Ranbir C Sobti

Summary

Affiliation: Panjab University
Country: India

Publications

  1. ncbi request reprint CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Biomarkers 8:415-28. 2003
  2. ncbi request reprint Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 156:68-73. 2005
  3. ncbi request reprint Contrasting impact of DNA repair gene XRCC1 polymorphisms Arg399Gln and Arg194Trp on the risk of lung cancer in the north-Indian population
    Suparna S Pachouri
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 26:186-91. 2007
  4. ncbi request reprint XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 175:91-7. 2007
  5. ncbi request reprint Association of Fas-670 gene polymorphism with risk of cervical cancer in North Indian population
    D M Kordi Tamandani
    Department of Biotechnology, Panjab University, Chandigrah, India
    Clin Exp Obstet Gynecol 35:183-6. 2008
  6. doi request reprint Genetic variants of EGFR (142285G>A) and ESR1 (2014G>A) gene polymorphisms and risk of breast cancer
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 369:217-25. 2012
  7. pmc The complexities of malaria disease manifestations with a focus on asymptomatic malaria
    Dolie D Laishram
    Department of Biology, New York University, New York, NY 10003, USA
    Malar J 11:29. 2012
  8. pmc Susceptibility of XPD and RAD51 genetic variants to carcinoma of urinary bladder in North Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    DNA Cell Biol 31:199-210. 2012
  9. doi request reprint Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 362:263-8. 2012
  10. doi request reprint Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 37:317-24. 2010

