K Sekhar

Summary

Country: India

Publications

  1. ncbi request reprint Subacute (90 days) oral toxicity studies of Kombucha tea
    R Vijayaraghavan
    Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Biomed Environ Sci 13:293-9. 2000
  2. ncbi request reprint Lead exposure: health effects, prevention and treatment
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Environ Biol 23:25-41. 2002
  3. ncbi request reprint Arsenic and lead induced free radical generation and their reversibility following chelation
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Cell Mol Biol (Noisy-le-grand) 53:26-47. 2007
  4. pmc Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS
    Paban Kumar Dash
    Division of Virology, Defence R and D Establishment, Jhansi Road, Gwalior 474002, MP, India
    Virol J 3:55. 2006
  5. ncbi request reprint Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity
    R Vijayaraghavan
    Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Toxicology 163:83-91. 2001
  6. doi request reprint Co-administration of monoisoamyl dimercaptosuccinic acid and Moringa oleifera seed powder protects arsenic-induced oxidative stress and metal distribution in mice
    Deepshikha Mishra
    Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Gwalior, India
    Toxicol Mech Methods 19:169-82. 2009
  7. ncbi request reprint Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects
    S J S Flora
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Biol Trace Elem Res 120:235-47. 2007
  8. ncbi request reprint Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice
    Megha Mittal
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Chem Biol Interact 162:128-39. 2006
  9. ncbi request reprint Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review
    S J S Flora
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Environ Biol 28:333-47. 2007
  10. doi request reprint Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats
    Pratibha Gautam
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Nutrition 26:563-70. 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Subacute (90 days) oral toxicity studies of Kombucha tea
    R Vijayaraghavan
    Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Biomed Environ Sci 13:293-9. 2000
    ..The haematological and biochemical variables were within the clinical limits. The study indicates that rats fed KT for 90 days showed no toxic effects...
  2. ncbi request reprint Lead exposure: health effects, prevention and treatment
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Environ Biol 23:25-41. 2002
    ..e. chelation therapy against lead poisoning. Emphasis has been given to data, which have become available in the last decade...
  3. ncbi request reprint Arsenic and lead induced free radical generation and their reversibility following chelation
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Cell Mol Biol (Noisy-le-grand) 53:26-47. 2007
    ..A number of other strategies have been suggested to minimize the numerous problems. This article presents the recent development made in this area with possible directions for future research...
  4. pmc Reemergence of dengue virus type-3 (subtype-III) in India: implications for increased incidence of DHF & DSS
    Paban Kumar Dash
    Division of Virology, Defence R and D Establishment, Jhansi Road, Gwalior 474002, MP, India
    Virol J 3:55. 2006
    ..We have carried out a detailed investigation of the 2004 outbreak by Serosurveillance, RT-PCR, nested PCR, virus isolation and genotyping. We also report the molecular epidemiological investigation of these outbreaks...
  5. ncbi request reprint Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity
    R Vijayaraghavan
    Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Toxicology 163:83-91. 2001
    ..DNA damage induced by SM was also significantly reduced by amifostine and DRDE-07 (0.2 LD(50), p.o.). Further studies are in progress on the various pharmacological and toxicological properties of DRDE-07...
  6. doi request reprint Co-administration of monoisoamyl dimercaptosuccinic acid and Moringa oleifera seed powder protects arsenic-induced oxidative stress and metal distribution in mice
    Deepshikha Mishra
    Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Gwalior, India
    Toxicol Mech Methods 19:169-82. 2009
    ..The results suggest that concomitant administration of M. oleifera during chelation treatment with MiADMSA might be a better treatment option than monotherapy with the thiol chelator in chronic arsenic toxicity...
  7. ncbi request reprint Essential metal status, prooxidant/antioxidant effects of MiADMSA in male rats: age-related effects
    S J S Flora
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Biol Trace Elem Res 120:235-47. 2007
    ..Apart from this it also significantly reduced the glutathione disulfide levels in tissues. However, administration of MiADMSA caused some concern over the copper loss. MiADMSA was found to be safe in rats of all ages...
  8. ncbi request reprint Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice
    Megha Mittal
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Chem Biol Interact 162:128-39. 2006
    ..These results are new and interesting and require further exploration...
  9. ncbi request reprint Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review
    S J S Flora
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Environ Biol 28:333-47. 2007
    ....
  10. doi request reprint Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats
    Pratibha Gautam
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Nutrition 26:563-70. 2010
    ..The objective was to study the efficacy of oral supplementation of gossypin, a flavonoid, during lead exposure in preventive alterations in the heme synthesis pathway, brain oxidation, and tissue lead uptake in rats...
  11. ncbi request reprint Vitamin E supplementation protects oxidative stress during arsenic and fluoride antagonism in male mice
    Megha Mittal
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Drug Chem Toxicol 30:263-81. 2007
    ....
  12. doi request reprint Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats
    Anshu Jain
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Ecotoxicol Environ Saf 74:607-14. 2011
    ..These flavonoids can be incorporated into the diet or co-supplemented during chelation treatment, and thus may afford a protective effect against arsenite-induced cytotoxicity...
  13. ncbi request reprint Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats
    Richa Gupta
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    J Appl Toxicol 26:213-22. 2006
    ..Further studies are recommended for determining the effect of co-administration of Centella asiatica during chelation therapy with a thiol chelator...
  14. ncbi request reprint Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats
    Geetu Saxena
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, MP, India
    Toxicology 214:39-56. 2005
    ..The above results suggest DMSA monoesters to be a better treatment option than DMSA in eliciting recovery to the altered biochemical variables and in the depletion of body lead burden...
  15. ncbi request reprint Combined administration of taurine and meso 2,3-dimercaptosuccinic acid in the treatment of chronic lead intoxication in rats
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Hum Exp Toxicol 23:157-66. 2004
    ..It can thus be concluded from the study that concomitant administration of an antioxidant could play a significant and important role in abating a number of toxic effects of lead when administered along with the thiol chelators...
  16. doi request reprint Differential oxidative stress and DNA damage in rat brain regions and blood following chronic arsenic exposure
    D Mishra
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Toxicol Ind Health 24:247-56. 2008
    ..The present study, thus, leads us to suggest that arsenic induces differential oxidative stress in brain regions with cortex followed by hippocampus and causes single-strand DNA damage in lymphocytes...
  17. ncbi request reprint Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats
    Geetu Saxena
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    J Biochem Mol Toxicol 18:221-33. 2004
    ....
  18. ncbi request reprint Response of arsenic-induced oxidative stress, DNA damage, and metal imbalance to combined administration of DMSA and monoisoamyl-DMSA during chronic arsenic poisoning in rats
    S Bhadauria
    Defence Research and Development Establishment, Gwalior, India
    Cell Biol Toxicol 23:91-104. 2007
    ..This combination was also able to repair DNA damage caused following arsenic exposure. We thus recommend combined administration of DMSA and MiADMSA for achieving optimum effects of chelation therapy...
  19. ncbi request reprint Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Phytother Res 21:980-8. 2007
    ..The present study thus suggests a beneficial effect of Centella asiatica against arsenic-induced oxidative stress but possesses no chelating property...
  20. doi request reprint Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Neurol Sci 285:198-205. 2009
    ..Combined exposure to arsenic and fluoride does not necessarily lead to more pronounced toxicity and interestingly exhibit some antagonistic effects. Vitamin E supplementation may be of added value in reverting some of the toxic effects...
  21. ncbi request reprint Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats
    Ashish Mehta
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    J Appl Toxicol 22:359-69. 2002
    ..It can be concluded that repeated administration of MiADMSA is compromised with some mild toxic effect, particularly the loss of copper. The effects during oral administration are comparatively less pronounced than by the i.p. route...
  22. doi request reprint Quercetin administration during chelation therapy protects arsenic-induced oxidative stress in mice
    Deepshikha Mishra
    Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Jhansi Road, Gwalior, 474 002, India
    Biol Trace Elem Res 122:137-47. 2008
    ..The study supports our earlier conclusion that a co-administration of an antioxidant particularly flavonoids more beneficial than monotherapy with the chelating agents to achieve optimal effects of chelation in arsenite toxicity...
  23. ncbi request reprint Combined administration of iron and monoisoamyl-DMSA in the treatment of chronic arsenic intoxication in mice
    M Modi
    Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Cell Biol Toxicol 23:429-43. 2007
    ..The results lead us to conclude that iron supplementation during chelation has some beneficial effects particularly on heme synthesis pathway and blood arsenic concentration...
  24. ncbi request reprint Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats
    S J S Flora
    Defence Research and Development Establishment, Gwalior 474 002, India
    Cell Mol Biol (Noisy-le-grand) 50:OL543-51. 2004
    ..It can be concluded that, combined therapy with an antioxidant moiety and a thiol-chelating agent may be a better choice for treating plumbism...
  25. ncbi request reprint Therapeutic value of Hippophae rhamnoides L. against subchronic arsenic toxicity in mice
    Richa Gupta
    Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Gwalior, Madhya Pradesh, India
    J Med Food 8:353-61. 2005
    ..rhamnoides L. (HF-WRT) significantly protects against arsenic-induced oxidative stress but does not chelate arsenic, suggesting it may have a beneficial role as a supplementing agent during chelation of arsenic by other means...
  26. ncbi request reprint Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats
    Geetu Saxena
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Pharm Pharmacol 58:547-59. 2006
    ..Certain other biochemical variables responded favourably to combination therapy and monotherapy with MiADMSA. Thus, supplementation of C. asiatica during chelation could be recommended for achieving optimum effects of chelation therapy...
