Shiv Kumar Sarin

Summary

Affiliation: Sehgal Nursing Home
Country: India

Publications

  1. ncbi Extrahepatic portal vein obstruction
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Semin Liver Dis 22:43-58. 2002
  2. ncbi Consensus on extra-hepatic portal vein obstruction
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, New Delhi, India
    Liver Int 26:512-9. 2006
  3. ncbi Endoscopic variceal ligation plus propranolol versus endoscopic variceal ligation alone in primary prophylaxis of variceal bleeding
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 100:797-804. 2005
  4. ncbi Differentiating acute hepatitis B from the first episode of symptomatic exacerbation of chronic hepatitis B
    Manoj Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Dig Dis Sci 51:594-9. 2006
  5. ncbi Noncirrhotic portal hypertension
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Room 201, Academic Block, New Delhi 110 002, India
    Clin Liver Dis 10:627-51, x. 2006
  6. ncbi Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding
    S K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    N Engl J Med 340:988-93. 1999
  7. ncbi A randomized trial of a 4- vs 12-week daily interferon dose regimen combined with ribavirin in treatment of patients with chronic hepatitis C
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi 110002, India
    Hepatobiliary Pancreat Dis Int 3:42-8. 2004
  8. pmc Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, Jawahar Lal Nehru Road, New Delhi, 110 002, India
    Hepatol Int 3:269-82. 2009
  9. pmc Noncirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and treatment
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, Room 201, Academic Block, New Delhi, 110 002, India
    Hepatol Int 1:398-413. 2007
  10. pmc Primary prophylaxis of gastroesophageal variceal bleeding: consensus recommendations of the Asian Pacific Association for the Study of the Liver
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, New Delhi, 110 002, India
    Hepatol Int 2:429-39. 2008

Collaborators

Detail Information

Publications114 found, 100 shown here

  1. ncbi Extrahepatic portal vein obstruction
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Semin Liver Dis 22:43-58. 2002
    ....
  2. ncbi Consensus on extra-hepatic portal vein obstruction
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, New Delhi, India
    Liver Int 26:512-9. 2006
    ..This article summarizes all the consensus statements approved by the APASL on various aspects of EHPVO...
  3. ncbi Endoscopic variceal ligation plus propranolol versus endoscopic variceal ligation alone in primary prophylaxis of variceal bleeding
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 100:797-804. 2005
    ..This prospective randomized controlled trial compared endoscopic variceal ligation (EVL) with propranolol and EVL alone in the prevention of first variceal bleed among patients with high-risk varices...
  4. ncbi Differentiating acute hepatitis B from the first episode of symptomatic exacerbation of chronic hepatitis B
    Manoj Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Dig Dis Sci 51:594-9. 2006
    ..Clinical and biochemical features do not help in differentiating the two...
  5. ncbi Noncirrhotic portal hypertension
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Room 201, Academic Block, New Delhi 110 002, India
    Clin Liver Dis 10:627-51, x. 2006
    ..These are described in detail...
  6. ncbi Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding
    S K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    N Engl J Med 340:988-93. 1999
    ....
  7. ncbi A randomized trial of a 4- vs 12-week daily interferon dose regimen combined with ribavirin in treatment of patients with chronic hepatitis C
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi 110002, India
    Hepatobiliary Pancreat Dis Int 3:42-8. 2004
    ..However, the duration of daily dosage protocol and the likely side-effects have not been well studied. We compared the efficacy and safety of a 4- vs 12-week daily IFN dosage in patients with CHC...
  8. pmc Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, Jawahar Lal Nehru Road, New Delhi, 110 002, India
    Hepatol Int 3:269-82. 2009
    ..The consensus statements along with relevant background information are presented in this review...
  9. pmc Noncirrhotic portal fibrosis/idiopathic portal hypertension: APASL recommendations for diagnosis and treatment
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, Room 201, Academic Block, New Delhi, 110 002, India
    Hepatol Int 1:398-413. 2007
    ..This article includes the statements approved by the APASL along with brief backgrounds of various aspects of the disease...
  10. pmc Primary prophylaxis of gastroesophageal variceal bleeding: consensus recommendations of the Asian Pacific Association for the Study of the Liver
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, New Delhi, 110 002, India
    Hepatol Int 2:429-39. 2008
    ..Only those statements that were unanimously approved by the experts were accepted. These statements were circulated to all the experts and were subsequently presented at the annual conference of the APASL at Kyoto, Japan, in March 2007...
  11. ncbi Beneficial effects of 'lamivudine pulse' therapy in HBeAg-positive patients with normal ALT*
    S K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Viral Hepat 11:552-8. 2004
    ..5 ULN) patients to treat-worthy (ALT > 1.5 ULN) in 42%, with sustained HBeAg and HBV DNA loss in 31% patients. The effects are possibly because of a combination of antiviral and immunomodulating activities of lamivudine...
