be associated with cell-cycle progression in the benign or malignant endometrium...
- Hypoxia-inducible factors HIF-1alpha and HIF-2alpha expression in bladder cancer and their associations with other angiogenesis-related proteins
E Ioachim
Department of Pathology and Cytology, University Hospital of Ioannina, Ioannina, Greece
Urol Int 77:255-63. 2006
..In addition, the expression of HIF-1alpha and HIF-2alpha, appear to play a role in bladder cancer, vascularization possibly and in cooperation with other angiogenic factors...
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix componentsE Ioachim
Department of Pathology, University Hospital of Ioannina, Ioannina, Greece
BMC Cancer 6:140. 2006
....
- Immunohistochemical expression of superoxide dismutase (MnSOD) anti-oxidant enzyme in invasive breast carcinoma
E Tsanou
Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
Histol Histopathol 19:807-13. 2004
..In addition, MnSOD content varies according to the degree of differentiation of breast carcinoma...
- Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21(Waf1/Cip1) and p27(Kip1) in urothelial carcinoma: correlation with other cell-cycle-related proteins (Rb, p53, Ki-67 and PCNA) and clinicopathological features
E Ioachim
Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
Urol Int 73:65-73. 2004
..The expression of these proteins was also analyzed along with other cell-cycle-related proteins such as: p53, pRb and the proliferation-associated indices Ki-67 and proliferating cell nuclear antigen (PCNA)...
- E-cadherin adhesion molecule and syndecan-1 expression in various thyroid pathologies
A Mitselou
Department of Forensic Pathology, Medical School, University of Ioannina, Ioannina, Greece
Exp Oncol 29:54-60. 2007
....
- Thymidine phoshorylase expression in breast cancer: the prognostic significance and its association with other angiogenesis related proteins and extracellular matrix components
E Ioachim
Pathology Department, University of Ioannina, Medical School, Ioannina, Greece
Histol Histopathol 23:187-96. 2008
..In addition, tumour cell TP expression could be considered as a prognostic indicator of breast cancer patients...
- Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer
E Ioachim
Department of Pathology, Medical School, University of Ioannina, Greece
Breast 12:111-9. 2003
....
- Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components
E Ioachim
Department of Pathology and Cytology, University of Ioannina, Ioannina, Greece
Histol Histopathol 27:209-16. 2012
..In addition, TSP-1 might not be a direct anti-angiogenic factor, although it seems to be implicated in the remodeling of breast cancer tissue through interaction with other extracellular matrix components...
- Immunohistochemical expression of retinoblastoma gene product (Rb), p53 protein, MDM2, c-erbB-2, HLA-DR and proliferation indices in human urinary bladder carcinoma
E Ioachim
Department of Pathology, Medical School, University of Ioannina, Greece
Histol Histopathol 15:721-7. 2000
..In addition, p53 and HLA-DR antigen expression could be indicators of aggressive behavior of bladder cancer...
- CD44 standard form expression as a predictor of progression in high risk superficial bladder tumors
N E Stavropoulos
Department of Urology and Cytology, G Hatzikosta General Hospital, Ioannina, Greece
Int Urol Nephrol 33:479-83. 2001
..The purpose of this study was to assess the significance of the standard CD44 adhesion molecule expression in predicting progression of high risk superficial bladder carcinoma in the short term...
- Immunohistochemical expression of heat shock protein 27, in normal hyperplastic and neoplastic endometrium: correlation with estrogen and progesterone receptor status, p53, pRb and proliferation associated indices (PCNA, MIB1)
N Zagorianakou
Department of Pathology, Medical School, University of Ioannina, Greece
Eur J Gynaecol Oncol 24:299-304. 2003
..This expression could be under hormonal control and does not seem to be correlated with other conventional or possible prognostic parameters...
- Immunohistochemical study of extracellular matrix components in epiretinal membranes of vitreoproliferative retinopathy and proliferative diabetic retinopathy
E Ioachim
Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
Eur J Ophthalmol 15:384-91. 2005
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- Presence and possible significance of immunohistochemically demonstrable metallothionein expression in pterygium versus pinguecula and normal conjunctiva
S Tsironi
Department of Ophthalmology, University of Ioannina, Medical School, Greece
Eye 15:89-96. 2001
..MT may serve a photoprotective role in this region. In pterygium in particular, the biochemical pathway of MT synthesis seems interestingly to cross the pathways of cell proliferation, inflammation and immune activation...
- Angiogenesis in pterygium: study of microvessel density, vascular endothelial growth factor, and thrombospondin-1
M Aspiotis
Department of Ophthalmology, University of Ioannina, Ioannina, Epirus, Greece
Eye (Lond) 21:1095-101. 2007
..This retrospective study aims to elucidate the role of angiogenesis in the pathogenesis of pterygium. We evaluated microvessel density (MVD), and expression of vascular endothelial growth factor (VEGF) and thrombospondin-1 (TSP-1)...
- Lung, pleural and colon actinomycosis in an immunocompromised patient: a rare form of presentation
K Charalabopoulos
Department of Physiology, Clinical Unit, Ioannina University Medical School, Ioannina, Greece
Chemotherapy 49:209-11. 2003
..Clinical manifestations and treatment are discussed. Actinomycetes are rarely opportunistic agents in immunocompromised patients; thus the disease deserves special attention in those patients...
- Early ischaemic preconditioning of spinal cord enhanced the binding profile of heat shock protein 70 with neurofilaments and promoted its nuclear translocation after thoraco-abdominal aortic occlusion in pigs
I E Kyrou
Department of Surgery Vascular Surgery Unit, Medical School, University of Ioannina, Ioannina University Campus, S Niarchos Avenue, 45110 Ioannina, Greece
Eur J Vasc Endovasc Surg 43:408-14. 2012
..These were performed to study the binding relationship of Hsp70/cytoskeleton elements and the cellular distribution of Hsp70, respectively...
- Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices
E Ioachim
Department of Pathology, Medical School, University of Ioannina, Ioannina, Greece
Int J Gynecol Cancer 13:344-51. 2003
..015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas...
- Seropositive rheumatoid arthritis associated with Crohn's disease
A N Georgiadis
Division of Rheumatology, Medical School, University of Ioannina, 45110 Ioannina, Greece
Clin Exp Rheumatol 21:363-5. 2003
..In the present study we report a patient with long-standing seropositive rheumatoid arthritis, who developed Crohn's disease. We discuss the possible pathophysiologic mechanisms and their associations between these two entities...
- Inhibition of benzo(a)pyrene-induced carcinogenesis by vitamin C alone and by vitamin C/vitamin E and selenium/glutathione
K Charalabopoulos
Department of Experimental Physiology, Faculty of Medicine, University of Ioannina, Ioannina, Greece
Biol Trace Elem Res 93:201-12. 2003
..This is considered a potent anticarcinogenic effect. The question of an additional supportive administration of such agents complementary to the conventional cancer chemotherapy in humans is raised. Of course, further studies are needed...