  27. ncbi request reprint Response of lead-induced oxidative stress and alterations in biogenic amines in different rat brain regions to combined administration of DMSA and MiADMSA
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Chem Biol Interact 170:209-20. 2007
    ....
  28. ncbi request reprint Protective effects of fruit extracts of Hippophae rhamnoides L. against arsenic toxicity in Swiss albino mice
    R Gupta
    Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Hum Exp Toxicol 25:285-95. 2006
    ....
  29. ncbi request reprint Concomitant administration of Moringa oleifera seed powder in the remediation of arsenic-induced oxidative stress in mouse
    Richa Gupta
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, M P, India
    Cell Biol Int 31:44-56. 2007
    ..Administration of M. oleifera seed powder thus could also be beneficial during chelation therapy with a thiol chelator...
  30. ncbi request reprint The efficacy of monoisoamyl ester of dimercaptosuccinic acid in chronic experimental arsenic poisoning in mice
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    J Environ Sci Health A Tox Hazard Subst Environ Eng 38:241-54. 2003
    ..The treatment with MiADMSA although, produced essential metals imbalance which could be a restrictive factor for the possible therapeutic use of this compound in chronic arsenic poisoning and thus require further exploration...
  31. doi request reprint Fluoride-induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats
    Swapnila Chouhan
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Appl Toxicol 30:63-73. 2010
    ..These changes support our earlier findings regarding the role of decreased ionic mobility of fluoride ion at higher concentrations, leading to less pronounced toxicity...
  32. doi request reprint Monoisoamyl dimercaptosuccinic acid abrogates arsenic-induced developmental toxicity in human embryonic stem cell-derived embryoid bodies: comparison with in vivo studies
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 001, India
    Biochem Pharmacol 78:1340-9. 2009
    ..We conclude that the ES-EB model seems to be an effective, faster, cost effective method for predicting efficacy of a drug...
  33. ncbi request reprint Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats
    Manisha Pande
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior, India
    Toxicology 177:187-96. 2002
    ..The results thus provide evidence of an encouraging role of LA when given in combination with a thiol chelator in the therapeutic intervention of lead poisoning, particularly in reducing the oxidative stress and brain lead concentration...
  34. doi request reprint Effects of combined exposure to dichlorvos and monocrotophos on blood and brain biochemical variables in rats
    Nidhi Dwivedi
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Hum Exp Toxicol 29:121-9. 2010
    ..It can be concluded that only moderate synergistic effects occur between MC and DDVP during co-exposure. A more detailed study with variable doses, prolonged exposure and alterations in different brain regions is recommended...
  35. ncbi request reprint Comparative hepatic and renal toxicity of cadmium in male and female rats
    Udita Gubrelay
    Department of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    J Environ Biol 25:65-73. 2004
    ..The results suggested that females were comparatively more vulnerable to the toxic effects of cadmium than males...
  36. ncbi request reprint Heavy metal induced oxidative stress & its possible reversal by chelation therapy
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India
    Indian J Med Res 128:501-23. 2008
    ..We have selected only arsenic, lead, mercury and cadmium for this article keeping in view current concerns and literature available...
  37. doi request reprint Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data
    Swapnila Chouhan
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    Toxicology 254:61-7. 2008
    ....
  38. ncbi request reprint Acute toxicity and cardio-respiratory effects of 2-deoxy-D-glucose: a promising radio sensitiser
    R Vijayaraghavan
    Defence Research and Development Establishment, Gwalior 474002, India
    Biomed Environ Sci 19:96-103. 2006
    ..To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models...
  39. ncbi request reprint Role of free radicals and antioxidants in health and disease
    S J S Flora
    Division of Pharmacology and Toxicology Defence Research and Development Establishment Jhansi Road, Gwalior 474 002, India
    Cell Mol Biol (Noisy-le-grand) 53:1-2. 2007
  40. ncbi request reprint Meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA effect on gallium arsenide induced pathological liver injury in rats
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Raod, 474 002, Gwalior, India
    Toxicol Lett 132:9-17. 2002
    ..Histopathological lesions also, responded more favorably to chelation treatment with MiADMSA than DMSA...
  41. ncbi request reprint Arsenic and fluoride: two major ground water pollutants
    Swapnila Chouhan
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior 474 002, India
    Indian J Exp Biol 48:666-78. 2010
    ....
  42. doi request reprint Electroantennogram, flight orientation, and oviposition responses of Aedes aegypti to the oviposition pheromone n-heneicosane
    T Seenivasagan
    Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002 MP, India
    Parasitol Res 104:827-33. 2009
    ..The possible use of this compound in monitoring of mosquito population in endemic areas in relevance to integrated vector management strategies is discussed in detail...
  43. doi request reprint Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species
    S J S Flora
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, India
    Biometals 24:615-28. 2011
    ..Moreover, it may be concluded that arsenic and/or fluoride cardio-respiratory toxicity may be mediated via oxidative stress. However, these results are new in the discipline thus requires further exploration...