Research Topics
Genomes and Genes | Mi Na KweonSummaryAffiliation: International Vaccine Institute Publications
| Collaborators
|
Detail Information
Publications
New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studiesDoo Hee Shim
Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea
J Immunol 178:2476-82. 2007..In the guinea pig, administration of Shigella by i.r. route induces acute inflammation, making this animal model useful for assessing the protective efficacy of Shigella vaccine candidates...
Sublingual mucosa: A new vaccination route for systemic and mucosal immunityMi Na Kweon
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Republic of Korea
Cytokine 54:1-5. 2011..l. administration. This review highlights current knowledge about the safety and effectiveness of s.l. vaccination and describes how s.l. vaccination can induce both systemic and mucosal immunity...- Shigellosis: the current status of vaccine developmentMi Na Kweon
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Kwanak gu, Seoul, Korea
Curr Opin Infect Dis 21:313-8. 2008..Owing to the wide range of Shigella serotypes and subtypes, there is a need for a multivalent vaccine representing prevalent species and serotypes... - Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestineMi Na Kweon
Mucosal Immunology Section, International Vaccine Institute, Seoul National University Research Park, Kwanak gu, Korea
J Immunol 174:4365-72. 2005.... - Lack of retinoic acid leads to increased langerin-expressing dendritic cells in gut-associated lymphoid tissuesSun Young Chang
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
Gastroenterology 138:1468-78, 1478.e1-6. 2010..To investigate the effects of RA on DCs of gut-associated lymphoid tissue (GALT), we analyzed the phenotype and function of DC subsets from GALT of vitamin A-deficient (VAD) mice... - A single intranasal immunization with inactivated influenza virus and alpha-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous systemHyun Jun Youn
Laboratory of Immunology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
Vaccine 25:5189-98. 2007..These results suggest for the first time that a single nasal immunization of inactivated virus and alpha-GalCer is a safe and effective means of preventing influenza infection... - Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2aDoo Hee Shim
Mucosal Immunology Section, International Vaccine Institute, Seoul National University Research Park, Kwanak gu, Seoul 151 818, Republic of Korea
Vaccine 25:4828-36. 2007..It can also be surmised that a mucosal SRV vaccine would be particularly relevant in targeting shigellosis, which provokes inflammation in the human colon... - Sublingual immunization with nonreplicating antigens induces antibody-forming cells and cytotoxic T cells in the female genital tract mucosa and protects against genital papillomavirus infectionNicolas Cuburu
Laboratory Sciences Division, International Vaccine Institute, Seoul, Korea
J Immunol 183:7851-9. 2009..l. immunization as an efficient vaccination strategy for inducing genital immune responses and should impact on the development of vaccines against sexually transmitted diseases... - Eye mucosa: an efficient vaccine delivery route for inducing protective immunityKyoung Yul Seo
Institute for Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea
J Immunol 185:3610-9. 2010..On the basis of these findings, we propose that the eyedrop route is an alternative to mucosal routes for administering vaccines... - Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunitySun Young Chang
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Republic of Korea
J Immunol 180:1609-18. 2008..Taken together, our results suggest the possibility that cross-talk could occur between the large intestine and the systemic immune compartments via the colonic patches without the assistance of innate immunity... - Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acidHye Ran Cha
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
J Immunol 184:6799-806. 2010..The results strongly suggest that RA deficiency altered gut microbiome, which in turn inhibited Th17 differentiation in the small intestine lamina propria... - CD8alpha-11b+ dendritic cells but not CD8alpha+ dendritic cells mediate cross-tolerance toward intestinal antigensYeonseok Chung
Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shillimdong, Kwanak gu, Seoul 151 742, Korea
Blood 106:201-6. 2005..Thus, CD8alpha-CD11b+ DCs in the MLNs play a critical role for induction of cross-tolerance to dietary proteins... - Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen controlHye Ran Cha
Mucosal Immunology Section, International Vaccine Institute, Seoul 151 818, South Korea
