N Kumarasamy

Summary

Affiliation: YRG Centre for AIDS Research and Education
Country: India

Publications

  1. pmc Impact of highly active antiretroviral therapy on ophthalmic manifestations in human immunodeficiency virus / acquired immune deficiency syndrome
    Kartik K Venkatesh
    Brown University Medical School, Providence, RI, USA
    Indian J Ophthalmol 56:391-3. 2008
  2. pmc Correlates of HIV and malaria co-infection in Southern India
    Ajay R Bharti
    University of California San Diego, San Diego, CA, USA
    Malar J 11:306. 2012
  3. pmc Ocular lesions in 1,000 consecutive HIV-positive patients in India: a long-term study
    Sridharan Sudharshan
    Medical Research Foundation, 18, College Road, Sankara Nethralaya, Chennai, 600006, India
    J Ophthalmic Inflamm Infect 3:2. 2013
  4. pmc Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings
    Alexandra Calmy
    HIV Unit, Geneva University Hospital, Geneva, Switzerland
    BMC Infect Dis 12:147. 2012
  5. doi request reprint Clinical outcomes among HIV/tuberculosis-coinfected patients developing immune reconstitution inflammatory syndrome after HAART initiation in South India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services VHS, Chennai, India
    J Int Assoc Provid AIDS Care 12:28-31. 2013
  6. pmc Antiretroviral therapy in Indian setting: when & what to start with, when & what to switch to?
    N Kumarasamy
    YRG CARE Medical Centre, Voluntary Health Services, Chennai, India
    Indian J Med Res 134:787-800. 2011
  7. pmc Failure to prescribe pneumocystis prophylaxis is associated with increased mortality, even in the cART era: results from the Treat Asia HIV observational database
    Poh Lian Lim
    Tan Tock Seng Hospital, Singapore
    J Int AIDS Soc 15:1. 2012
  8. pmc Cancers in the TREAT Asia HIV Observational Database (TAHOD): a retrospective analysis of risk factors
    Kathy Petoumenos
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia
    J Int AIDS Soc 13:51. 2010
  9. pmc Design of a randomized trial to evaluate the influence of mobile phone reminders on adherence to first line antiretroviral treatment in South India--the HIVIND study protocol
    Ayesha De Costa
    Division of Global Health, Nobels väg 9, Karolinska Institutet, 171 77 Stockholm, Sweden
    BMC Med Res Methodol 10:25. 2010
  10. pmc Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database
    Jialun Zhou
    National Centre in HIV Epidemiology and Clinical Research The University of New South Wales, Sydney, Australia
    BMC Infect Dis 9:46. 2009

Collaborators

Detail Information

Publications98

  1. pmc Impact of highly active antiretroviral therapy on ophthalmic manifestations in human immunodeficiency virus / acquired immune deficiency syndrome
    Kartik K Venkatesh
    Brown University Medical School, Providence, RI, USA
    Indian J Ophthalmol 56:391-3. 2008
    ..This review focuses on the impact of HAART on the ocular manifestations of HIV...
  2. pmc Correlates of HIV and malaria co-infection in Southern India
    Ajay R Bharti
    University of California San Diego, San Diego, CA, USA
    Malar J 11:306. 2012
    ..Plasmodium vivax contributes to almost half of the malaria cases in India, but the disease burden of HIV and P. vivax co-infection is unclear...
  3. pmc Ocular lesions in 1,000 consecutive HIV-positive patients in India: a long-term study
    Sridharan Sudharshan
    Medical Research Foundation, 18, College Road, Sankara Nethralaya, Chennai, 600006, India
    J Ophthalmic Inflamm Infect 3:2. 2013
    ..Ocular findings and systemic correlation in 1,000 consecutive patients with HIV seen at a tertiary eye care center were analyzed. This study uses a prospective observational case series design...
  4. pmc Mean CD4 cell count changes in patients failing a first-line antiretroviral therapy in resource-limited settings
    Alexandra Calmy
    HIV Unit, Geneva University Hospital, Geneva, Switzerland
    BMC Infect Dis 12:147. 2012
    ..We assessed the impact of on-going HIV-RNA replication on CD4 cell count slopes in patients treated with a first-line combination ART...
  5. doi request reprint Clinical outcomes among HIV/tuberculosis-coinfected patients developing immune reconstitution inflammatory syndrome after HAART initiation in South India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services VHS, Chennai, India
    J Int Assoc Provid AIDS Care 12:28-31. 2013
    ..We determine the frequency and immunological outcome of developing immune reconstitution inflammatory syndrome (IRIS) among HIV/tuberculosis (TB)-coinfected Indians receiving highly active antiretroviral therapy (HAART)...
  6. pmc Antiretroviral therapy in Indian setting: when & what to start with, when & what to switch to?
    N Kumarasamy
    YRG CARE Medical Centre, Voluntary Health Services, Chennai, India
    Indian J Med Res 134:787-800. 2011
    ..This review focuses on evolving science on Indian policy--antiretroviral therapy initiation, which drugs to start with, when to change the initial regimen and what to change...
