Research Topics

Genomes and Genes


Vandana Rai


Country: India


  1. request reprint
    Rai V. Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations. Asian Pac J Cancer Prev. 2014;15:9259-64 pubmed
    ..1, 95%CI= 0.95-1.2 ; for TT+CT vs CC: OR=1.13, 95%CI=1.0-1.30; for TT vs CC: OR=1.25, 95%CI=1.01-1.30; for TT vs CT+CC: OR=1.16, 95%CI=1.0-1.36). MTHFR C677T polymorphism is significantly associated with lung cancer in Asians. ..
  2. Rai V. Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis. Mol Neurobiol. 2017;54:1173-1186 pubmed publisher
    ..24, 95 % CI?=?1.13-1.35, p?<?0.004; and for TT vs CT + CC OR?=?1.13, 95 % CI?=?1.00-1.28, p?=?0.02). Results of present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD. ..
  3. Yadav U, Kumar P, Gupta S, Rai V. Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis. Asian J Psychiatr. 2016;20:41-51 pubmed publisher
    ..001), Asian (OR=1.21; 95%CI=1.10-1.33; p=<0.001) and Caucasian (OR=1.07; 95%CI=1.01-1.14; p=0.01). In conclusion the results of the present meta-analysis suggested that the MTHFR C677T polymorphism is a risk factor for schizophrenia. ..
  4. request reprint
    Rai V. Evaluation of the MTHFR C677T Polymorphism as a Risk Factor for Colorectal Cancer in Asian Populations. Asian Pac J Cancer Prev. 2015;16:8093-100 pubmed
    ..Further investigations are needed to offer better insight into any role of this polymorphism in colorectal carcinogenesis. ..
  5. Rai V. Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility. Metab Brain Dis. 2016;31:727-35 pubmed publisher
    ..C = 1.68; 95 % CI = 1.02-2.77; p = 0.04) using allele contrast model. In conclusion, present meta-analysis strongly suggested a significant association of the MTHFR C677T polymorphism with autism. ..
  6. Rai V, Yadav U, Kumar P, Yadav S. Methylenetetrahydrofolate reductase polymorphism (c677t) in Muslim population of eastern Uttar Pradesh, India. Indian J Med Sci. 2010;64:219-23 pubmed publisher
    ..The low frequency of T/T genotype in the Muslim population may be due to malnutrition in pregnant women, because of insufficient intake of folate is considered to be a survival disadvantage for foetuses with T/T genotype. ..
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    Rai V. The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations. Asian Pac J Cancer Prev. 2014;15:5853-60 pubmed
    ..63, p=0.0003; TT+CT vs CC (dominant model): OR=1.12, 95%CI=1.01-1.23, p=0.02). The present meta-analysis strongly suggested a significant association between the MTHFR C677T polymorphism and risk of breast cancer in Asian populations. ..