Mange R Yadav

Summary

Country: India

Publications

  1. ncbi request reprint Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors
    Mange R Yadav
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Vadodara, India
    J Enzyme Inhib Med Chem 23:190-7. 2008
  2. doi request reprint Design and synthesis of 6,7-dimethoxyquinazoline analogs as multi-targeted ligands for α1- and AII-receptors antagonism
    M R Yadav
    Pharmacy Department, Faculty of Tech and Engg, The M S University of Baroda, Vadodara 390001, Gujarat, India
    Bioorg Med Chem Lett 23:3959-66. 2013
  3. ncbi request reprint ACAT inhibitors: the search for novel cholesterol lowering agents
    Palash Pal
    Pharmacy Department, Faculty of Tech and Engg, The M S University of Baroda, Vadodara 390 001, Gujarat, India
    Mini Rev Med Chem 13:1195-219. 2013
  4. doi request reprint Steroidal carbonitriles as potential aromatase inhibitors
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The MS University of Baroda, Vadodara, India
    Steroids 77:850-7. 2012
  5. doi request reprint Advances in studies on collagenase inhibitors
    Mange Ram Yadav
    Pharmacy Department, The M S University of Baroda, Vadodara 390 001, Gujarat, India
    EXS 103:83-135. 2012
  6. doi request reprint Revelation on the potency of α(1) -blockers - parallel blockade of angiotensin II receptor: a new finding
    M R Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara, Gujarat, India
    Pharm Biol 50:439-42. 2012
  7. doi request reprint Cytotoxic potential of novel 6,7-dimethoxyquinazolines
    Mange R Yadav
    Pharmacy Department, The M S University of Baroda, Vadodara, 390001 Gujarat, India
    Eur J Med Chem 48:231-43. 2012
  8. ncbi request reprint Studies on the crystal forms of pefloxacin: preparation, characterization, and dissolution profile
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Baroda, Vadodara 390 001, India
    J Pharm Sci 97:2637-48. 2008
  9. doi request reprint Synthesis of some novel androstanes as potential aromatase inhibitors
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara 390 001, Gujarat, India
    Steroids 76:464-70. 2011
  10. ncbi request reprint Studies in 3,4-diaryl-1,2,5-oxadiazoles and their N-oxides: search for better COX-2 inhibitors
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara 390 001, India
    Acta Pharm 57:13-30. 2007

Collaborators

  • Rolf W Hartmann
  • Renu Chadha
  • Fr Mégraud
  • Kishor S Jain
  • Rajani Giridhar
  • Parmeshwari K Halen
  • Anwar R Shaikh
  • Prashant R Murumkar
  • Uttam Rajaram Mane
  • Palash Pal
  • Kewal K Chagti
  • R Ramajayam
  • Devendra Sharad Puntambekar
  • Parmeshwari Kuldeep Kumar Halen
  • Rajani R Giridhar
  • Prashant Prakash Naik
  • Ramesh C Gupta
  • Sunil Sadanand Nadkarni
  • Hardik Gandhi
  • Sneha R Chandani
  • Shirshendu DasGupta
  • Manisha K Raval
  • Hakim Djaballah
  • David Shum
  • Constantin Radu
  • Kewal Krishna Chagti