  7. pmc Failure to prescribe pneumocystis prophylaxis is associated with increased mortality, even in the cART era: results from the Treat Asia HIV observational database
    Poh Lian Lim
    Tan Tock Seng Hospital, Singapore
    J Int AIDS Soc 15:1. 2012
    ..This study examines the proportion of patients in the TREAT Asia HIV Observational Database (TAHOD) receiving PCP prophylaxis, and its effect on PCP and mortality...
  8. pmc Cancers in the TREAT Asia HIV Observational Database (TAHOD): a retrospective analysis of risk factors
    Kathy Petoumenos
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, Australia
    J Int AIDS Soc 13:51. 2010
    ..This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer...
  9. pmc Design of a randomized trial to evaluate the influence of mobile phone reminders on adherence to first line antiretroviral treatment in South India--the HIVIND study protocol
    Ayesha De Costa
    Division of Global Health, Nobels väg 9, Karolinska Institutet, 171 77 Stockholm, Sweden
    BMC Med Res Methodol 10:25. 2010
    ..This paper presents the study protocol for a trial, to evaluate the influence of mobile phone reminders on adherence to first-line antiretroviral treatment in South India...
  10. pmc Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database
    Jialun Zhou
    National Centre in HIV Epidemiology and Clinical Research The University of New South Wales, Sydney, Australia
    BMC Infect Dis 9:46. 2009
    ....
  11. pmc Trends in CD4 counts in HIV-infected patients with HIV viral load monitoring while on combination antiretroviral treatment: results from The TREAT Asia HIV Observational Database
    Jialun Zhou
    National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, Australia
    BMC Infect Dis 10:361. 2010
    ....
  12. pmc Prevalence and incidence of sexually transmitted infections among South Indians at increased risk of HIV infection
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Service, Chennai, India
    AIDS Patient Care STDS 22:677-82. 2008
    ..With the high incidence of STIs, targeted prevention and clinical management strategies among individuals practicing high risk behaviors may help to slow the continued spread of HIV in India...
  13. ncbi request reprint Reasons for modification of generic highly active antiretroviral therapeutic regimens among patients in southern India
    Nagalingeswaran Kumarasamy
    YRG Centre for AIDS Research and Education, Chennai, India
    J Acquir Immune Defic Syndr 41:53-8. 2006
    ..To describe reasons for modification and discontinuation of antiretroviral regimens in association with adverse events (AEs), treatment failure, and cost among patients in southern India...
  14. doi request reprint Regression of Kaposi's sarcoma lesions following highly active antiretroviral therapy in an HIV-infected patient
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services, Chennai, India
    Int J STD AIDS 19:786-8. 2008
    ..In resource-limited settings where administering anti-KS chemotherapeutic agents may not be feasible, HAART alone can be an option in HIV-infected individuals with KS...
  15. doi request reprint Safety, tolerability and effectiveness of generic HAART in HIV-infected children in South India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, VHS, Chennai 600113, Tamil Nadu, India
    J Trop Pediatr 55:155-9. 2009
    ..4%) substituted therapy due to toxicities and 19.4% of patients switched to second-line protease inhibitor-containing regimens. In this South Indian pediatric cohort, generic HAART was safe, effective and relatively well tolerated...
  16. ncbi request reprint The changing natural history of HIV disease: before and after the introduction of generic antiretroviral therapy in southern India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services, Chennai, India
    Clin Infect Dis 41:1525-8. 2005
    ..The incidence of tuberculosis and opportunistic infections decreased to <2 cases per 100 person-years. Death rates decreased from 25 to 5 deaths per 100 person-years between 1997 and 2003...
  17. doi request reprint Safe substitution to zidovudine among HIV-infected patients initiated on stavudine-containing highly active antiretroviral therapy from a resource-limited setting
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    Int J Infect Dis 13:e360-4. 2009
    ..To describe the safe substitution with zidovudine (AZT) among South Indian HIV-infected patients who were initiated with stavudine (d4T)-containing highly active antiretroviral therapy (HAART) due to anemia...
  18. pmc Gender-based differences in treatment and outcome among HIV patients in South India
    N Kumarasamy
    YRGCARE, VHS, Chennai, India
    J Womens Health (Larchmt) 17:1471-5. 2008
    ..To describe gender-based differences in disease progression, treatment, and outcome among patients receiving highly active antiretroviral therapy (HAART) in South India...
  19. doi request reprint Spectrum of adverse events after generic HAART in southern Indian HIV-infected patients
    N Kumarasamy
    YRG Centre for AIDS Research and Education, VHS, Chennai, India
    AIDS Patient Care STDS 22:337-44. 2008
    ..05). Anemia and hepatitis often occur within 12 weeks of initiating generic HAART. Frequent and early monitoring for these toxicities is warranted in developing countries where generic HAART is increasingly available...
  20. doi request reprint Factors associated with mortality among HIV-infected patients in the era of highly active antiretroviral therapy in southern India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services, Taramani, Chennai 600113, India
    Int J Infect Dis 14:e127-31. 2010
    ..To describe the causes of mortality among the HIV-infected in southern India in the era of highly active antiretroviral therapy (HAART)...
