Amita Aggarwal

Summary

Affiliation: Sanjay Gandhi Postgraduate Institute of Medical Sciences
Country: India

Publications

  1. ncbi request reprint Elevated concentrations of monocyte derived cytokines in synovial fluid of children with enthesitis related arthritis and polyarticular types of juvenile idiopathic arthritis
    Nandita Saxena
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 32:1349-53. 2005
  2. ncbi request reprint Physical, psychosocial and economic impact of rheumatoid arthritis: a pilot study of patients seen at a tertiary care referral centre
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, Uttar Pradesh
    Natl Med J India 19:187-91. 2006
  3. ncbi request reprint TLR4 endogenous ligand MRP8/14 level in enthesitis-related arthritis and its association with disease activity and TLR4 expression
    Mujeeb T Rahman
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India or
    Rheumatology (Oxford) 53:270-4. 2014
  4. doi request reprint IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA)
    A Aggarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 31:607-11. 2012
  5. pmc Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study
    Tuulikki Sokka
    Jyvaskyla Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    Arthritis Res Ther 12:R42. 2010
  6. doi request reprint Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis
    Vishad Viswanath
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 38:2482-7. 2011
  7. doi request reprint Primary central nervous system lymphoma in rheumatoid arthritis
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India
    J Clin Rheumatol 14:54-5. 2008
  8. ncbi request reprint Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis
    Amita Aggarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226 014
    Rheumatol Int 23:134-7. 2003
  9. ncbi request reprint Cytokine production by peripheral blood mononuclear cells from patients with juvenile idiopathic arthritis
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, UP, India
    Indian Pediatr 39:739-42. 2002
  10. pmc Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA)
    A Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Exp Immunol 148:515-9. 2007

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Elevated concentrations of monocyte derived cytokines in synovial fluid of children with enthesitis related arthritis and polyarticular types of juvenile idiopathic arthritis
    Nandita Saxena
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 32:1349-53. 2005
    ..We measured levels of different monocyte derived cytokines, T cell derived cytokines, and a proinflammatory chemokine in SF specimens from children with ERA or polyarticular (Poly) rheumatoid factor (RF)-negative JIA...
  2. ncbi request reprint Physical, psychosocial and economic impact of rheumatoid arthritis: a pilot study of patients seen at a tertiary care referral centre
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareli Road, Lucknow 226014, Uttar Pradesh
    Natl Med J India 19:187-91. 2006
    ..The impact of the disease in different cultural and social backgrounds is varied. Limited data are available from India on this aspect...
  3. ncbi request reprint TLR4 endogenous ligand MRP8/14 level in enthesitis-related arthritis and its association with disease activity and TLR4 expression
    Mujeeb T Rahman
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India or
    Rheumatology (Oxford) 53:270-4. 2014
    ..Myeloid-related proteins (MRPs) 8 and 14 are calcium binding proteins that act as an endogenous ligand of TLR4. MRP8/14 levels are elevated in patients with systemic-onset arthritis. Thus we studied the role of MRP8/14 in ERA...
  4. doi request reprint IL1 gene polymorphisms in enthesitis related arthritis category of juvenile idiopathic arthritis (ERA-JIA)
    A Aggarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 31:607-11. 2012
    ..IL1*RN2 homozygosity was more common in patients, whereas carriage rate for IL1*RN1 was less frequent in patients. Haplotype frequencies were also similar in both groups. IL-1 gene cluster is not a susceptibility locus for ERA...
  5. pmc Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA study
    Tuulikki Sokka
    Jyvaskyla Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    Arthritis Res Ther 12:R42. 2010
    ..Recent reports suggest that the use of biologic agents offers potential for reduced work disability rates, but the conclusions are based on surrogate disease activity measures derived from studies primarily from Western countries...
  6. doi request reprint Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis
    Vishad Viswanath
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 38:2482-7. 2011
    ....
  7. doi request reprint Primary central nervous system lymphoma in rheumatoid arthritis
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India
    J Clin Rheumatol 14:54-5. 2008
  8. ncbi request reprint Methotrexate inhibits interleukin-6 production in patients with juvenile rheumatoid arthritis
    Amita Aggarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226 014
    Rheumatol Int 23:134-7. 2003
    ..We studied its effect on the production of two proinflammatory cytokines, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha), by peripheral blood cells in patients with JRA...
  9. ncbi request reprint Cytokine production by peripheral blood mononuclear cells from patients with juvenile idiopathic arthritis
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, UP, India
    Indian Pediatr 39:739-42. 2002
  10. pmc Chemokine and chemokine receptor analysis reveals elevated interferon-inducible protein-10 (IP)-10/CXCL10 levels and increased number of CCR5+ and CXCR3+ CD4 T cells in synovial fluid of patients with enthesitis-related arthritis (ERA)
    A Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Exp Immunol 148:515-9. 2007
    ..05). TARC/CCL17 levels in SF were lower than serum. There is increased homing of CCR5 and CXCR3(+) CD4 cells to the SF. Increased SF levels of IP-10/CXCL10 may be responsible for this migration in patients with ERA...
  11. ncbi request reprint Juvenile ankylosing spondylitis--is it the same disease as adult ankylosing spondylitis?
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Rheumatol Int 25:94-6. 2005
    ..Juvenile and adult forms of ankylosing spondylitis (AS) have been shown to have different clinical presentation and outcome in Caucasians. We did this retrospective analysis to see if similar differences exist in the Indian population...
  12. ncbi request reprint Clinical application of tests used in rheumatology
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Pediatr 69:889-92. 2002
    ..Tests with high sensitivity should be used for screening whereas tests with high specificity should be used for confirmation of diagnosis. Finally, mere presence of an abnormal test does not mean disease...
  13. ncbi request reprint A novel predictor of clinical response to methotrexate in patients with rheumatoid arthritis: a pilot study of in vitro T cell cytokine suppression
    Nigil Haroon
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 35:975-8. 2008
    ..MTX inhibits T cell cytokine production, with significant interindividual variability in the dose required. We investigated if the variability in clinical response was related to variability in the in vitro assay...
  14. ncbi request reprint Withania somnifera inhibits NF-kappaB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells
    Divya Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India
    Phytother Res 21:905-13. 2007
    ..The role of additional constituents needs to be studied. Studies on the mechanism of action of the extract may yield potentially useful compounds for the treatment of inflammatory diseases...
  15. ncbi request reprint Juvenile dermatomyositis at a tertiary care hospital: is there any change in the last decade?
    Shiva Prasad
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Int J Rheum Dis 16:556-60. 2013
    ..Juvenile dermatomyositis (JDM) is a rare multisystem disorder of childhood primarily involving the skeletal muscles and skin...
  16. ncbi request reprint Association of tumor necrosis factor alpha and IL-10 promoter polymorphisms with rheumatoid arthritis in North Indian population
    Deepali Gambhir
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Rheumatol Int 30:1211-7. 2010
    ..On the other hand promoter polymorphisms of IL-10 did not affect susceptibility but polymorphism at -819/-592A was associated with higher disease activity scores at baseline...
  17. ncbi request reprint Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases
    Shilpi Agarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 35:515-9. 2008
    ....
  18. doi request reprint Subclinical atherosclerosis and endothelial dysfunction in young South-Asian patients with systemic lupus erythematosus
    Parasar Ghosh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 28:1259-65. 2009
    ..Indian patients with SLE have higher prevalence of subclinical atherosclerosis and endothelial dysfunction. Presence of damage was associated with abnormal IMT in SLE patients...
  19. doi request reprint Identification of immunogenic HLA-B*27:05 binding peptides of salmonella outer membrane protein in patients with reactive arthritis and undifferentiated spondyloarthropathy
    Amit Kumar Singh
    Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 40:173-85. 2013
    ..Because these patients have genetic predisposition to HLA-B*27 and its subtype HLA-B*27:05, we sought to identify immunogenic HLA-B*27:05-binding salmonella OMP peptides in patients with ReA/uSpA...