Detail Information

Publications23

  1. ncbi request reprint Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors
    Mange R Yadav
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Vadodara, India
    J Enzyme Inhib Med Chem 23:190-7. 2008
    ..3 microM for cathepsin L and Ki > 100 microM for cathepsin B). This compound could act as a new lead for the further development of improved inhibitors within this inhibitor type...
  2. doi request reprint Design and synthesis of 6,7-dimethoxyquinazoline analogs as multi-targeted ligands for α1- and AII-receptors antagonism
    M R Yadav
    Pharmacy Department, Faculty of Tech and Engg, The M S University of Baroda, Vadodara 390001, Gujarat, India
    Bioorg Med Chem Lett 23:3959-66. 2013
    ..These findings shed a new light on the structural requirements for both α1- as well as AII-receptor antagonists...
  3. ncbi request reprint ACAT inhibitors: the search for novel cholesterol lowering agents
    Palash Pal
    Pharmacy Department, Faculty of Tech and Engg, The M S University of Baroda, Vadodara 390 001, Gujarat, India
    Mini Rev Med Chem 13:1195-219. 2013
    ..Literature survey shows that structurally diverse compounds possess ACAT inhibitory properties. In this review, a comprehensive presentation of the literature on diverse ACAT inhibitors has been given...
  4. doi request reprint Steroidal carbonitriles as potential aromatase inhibitors
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The MS University of Baroda, Vadodara, India
    Steroids 77:850-7. 2012
    ..The D-seco derivatives (13-15 and 17) having unsaturation at C-4, C-1 & 4 or C-4 & 6 along with carbonitrile function in ring-D showed complete loss of aromatase inhibiting activity...
  5. doi request reprint Advances in studies on collagenase inhibitors
    Mange Ram Yadav
    Pharmacy Department, The M S University of Baroda, Vadodara 390 001, Gujarat, India
    EXS 103:83-135. 2012
    ..This chapter tries to make an attempt in providing the reader with an overall flavor of the type of scaffolds reported in the past few years along with the molecular modeling studies...
  6. doi request reprint Revelation on the potency of α(1) -blockers - parallel blockade of angiotensin II receptor: a new finding
    M R Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara, Gujarat, India
    Pharm Biol 50:439-42. 2012
    ..Sympathetic nervous system and the renin-angiotensin-aldosterone system are primary contributors of blood pressure homeostasis...
  7. doi request reprint Cytotoxic potential of novel 6,7-dimethoxyquinazolines
    Mange R Yadav
    Pharmacy Department, The M S University of Baroda, Vadodara, 390001 Gujarat, India
    Eur J Med Chem 48:231-43. 2012
    ..Nine of the tested compounds showed significant cytotoxicity in all cell lines at 10μM. The most promising derivative (7c) showed IC(50)values of 0.7 and 1.7μM in the two colon cancer cell lines...
  8. ncbi request reprint Studies on the crystal forms of pefloxacin: preparation, characterization, and dissolution profile
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Baroda, Vadodara 390 001, India
    J Pharm Sci 97:2637-48. 2008
    ..The polymorphs differed in their dissolution profile and all of them showed unusual behavior of highest dissolution in the first 15 min. The rate of dissolution went on decreasing and got stabilized to a constant value after 4 h...
  9. doi request reprint Synthesis of some novel androstanes as potential aromatase inhibitors
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara 390 001, Gujarat, India
    Steroids 76:464-70. 2011
    ..Isomeric forms of isoxazole (7 and 8) showed very poor activity compared to fadrozole and aminoglutethimide. Preliminary kinetic studies have shown that both of the active compounds (6 and 9) are reversible inhibitors of the enzyme...
  10. ncbi request reprint Studies in 3,4-diaryl-1,2,5-oxadiazoles and their N-oxides: search for better COX-2 inhibitors
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara 390 001, India
    Acta Pharm 57:13-30. 2007
    ..These preliminary studies suggest that p-methoxy (p-OMe) group in one of benzene rings may give potentially active leads in this series of oxadiazole/N-oxides...
  11. ncbi request reprint Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara 390 001, India
    Bioorg Med Chem 14:8701-6. 2006
    ..These compounds elicited no ulcerogenicity unlike their parent drugs...