J Immunol 187:3044-52. 2011..n. route migrate into the uterus in a MEC/CCL28-dependent manner and that estrogen might have a crucial role in the protection against genital infection by regulating MEC/CCL28 expression in the uterus... - Efficacy of poly[di(sodium carboxylatophenoxy)phosphazene] (PCPP) as mucosal adjuvant to induce protective immunity against respiratory pathogensDoo Hee Shim
Mucosal Immunology Section, International Vaccine Institute, Seoul 151 818, Republic of Korea
Vaccine 28:2311-7. 2010..Taken together, these results suggest that PCPP may be a promising candidate for mucosal adjuvant to elicit protective immunity against respiratory infectious diseases... - IFN-gamma secreted by CD103+ dendritic cells leads to IgG generation in the mesenteric lymph node in the absence of vitamin AJae Hoon Chang
Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea 151 818
J Immunol 186:6999-7005. 2011..Collectively, vitamin A deficiency provokes the generation of IFN-γ-secreting CD103(+) DCs, which may be a critical regulator for IgG generation in the MLN... - Mediastinal lymph node CD8alpha- DC initiate antigen presentation following intranasal coadministration of alpha-GalCerSung Youl Ko
Laboratory of Immunology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
Eur J Immunol 37:2127-37. 2007.... - MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigenSung Moo Park
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
J Immunol 181:6447-55. 2008.... - Langerin-expressing dendritic cells in gut-associated lymphoid tissuesSun Young Chang
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
Immunol Rev 234:233-46. 2010..In this review, we focus on the phenotypic and functional characteristics of langerin(+) DCs in the mucosal tissues, especially MLNs... - Dendritic cells in colonic patches and iliac lymph nodes are essential in mucosal IgA induction following intrarectal administration via CCR7 interactionAh Young Lee
Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea
Eur J Immunol 38:1127-37. 2008..These results indicate that IR vaccination primarily mobilizes CD11c+ cells in the CP and ILN to induce optimal mucosal immune responses by CCR7 interaction... 
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in miceSang Uk Seo
Mucosal Immunology Section, International Vaccine Institute, Seoul, South Korea
PLoS Pathog 7:e1001304. 2011..Collectively, these data suggest that IFN-I contributes to resistance of influenza infection by control of monocytes and neutrophils in the lung...- Expansion of Tfh-like cells during chronic Salmonella exposure mediates the generation of autoimmune hypergammaglobulinemia in MyD88-deficient miceHyun Jeong Ko
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
Eur J Immunol 42:618-28. 2012..Overall, these results suggest that Tfh-like cells in chronic bacterial infection trigger autoimmune hypergammaglobulinemia in a PD-1- and ICOS-dependent manner... - Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talkSun Young Chang
Mucosal Immunology Section, International Vaccine Institute, Seoul, Republic of Korea
J Immunol 180:4361-5. 2008.... - Innate immunity mediated by MyD88 signal is not essential for induction of lipopolysaccharide-specific B cell responses but is indispensable for protection against Salmonella enterica serovar Typhimurium infectionHyun Jeong Ko
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
J Immunol 182:2305-12. 2009..These results suggest that innate immunity mediated by MyD88 signal is dispensable for induction of LPS-specific Ab responses following oral administration of attenuated Salmonella strains but indispensable for efficient protection... - Sublingual vaccination with influenza virus protects mice against lethal viral infectionJoo Hye Song
Mucosal Immunology Section, Viral Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul 151 818, Korea
Proc Natl Acad Sci U S A 105:1644-9. 2008..l. administration. Based on these promising findings, we propose that the s.l. mucosal route offers an attractive alternative to mucosal routes for administering influenza vaccines... - Sublingual vaccinationCecil Czerkinsky
Laboratory Science Division, International Vaccine Institute, Seoul, Korea
Hum Vaccin 7:110-4. 2011..Here we review the results of pre-clinical studies using animal models of respiratory, intestinal and genital infections. These promising results provide a foundation for testing the approach in humans... - Interleukin-1 Promotes Coagulation, Which Is Necessary for Protective Immunity in the Lung Against Streptococcus pneumoniae InfectionHyungjun Yang
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul 151 818
J Infect Dis 207:50-60. 2013..Our findings suggest that IL-1 signaling leads to the synthesis of fibrinogen in the lung after pneumococcus infection and is followed by coagulation, which contributes to the control of bacterial infection in the pulmonary tract... - Functional maturation of lamina propria dendritic cells by activation of NKT cells mediates the abrogation of oral toleranceJae Hoon Chang
Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Gwanak Gu, Seoul, Korea
Eur J Immunol 38:2727-39. 2008..Our results demonstrate that triggered by NKT cells in SI-LP, functional maturation of Ag-capturing DC from SI-LP is necessary for the abrogation of oral tolerance induction... - Defensins play a crucial role in protecting mice against oral Shigella flexneri infectionDoo Hee Shim
Mucosal Immunology Section, International Vaccine Institute, Seoul 151 818, Republic of Korea Department of Food and Animal Biotechnology, School of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul 151 742, Republic of Korea
Biochem Biophys Res Commun 401:554-60. 2010..This suggests that cryptdin-related antimicrobial molecules are indispensable for efficient protection against oral Shigella infection... - Sublingual immunization with a live attenuated influenza a virus lacking the nonstructural protein 1 induces broad protective immunity in miceHae Jung Park
International Vaccine Institute, Seoul, Korea
PLoS ONE 7:e39921. 2012..Thus, SL immunization with DeltaNS1 offers a novel potential vaccination strategy for the control of influenza outbreaks including pandemics... - Effective protection against secondary pneumococcal pneumonia by oral vaccination with attenuated Salmonella delivering PspA antigen in miceSang Uk Seo
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul 151 818l, Republic of Korea
Vaccine 30:6816-23. 2012.... - MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infectionSang Uk Seo
Mucosal Immunology Section, International Vaccine Institute, Seoul National University Research Park, Kwanak gu, Seoul, South Korea 151 818
J Virol 84:12713-22. 2010..Taken together, these results show that MyD88 signaling plays an important role for resisting primary influenza virus infection but is dispensable for protection against a secondary lethal challenge... - 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitisJae Hoon Chang
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
PLoS ONE 5:e12925. 2010..Vitamin D(3) ameliorates the onset of the experimental autoimmune encephalomyelitis (EAE); however, the direct effect of vitamin D(3) on T cells is largely unknown... - Pathological effect of IL-17A-producing TCRγδ(+) T cells in mouse genital mucosa against HSV-2 infectionJae Ouk Kim
Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul National University Research Park, Kwanak gu, Seoul 151 919, Republic of Korea
Immunol Lett 147:34-40. 2012..These results imply that genital IL-17A-producing TCRγδ(+) T cells constitutively exist at steady state and that they play a pathogenic effect against HSV-2 infection and are not affected by microflora, unlike conventional Th17 cells... - CCR7-CCL19/CCL21-regulated dendritic cells are responsible for effectiveness of sublingual vaccinationJoo Hye Song
Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea
J Immunol 182:6851-60. 2009..l. challenge. We propose that the s.l. mucosa is one of the effective mucosal inductive sites regulated by the CCR7-CCL19/CCL21 pathway... - Staphylococcus aureus accelerates an experimental allergic conjunctivitis by Toll-like receptor 2-dependent mannerSo Hyang Chung
Department of Ophthalmology and Visual Science, Kangnam St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Clin Immunol 131:170-7. 2009..aureus had no effect on severity of allergic conjunctivitis. The findings suggest that activation of TLR2 signal by S. aureus induces Th2-type immune responses and accelerates experimental allergic conjunctivitis... - Toll-like receptor 4 initiates an innate immune response to lipopolysaccharide in human conjunctival epithelial cellsSo Hyang Chung
Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Exp Eye Res 88:49-56. 2009..Our results demonstrate that surface expression of TLR4 in HCECs can elicit a TLR4-mediated innate immune response through TRAF6-NF-kappaB and contribute to an inflammatory environment on the ocular surface... - alpha-Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumorSung-Youl Ko
Laboratory of Immunology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
J Immunol 175:3309-17. 2005..Overall, our results are the first to show that alpha-GalCer can act as a nasal vaccine adjuvant inducing protective immune responses against viral infections and tumors... - Pathological role of large intestinal IL-12p40 for the induction of Th2-type allergic diarrheaAyako Hino
Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Am J Pathol 164:1327-35. 2004..These results show that over-expression of IL-12p40 is an important contributing factor for the generation of the dominant Th2-type environment in the large intestine of mice with allergic diarrhea... - Isolated lymphoid follicles are not IgA inductive sites for recombinant SalmonellaTomomi Hashizume
