Dirk Inze



  1. Van Dingenen J, Vermeersch M, De Milde L, Hulsmans S, De Winne N, Van Leene J, et al. The role of HEXOKINASE1 in Arabidopsis leaf growth. Plant Mol Biol. 2018;: pubmed publisher
    ..Finally, using tandem affinity purification of protein complexes from cell cultures, we identified KINγ, a protein containing four cystathionine β-synthase domains, as an interacting protein of HXK1. ..
  2. Baekelandt A, Pauwels L, Wang Z, Li N, De Milde L, Natran A, et al. Arabidopsis Leaf Flatness Is Regulated by PPD2 and NINJA through Repression of CYCLIN D3 Genes. Plant Physiol. 2018;178:217-232 pubmed publisher
  3. González N, Inzé D. Molecular systems governing leaf growth: from genes to networks. J Exp Bot. 2015;66:1045-54 pubmed publisher
    ..In this review, we describe these different approaches that should help to obtain a holistic image of the molecular regulation of organ growth which is of high interest in view of the increasing needs for plant-derived products. ..
  4. Wuyts N, Dhondt S, Inzé D. Measurement of plant growth in view of an integrative analysis of regulatory networks. Curr Opin Plant Biol. 2015;25:90-7 pubmed publisher
  5. Dell Acqua M, Gatti D, Pea G, Cattonaro F, Coppens F, Magris G, et al. Genetic properties of the MAGIC maize population: a new platform for high definition QTL mapping in Zea mays. Genome Biol. 2015;16:167 pubmed publisher
    ..MAGIC maize is available to researchers. ..
  6. Vanhaeren H, Inzé D, Gonzalez N. Plant Growth Beyond Limits. Trends Plant Sci. 2016;21:102-109 pubmed publisher
    ..We discuss the observation that simultaneous perturbations of multiple genes have more pronounced effects, and present novel perspectives to use knowledge of growth regulatory networks to enhance crop yield in a targeted manner. ..
  7. Baute J, Herman D, Coppens F, De Block J, Slabbinck B, Dell Acqua M, et al. Combined Large-Scale Phenotyping and Transcriptomics in Maize Reveals a Robust Growth Regulatory Network. Plant Physiol. 2016;170:1848-67 pubmed publisher
    ..Our results illustrate the power of combining in-depth phenotyping with transcriptomics in mapping populations to dissect the genetic control of complex traits and present a set of candidate genes for use in biomass improvement. ..
  8. Nelissen H, Gonzalez N, Inzé D. Leaf growth in dicots and monocots: so different yet so alike. Curr Opin Plant Biol. 2016;33:72-76 pubmed publisher
    ..We also show that there are similarities in the molecular wiring that coordinates these two processes during leaf development. ..
  9. Clauw P, Coppens F, De Beuf K, Dhondt S, Van Daele T, Maleux K, et al. Leaf responses to mild drought stress in natural variants of Arabidopsis. Plant Physiol. 2015;167:800-16 pubmed publisher
    ..In addition to these known severe drought-related responses, 87 genes were found to be specific for the response of young developing leaves to mild drought stress. ..

More Information


  1. Gonzalez N, Pauwels L, Baekelandt A, De Milde L, Van Leene J, Besbrugge N, et al. A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis. Plant Cell. 2015;27:2273-87 pubmed publisher
    ..The identified conserved complex might be specific for leaf growth in the second dimension, since it is not present in Poaceae (grasses), which also lack the developmental program it controls. ..
  2. Brasil J, Cabral L, Eloy N, Primo L, Barroso Neto I, Grangeiro L, et al. AIP1 is a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication, transcription and chromatin remodeling. BMC Plant Biol. 2015;15:270 pubmed publisher
    ..AIP1 is a novel Agenet/Tudor domain protein in plants that could act as a link between DNA replication, transcription and chromatin remodeling during flower development. ..
  3. Nam Y, Herman D, Blomme J, Chae E, Kojima M, Coppens F, et al. Natural Variation of Molecular and Morphological Gibberellin Responses. Plant Physiol. 2017;173:703-714 pubmed publisher
    ..These findings demonstrate a surprising level of flexibility in the wiring of regulatory networks underlying hormone metabolism and signaling. ..
  4. Vanhaeren H, Nam Y, De Milde L, Chae E, Storme V, Weigel D, et al. Forever Young: The Role of Ubiquitin Receptor DA1 and E3 Ligase BIG BROTHER in Controlling Leaf Growth and Development. Plant Physiol. 2017;173:1269-1282 pubmed publisher
    ..With these results, we demonstrate that DA1 and BB restrict leaf size and promote senescence through converging and different mechanisms. ..
  5. Blomme J, Van Aken O, Van Leene J, Jégu T, De Rycke R, De Bruyne M, et al. The Mitochondrial DNA-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination. Plant Cell. 2017;29:1137-1156 pubmed publisher
    ..Taken together, our work presents a protein family that influences mtDNA architecture and homologous recombination in plants and suggests a link between organelle functioning and plant development. ..
  6. Van den Broeck L, Dubois M, Vermeersch M, Storme V, Matsui M, Inze D. From network to phenotype: the dynamic wiring of an Arabidopsis transcriptional network induced by osmotic stress. Mol Syst Biol. 2017;13:961 pubmed publisher
    ..Finally, a phenotypic analysis of loss-of-function and gain-of-function lines of the transcription factors established multiple connections between the stress-responsive network and leaf growth. ..
  7. Vercruyssen L, Tognetti V, Gonzalez N, Van Dingenen J, De Milde L, Bielach A, et al. GROWTH REGULATING FACTOR5 stimulates Arabidopsis chloroplast division, photosynthesis, and leaf longevity. Plant Physiol. 2015;167:817-32 pubmed publisher
    ..Taken together with the increased leaf size, ectopic expression of GRF5 has great potential to improve plant productivity. ..