  21. ncbi request reprint A randomised control trial of structured interrupted generic antiretroviral therapy versus continuous therapy in HIV-infected individuals in Southern India
    N Kumarasamy
    YRG Center for AIDS Research and Education, VHS, Chennai, India
    AIDS Care 19:507-13. 2007
    ..Adverse events were comparable in both groups, with 50% reduction in cost for SIT. Further research on such strategies may benefit resource-constrained settings...
  22. pmc Financial burden of health services for people with HIV/AIDS in India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Voluntary Health Services, Chennai, Tamil Nadu, India
    Indian J Med Res 126:509-17. 2007
    ..Future studies should more thoroughly examine the financial impact of HIV-related costs incurred by households over time and examine household responses to these costs...
  23. pmc Safety, Tolerability, and Efficacy of Second-Line Generic Protease Inhibitor Containing HAART after First-Line Failure among South Indian HIV-Infected Patients
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Chennai, India
    J Int Assoc Physicians AIDS Care (Chic) 10:71-5. 2011
    ....
  24. ncbi request reprint Generic antiretroviral drugs--will they be the answer to HIV in the developing world?
    N Kumarasamy
    YRG Centre for AIDS Research and Education, VHS, Chennai 600113, India
    Lancet 364:3-4. 2004
  25. pmc Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease?
    Esaki Muthu Shankar
    YRG Centre for AIDS Research and Education, VHS Hospital Campus, Rajiv Gandhi Salai Information Technology Corridor, Taramani, Chennai 600 113, India
    J Inflamm (Lond) 5:2. 2008
    ..Although certain technical limitations are described herein, we advocate measures to test the role of Tregs in IRIS...
  26. doi request reprint Couples at risk for HIV infection in Southern India: characteristics of HIV-infected patients in concordant and discordant heterosexual relationships
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Chennai, India
    Int J STD AIDS 21:96-100. 2010
    ..The spouses of HIV-infected index patients are at increased risk for HIV infection, and further preventive measures are needed...
  27. doi request reprint Risk factors for HIV transmission among heterosexual discordant couples in South India
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Chennai, India
    HIV Med 11:178-86. 2010
    ..To assess the risk factors associated with heterosexual HIV transmission among South Indian discordant couples enrolled in clinical care...
  28. ncbi request reprint Clinical profile of HIV in India
    N Kumarasamy
    Y R G Center for AIDS Research and Education CARE, Voluntary Health Services, Tharamani, Chennai 600 113, India
    Indian J Med Res 121:377-94. 2005
    ..With the availability of antiretroviral therapy at lower cost, the clinical profile of HIV disease in India is now changing to include drug-related toxicities and immune reconstitution syndrome...
  29. doi request reprint High frequency of clinically significant mutations after first-line generic highly active antiretroviral therapy failure: implications for second-line options in resource-limited settings
    N Kumarasamy
    YRG Centre for AIDS Research and Education, VHS, Chennai, India
    Clin Infect Dis 49:306-9. 2009
    ..This study demonstrates a high frequency of drug resistance mutations in human immunodeficiency virus-infected Indians who experience immunologic treatment failure and suggests the need for viral load monitoring...
  30. ncbi request reprint Oral lesions and conditions associated with human immunodeficiency virus infection in 300 south Indian patients
    K Ranganathan
    Department of Oral Pathology, Ragas Dental College and Hospital, 116, Dr Radhakrishnan Salai, Mylapore, 600 004, Chennai, India
    Oral Dis 6:152-7. 2000
    ..In spite of this high prevalence there are very few reports of oral lesions and conditions in Indian HIV/AIDS patients, which are important in early diagnosis and management of these patients...
  31. doi request reprint A rapid and low-cost microscopic observation drug susceptibility assay for detecting TB and MDR-TB among individuals infected by HIV in South India
    S Solomon
    Infectious Diseases Laboratory, YRG Centre for AIDS Research and Education YRG CARE, Chennai, India
    Indian J Med Microbiol 31:130-7. 2013
    ..Rapid diagnosis of TB is essential in view of its infectious nature, high burden of cases, and emergence of drug resistance...
  32. ncbi request reprint Total lymphocyte count (TLC) is a useful tool for the timing of opportunistic infection prophylaxis in India and other resource-constrained countries
    N Kumarasamy
    Y R G Centre for AIDS Research and Education, Chennai, India
    J Acquir Immune Defic Syndr 31:378-83. 2002
    ..To determine a range of TLC cutoffs for the initiation of OI prophylaxis that is appropriate for resource-constrained settings...
  33. ncbi request reprint Weight and body shape changes in a treatment-naive population after 6 months of nevirapine-based generic highly active antiretroviral therapy in South India
    Suneeta Saghayam
    YR Gaitonde Centre for AIDS Research and Education, Chennai, 600 113, India
    Clin Infect Dis 44:295-300. 2007
    ..In this environment, nutritional compromise is a common complication of human immunodeficiency virus (HIV) infection...
  34. ncbi request reprint Gender-related differences in quality of life domains of persons living with HIV/AIDS in South India in the era prior to greater access to antiretroviral therapy
    S Solomon
    Y R Gaitonade Centre for AIDS Research and Education, Chennai, India
    AIDS Patient Care STDS 22:999-1005. 2008
    ..05). In light of the increasing feminization of the HIV epidemic in India, greater emphasis should be placed on examining the long-term experiences of Indian women living with HIV/AIDS, particularly their psychosocial well-being...