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, 2 870 1, Sakaecho Nishi, Matsudo, Chiba 271 8587, Japan
Biochem Biophys Res Commun 360:388-93. 2007..On the basis of these findings, ILF can be presumed to play a role in the production of IgA Abs, but lymphoid nodules are not inductive sites for the regulation of Ag-specific intestinal IgA responses to recombinant Salmonella... - Protective mucosal immunity in aging is associated with functional CD4+ T cells in nasopharyngeal-associated lymphoreticular tissueYukari Hagiwara
Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama, 845 19th Street South, Birmingham, AL 35294, USA
J Immunol 170:1754-62. 2003.... - Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella sppTomomi Hashizume
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, 2 870 1 Sakaecho nishi, Matsudo, Chiba 271 8587, Japan
Infect Immun 76:927-34. 2008.... - Intestinal villous M cells: an antigen entry site in the mucosal epitheliumMyoung Ho Jang
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 101:6110-5. 2004..Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment... - Role of gut-associated lymphoreticular tissues in antigen-specific intestinal IgA immunityMasafumi Yamamoto
Department of Oral Medicine, Nihon University School of Dentistry, Matsudo, Chiba, Japan
J Immunol 173:762-9. 2004..Furthermore, the induction of intestinal IgA Ab responses requires the proper maintenance of the MLN microarchitecture, including a follicular dendritic cell network... - Biological role of Ep-CAM in the physical interaction between epithelial cells and lymphocytes in intestinal epitheliumTomonori Nochi
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
Clin Immunol 113:326-39. 2004..These data suggest that the Ep-CAM may act as a physical homophilic interaction molecule between IELs and IECs at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection... - Immediate and broad-spectrum protection against heterologous and heterotypic lethal challenge in mice by live influenza vaccineSang Uk Seo
Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun Ku, Seoul 120 749, South Korea
Vaccine 25:8067-76. 2007..The broad-spectrum and immediate protection provided by live attenuated influenza vaccine may offer a prompt measure for minimizing the initial spread of virus and mitigating the impact of unexpected influenza outbreaks... - Sublingual immunization induces broad-based systemic and mucosal immune responses in miceNicolas Cuburu
Institut National de la Sante et de la Recherche Medicale INSERM, Unité Mixte de Recherche UMR 721, Universite de Nice Sophia Antipolis, Nice, France
Vaccine 25:8598-610. 2007..These features underscore the potential of the s.l. mucosa to serve as an alternative vaccine delivery route... - A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunityShee Eun Lee
National Research Laboratory of Molecular Microbial Pathogenesis and Department of Microbiology, Chonnam National University Medical School, 5 Hak-dong, Dong-Ku, Gwangju 501-746, South Korea
Infect Immun 74:694-702. 2006..These results indicate that flagellin would serve as an efficacious mucosal adjuvant inducing protective immune responses through TLR5 activation... - Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4(+) CD45RB(high) T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activationNamju Kim
Department of Food and Nutrition, Seoul National University, Seoul, South Korea
Clin Immunol 123:30-9. 2007..These findings suggested that a BGN4 supplemented diet could be helpful for the control of aberrant immune responses in the intestinal tissue... - Nasal vaccination induces the ability to eliminate Candida colonization without influencing the pre-existing antigen-specific IgE Abs: a possibility for the control of Candida-related atopic dermatitisNoriko Suenobu
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
Vaccine 20:2972-80. 2002..albicans in patients with allergic diseases, including AD, although more research is needed to establish this therapeutic approach for mucosal vaccination... - Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrheaNaoko Takayama
Division of Mucosal Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, 108 8639, Japan
Clin Immunol 123:199-208. 2007..These studies demonstrate that PP, as the site where IL-10-producing Treg cells are created, mediate the mucosal regulatory network for the control of undesired allergic responses in the intestine... - Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrheaAyako Hino
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Japan
J Immunol 174:7423-32. 2005..These results suggest that the mucosal administration of naked IL-12p70 DNA plasmid should be considered as a possible preventive and therapeutic treatment for Th2 cell-mediated food allergic diseases in the intestinal tract...