Deepak Sharma

Summary

Country: India

Publications

  1. doi request reprint Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions
    Deepak Sharma
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Biogerontology 10:489-502. 2009
  2. doi request reprint Aluminium-induced electrophysiological, biochemical and cognitive modifications in the hippocampus of aging rats
    Pallavi Sethi
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Neurotoxicology 29:1069-79. 2008
  3. ncbi request reprint Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    J Ethnopharmacol 111:56-62. 2007
  4. doi request reprint Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Epilepsy Behav 14:300-8. 2009
  5. doi request reprint Aging accelerates the progression and manifestation of seizures in post-traumatic model of epilepsy
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Neurosci Lett 453:86-91. 2009
  6. doi request reprint A metabolic and functional overview of brain aging linked to neurological disorders
    Najma Z Baquer
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Biogerontology 10:377-413. 2009
  7. ncbi request reprint Effect of L-deprenyl treatment on electrical activity, Na+, K+ ATPase, and protein kinase C activities in hippocampal subfields (CA1 and CA3) of aged rat brain
    Rameshwar Singh
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Indian J Exp Biol 50:101-9. 2012
  8. ncbi request reprint Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions
    Kiran Bala
    School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India
    Biogerontology 7:81-9. 2006
  9. ncbi request reprint Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Neurotoxicology 27:451-7. 2006
  10. doi request reprint Antiepileptic action of exogenous dehydroepiandrosterone in iron-induced epilepsy in rat brain
    Monika Mishra
    Laboratory of Neurobiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Epilepsy Behav 19:264-71. 2010

Collaborators

  • Pallavi Sethi
  • Najma Z Baquer
  • R Singh
  • Amar Jyoti
  • Monika Mishra
  • Asia Taha
  • Shikha Sharma
  • Pardeep Kumar
  • Kiran Bala
  • Nupur Sinha
  • Jaspreet Kaur
  • Somnath Mukherjee
  • Debasis Sahu
  • Hasi Rani Das
  • R K Kale
  • B C Tripathy
  • Sangeeta Singh

Detail Information

Publications18

  1. doi request reprint Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions
    Deepak Sharma
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Biogerontology 10:489-502. 2009
    ..Therefore, it is suggested that curcumin counters aluminium-induced enhancement in ageing-related processes...
  2. doi request reprint Aluminium-induced electrophysiological, biochemical and cognitive modifications in the hippocampus of aging rats
    Pallavi Sethi
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Neurotoxicology 29:1069-79. 2008
    ..In conclusion, the results of the present study implicates that aluminium treatment exerts its neurotoxic effects by altering the overall physiology of brain, and the induced changes were strongly correlated with each other...
  3. ncbi request reprint Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    J Ethnopharmacol 111:56-62. 2007
    ..These findings strongly implicate that Bacopa monniera has potential to protect brain from oxidative damage resulting from aluminium toxicity...
  4. doi request reprint Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Epilepsy Behav 14:300-8. 2009
    ..Our results indicate that curcumin significantly prevents generalization of electroclinical seizure activity as well as the pathogenesis associated with iron-induced epileptogenesis...
  5. doi request reprint Aging accelerates the progression and manifestation of seizures in post-traumatic model of epilepsy
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Neurosci Lett 453:86-91. 2009
    ..The observed biochemical and microscopic alterations associated with old age positively correlate with the altered susceptibility to develop seizures in old epileptic groups...
  6. doi request reprint A metabolic and functional overview of brain aging linked to neurological disorders
    Najma Z Baquer
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Biogerontology 10:377-413. 2009
    ..A close correlation was observed in parameters like oxidative stress, enzyme changes, and pathological changes like lipofuscin accumulation in aging and diabetic brain...
  7. ncbi request reprint Effect of L-deprenyl treatment on electrical activity, Na+, K+ ATPase, and protein kinase C activities in hippocampal subfields (CA1 and CA3) of aged rat brain
    Rameshwar Singh
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Indian J Exp Biol 50:101-9. 2012
    ..The drug also countered the ageing-related loss of hippocampal protein kinase C activity...
  8. ncbi request reprint Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions
    Kiran Bala
    School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India
    Biogerontology 7:81-9. 2006
    ..The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain...
  9. ncbi request reprint Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain
    Amar Jyoti
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Neurotoxicology 27:451-7. 2006
    ..Observations showed that Bacopa's neuroprotective effects were comparable to those of l-deprenyl at both biochemical and microscopic levels...
  10. doi request reprint Antiepileptic action of exogenous dehydroepiandrosterone in iron-induced epilepsy in rat brain
    Monika Mishra
    Laboratory of Neurobiology, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Epilepsy Behav 19:264-71. 2010
    ..Moreover, alterations in epileptogenesis-related biochemical parameters-lipid peroxidation, protein oxidation and Na(+), K(+)-ATPase (sodium pump) activity--were also countered by DHEA...
  11. doi request reprint Effect of paradoxical sleep deprivation on oxidative stress parameters in brain regions of adult and old rats
    Rameshwar Singh
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Biogerontology 9:153-62. 2008
    ..However, the oxidative stress was elevated in the hippocampus, thalamus and hypothalamus, and old animals were more severely affected than the adult ones...
  12. doi request reprint Effect of dehydroepiandrosterone (DHEA) on monoamine oxidase activity, lipid peroxidation and lipofuscin accumulation in aging rat brain regions
    Pardeep Kumar
    Neurobiology Laboratory School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India
    Biogerontology 9:235-46. 2008
    ..The results of this study will be useful for pharmacological modification of the aging process and development of new drugs for age related disorders...
  13. doi request reprint Curcumin attenuates aluminium-induced functional neurotoxicity in rats
    Pallavi Sethi
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Pharmacol Biochem Behav 93:31-9. 2009
    ..Our results indicate that curcumin's ability to bind redox active metals and cross the blood-brain barrier could be playing crucial role in preventing against Al-induced neurotoxicity...
  14. ncbi request reprint Na+ K(+)-ATPase activity in response to exogenous dehydroepiandrosterone administration in aging rat brain
    Asia Taha
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India
    Indian J Exp Biol 46:852-4. 2008
    ..It was concluded that exogenous DHEA might be beneficial in terms of neuroprotection against age-related loss of Na+ K+ ATPase mediated brain functions like learning and memory...
  15. ncbi request reprint Neurostimulatory and antioxidative effects of L-deprenyl in aged rat brain regions
    Jaspreet Kaur
    School of Life Sciences, Neurobiology Laboratory, Jawaharlal Nehru University, New Delhi, 110 067, India
    Biogerontology 4:105-11. 2003
    ..These novel data on the effect of L-deprenyl on parameters of normal ageing provide new additional evidence concerning the anti-ageing therapeutic potential of L-deprenyl...
  16. doi request reprint Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress
    Shikha Sharma
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Food Chem Toxicol 49:3395-406. 2011
    ..Increased oxidative stress observed in the arthritic animals was also found to be significantly restored in SNME- treated rats. Taken together, our studies clearly indicate the potential of S. nigra as an anti-arthritic agent...
  17. ncbi request reprint Anti-lipidperoxidative role of exogenous dehydroepiendrosterone (DHEA) administration in normal ageing rat brain
    Nupur Sinha
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Indian J Exp Biol 43:420-4. 2005
    ..The results suggest that older the animal, better will be the response of exogenous DHEA administration against age-related peroxidative products...
  18. doi request reprint Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters
    Monika Mishra
    Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    Epilepsy Res 106:83-91. 2013
    ..The results are of significance in respect of the mechanism of the antiepileptic action of neurosteroids and the glutamate transporters as therapeutic targets in glutamatergic epileptogenesis. ..