  35. ncbi request reprint Incidence of immune reconstitution syndrome in HIV/tuberculosis-coinfected patients after initiation of generic antiretroviral therapy in India
    N Kumarasamy
    YRG Center for Research and Education, VHS, Tharamani, Chennai, India
    J Acquir Immune Defic Syndr 37:1574-6. 2004
    ....
  36. doi request reprint Cofactors for low serum albumin levels among HIV-infected individuals in Southern India
    M Sundaram
    YRG Centre for AIDS Research and Education YRG CARE, Voluntary Health Services Campus, Chennai, India
    J Int Assoc Physicians AIDS Care (Chic) 8:161-4. 2009
    ..The present study aimed to identify the proportion of HIV-infected individuals with low serum albumin and the possible cofactors among highly active antiretroviral therapy (HAART) experienced and HAART naïve individuals...
  37. ncbi request reprint Use of an HIV-1 reverse-transcriptase enzyme-activity assay to measure HIV-1 viral load as a potential alternative to nucleic acid-based assay for monitoring antiretroviral therapy in resource-limited settings
    H Syed Iqbal
    YRG Centre for AIDS Research and Education YRG CARE, Voluntary Health Services Hospital Campus, Taramani, Chennai 600113, India
    J Med Microbiol 56:1611-4. 2007
    ..Hence, the ExaVir Load assay could be considered for use in resource-limited settings as an alternative viral-load assay to the standard NAAT-based assay after further evaluation with prospective specimens...
  38. ncbi request reprint High proportion of isosporiasis among HIV-infected patients with diarrhea in southern India
    R Vignesh
    YRG Center for AIDS Research and Education, Voluntary Health Services Campus, IT Corridor, Taramani, Chennai 600113, India
    Am J Trop Med Hyg 77:823-4. 2007
    ..2.9%), Giardia intestinalis (1.6%), and Strongyloides stercoralis (1.2%). Interesting trends of significant increase in the number of cases of I. belli and decline in Cryptosporidium spp. were observed during the study period...
  39. ncbi request reprint Sexual behaviors of individuals with HIV living in South India: a qualitative study
    A K Sri Krishnan
    YRG CARE, Chennai, India
    AIDS Educ Prev 19:334-45. 2007
    ....
  40. pmc Evaluation of two human immunodeficiency virus-1 genotyping systems: ViroSeq 2.0 and an in-house method
    S Saravanan
    YRG Centre for AIDS Research and Education, Chennai 600 113, India
    J Virol Methods 159:211-6. 2009
    ..Overall, the in-house assay provided comparable results to those of US FDA approved ViroSeq, which costs about a half of the commercial assay ($ 100 vs. $ 230), making it suitable for resource-limited settings...
  41. ncbi request reprint Greater severity and extent of periodontal breakdown in 136 south Indian human immunodeficiency virus seropositive patients than in normal controls: a comparative study using community periodontal index of treatment needs
    K Ranganathan
    Department of Oral Pathology, Ragas Dental College and Hospital, Chennai, India
    Indian J Dent Res 18:55-9. 2007
    ..The assessment of periodontal statuscould thus be a useful tool in minimally invasive screening of populations for HIV disease, especially in those parts of the world, like India and Africa, with high prevalence and rising incidence...
  42. ncbi request reprint Usefulness of an observational database to assess antiretroviral treatment trends in India
    A J Cecelia
    YR Gaitonde Cente for AIDS Research and Education, Chennai, Tamil Nadu, India
    Natl Med J India 19:14-7. 2006
    ..We describe the YRG CARE Chennai HIV observation database (YCHOD) and highlight its utility in monitoring trends in antiretroviral treatment use and HIV disease outcomes in India...
  43. ncbi request reprint Ocular and systemic lesions in children with HIV
    J Biswas
    Medical and Vision Research Foundation, Chennai, India
    Indian J Pediatr 67:721-4. 2000
    ..The most common lesions were anterior uveitis followed by CMV retinitis. The management in such cases was often challenging in a developing country like India...
  44. ncbi request reprint Oral lesions among persons with HIV disease with and without highly active antiretroviral therapy in southern India
    K M R Umadevi
    Ragas Dental College and Hospital, Uthandi, Chennai, India
    J Oral Pathol Med 36:136-41. 2007
    ..HIV patients in India have now access to generic HAART and this is the first report describing oral lesions in patients on HAART from our country...
  45. ncbi request reprint Clinical manifestations of HIV infected children
    Purnima Madhivanan
    YR Gaitonde Centerfor AIDS Research and Education, Chennai, Tamil Nadu, India
    Indian J Pediatr 70:615-20. 2003
    ..Consequently, children in India increasingly getting infected, primarily from vertical transmission. A retrospective review of the profile of HIV infected children attending an HIV clinic in South India is reported...
  46. ncbi request reprint Monitoring HIV treatment in the developing world
    N Kumarasamy
    YRG Centre for AIDS Research and Education, Chennai, India
    Lancet Infect Dis 2:656-7. 2002
  47. ncbi request reprint HIV-1 western blot assay: What determines an indeterminate status?