  12. pmc Should chronic HBV infected patients with normal ALT treated: debate
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, 110002, India
    Hepatol Int 2:179-84. 2008
    ..Patients with CHBV infection with normal ALT should be considered for treatment based on the HBV DNA levels and histological injury...
  13. ncbi Evaluation of endoscopic variceal ligation (EVL) versus propanolol plus isosorbide mononitrate/nadolol (ISMN) in the prevention of variceal rebleeding: comparison of cirrhotic and noncirrhotic patients
    Shiv K Sarin
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Dig Dis Sci 50:1538-47. 2005
    ..However, in view of the small number of NCPH patients, further studies are needed before this can be stated conclusively...
  14. ncbi Hepatic venous pressure gradient in cirrhosis: role in variceal bleeding, non-bleeding complications and outcome
    B C Sharma
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Asian J Surg 29:113-9. 2006
  15. ncbi Isolated gastric varices: prevalence, clinical relevance and natural history
    S K Sarin
    Departments of Gastroenterology and Gastrointestinal Surgery, GB Pant Hospital, New Delhi, India
    Dig Surg 20:42-7. 2003
    ..Isolated ectopic gastric varices (IGV2) are present either in the body or antrum of the stomach or upper duodenum. The prevalence, natural history and clinical significance of these varices has not been adequately described...
  16. ncbi High dose vitamin K3 infusion in advanced hepatocellular carcinoma
    Shiv K Sarin
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 21:1478-82. 2006
    ..The aim of this study was to assess the clinical efficacy of high dose vitamin K3 in the treatment of advanced HCC with portal vein thrombosis...
  17. ncbi Profile of hepatocellular carcinoma in India: an insight into the possible etiologic associations
    S K Sarin
    Department of Gastroenterology, Govid Ballabh Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 16:666-73. 2001
    ..Several etiologic factors including hepatitis viruses, alcohol and aflatoxin have been implicated in the pathogenesis of hepatocellular carcinoma (HCC). There is, however, limited information from the Indian subcontinent...
  18. ncbi Gastric varices and portal hypertensive gastropathy
    S K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Clin Liver Dis 5:727-67, x. 2001
    ..Further advances are still needed regarding natural history, risk factors, bleeding, and mechanism of GV rupture...
  19. ncbi Non-cirrhotic portal fibrosis: current concepts and management
    S K Sarin
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 17:526-34. 2002
    ..The prognosis of patients with NCPF is good and 5 years survival in patients in whom variceal bleeding can be controlled has been reported to be approximately 95-100%...
  20. pmc Diagnosis and management of acute variceal bleeding: Asian Pacific Association for Study of the Liver recommendations
    Shiv Kumar Sarin
    Department of Hepatology, Institute of Liver and Biliary Sciences ILBS, New Delhi, India
    Hepatol Int 5:607-24. 2011
    ..There is also a need to include the literature from the Eastern and Asian countries where majority of patients with portal hypertension (PHT) live...
  21. ncbi Non-cirrhotic portal fibrosis
    S K Sarin
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 17:S214-23. 2002
    ..The prognosis of patients with NCPF is good and 5-years survival rates in patients in whom variceal bleeding can be controlled is about > 95%...
  22. ncbi Summary and recommendations of single theme conferences on hepatitis B and C: Indian Association for Study of the Liver (INASL)
    S K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 17:S197-203. 2002
  23. doi Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India
    - Sukriti
    Department of Gastroenterology, G B Pant Hospital, New Dehli, India
    J Gastroenterol Hepatol 23:1710-5. 2008
    ..India is second to China in the numbers of people with chronic HBV. This study aimed to investigate the vaccination practices and the prevalence of HBV infection in HCWs in India...
  24. doi Gene expression profiles of T cells from hepatitis E virus infected patients in acute and resolving phase
    Nirupma TrehanPati
    Institute of Liver and Biliary Sciences, d 1, Vasant Kunj, 110 070, New Delhi, India
    J Clin Immunol 31:498-508. 2011
    ..However, there is a paucity of data on the global gene expression programs activated on T cells, which are subsequently responsible for T cell recruitment to the liver and triggering of immune injury...
  25. doi Hepatitis B virus genotypes and hepatitis B surface antigen mutations in family contacts of hepatitis B virus infected patients with occult hepatitis B virus infection
    Gollapudi Tarun Kumar
    Department of Gastroenterology, G B Pant Hospital, New Dehli 110002, India
    J Gastroenterol Hepatol 24:588-98. 2009
    ..The association and profile of surface gene mutations with viral genotypes have been studied in patients with chronic hepatitis B virus (HBV) but not in subjects with occult HBV infection...