  20. ncbi request reprint Presence of antibodies to SSB/La is associated with decreased phagocytic efficiency of neutrophils in patients with systemic lupus erythematosus
    Debasis Biswas
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, India
    Clin Rheumatol 27:717-22. 2008
    ..However, there was no difference in the levels of IL-12 between patients with and without history of infection. These data suggest that the autoantibodies to SSB/La may modulate PMN function in SLE...
  21. doi request reprint Th-17 associated cytokines in patients with reactive arthritis/undifferentiated spondyloarthropathy
    Amit Kumar Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 30:771-6. 2011
    ..However, IL-23 was not detectable in SF. Good correlation between IL-17, IL-6, and IL 1β suggest that either they are co-regulated or they regulate each other...
  22. ncbi request reprint Induction of metalloproteinases expression by TLR ligands in human fibroblast like synoviocytes from juvenile idiopathic arthritis patients
    Shilpi Agarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 131:771-9. 2010
    ..We studied the ability of bacterial and viral products to produce matrix metalloproteinases (MMPs) and cytokines by fibroblast like synoviocytes (FLS) from patients with JIA...
  23. doi request reprint Non-organ-specific autoantibodies in Indian patients with chronic liver disease
    Sunilbaran Daschakraborty
    Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India
    Indian J Gastroenterol 31:237-42. 2012
    ..However, various autoantibodies are often detectable in patients with CLD due to other causes too. Since data on autoantibody prevalence in Indian patients with CLD are limited, we decided to undertake the current study...
  24. ncbi request reprint IL1RN*2 allele of IL-1receptor antagonist VNTR polymorphism is associated with susceptibility to ankylosing [corrected] spondylitis in Indian patients
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 27:573-6. 2008
    ..015 and 0.0002). The IL-1RN*2 allele was not associated with any difference in clinical disease expression. The IL-1RN*2 allele is a susceptibility marker for AS in the Indian population but does not influence disease phenotype...
  25. ncbi request reprint Autoantibodies in rheumatoid arthritis: association with severity of disease in established RA
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 26:201-4. 2007
    ..Data on their role in established RA is limited. We studied the association of various autoantibodies in RA with its severity...
  26. doi request reprint Fibromyalgia is common and adversely affects pain and fatigue perception in North Indian patients with rheumatoid arthritis
    Varun Dhir
    Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 36:2443-8. 2009
    ..We studied prevalence and effects of FM in North Indian patients with RA and associations of RA with disease activity...
  27. ncbi request reprint Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy
    Rajeev Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 34:2285-90. 2007
    ..We measured levels of several proinflammatory and immunoregulatory cytokines in SF and sera from patients with ReA/uSpA...
  28. ncbi request reprint Impact of rheumatoid arthritis on quality of life
    Nigil Haroon
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebarelli Road, Lucknow, Uttar Pradesh, 226014, India
    Mod Rheumatol 17:290-5. 2007
    ..Quality of life is compromised in patients with RA. Patients and normal controls scored higher in the social relationship domain. Functional disability is the most important factor affecting QOL in RA...
  29. ncbi request reprint Osteopenia is common in adult male patients with active juvenile idiopathic arthritis
    Parshant Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 33:1642-5. 2006
    ..To assess the prevalence of osteopenia in Southeast Asian men with active juvenile idiopathic arthritis (JIA) and to identify predictors of reduced bone mineral density (BMD)...
  30. doi request reprint Th1 and Th17 Predominance in the Enthesitis-related Arthritis Form of Juvenile Idiopathic Arthritis
    Ankit Mahendra
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 36:1730-6. 2009
    ..We investigated T cell phenotypes including Th1, Th2, Th17, and Treg with emphasis on Th17 and Treg, in order to differentiate cytokines in the enthesitis-related arthritis (ERA) form of JIA...
  31. doi request reprint Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis
    Shilpi Agarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Rheumatol Int 29:907-11. 2009
    ..In addition, ERA patients had lower MMP level as well as MMP/TIMP ratio as compared to poly JIA which may partly explain lesser degree of joint damage seen in ERA as compared to poly JIA...