    Iqbal H Syed
    YRG Centre for AIDS Research and Education, VHS Campus, Taramani, Chennai, India
    Indian J Med Sci 59:443-50. 2005
    ..However, indeterminate Western blot reactivity to HIV-1 proteins may occur in individuals, who may not be infected with HIV...
  48. ncbi request reprint Acute panuveitis with haemorrhagic hypopyon as a presenting feature of acquired immunodeficiency syndrome (AIDS)
    J Biswas
    Medical Research Foundation, Chennai, India
    Indian J Ophthalmol 48:311-2. 2000
    ..However, reports of acute haemorrhagic hypopyon uveitis in such cases are lacking. Herein we describe a young male patient presenting with acute panuveitis with haemorrhagic hypopyon, who was found HIV positive on investigation...
  49. ncbi request reprint Neurocognitive consequences of HIV in southern India: a preliminary study of clade C virus
    Tokugha Yepthomi
    YRG Center for AIDS Research and Education, Chennai, India
    J Int Neuropsychol Soc 12:424-30. 2006
    ..Furthermore, the impact of antiretroviral therapy on neurocognitive dysfunction in clade C virual infection needs to be determined...
  50. doi request reprint A longitudinal quality-of-life study of HIV-infected persons in South India: the case for comprehensive clinical care and support services
    Suniti Solomon
    YRG CARE, Chennai, India
    AIDS Educ Prev 21:104-12. 2009
    ..01). We conclude that a multidisciplinary approach to managing HIV infection can enhance patients' QOL, independent of antiretroviral therapy...
  51. ncbi request reprint Barriers and facilitators to antiretroviral medication adherence among patients with HIV in Chennai, India: a qualitative study
    N Kumarasamy
    YRG CARE, Chennai, India
    AIDS Patient Care STDS 19:526-37. 2005
    ..These data highlight the importance of reducing the cost of antiretroviral medications, involving family members in HIV care, and addressing privacy issues and stigma in counseling interventions in this setting...
  52. ncbi request reprint Why are people getting tested? Self-reported reasons for seeking voluntary counseling and testing at a clinic in Chennai, India
    Suniti Solomon
    Y R Gaitonde Centre for AIDS Research and Education, Chennai, Chennai, India
    AIDS Behav 10:415-20. 2006
    ..Understanding why people seek VCT informs an understanding of knowledge and attitudes about HIV and HIV testing, which has implications for the development of education, outreach and other HIV prevention services...
  53. ncbi request reprint Central retinal vein occlusion due to herpes zoster as the initial presenting sign in a patient with acquired immunodeficiency syndrome (AIDS)
    J Biswas
    Medical and Vision Research Foundation, Chennai, India
    Ocul Immunol Inflamm 9:125-30. 2001
    ..The paper highlights CRVO as the initial presentation in an AIDS patient with herpes zoster ophthalmicus...
  54. ncbi request reprint Rapid viral load suppression following generic highly active antiretroviral therapy in Southern Indian HIV-infected patients
    Nagalingeswaran Kumarasamy
    YRG Centre for AIDS Research and Education, VHS, Chennai, India
    AIDS 19:625-7. 2005
    ..The data support the use of generic non-nucleoside reverse transcriptase inhibitor-based regimens in resource-limited settings...
  55. ncbi request reprint The safety, tolerability and effectiveness of generic antiretroviral drug regimens for HIV-infected patients in south India
    Nagalingeswaran Kumarasamy
    YRG Centre for AIDS Research and Education, Chennai, India
    AIDS 17:2267-9. 2003
    ..In this cohort, generic HAART was safe, well tolerated and effective at increasing CD4 T-lymphocyte counts in patients with advanced HIV, comparable to the experience with proprietary HAART...
  56. ncbi request reprint Hydrothorax in association with Scopulariopsis brumptii in an AIDS patient in Chennai, India
    E M Shankar
    Department of Microbiology, Faculty of Medicine, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India
    Trans R Soc Trop Med Hyg 101:1270-2. 2007
    ..However, the patient developed obstructive shock and died due to cardiac dysfunctions. This report underlines the need for a direct, intensive approach to investigations in immunocompromised patients, especially those with AIDS...
  57. doi request reprint Ethnic variation in certain hematological and biochemical reference intervals in a south Indian healthy adult population
    M Sundaram
    YRG Centre for AIDS Research and Education, Voluntary Health Services Hospital Campus, Taramani, Chennai 600 113, India
    Eur J Intern Med 19:46-50. 2008
    ..We established the biochemical and hematological reference intervals among a south Indian healthy adult population attending an HIV referral centre in Chennai, southern India...
  58. ncbi request reprint Efficacy of fluconazole and itraconazole in the treatment of oral candidiasis in HIV patients
    T Menon
    Department of Microbiology, Dr A L Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, India
    Acta Trop 80:151-4. 2001
    ..In vitro MIC values correlated well with in vivo responses in patients. Hence, itraconazole may be used as an alternative in the treatment of candidiasis, which does not respond to fluconazole therapy...
  59. pmc Genotypic HIV type-1 drug resistance among patients with immunological failure to first-line antiretroviral therapy in south India
    Madhavan Vidya
    YRG Centre for AIDS Research and Education, Chennai, India
    Antivir Ther 14:1005-9. 2009
    ..The objective of this study was to study the frequency and pattern of reverse transcriptase (RT) drug resistance among patients with immunological failure (IF) to first-line therapy...
  60. doi request reprint Changes in antioxidant profile among HIV-infected individuals on generic highly active antiretroviral therapy in southern India
    Muthu Sundaram
    Infectious Diseases Laboratory, YRG Centre for AIDS Research and Education YRG CARE, VHS Hospital Campus, Rajiv Gandhi Salai, Taramani, Chennai 600 113, India
    Int J Infect Dis 12:e61-6. 2008
    ....
  61. ncbi request reprint Panophthalmitis due to rhizopus in an AIDS patient: a clinicopathological study
    T K Samanta
    Medical and Vision Research Foundation, YRG Centre for AIDS Research and Education, Chennai, India
    Indian J Ophthalmol 49:49-51. 2001
    ..Various opportunistic infections in the eye have been reported earlier in AIDS. We report a case of panophthalmitis in an AIDS patient where the eviscerated tissue on histopathologic and microbiologic examination showed the fungus Rhizopus...
  62. ncbi request reprint Stopping HIV before it begins: issues faced by women in India
    Suniti Solomon
    YRG Centre for AIDS Research and Education, Voluntary Health Services, Tharamani, Chennai 600113, India
    Nat Immunol 4:719-21. 2003
    ..Despite advances in understanding HIV pathogenesis, the economic, social and legal constraints in India continue to make women particularly vulnerable to HIV infection...
  63. ncbi request reprint Multiple cranial nerve palsy in an HIV-positive patient
    S Karna
    Medical Research Foundation, Chennai, India
    Indian J Ophthalmol 49:118-20. 2001
    ..Cytomegalovirus serology was positive and the patient was treated as presumed CMV. HIV can present with multiple cranial neuropathy and varied neurological involvement...
  64. ncbi request reprint Trends in HIV-related morbidity among patients admitted to a South Indian tertiary hospital between 1997 and 2003
    S S Solomon
    Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    AIDS Care 18:366-70. 2006
    ....
  65. ncbi request reprint Low-cost monitoring of HIV infected individuals on highly active antiretroviral therapy (HAART) in developing countries
    Pachamuthu Balakrishnan
    YRG Centre for AIDS Research and Education, Voluntary Health Services Campus, Taramani, Chennai 600 113, India
    Indian J Med Res 121:345-55. 2005
    ..This review discusses the low-cost assays and their role in clinical monitoring of HIV infected individuals in resource-limited countries like as India...
  66. ncbi request reprint Hepatitis B virus and hepatitis C virus dual infection among patients with chronic liver disease
    Shanmugam Saravanan
    Department of Microbiology, Faculty of Medicine, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India
    J Microbiol Immunol Infect 42:122-8. 2009
    ..This study was performed to determine the prevalence of HBV and HCV dual infection among patients with CLD in Chennai, India...
  67. ncbi request reprint Low frequency of precore mutants in anti-hepatitis B e antigen positive subjects with chronic hepatitis B virus infection in Chennai, Southern India
    Saravanan Shanmugam
    YR Gaitonde Centre for AIDS Research and Education, Voluntary Health Services, Chennai 600 113, India
    J Microbiol Biotechnol 18:1722-8. 2008
    ..HBV precore and core promoter variants were less often detected in subjects with "e" negative chronic HBV infection and, therefore, may not have a prognostic role in determining liver disease sequelae in this part of tropical India...
  68. ncbi request reprint HIV type 1 genotypic variation in an antiretroviral treatment-naive population in southern India
    Pachamuthu Balakrishnan
    YRG CARE, Centre for AIDS Research and Education, VHS, Taramani, Chennai 600 113, India
    AIDS Res Hum Retroviruses 21:301-5. 2005
    ..Larger scale studies need to be undertaken to better define the genotypic variation of circulating Indian subtype C viruses and their potential impact on drug susceptibility and clinical outcome in treated individuals...
  69. ncbi request reprint Effective evaluation of novel low-cost CD4 monitoring assays
    Anitha Jebaraj Cecelia
    Y R Gaitonde Centre for AIDS Research and Education, VHS Taramani, Chennai 600113, India
    J Immunol Methods 316:158-62. 2006
    ..The results from these different analyses have been compared and the significance of each has been explained. Hence, to validate a low-cost assay Bland-Altman analysis and plot is recommended...
  70. ncbi request reprint Coinfection of hepatitis B and hepatitis C virus in HIV-infected patients in south India
    Shanmugam Saravanan
    YRG Centre for AIDS Research and Education, VHS Campus, Taramani, Chennai 600 113, India
    World J Gastroenterol 13:5015-20. 2007
    ..To screen for the co-infection of hepatitis B (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected patients in southern India...
  71. ncbi request reprint A reliable and inexpensive EasyCD4 assay for monitoring HIV-infected individuals in resource-limited settings
    Pachamuthu Balakrishnan
    YRG Centre for AIDS Research and Education, Chennai, India
    J Acquir Immune Defic Syndr 43:23-6. 2006
    ..Our data suggest that EasyCD4 assay could be a useful alternative assay to conventional flow cytometry, may be appropriate for use in resource-limited settings...