  26. pmc Identification and characterization of genotype A and D recombinant hepatitis B virus from Indian chronic HBV isolates
    Ranjit Chauhan
    Department of Gastroenterology, G B Pant Hospital, Delhi University Affiliated, Room No 201, Academic Block, New Delhi 110002, India
    World J Gastroenterol 14:6228-36. 2008
    ..To confirm the presence of recombination, full-length hepatitis B virus (HBV) from chronic patients was sequenced and analyzed...
  27. doi Liver stiffness measurements in patients with different stages of nonalcoholic fatty liver disease: diagnostic performance and clinicopathological correlation
    Ramesh Kumar
    Department of Hepatology, Institute of Liver and Biliary Sciences ILBS, Sector D1, Vasant Kunj, New Delhi, 110070, India
    Dig Dis Sci 58:265-74. 2013
    ..The present study evaluated performance characteristics of liver stiffness measurement (LSM) by FibroScan in patients with different stages of nonalcoholic fatty liver disease (NAFLD)...
  28. doi Addition of propranolol and isosorbide mononitrate to endoscopic variceal ligation does not reduce variceal rebleeding incidence
    Ashish Kumar
    Department of Medical Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India
    Gastroenterology 137:892-901, 901.e1. 2009
    ..Addition of isosorbide mononitrate (ISMN) to propranolol improves its hemodynamic efficacy; we investigated whether a combination of EVL and propranolol/ISMN was more effective than EVL alone for secondary prophylaxis...
  29. ncbi Endoscopic cyanoacrylate injection versus beta-blocker for secondary prophylaxis of gastric variceal bleed: a randomised controlled trial
    Smruti Ranjan Mishra
    Department of Gastroenterology, G B Pant Hospital, 201 Academic Block, New Delhi 110002, India
    Gut 59:729-35. 2010
    ..A comparison of the efficacy of beta-blocker treatment and cyanoacrylate injection for the prevention of gastric variceal rebleeding was carried out...
  30. doi Equal efficacy of endoscopic variceal ligation and propranolol in preventing variceal bleeding in patients with noncirrhotic portal hypertension
    Shiv Kumar Sarin
    Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India
    Gastroenterology 139:1238-45. 2010
    ..We compared the efficacy and safety of the β-blocker propranolol with that of EVL in preventing the recurrence of variceal bleeding in patients with NCPH...
  31. doi Predictors of nonresponse to lactulose in patients with cirrhosis and hepatic encephalopathy
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Eur J Gastroenterol Hepatol 22:526-31. 2010
    ..Lactulose is commonly used in the treatment of hepatic encephalopathy (HE). However, all patients do not respond to lactulose. We evaluated predictors of nonresponse to lactulose in patients with cirrhosis and HE...
  32. doi Secondary prophylaxis of hepatic encephalopathy in cirrhosis: an open-label, randomized controlled trial of lactulose, probiotics, and no therapy
    Amit Agrawal
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 107:1043-50. 2012
    ..No study has been conducted on the secondary prophylaxis of HE using probiotics. Our objective was to study the effects of lactulose and probiotics for secondary prophylaxis of HE...
  33. doi Neuropsychological impairment in severe acute viral hepatitis is due to minimal hepatic encephalopathy
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Liver Int 29:260-4. 2009
    ..Its prevalence in acute viral hepatitis (AVH) is not known...
  34. doi An open-label randomized controlled trial of lactulose and probiotics in the treatment of minimal hepatic encephalopathy
    Praveen Sharma
    Departments of aGastroenterology bNeurology, G B Pant Hospital, New Delhi, India
    Eur J Gastroenterol Hepatol 20:506-11. 2008
    ..Treatment with lactulose and probiotics has shown some benefit. We compared lactulose with probiotics and a combination of lactulose plus probiotics in the treatment of MHE...
  35. doi Steatosis in chronic hepatitis B: prevalence and correlation with biochemical, histologic, viral, and metabolic parameters
    Archana Rastogi
    Department of Pathology, GB Pant Hospital, New Delhi, India
    Indian J Pathol Microbiol 54:454-9. 2011
    ..There are limited data on HS in patients with chronic hepatitis B (CHB). This is relevant since response to current antiviral therapies for CHB is rather limited. We investigated the spectrum and predictors of HS in CHB patients...
  36. ncbi Inhibition of hepatitis B virus DNA replicative intermediate forms by recombinant interferon-gamma
    Mohammad Khalid Parvez
    Department of Biosciences, Jamia Millia Islamia, New Delhi, Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    World J Gastroenterol 12:3006-14. 2006
    ..To evaluate the in vitro anti-HBV activity of recombinant human IFN-gamma, alone and in combination with lamivudine...
  37. doi Serum endotoxin and inflammatory mediators in patients with cirrhosis and hepatic encephalopathy
    Lokesh Jain
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Dig Liver Dis 44:1027-31. 2012
    ..The aim of the study was to measure arterial ammonia, tumour necrosis factor-alpha, Interleukin-6, Interleukin-18, and serum endotoxin levels and their correlation with different grades of hepatic encephalopathy...
  38. doi Primary prophylaxis of overt hepatic encephalopathy in patients with cirrhosis: an open labeled randomized controlled trial of lactulose versus no lactulose
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 27:1329-35. 2012
    ..Lactulose is used for the treatment of HE. There is no study on the prevention of overt HE using lactulose in patients who never had HE earlier...
  39. doi Clinical profile and predictors of mortality in patients of acute-on-chronic liver failure
    Hitendra Garg
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Dig Liver Dis 44:166-71. 2012
    ..We studied the clinical, biochemical and etiological profiles of ACLF patients investigating variables which could predict mortality...
  40. doi Clinical, laboratory, and hemodynamic parameters in portal hypertensive gastropathy: a study of 254 cirrhotics
    Ashish Kumar
    Department of Hepatology, Institute of Liver and Biliary Sciences, G B Pant Hospital, University of Delhi, New Delhi, India
    J Clin Gastroenterol 44:294-300. 2010
    ..It is also not clear whether altered vascular hemodynamics occurring in PHG is purely a local phenomenon of the stomach or is it a part of a generalized vascular abnormality of cirrhosis and portal hypertension...
  41. ncbi Higher efficacy of sequential therapy with interferon-alpha and lamivudine combination compared to lamivudine monotherapy in HBeAg positive chronic hepatitis B patients
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, Affiliated to the University of Delhi, India
    Am J Gastroenterol 100:2463-71. 2005
    ..A sequential combination may have better therapeutic effects by sustained viral suppression combined with immunomodulation...
  42. doi Circulating Tregs correlate with viral load reduction in chronic HBV-treated patients with tenofovir disoproxil fumarate
    Nirupma TrehanPati
    Institute of Liver and Biliary Sciences ILBS, d 1, Vasant Kunj, New Delhi, 110 070, India
    J Clin Immunol 31:509-20. 2011
    ..Blockage of PD-1/PDL1, enhanced cytokine production in eAg+ve patients but not in eAg-ve, suggests that distinctly different immunologic mechanisms are involved in eAg+ve and eAg-ve patients...
  43. ncbi Prevalence of abnormal psychometric tests and critical flicker frequency after clinical recovery of overt hepatic encephalopathy
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi 110 002, India
    Neurol India 58:220-4. 2010
    ..It may seriously impair the patient's daily functioning and quality of life. Prevalence of abnormal psychometric tests after the clinical recovery of overt encephalopathy has not been studied...
  44. ncbi Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Hepatobiliary Pancreat Dis Int 9:27-32. 2010
    ..Diagnosis of MHE requires cumbersome tests. Lactulose is effective in the treatment of MHE. This study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after treatment...
  45. ncbi Distribution of hepatitis C virus genotypes in patients with chronic hepatitis C infection in India
    Sompal Singh
    Department of Pathology, G B Pant Hospital, New Delhi, India
    Indian J Med Res 119:145-8. 2004
    ..The present study was undertaken with the objective to find out various genotypes of hepatitis C virus prevalent in Indian patients with chronic hepatitis C infection...
  46. ncbi Risk factors analysis for hepatocellular carcinoma in patients with and without cirrhosis: a case-control study of 213 hepatocellular carcinoma patients from India
    Manoj Kumar
    Department of Gastroenterology, GB Pant Hospital, Affiliated to the University of Delhi, New Delhi, India
    J Gastroenterol Hepatol 22:1104-11. 2007
    ..To assess the role of hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol intake as risk factors for hepatocellular carcinoma (HCC) in the presence or absence of cirrhosis in Indian population...
  47. doi Hepatic and systemic hemodynamic derangements predict early mortality and recovery in patients with acute-on-chronic liver failure
    Hitendra Garg
    Department of Hepatology, Institute of Liver and Biliary Sciences ILBS, New Delhi, India Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 28:1361-7. 2013
    ..The portal and systemic hemodynamics in ACLF patients to study its relevance in determining the clinical outcomes was studied...
  48. doi Cirrhosis histology and Laennec staging system correlate with high portal pressure
    Archana Rastogi
    Department of Pathology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India
    Histopathology 62:731-41. 2013
    ..To correlate cirrhosis histology and Laennec fibrosis scoring with portal pressure, as determined by hepatic venous pressure gradient (HVPG)...
  49. doi Liver and spleen stiffness in patients with extrahepatic portal vein obstruction
    Praveen Sharma
    Department of Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi 110070, India
    Radiology 263:893-9. 2012
    ..To evaluate liver stiffness (LS) and spleen stiffness (SS) in patients with extrahepatic portal vein obstruction (EHPVO)...
  50. doi A randomized controlled trial comparing lactulose, probiotics, and L-ornithine L-aspartate in treatment of minimal hepatic encephalopathy
    Vibhu Vibhas Mittal
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, New Delhi, India
    Eur J Gastroenterol Hepatol 23:725-32. 2011
    ..Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL). The modalities of treatment of MHE have not been adequately studied...
  51. doi Natural history of minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 104:885-90. 2009
    ..Whether MHE predicts HE in extrahepatic portal vein obstruction (EHPVO) is not known. We studied the incidence of overt HE in EHPVO patients with MHE...
  52. ncbi Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India
    Syed Naqui Kazim
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Intervirology 49:152-60. 2006
    ..Besides vaccine escape or immune escape hepatitis B virus (HBV) mutants, naturally occurring and drug-induced mutations have been reported in the surface gene (S-gene) of HBV...
  53. ncbi Effect of lowering HBV DNA levels by initial antiviral therapy before adding immunomodulator on treatment of chronic hepatitis B
    Shiv Kumar Sarin
    Department of Gastroenterology and Hepatology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 102:96-104. 2007
    ..It is unclear whether an initial phase of antiviral treatment to lower HBV DNA levels before adding immunomodulator therapy is more effective than the strategy of using immunomodulators from the beginning...
  54. ncbi Two-tier regenerative response in liver failure in humans
    Archana Rastogi
    Department of Pathology, Institute of Liver and Biliary Sciences, d 1, Vasant Kunj, New Delhi, 110070, India
    Virchows Arch 464:565-73. 2014
    ..More HPC differentiate to hepatocytes in ACLF than in CHD, reflecting better regenerative potential in ACLF...
  55. doi Randomized controlled trial for endoscopy with propofol versus midazolam on psychometric tests and critical flicker frequency in people with cirrhosis
    Amit Agrawal
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 27:1726-32. 2012
    ..The aim of the present study was to compare the effects of sedation for upper gastrointestinal endoscopy (UGIE) with propofol and midazolam on psychometric tests and critical flicker frequency (CFF) in people with cirrhosis...
  56. doi Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure
    Vishal Garg
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Gastroenterology 142:505-512.e1. 2012
    ..Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration...
  57. doi Primary prophylaxis of gastric variceal bleeding comparing cyanoacrylate injection and beta-blockers: a randomized controlled trial
    Smruti Ranjan Mishra
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Hepatol 54:1161-7. 2011
    ..Gastric variceal bleeding is severe and is associated with high mortality. We compared the efficacy of cyanoacrylate injection and beta-blockers in primary prophylaxis of gastric variceal bleeding...
  58. ncbi Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection
    Nirupma TrehanPati
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Hepatology 49:781-90. 2009
    ..Subsequent down-regulated effector functions support the hypothesis of suppressed CD4+ effector T cells favoring viral persistence in the chronic infection stage...
  59. ncbi Independent predictors of steatohepatitis and fibrosis in Asian Indian patients with non-alcoholic steatohepatitis
    Deepak Kumar Singh
    Department of Pathology, Govind Ballabh Pant Hospital, Jawahar Lal Nehru Marg, New Delhi 110002, India
    Dig Dis Sci 53:1967-76. 2008
    ..To identify the clinical and biochemical predictors of histologic disease severity in patients with non-alcoholic steatohepatitis (NASH)...
  60. doi Prevalence of hepatitis C virus in a selected geographical area of northern India: a population based survey
    Ajit Sood
    Department of Gastroenterology, Dayanand Medical College, Tagore Nagar, Civil Lines, Ludhiana, 141 001, India
    Indian J Gastroenterol 31:232-6. 2012
    ..Epidemiological data on hepatitis C virus (HCV) infection from India are scanty. We conducted a population-based seroepidemiologic survey to estimate the prevalence of hepatitis C in Punjab state of northern India...
  61. doi Hepatic stellate cells are involved in the pathogenesis of acute-on-chronic liver failure (ACLF)
    Archana Rastogi
    Department of Pathology, Institute of Liver and Biliary Sciences, d 1, Vasant Kunj, New Delhi 110070, India
    Virchows Arch 461:393-8. 2012
    ..There is a significant relationship between the presence of HSCs and that of HPCs, indicating a possible dynamic role of HSCs in liver regeneration and pathobiology of ACLF...
  62. doi Prevalence, risk factors and virological profile of chronic hepatitis B virus infection in pregnant women in India
    Chandana Pande
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Med Virol 83:962-7. 2011
    ..In conclusion, the prevalence of HBsAg positivity among asymptomatic pregnant women in North India is 1.1% with 71% having high HBV DNA levels. These women may have a high risk of transmitting infection to their newborns...
  63. doi Addition of probiotics to norfloxacin does not improve efficacy in the prevention of spontaneous bacterial peritonitis: a double-blind placebo-controlled randomized-controlled trial
    Chandana Pande
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Eur J Gastroenterol Hepatol 24:831-9. 2012
    ..Spontaneous bacterial peritonitis (SBP) may occur despite antibiotic prophylaxis. We investigated whether the addition of probiotics to norfloxacin enhances its efficacy in the prevention of SBP...
  64. ncbi Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent
    Varsha Thakur
    Department of Gastroenterology, Gobind Ballabh Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 17:165-70. 2002
    ..We undertook to study the prevalence and significance of HBV genotypes in the Indian subcontinent...
  65. ncbi Hemodynamic studies in acute-on-chronic liver failure
    Ashish Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Dig Dis Sci 54:869-78. 2009
    ..We studied the portal, systemic, and pulmonary hemodynamics in patients with ACLF and compared them with compensated and decompensated cirrhotics...
  66. doi Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients
    Deepak Kumar Singh
    Department of Pathology, G B Pant Hospital, Delhi, India
    Indian J Pathol Microbiol 53:408-13. 2010
    ..The most difficult aspect of establishing a diagnosis of NASH is distinguishing it from ASH. Laboratory markers such as AST, ALT and GGT lack sufficient sensitivity and specificity...
  67. ncbi Association of core promoter mutations with viral breakthrough in chronic hepatitis B patients on long-term lamivudine therapy
    Syed Naqui Kazim
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 21:1525-32. 2006
    ..The YMDD mutant at the onset of VBTH and/or subsequently was seen in eight (47%) of 17 such patients. We investigated other potential loci in the viral genome contributing to VBTH...
  68. doi Association of adiponectin gene functional polymorphisms (-11377C/G and +45T/G) with nonalcoholic fatty liver disease
    Abhishak Chandra Gupta
    Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India
    Gene 496:63-7. 2012
    ..02 and 0.01) respectively. -11377G and +45G alleles are associated with severity of liver disease and hypoadiponectemia, in the patients with NAFLD, respectively...
  69. ncbi Liver histology as predictor of outcome in patients with acute-on-chronic liver failure (ACLF)
    Archana Rastogi
    Department of Pathology, Institute of Liver and Biliary Sciences ILBS, d 1, Vasant Kunj, New Delhi, 110 070, India
    Virchows Arch 459:121-7. 2011
    ..Two distinct patterns of liver histology are seen which help in prognostication...
  70. doi Prevention of hepatorenal syndrome in patients with cirrhosis and ascites: a pilot randomized control trial between pentoxifylline and placebo
    Pankaj Tyagi
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Eur J Gastroenterol Hepatol 23:210-7. 2011
    ..Pentoxifylline is effective in prevention of hepatorenal syndrome (HRS) in alcoholic hepatitis. The aim of this study was to assess the efficacy of pentoxifylline for prophylaxis of HRS in patients with cirrhosis and ascites...
  71. doi Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure
    Hitendra Garg
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Hepatology 53:774-80. 2011
    ..More than 2 log reduction in HBV DNA levels at 2 weeks was found to be an independent predictor of survival...
  72. doi Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo
    Barjesh Chander Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Gastroenterology 137:885-91, 891.e1. 2009
    ..Hepatic encephalopathy (HE) is associated with a poor prognosis. Lactulose is used for the treatment of HE. There is no study on the prevention of recurrence of HE using lactulose...
  73. doi Infliximab monotherapy for severe alcoholic hepatitis and predictors of survival: an open label trial
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, New Delhi, India
    J Hepatol 50:584-91. 2009
    ..There is a scarcity of data regarding the safety and efficacy of infliximab monotherapy in the treatment of AH. We evaluated infliximab monotherapy in patients with severe AH...
  74. ncbi Association between vitamin D receptor, CCR5, TNF-alpha and TNF-beta gene polymorphisms and HBV infection and severity of liver disease
    Pothakamuri Venkata Suneetha
    Department of Gastroenterology, GB Pant Hospital, New Delhi 2, India
    J Hepatol 44:856-63. 2006
    ..We studied the association of single nucleotide polymorphisms in genes involved in immunoregulatory functions of vitamin-D with susceptibility, severity and persistence of HBV infection...
  75. ncbi Primary biliary cirrhosis in India
    Shiv Kumar Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi 110002, India
    Hepatobiliary Pancreat Dis Int 5:105-9. 2006
    ..Primary biliary cirrhosis (PBC) is a rare cause of chronic liver disease in India. We analyzed the clinical, biochemical, serological and histological features of patients with PBC for over a 10-year period...
  76. doi Impaired antigen processing and presentation machinery is associated with immunotolerant state in chronic hepatitis B virus infection
    Sukriti Sukriti
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, 201, Academic Block, New Delhi, India
    J Clin Immunol 30:419-25. 2010
    ....
  77. ncbi Hepatic venous pressure gradient measurement: time to learn!
    Ashish Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Indian J Gastroenterol 27:74-80. 2008
    ..HVPG above 12 mmHg is the threshold pressure for variceal rupture. The main advantages of HVPG are its simplicity, reproducibility, and safety. This review summarizes the technique of the HVPG measurement...
  78. doi Natural history of hepatic fibrosis progression in chronic hepatitis C virus infection in India
    Syed S Hissar
    Department of Gastroenterology, G B Pant Hospital, New Dehli 110002, India
    J Gastroenterol Hepatol 24:581-7. 2009
    ..The rate of fibrosis progression per year can predict the time for the development of cirrhosis in chronic hepatitis C (CHC). We assessed the rate of fibrosis progression and the predictors of disease severity in Indian CHC patients...
  79. ncbi Antiviral therapy in advanced chronic liver disease due to hepatitis C virus infection: pilot study
    Rakesh Kumar
    Department of Gastroenterolgy, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 20:527-35. 2005
    ..The titrable dose of interferon (IFN)-alpha and ribavirin was evaluated in a flexible regimen in a pilot study...
  80. pmc Systemic and pulmonary hemodynamics in patients with extrahepatic portal vein obstruction is similar to compensated cirrhotic patients
    Sanjeev Kumar Jha
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, Room 201, Academic Block, New Delhi, 110 002, India
    Hepatol Int 3:384-91. 2009
    ..The main aim of our study was, therefore, to evaluate alterations of systemic and pulmonary vascular systems in patients with EHPVO and compare them with patients with compensated cirrhosis...
  81. pmc Systemic and pulmonary hemodynamics in patients with non-cirrhotic portal fibrosis (NCPF) is similar to compensated cirrhosis
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, Affiliated to University of Delhi, Room 201, Academic Block, New Delhi, 110 002, India
    Hepatol Int 1:275-80. 2007
    ..While the hepatic parenchyma and liver functions are normal, the patho-anatomic defect in these patients is pre- and peri-sinusoidal in nature...
  82. doi Predictors of nonresponse to lactulose for minimal hepatic encephalopathy in patients with cirrhosis
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Liver Int 29:1365-71. 2009
    ..Lactulose is effective in the treatment of MHE. However, not all patients respond to lactulose. We evaluated predictors of nonresponse to lactulose...
  83. ncbi CCR5Delta32 mutation does not influence the susceptibility to HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C
    Ankur Goyal
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, New Delhi 110002 and Adjunct Professor, Molecular Medicine, Jawaharlal Lal Nehru University, New Delhi, India
    World J Gastroenterol 12:4721-6. 2006
    ..To study whether CCR5Delta32 mutation was associated with viral infection and severity of liver disease...
  84. ncbi A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices
    Shiv K Sarin
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 97:1010-5. 2002
    ..A prospective study was undertaken to compare the efficacy and safety of GV sclerotherapy using alcohol and GV obturation using cyanoacrylate glue...
  85. ncbi The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India
    Ankur Goyal
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, New Delhi, India
    Med Microbiol Immunol 196:11-21. 2007
    ....
  86. ncbi Predictors of histological activity and fibrosis in chronic Hepatitis C infection: a study from North India
    Sompal Singh
    Department of Pathology, G B Pant Hospital, New Delhi 110 002, India
    Indian J Pathol Microbiol 53:238-43. 2010
    ..An attempt has also been made to perform a multivariate analysis to identify the predictors of severity of liver disease in chronic HCV infection...
  87. ncbi Norfloxacin and cisapride combination decreases the incidence of spontaneous bacterial peritonitis in cirrhotic ascites
    Bimaljit S Sandhu
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 20:599-605. 2005
    ..The purpose of the present paper was (i) to study whether addition of a prokinetic agent to norfloxacin ameliorates the development of SBP in high-risk patients; and (ii) to identify risk factors for SBP development...
  88. ncbi Prevalence of autonomic dysfunction in cirrhotic and noncirrhotic portal hypertension
    Manisha Rangari
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 97:707-13. 2002
    ..We evaluated the presence and extent of autonomic dysfunction in patients with extrahepatic portal venous obstruction (EHPVO) and noncirrhotic portal fibrosis (NCPF), diseases with relatively preserved liver functions...
  89. ncbi Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease
    Syed S Hissar
    Department of Gastroenterology and Advanced Center for Liver Diseases, GB Pant Hospital, Affiliated to the University of Delhi, New Delhi, India
    J Med Virol 78:452-8. 2006
    ..In conclusion, genotype 3 is the most prevalent genotype in patients with chronic hepatitis C in North and Central India and this is associated with significant hepatic steatosis and fibrosis...
  90. ncbi Efficacy of granulocyte-macrophage colony-stimulating factor or lamivudine combination with recombinant interferon in non-responders to interferon in hepatitis B virus-related chronic liver disease patients
    Rajkumar C Guptan
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    J Gastroenterol Hepatol 17:765-71. 2002
    ....
  91. ncbi Association of TNF-beta polymorphism with disease severity among patients infected with hepatitis C virus
    Ankur Goyal
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    J Med Virol 72:60-5. 2004
    ..Larger studies including cytokine expression profiles are needed to fully understand the contribution of the polymorphisms described in the pathogenesis of chronic hepatitis C...
  92. ncbi Beneficial effects of pentoxifylline on hepatic steatosis, fibrosis and necroinflammation in patients with non-alcoholic steatohepatitis
    Sanjaya K Satapathy
    Department of Gastroenterology, GB Plant Hospital, New Delhi, India
    J Gastroenterol Hepatol 22:634-8. 2007
    ..Pentoxifylline reduces TNF-alpha and alanine aminotransferase (ALT) levels in patients with NASH. The aim of the present paper was to study if pentoxifylline can improve histological injury in patients with NASH...
  93. doi Hepatic venous pressure gradient as a predictor of fibrosis in chronic liver disease because of hepatitis B virus
    Manoj Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Liver Int 28:690-8. 2008
    ..Sample variability, interobserver variability and step-wise evaluation limit its use. Hepatic venous pressure gradient (HVPG) correlates with hepatic fibrosis in chronic liver disease (CLD) because of hepatitis C...
  94. ncbi Histological profile of liver disease in patients with dual hepatitis B and C virus infection
    Puja Sakhuja
    Department of Pathology, G B Pant Hospital, New Delhi
    Indian J Pathol Microbiol 46:555-8. 2003
    ..Liver biopsies of 25 patients serologically diagnosed as HBV and HCV dual infection (Group I), were compared with 25 age and sex matched cases of HBV infection (Group II) and HCV infection (Group III)...
  95. ncbi Altered alpha adrenergic vasoresponsiveness in a non-cirrhotic portal hypertension model of E. coli injection
    Moattar Raza Rizvi
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, New Delhi, India
    J Gastroenterol Hepatol 22:870-6. 2007
    ..The etiopathogenesis of non-cirrhotic portal fibrosis (NCPF), a common cause of portal hypertension, is still poorly understood. The aim of this study was to investigate the pathophysiology of NCPF in a rabbit model...
  96. ncbi Endoscopic management of postoperative bile leaks
    Naresh Agarwal
    Department of Gastroenterology, GB Pant Hospital, New Delhi, India
    Hepatobiliary Pancreat Dis Int 5:273-7. 2006
    ..Surgical management of biliary fistulae is associated with high morbidity and mortality. Biliary endoscopic procedures have become the treatment of choice for management of biliary fistulae...
  97. ncbi Hepatitis E virus as an etiology of acute exacerbation of previously unrecognized asymptomatic patients with hepatitis B virus-related chronic liver disease
    Manoj Kumar
    Department of Gastroenterology, G B Pant Hospital, University of Delhi, Delhi, India
    J Gastroenterol Hepatol 23:883-7. 2008
    ..We also investigated the effect of superinfection on the clinical spectrum of underlying HBV infection...
  98. doi Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT
    Manoj Kumar
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Gastroenterology 134:1376-84. 2008
    ..We studied the ALT, HBV DNA levels, and spectrum of histologic lesions in such patients...
  99. ncbi Minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 103:1406-12. 2008
    ..Its prevalence in extrahepatic portal vein obstruction (EHPVO) is not known. We studied the prevalence of MHE in EHPVO patients and utility of critical flicker frequency (CFF) for diagnosing MHE...
  100. doi An open label, pilot, randomized controlled trial of noradrenaline versus terlipressin in the treatment of type 1 hepatorenal syndrome and predictors of response
    Praveen Sharma
    Department of Gastroenterology, G B Pant Hospital, New Delhi, India
    Am J Gastroenterol 103:1689-97. 2008
    ..PATIENTS AND Forty consecutive patients with HRS-1 were randomized to receive noradrenaline 0.5-3.0 mg/h and..