Collaborators

Detail Information

Publications46

  1. ncbi request reprint CYP1A1 and CYP2D6 polymorphism and risk of lung cancer in a North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Biomarkers 8:415-28. 2003
    ..This study is the first to be carried out on a North Indian population, and, although small, suggests that CYP1A1 and CYP2D6 polymorphisms might have a role in determining the risk for lung cancer and should be investigated further...
  2. ncbi request reprint Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 156:68-73. 2005
    ..The results indicated that there is a 3-fold increase in risk of developing this cancer in the presence of one copy of the variant CYP2D6 (HEM) allele and null GSTT1...
  3. ncbi request reprint Contrasting impact of DNA repair gene XRCC1 polymorphisms Arg399Gln and Arg194Trp on the risk of lung cancer in the north-Indian population
    Suparna S Pachouri
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 26:186-91. 2007
    ..Smoking also seemed to significantly interact with the combined genotypes of XRCC1 codon 399 Arg/Gln/Gln/Gln. In conclusion, the results have suggested that the XRCC1 gene might be the risk genotype for lung cancer in this population...
  4. ncbi request reprint XRCC1 codon 399 and ERCC2 codon 751 polymorphism, smoking, and drinking and risk of esophageal squamous cell carcinoma in a North Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 175:91-7. 2007
    ..36, 95% CI = 0.11-1.17) and reduced risk of ESQCC in the North Indian population. These observations suggest that the Gln/Gln genotype of XRCC1 might play an important role in DNA repair in ESQCC...
  5. ncbi request reprint Association of Fas-670 gene polymorphism with risk of cervical cancer in North Indian population
    D M Kordi Tamandani
    Department of Biotechnology, Panjab University, Chandigrah, India
    Clin Exp Obstet Gynecol 35:183-6. 2008
    ..The Fas gene plays a key role in regulation of apoptotic cell death and corruption of this signaling pathway has been shown to participate in immune escape and tumorgenesis...
  6. doi request reprint Genetic variants of EGFR (142285G>A) and ESR1 (2014G>A) gene polymorphisms and risk of breast cancer
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 369:217-25. 2012
    ..05}. The different ethnic backgrounds and geographical locations have complimented the present genotypic analysis and have highlighted the influence of ethnicity, race and geographic location in genetic predisposition to breast cancer...
  7. pmc The complexities of malaria disease manifestations with a focus on asymptomatic malaria
    Dolie D Laishram
    Department of Biology, New York University, New York, NY 10003, USA
    Malar J 11:29. 2012
    ..Further, the crucial gaps in the knowledge of asymptomatic malaria that should be the focus of future research towards development of more effective malaria control strategies are highlighted...
  8. pmc Susceptibility of XPD and RAD51 genetic variants to carcinoma of urinary bladder in North Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    DNA Cell Biol 31:199-210. 2012
    ..51, 95% CI=0.27-0.99) and with those having G2 grade (OR=0.24, 95% CI=0.09-0.62) of bladder cancer. XPD polymorphism may be a predisposing factor, but the same cannot be said for RAD51 gene polymorphism...
  9. doi request reprint Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 362:263-8. 2012
    ..The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI)...
  10. doi request reprint Association and impact of XPG Asp 1104 His gene polymorphism in HIV 1 disease progression to AIDS among north Indian HIV seropositive individuals
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 37:317-24. 2010
    ..There was significant difference in the frequency of the His/His variant genotype (OR 1.95, 95% CI = 1.93-3.63, P = 0.04) between cases and controls indicating a probable role of this gene in host viral interactions...
  11. doi request reprint Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population
    Ranbir C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 28:443-9. 2009
    ..In conclusion, these findings suggest that the influence of NAT2 genotype, alone or in combination with p53 genotype, may confer increased susceptibility to lung cancer...
  12. ncbi request reprint CYP17 gene polymorphism and its association in north Indian prostate cancer patients
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Sec 14, Chandigarh 160014, India
    Anticancer Res 29:1659-63. 2009
    ....
  13. doi request reprint Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis
    Ranbir C Sobti
    Department of Biotechnology, Panjab University, Sector 14, Chandigarh, India
    J Recept Signal Transduct Res 30:178-88. 2010
    ....
  14. doi request reprint Sequence analysis of a few species of termites (Order: Isoptera) on the basis of partial characterization of COII gene
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 331:145-51. 2009
    ..5 with Odontotermes sp. to 19.0% with O. bhagwatii. Phylogenetic trees drawn on the basis of distance neighbour-joining method revealed three main clades clustering all the individuals according to their genera and families...
  15. doi request reprint Overexpression of STAT3 in HPV-mediated cervical cancer in a north Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, 160014, India
    Mol Cell Biochem 330:193-9. 2009
    ..To our knowledge, this is the first such study to be reported from India. Further investigations are needed to determine the influence of STAT3 expression on cervical carcinogenesis and its possible interaction with HPV infection status...
  16. ncbi request reprint The influence of variations in the DNA repair (XRCC1) gene on HIV-1/AIDS among Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Folia Biol (Praha) 55:183-6. 2009
    ..10-2.94), while no association was found with the Arg399Gln genotype. Polymorphisms in the XRCC1 homozygous variant genotype for the 399Gln allele were associated with the risk of HIV-1/AIDS disease in a sample of North Indian population...
  17. doi request reprint Polymorphisms of IL-6 174 G/C, IL-10 -592 C/A and risk of HIV/AIDS among North Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 337:145-52. 2010
    ..62, 95% CI = 0.38-6.91. Therefore, combined effects of the CC of IL-6 and CC of IL-10 might reduce the hosts ability to hinder viral replication after infection...
  18. doi request reprint Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, Chandigarh 16 00 14, India
    Mol Biol Rep 38:2945-52. 2011
    ..047, OR 1.71, 95% CI 1.00-2.93), indicating a possible role of susceptibility in reference to controls and disease progression when compared within cases...
  19. doi request reprint Association of ACE and FACTOR VII gene variability with the risk of coronary heart disease in north Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 341:87-98. 2010