  72. doi request reprint The prevalence of hepatitis B virus and hepatitis C virus infection among patients with chronic liver disease in South India
    Shanmugam Saravanan
    Department of Microbiology, Faculty of Medicine, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai 600 113, India
    Int J Infect Dis 12:513-8. 2008
    ..We investigated the presence of various genotypes of HCV among 69 chronic liver diseased (CLD) patients with chronic HCV infection...
  73. doi request reprint GB virus infection: a silent anti-HIV panacea within?
    Esaki Muthu Shankar
    YRG Centre for AIDS Research and Education YRG CARE, Voluntary Health Services Hospital Campus, IT Corridor, Taramani, Chennai 600 113, India
    Trans R Soc Trop Med Hyg 102:1176-80. 2008
    ..With sufficient knowledge of resistance patterns studied in tropical south India, researchers are now keen to study the competitive interactions between GBV-induced chemokines and HIV ligands to bind CCR5...
  74. doi request reprint Seroprevalence of hepatitis delta virus infection among subjects with underlying hepatic diseases in Chennai, southern India
    Shanmugam Saravanan
    Indian Council of Medical Research Referral Centre for Chronic Hepatitis and Molecular Virology, Department of Microbiology, University of Madras, Chennai 600 113, India
    Trans R Soc Trop Med Hyg 102:793-6. 2008
    ..6%), compared with previous Indian reports varying from 10.7% to >30%. HDV infection was relatively low and seems to play a minor determining factor of liver diseases in the tropical south Indian population...
  75. ncbi request reprint Establishment of T-lymphocyte subset reference intervals in a healthy adult population in Chennai, India
    K G Murugavel
    YRG Centre for AIDS Research and Education, Voluntary Health Services Hospital Campus Rajiv Gandhi Salai, Chennai India
    Indian J Med Res 129:59-63. 2009
    ..Further studies with greater sample size may be required to define the staging of HIV disease in relation to the normal CD4 T-lymphocyte count in the general population...
  76. doi request reprint Co-factors for abnormal lactate levels among persons with HIV disease at a tertiary HIV care setting in South India
    Muthu Sundaram
    YRG Centre for AIDS Research and Education YRG CARE, Voluntary Health Services, Rajiv Gandhi Salai, Chennai 600 113, India
    Food Chem Toxicol 46:2823-5. 2008
    ....
  77. ncbi request reprint Detection of pulmonary Mycoplasma pneumoniae infections in HIV-infected subjects using culture and serology
    Esaki Muthu Shankar
    Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai 600113, India
    Int J Infect Dis 11:232-8. 2007
    ..This study examined the prevalence of M. pneumoniae in 100 HIV-infected individuals at an AIDS care center in Chennai, India, using conventional laboratory techniques and interpretation criteria...
  78. ncbi request reprint Serosurveillance of acute Mycoplasma pneumoniae infection among HIV infected patients with pulmonary complaints in Chennai, Southern India
    Esaki Muthu Shankar
    Mycoplasma Laboratory of the Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600 113, Tamil Nadu, India
    J Infect 53:325-30. 2006
    ..The true seroepidemiology of acute Mycoplasma pneumoniae infection in HIV infected individuals is ambiguous...
  79. pmc Impact of highly active antiretroviral therapy on salivary flow in patients with human-immuno deficiency virus disease in Southern India
    S Pavithra
    Department of Oral and Maxillofacial Pathology, Madha Dental College and Hospital, Kundrathur, Tamil Nadu, India
    J Oral Maxillofac Pathol 17:17-22. 2013
    ....
  80. ncbi request reprint Oral lesions and conditions associated with human immunodeficiency virus infection in 1000 South Indian patients
    K Ranganathan
    Department of Oral Pathology, Ragas Dental College and Hospital, Chennai, India
    Ann Acad Med Singapore 33:37-42. 2004
    ..The importance of oral lesions as clinical features of HIV infection and their gender specificity have been reported worldwide. However, there are very few reports on this aspect from the Indian subcontinent...
  81. ncbi request reprint Epidemiological studies on pulmonary pathogens in HIV-positive and -negative subjects with or without community-acquired pneumonia with special emphasis on Mycoplasma pneumoniae
    Esaki Muthu Shankar
    Department of Microbiology, Faculty of Medicine, Dr ALM PG IBMS, University of Madras, Chennai, India
    Jpn J Infect Dis 60:337-41. 2007
    ..This study shows that the prevalence of M. pneumoniae in HIV-positive subjects is comparatively higher than in HIV-negative subjects with pulmonary symptoms, and concords with previous pilot studies carried out in Chennai, South India...
  82. ncbi request reprint Orofacial and systemic manifestations in 212 paediatric HIV patients from Chennai, South India
    Kannan Ranganathan
    Department of Oral Pathology, Ragas Dental College and Hospital, Uthandi, Chennai, India
    Int J Paediatr Dent 20:276-82. 2010
    ..Very little data exist for oral lesions in paediatric population in India...
  83. doi request reprint Urinary infections due to multi-drug-resistant Escherichia coli among persons with HIV disease at a tertiary AIDS care centre in South India
    Ramachandran Vignesh
    YRG Centre for AIDS Research and Education, VHS Campus, Rajiv Gandhi Salai, Taramani, Chennai, India
    Nephron Clin Pract 110:c55-7. 2008
    ....
  84. ncbi request reprint Seroprevalence of Mycoplasma pneumoniae in HIV-infected patients using a microparticle agglutination test
    Esaki Muthu Shankar
    Bacteriology Laboratory of the Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 60011, India
    J Med Microbiol 55:759-63. 2006
    ..High titres (> or =320) were found in 10 out of the 39 patients (25.6 %). This seroprevalence study reports a 16.2 % prevalence of M. pneumoniae infections in HIV-infected patients by a particle agglutination test...
  85. pmc Pneumonia and pleural effusion due to Cryptococcus laurentii in a clinically proven case of AIDS
    Esaki Muthu Shankar
    Mycoplasma Laboratory of the Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai, Tamilnadu, India
    Can Respir J 13:275-8. 2006
    ..A high degree of suspicion and improvement of techniques for culture and identification will contribute to the early diagnosis and treatment of unusual fungal infections...
  86. ncbi request reprint Ocular tuberculosis in acquired immunodeficiency syndrome
    Rajesh B Babu
    Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India
    Am J Ophthalmol 142:413-8. 2006
    ..To present the clinical, histopathological, and molecular biologic findings in fifteen cases of ocular tuberculosis (TB) in patients with acquired immune deficiency syndrome (AIDS)...
  87. pmc Clinical impact and cost-effectiveness of antiretroviral therapy in India: starting criteria and second-line therapy
    Kenneth A Freedberg
    Divisions of General Medicine and Infectious Disease and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA
    AIDS 21:S117-28. 2007
    ..India has more than 5.7 million people infected with human immunodeficiency virus (HIV). In 2004, the Indian government began providing antiretroviral therapy (ART), and there are now an estimated 56 500 people receiving ART...
  88. ncbi request reprint Adverse effects of highly active antiretroviral therapy in developing countries
    Ramnath Subbaraman
    Yale School of Medicine, New Haven, Connecticut, USA
    Clin Infect Dis 45:1093-101. 2007
    ....
  89. ncbi request reprint A diagnostic dilemma in a patient receiving antiretroviral and antituberculosis therapy
    Snigdha Vallabhaneni
    Brown University, Providence, Rhode Island, USA
    AIDS Read 15:72-5. 2005
    ..This case highlights the importance of developing guidelines for management of concurrent HIV infection and TB in the developing world...
  90. ncbi request reprint Bacterial vaginosis in female sex workers in Chennai, India
    Shanmugasundaram Uma
    Sex Health 2:261-2. 2005
    ..3, AR 12, P = 0.00), T vaginalis (RR 1.5, AR 10, P = 0.01) T. pallidum (RR 2.8, AR 16, P = 0.00) and HIV (RR 4.1, AR 52, P = 0.01). Future studies are needed to focus on the risk factors for BV...
  91. pmc Scaling up antiretroviral therapy in South Africa: the impact of speed on survival
    Rochelle P Walensky
    The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Infect Dis 197:1324-32. 2008
    ..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012...
  92. ncbi request reprint C-reactive protein in HIV-infected patients--could it be a marker of immunosuppression?
    Sundaram Muthu
    Clin Chim Acta 376:246-7. 2007
  93. doi request reprint Laboratory characteristics of HIV-1 clade C-infected long-term non-progressors at a tertiary human immunodeficiency virus care centre in South India
    Uma Shanmugasundaram
    J Med Microbiol 57:913-5. 2008
  94. ncbi request reprint Value of single acid-fast bacilli sputum smears in the diagnosis of tuberculosis in HIV-positive subjects
    Ramachandran Vignesh
    J Med Microbiol 56:1709-10. 2007
  95. ncbi request reprint Aspergillus fumigatus, Pneumocystis jiroveci, Klebsiella pneumoniae & Mycoplasma fermentans co-infection in a HIV infected patient with respiratory conditions from Southern India
    E M Shankar
    Indian J Med Res 123:181-4. 2006
  96. ncbi request reprint Bacterial vaginosis in women of low socioeconomic status living in slum areas in Chennai, India
    Shanmugasundaram Uma
    Sex Health 3:297-8. 2006
    ..vaginalis (relative risk (RR) = 6.6, 95% CI 2.8-15.5, P = 0.000) and HSV-2 (RR = 2, 95% CI 1.3-2.9; P = 0.0031). The role of other possible risk factors needs to be explored...
  97. ncbi request reprint Isospora belli, Strongyloides stercoralis & hookworm multiple-infection in a person with HIV infection & normal CD4+ T-lymphocyte count
    Ramachandran Vignesh
    Indian J Med Res 127:403-5. 2008
  98. pmc Filarial/human immunodeficiency virus coinfection in urban southern India
    Kawsar R Talaat
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 79:558-60. 2008
    ..bancrofti infections among HIV-positive persons was 5-9.5%, and there were no quantitative differences in circulating filarial antigen levels between HIV-positive and HIV-negative filarial-infected patients...