  12. doi request reprint Site specific chemical delivery of NSAIDs to inflamed joints: synthesis, biological activity and gamma-imaging studies of quaternary ammonium salts of tropinol esters of some NSAIDs or their active metabolites
    Mange Ram Yadav
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara 390001, India
    Bioorg Med Chem 16:9443-9. 2008
    ....
  13. ncbi request reprint Combining anticholinergic and anti-inflammatory activities into a single moiety: a novel approach to reduce gastrointestinal toxicity of ibuprofen and ketoprofen
    Parmeshwari K Halen
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara, Gujarat, India
    Chem Biol Drug Des 70:450-5. 2007
    ..The study offers a new strategy for design and development of compounds with safer therapeutic profile for long-term treatment of inflammation-associated disorders...
  14. doi request reprint Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review
    Uttam Rajaram Mane
    The M S University of Baroda, Pharmacy Department, Faculty of Tech and Engg, Vadodara, 390001, Gujarat, India
    Expert Opin Ther Pat 23:165-87. 2013
    ..These studies could provide important insight into rational designing of FP inhibitors as potential antimalarial drugs...
  15. ncbi request reprint Synthesis and evaluation of some gastrointestinal sparing anti-inflammatory aminoethyl ester derivatives of naphthalene-based NSAIDs
    Parmeshwari K Halen
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara, Gujarat, India
    Arch Pharm (Weinheim) 340:88-94. 2007
    ....
  16. ncbi request reprint Synthesis and pharmacological evaluation of some dual-acting amino-alcohol ester derivatives of flurbiprofen and 2-[1,1'-biphenyl-4-yl]acetic acid: a potential approach to reduce local gastrointestinal toxicity
    Parmeshwari Kuldeep Kumar Halen
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, India
    Chem Biodivers 3:1238-48. 2006
    ....
  17. ncbi request reprint Bismuth-norfloxacin complex: synthesis, physicochemical and antimicrobial evaluation
    Anwar R Shaikh
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Vadodara 390 001, India
    Int J Pharm 332:24-30. 2007
    ..This increase in activity is being considered due to increased bioavailability of the metal drug complex. Thus, the use of the BNC may be preferable over norfloxacin alone...
  18. ncbi request reprint 3D-QSAR CoMFA/CoMSIA studies on 5-aryl-2,2-dialkyl-4-phenyl-3(2H)-furanone derivatives, as selective COX-2 inhibitors
    Devendra Sharad Puntambekar
    Pharmacy Department, Faculty of Technology and Engineering, Kalabavan, India
    Acta Pharm 56:157-74. 2006
    ..The data generated from the present study will further help design novel, potent and selective COX-2 inhibitors...
  19. doi request reprint Metalloantibiotics: synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori
    Anwar R Shaikh
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Vadodara 390001, India
    Acta Pharm 59:259-71. 2009
    ..These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments...
  20. ncbi request reprint Prodrug designing of NSAIDs
    Parmeshwari K Halen
    Pharmacy Department, Faculty of Tech and Engg, Kalabhavan, P B No 51, The M S University of Baroda, Vadodara 390001, India
    Mini Rev Med Chem 9:124-39. 2009
    ..In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented...
  21. doi request reprint Novel TACE inhibitors in drug discovery: a review of patented compounds
    Prashant R Murumkar
    The M S University of Baroda, Faculty of Technology and Engineering, Department of Pharmacy, Kalabhavan, Vadodara, 390 001, India
    Expert Opin Ther Pat 20:31-57. 2010
    ..A review of patented compounds as TACE inhibitors in drug discovery is given. A selection of interesting patents recorded from 2001 to 2009 is presented. Various novel TACE inhibitors developed by different companies have been discussed...
  22. doi request reprint Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents
    Kishor S Jain
    Sinhgad College of Pharmacy, Pune 411041, India
    Bioorg Med Chem 16:4759-800. 2008
    ..Herein, the research done on the discovery and evaluation of a variety of chemically diverse structures as selective antagonists of alpha(1)-adr and alpha(1)-adr subtypes in recent years has been reviewed...
  23. ncbi request reprint Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines
    R Ramajayam
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M S University of Baroda, Vadodara, India
    J Enzyme Inhib Med Chem 22:716-21. 2007
    ..The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined...