Deepak Sharma

..Therefore, it is suggested that curcumin counters aluminium-induced enhancement in ageing-related processes...

..In conclusion, the results of the present study implicates that aluminium treatment exerts its neurotoxic effects by altering the overall physiology of brain, and the induced changes were strongly correlated with each other...

..These findings strongly implicate that Bacopa monniera has potential to protect brain from oxidative damage resulting from aluminium toxicity...

..Our results indicate that curcumin significantly prevents generalization of electroclinical seizure activity as well as the pathogenesis associated with iron-induced epileptogenesis...

..A close correlation was observed in parameters like oxidative stress, enzyme changes, and pathological changes like lipofuscin accumulation in aging and diabetic brain...

..The observed biochemical and microscopic alterations associated with old age positively correlate with the altered susceptibility to develop seizures in old epileptic groups...

..However, the oxidative stress was elevated in the hippocampus, thalamus and hypothalamus, and old animals were more severely affected than the adult ones...

..The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain...

..Observations showed that Bacopa's neuroprotective effects were comparable to those of l-deprenyl at both biochemical and microscopic levels...

..Moreover, alterations in epileptogenesis-related biochemical parameters-lipid peroxidation, protein oxidation and Na(+), K(+)-ATPase (sodium pump) activity--were also countered by DHEA...

..Our results indicate that curcumin's ability to bind redox active metals and cross the blood-brain barrier could be playing crucial role in preventing against Al-induced neurotoxicity...

..The results of this study will be useful for pharmacological modification of the aging process and development of new drugs for age related disorders...

..It was concluded that exogenous DHEA might be beneficial in terms of neuroprotection against age-related loss of Na+ K+ ATPase mediated brain functions like learning and memory...

..These novel data on the effect of L-deprenyl on parameters of normal ageing provide new additional evidence concerning the anti-ageing therapeutic potential of L-deprenyl...

..The drug also countered the ageing-related loss of hippocampal protein kinase C activity...

..Increased oxidative stress observed in the arthritic animals was also found to be significantly restored in SNME- treated rats. Taken together, our studies clearly indicate the potential of S. nigra as an anti-arthritic agent...

..The results suggest that older the animal, better will be the response of exogenous DHEA administration against age-related peroxidative products...