  32. doi request reprint Leprosy revealed in a rheumatology clinic: a case series
    Shiva Prasad
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Int J Rheum Dis 16:129-33. 2013
    ..At times, these may present to a rheumatology clinic prior to the diagnosis of leprosy. Herein, we present our experience with patients referred with various rheumatological disorders who were subsequently diagnosed as having leprosy...
  33. doi request reprint Adult onset Still's disease: experience from a tertiary care rheumatology unit
    Vishnu V Reddy Munagala
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Int J Rheum Dis 15:e136-41. 2012
    ..Adult-onset Still's disease (AOSD) is a rare chronic inflammatory disorder presenting with prolonged fever and polyarthritis...
  34. ncbi request reprint Outcome in juvenile rheumatoid arthritis in India
    Amita Aggarwal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian Pediatr 41:180-4. 2004
    ..Intramuscular gold and D-Penicillamine were associated with significant drug toxicity. Outcome of children with JRA in our country is poorer as compared to developed countries...
  35. ncbi request reprint Cytochrome P450 polymorphism as a predictor of ovarian toxicity to pulse cyclophosphamide in systemic lupus erythematosus
    Gurmeet Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 34:731-3. 2007
    ..We studied the association of CYP2C19 and CYP2B6 genetic polymorphism with ovarian toxicity in patients with systemic lupus erythematosus (SLE) treated with CYC...
  36. ncbi request reprint Physical disability, articular, and extra-articular damage in patients with juvenile idiopathic arthritis
    Pradip Kumar Sarma
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India
    Clin Rheumatol 27:1261-5. 2008
    ..623), and parent's global assessment (0.446), Almost two-thirds of patients with JIA had articular damage and one third had extra-articular damage. JADI is a good tool to measure damage in children with JIA...
  37. doi request reprint Higher prevalence of extra-articular manifestations in ankylosing spondylitis with peripheral arthritis
    Gurmeet Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Clin Rheumatol 14:264-6. 2008
    ..To study the difference in the clinical presentation of patients of ankylosing spondylitis (AS) with and without peripheral arthritis...
  38. ncbi request reprint Cytokine generation in stored platelet concentrate: comparison of two methods of preparation
    Rajendra Chaudhary
    Department of Transfusion Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 124:427-30. 2006
    ..We compared the levels of these cytokines in stored platelet preparations prepared by two methods. Effect of pre-storage leucofiltration on these cytokine levels was also studied...
  39. ncbi request reprint Immunomodulatory activity of Semecarpus anacardium extract in mononuclear cells of normal individuals and rheumatoid arthritis patients
    Divya Singh
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226 014, India
    J Ethnopharmacol 108:398-406. 2006
    ..7. Our results for the first time show that SA extract can inhibit proinflammatory cytokine production and demonstrate its mechanism of action...
  40. doi request reprint Soluble receptor for advanced glycation endproducts is decreased in patients with juvenile idiopathic arthritis (ERA category) and inversely correlates with disease activity and S100A12 levels
    Arpita Myles
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 38:1994-9. 2011
    ..Decreased sRAGE levels are associated with autoimmune diseases; however, limited data are available in juvenile idiopathic arthritis (JIA). We studied sRAGE levels in patients with JIA [enthesitis-related arthritis (ERA) category]...
  41. doi request reprint Long-term outcome of lupus nephritis in Asian Indians
    Varun Dhir
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Arthritis Care Res (Hoboken) 64:713-20. 2012
    ..There are sparse data on outcome of lupus nephritis from developing countries. This study looks at outcome in Asian Indians...
  42. ncbi request reprint Tailor-made therapy in rheumatoid arthritis: fact or fiction?
    Nigil Haroon
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Isr Med Assoc J 10:139-41. 2008
    ..We also look at specific scores or indices that can help predict the response in individual patients...
  43. ncbi request reprint Outer membrane protein of salmonella is the major antigenic target in patients with salmonella induced reactive arthritis
    Shweta Saxena
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 32:86-92. 2005
    ..The antigens recognized by the synovial T cells in Salmonella induced ReA are not known. We investigated the immunodominant antigens in Salmonella ReA...
  44. ncbi request reprint Low prevalence of IgA deficiency in north Indian population
    Shelly Chandran
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 123:653-6. 2006
    ..No data are available from India. We did a blood donor survey to look for prevalence of IgA deficiency in north India...
  45. ncbi request reprint Lack of clinical association with antibodies to ribosomal P proteins in Indian patients with systemic lupus erythematosus
    Vinod Chandran
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 33:1987-9. 2006
    ..We examined the prevalence and clinical association of the antiribosomal antibodies in our cohort of patients with systemic lupus erythematosus (SLE)...
  46. ncbi request reprint Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation
    Parshant Aggarwal
    Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 124:521-6. 2006
    ..We studied the relationship between the C677T gene polymorphism and toxicity and efficacy of MTX in patients with rheumatoid arthritis (RA) on folate supplementation...
  47. ncbi request reprint Antinuclear antibodies by indirect immunofluorescence : optimum screening dilution for diagnosis of systemic lupus erythematosus
    P Ghosh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Indian J Med Res 126:34-8. 2007
    ..As, there is paucity of such data, we aimed to define the optimum screening dilution that distinguishes the patient with SLE from healthy individuals...
  48. doi request reprint Lack of association of single nucleotide polymorphisms in toll-like receptors 2 and 4 with enthesitis-related arthritis category of juvenile idiopathic arthritis in Indian population
    Arpita Myles
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Rheumatol Int 33:417-21. 2013
    ..The TLR4 Thr399Ileu variant was not detected in patients. Out of 200 healthy controls, 10 were heterozygous (5 %) and only one was homozygous for rare variant (0.5 %). Polymorphisms in TLR2 and TLR4 are not associated with ERA...
  49. ncbi request reprint Methotrexate twice weekly vs once weekly in rheumatoid arthritis: a pilot double-blind, controlled study
    Sapan Pandya
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India
    Rheumatol Int 22:1-4. 2002
    ..Our study suggests that MTX twice weekly has no advantage over once weekly regarding efficacy, and thus the currently used once weekly regimen is good enough till alternate dosing schedules are evaluated in a large multicentric trial...
  50. ncbi request reprint Low levels of anti-histone antibodies in north Indian children with juvenile rheumatoid arthritis
    A Wakhlu
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Indian J Med Res 118:204-7. 2003
    ..There is a paucity of information from India on the levels of AHA in patients of JRA. In this study, an attempt was made to evaluate the levels of IgG and IgM antibodies to histones in children with JRA in north India...
  51. doi request reprint Evidence of cellular immune response to outer membrane protein of Salmonella typhimurium in patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis
    Yogesh Preet Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226014
    J Rheumatol 38:161-6. 2011
    ..In patients with ReA the immune response is targeted at the outer membrane protein (OMP) of Salmonella typhimurium. We studied the immune response in JIA-ERA to S. typhimurium OMP...
  52. ncbi request reprint Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis
    Pradip Kumar Sarma
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 27:289-94. 2008
    ..Further, our data suggest that patients with ERA have similar levels to other forms of JIA. Association of the MMP3/TIMP-1 ratio with disease activity suggests that it may be a useful biomarker for follow-up...
  53. ncbi request reprint Low-dose methotrexate-induced pancytopenia
    Yogesh Preet Singh
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 26:84-7. 2007
    ..There is an urgent need to increase awareness in primary care physicians, patients, and pharmacists toward informed prescribing, dispensing, and monitoring of MTX to prevent such mishaps in the future...
  54. ncbi request reprint Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India
    Rheumatol Int 26:1091-5. 2006
    ..Partial response to iron replacement suggests a component of ACD in these patients. Anemic patients with ACD had more active disease as compared with non-anemic patients or those with IDA...
  55. ncbi request reprint Prevalence of subclinical amyloidosis in ankylosing spondylitis
    Gurmeet Singh
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 34:371-3. 2007
    ..To study the prevalence of secondary amyloidosis in Indian patients with ankylosing spondylitis (AS)...
  56. ncbi request reprint Juvenile onset systemic sclerosis: a single center experience of 23 cases from Asia
    Ramnath Misra
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India
    Clin Rheumatol 26:1259-62. 2007
    ..DSSc and LSSc in childhood have a clinical presentation similar to adult patients, with cardiopulmonary involvement being the major predictor of outcome. The short-term prognosis of JSSc is good...
  57. doi request reprint Membrane-bound toll-like receptors are overexpressed in peripheral blood and synovial fluid mononuclear cells of enthesitis-related arthritis category of juvenile idiopathic arthritis (JIA–ERA) patients and lead to secretion of inflammatory mediators
    Arpita Myles
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    J Clin Immunol 32:488-96. 2012
    ..IL-6 and IL-8 levels were higher in stimulated ERA SFMC compared to ERA PBMC and in ERA PBMC compared to control PBMC. TLRs 1, 3, and 6 were also overexpressed at the protein level...
  58. doi request reprint Translation, cultural adaptation, and validation of the Bath questionnaires and HAQ-S in Hindi for Indian patients with ankylosing spondylitis
    Varun Dhir
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Clin Rheumatol 31:1511-5. 2012
    ..82-0.94), BAS-G ICC 0.75 (0.58-0.86), and HAQ-S ICC 0.91 (0.84-0.95). The Hindi versions of the BASDAI, BASFI, BAS-G, and HAQ-S were found to be valid and reliable for use in Hindi-speaking Indian patients with ankylosing spondylitis...
  59. doi request reprint mTOR signaling pathway regulates the IL-12/IL-10 axis in Leishmania donovani infection
    Satyanarayana Swamy Cheekatla
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Med Microbiol Immunol 201:37-46. 2012
    ..Thus, our data suggests that intracellular network of PI3K and mTOR pathway control IL-12/IL-10 modulation by L. donovani. mTOR inhibitors may be attractive molecules to reverse this modulation and may result in control of disease...
  60. ncbi request reprint Angiomatous malformation: a rare cause of recurrent swelling of the knee joint
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Indian Pediatr 42:937-9. 2005
    ..We report a case of a 13-year-old boy who presented with recurrent episodes of knee joint swelling. Though the history and physical examination was typical, magnetic resonance imaging clinched the diagnosis...
  61. ncbi request reprint Prevalence of secondary amyloidosis in Asian North Indian patients with rheumatoid arthritis
    Anupam Wakhlu
    Department of Immunology and Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 30:948-51. 2003
    ..To study the prevalence of secondary amyloidosis in Asian North Indian patients with rheumatoid arthritis (RA) and to determine its clinical significance...
  62. ncbi request reprint Fibrodysplasia ossificans progressiva: a rare cause of subcutaneous nodules in childhood
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Clin Rheumatol 13:234. 2007
  63. ncbi request reprint Subclinical atherosclerosis in rheumatoid arthritis in India
    Sundeep Grover
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 33:244-7. 2006
    ..Carotid intima-media thickness as measured by ultrasound is a validated surrogate marker of atherosclerosis. We studied the prevalence of subclinical atherosclerosis in Indian patients with RA...
  64. ncbi request reprint Eosinophilic fasciitis
    V Agarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014
    J Assoc Physicians India 52:244-5. 2004
    ..We present a young man who developed eosinophilic fasciitis following severe gymnastic activity...
  65. ncbi request reprint Gold sodium thiomalate (GSTM) inhibits lipopolysaccharide stimulated tumor necrosis factor-alpha through ceramide pathway
    Ashutosh Kumar Mangalam
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, 226014, Lucknow, India
    Cell Immunol 219:1-10. 2002
    ....
  66. ncbi request reprint Methotrexate induced accelerated nodulosis
    V Agarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Assoc Physicians India 52:538-40. 2004
    ..Two patients each were treated with colchicine, D-penicillamine or hydroxy-chloroquine for 3-6 months without any response. We conclude that MIAN is a benign side effect of methotrexate treatment...
  67. ncbi request reprint Synovial fluid mononuclear cell gene expression profiling suggests dysregulation of innate immune genes in enthesitis-related arthritis patients
    Arpita Myles
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Rheumatology (Oxford) 51:1785-9. 2012
    ..PBMCs from healthy subjects were used as controls...
  68. doi request reprint Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis
    Arpita Myles
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India
    Rheumatology (Oxford) 50:481-8. 2011
    ..Microbes initiate immune responses through Toll-like receptors (TLRs). We studied TLR expression on blood and SF monocytes and the effect of TLR ligands on peripheral blood (PB) mononuclear cells (PBMCs) in ERA patients...
  69. ncbi request reprint Parry Romberg syndrome: a close differential diagnosis of linear scleroderma en coup de sabre
    A Wakhlu
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Assoc Physicians India 51:980. 2003
  70. ncbi request reprint Primary Sjogren's syndrome: rarity in India
    R Misra
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India 226 014
    J Assoc Physicians India 51:859-62. 2003
    ..Primary Sjogren's syndrome (SS) is rarely reported from India. We have studied the clinical spectrum and immunological profile of patients with primary SS...
  71. ncbi request reprint Active disease during pregnancy is associated with poor foetal outcome in Indian patients with systemic lupus erythematosus
    Vinod Chandran
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226014, India
    Rheumatol Int 26:152-6. 2005
    ..Thus, the live birth rate in developing countries in SLE mothers is worse compared with developed countries. Active disease during pregnancy is significantly associated with increased foetal loss...
  72. pmc Transfusion-associated immunomodulation: Quantitative changes in cytokines as a measure of immune responsiveness after one time blood transfusion in neurosurgery patients
    Prashant Pandey
    Department of Transfusion Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Asian J Transfus Sci 4:78-85. 2010
    ....
  73. ncbi request reprint Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis
    Dhanita Khanna
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 30:1248-52. 2003
    ..To study the prevalence and antigenic specificity of antineutrophil cytoplasmic autoantibodies (ANCA) in patients with systemic sclerosis (SSc)...
  74. ncbi request reprint Sporadic enteric reactive arthritis and undifferentiated spondyloarthropathy: evidence for involvement of Salmonella typhimurium
    Rajesh Sinha
    Department of Immunology and Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    J Rheumatol 30:105-13. 2003
    ..To define the candidate bacterial trigger and cytokine profile of synovial fluid mononuclear cells (SFMC) in patients with sporadic enteric reactive arthritis (ReA) and undifferentiated spondyloarthropathy (uSpA)...
  75. ncbi request reprint Does cyclophosphamide benefit relapsing thrombotic thrombocytopenic purpura?
    V Agarwal
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    J Assoc Physicians India 50:1440-2. 2002
    ..Cyclophosphamide in our case achieved partial remission without the need for plasma exchange therapy. The rationale of cyclophosphamide in management of relapsing TTP is discussed...
  76. pmc Intramuscular cavernous hemangioma with juxta-articular swelling
    Nigil Haroon
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow, India
    CMAJ 175:1059. 2006
  77. ncbi request reprint Aneurysm of the internal carotid artery in a female patient of Behcet's disease: a rare presentation
    Sumeet Agrawal
    Department of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Clin Rheumatol 26:994-5. 2007
    ....
  78. ncbi request reprint Natural products as a gold mine for arthritis treatment
    Dinesh Khanna
    Division of Immunology, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Curr Opin Pharmacol 7:344-51. 2007
    ....
  79. ncbi request reprint Detection of antinuclear antibodies from filter paper clots using indirect immunoenzyme technique: preliminary experience and results
    Amita Aggarwal
    J Assoc Physicians India 50:286. 2002
  80. ncbi request reprint Systemic lupus erythematosus with major organ involvement in a patient with systemic-onset juvenile idiopathic arthritis
    Pradip Kumar Sarma
    J Rheumatol 34:893-4. 2007