    ..18, 95% CI 0.09-0.36, P < 0.001. Our study showed D allele of ACE to be associated with marginal risk of CHD, AA genotype of FACTOR VII R353Q and H6H7 and H7H7 genotypes of FACTOR VII VNTR showed protective effect for CHD...
  20. doi request reprint VEGF and IL-4 gene variability and its association with the risk of coronary heart disease in north Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 341:139-48. 2010
    ..34, 95% CI 0.14-0.82, P < 0.01) and central obesity (OR 0.15, 95% CI 0.04-0.56, P < 0.001). GG genotype of VEGF has also shown significant association with IL-4 (P2P2 and P1P2) genotypes...
  21. ncbi request reprint Insights into the role of IL-12B and IFN-gamma cytokine gene polymorphisms in HIV-1/AIDS infection
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Folia Biol (Praha) 56:110-5. 2010
    ..The present study suggested that individuals with mutant homozygous IFN-gamma AA genotype were at risk of HIV-1/AIDS (OR = 1.88, 95% CI 1.14-3.10, P = 0.008)...
  22. doi request reprint Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Cell Oncol (Dordr) 34:533-43. 2011
    ....
  23. ncbi request reprint The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Acta Virol 55:353-6. 2011
    ..The data of the present study suggest that IL-18 -137 G allele and G/G genotype seem to be involved in the pathogenesis of HIV-1 infection among North Indians...
  24. ncbi request reprint Effect of NBS1 gene polymorphism on the risk of cervix carcinoma in a northern Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh India
    Int J Biol Markers 23:133-9. 2008
    ..The risk was increased 2.4-fold in oral contraceptive users with a Glu/Gln genotype. We conclude that the risk of cervical cancer is increased in passive smokers and in users of oral contraceptives with certain NBS1 genotypes...
  25. ncbi request reprint Association of interleukin-18 gene promoter polymorphism on the risk of cervix carcinogenesis in north Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    Oncol Res 17:159-66. 2008
    ..3, 95%CI 2.13-8.99, p = 0.00001). Our investigation suggests that IL-18 gene -137 in different genotypes, as also in passive smokers, may increase risk of cervix carcinogenesis in north Indian women...
  26. ncbi request reprint Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Cancer Genet Cytogenet 166:117-23. 2006
    ..4, 95% CI = 2.25-18.38, P = 0.0005) have an increased risk of developing cervix cancer. It is thus concluded that cervical cancer risk is increased in passive smokers with GSTM1 (null), GSTT1 (null), and GSTP1 (ile/val) genotypes...
  27. ncbi request reprint CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 25:287-94. 2006
    ....
  28. ncbi request reprint No association of DNA ligase-I polymorphism with the risk of lung cancer in north-Indian population
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    DNA Cell Biol 25:484-9. 2006
    ..8, 95% CI = 0.44-1.40) and (AA) (OR -0.8, 95% CI = 0.41-1.80) genotypes. The DNA repair gene (LIGI) may not be playing an important role in modulating the risk of lung cancer in the north Indian population...
  29. ncbi request reprint Effects of cyclin D1 (CCND1) polymorphism on susceptibility to lung cancer in a North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Cancer Genet Cytogenet 170:108-14. 2006
    ..9, 95% CI = 1.03-3.71, P = 0.03). No positive association was found between CCND1 genotypes in nonsmokers. The results suggest that the CCND1 A870G gene polymorphisms may increase the risk of lung cancer in smokers from north India...
  30. ncbi request reprint Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population
    R C Sobti
    Department of Biotechnology, Punjab University, Chandigarh, India
    Mol Cell Biochem 266:1-9. 2004
    ..008). Taken together, these findings, the first to be analyzed in north Indian population, suggest that combined GSTT1 , GSTM1 and CYP1A1 polymorphisms could be susceptible to lung cancer induced by bidi (an Indian cigarette) smoking...
  31. ncbi request reprint Interleukin 1 beta gene polymorphism and risk of cervical cancer
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Int J Gynaecol Obstet 101:47-52. 2008
    ....
  32. doi request reprint Role of hormonal genes and risk of prostate cancer: gene-gene interactions in a North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Cancer Genet Cytogenet 185:78-85. 2008
    ..This indicates the role of mutant allele of ER and CYP17 in the development and progression of prostate cancer and rules out any increased risk with PSA polymorphism in the north Indian population...
  33. ncbi request reprint Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Biomarkers 13:282-95. 2008
    ..However, the increased risk was limited to SqCC, and was not found for other histological subtypes. Further analyses on this topic are needed...
  34. doi request reprint Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population
    Hitender Thakur
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Biol Rep 38:1733-9. 2011
    ..36-3.65 P value = 0.001) and twofold risk in BPH (OR 2.09; 95% CI 1.26-3.46; P value = 0.005). In case of COPD only null genotype of GSTT1 has shown 2.1-fold (OR 2.11; 95% CI 1.22-3.62; P value = 0.007) significant increased risk...
  35. doi request reprint Overexpression of signal transducer and activator of transcription (STAT-3 and STAT-5) transcription factors and alteration of suppressor of cytokine signaling (SOCS-1) protein in prostate cancer
    Neha Singh
    Department of Biotechnology, Panjab University, Chandigarh, India
    J Recept Signal Transduct Res 32:321-7. 2012
    ..There is an important role of signal transducer and activator of transcriptions (STATs) particularly STAT-3 and STAT-5 and its negative regulator suppressor of cytokine signaling-1 (SOCS-1)...
  36. doi request reprint Role of genetic polymorphism of estrogen receptor-alpha gene and risk of prostate cancer in north Indian population
    Lipsy Gupta
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 335:255-61. 2010
    ..An association was observed between PvuII polymorphism of ER-alpha gene and that of prostate cancer. However, there was no such association with XbaI polymorphism in ER-alpha gene...
  37. doi request reprint Polymorphisms in the HPC/ELAC-2 and alpha 1-antitrypsin genes that correlate with human diseases in a North Indian population
    Ranbir C Sobti
    Department of Biotechnology, Panjab University, Chandigarh 160014, India
    Mol Biol Rep 38:3137-44. 2011
    ..82 (P = 0.03). Multivariate analysis adjusted by age sex and drinking habit showed 4.15-fold increased risk for COPD in PiZ heterozygous individuals. No increased risk was observed in the individuals carrying PiS alleles...
  38. doi request reprint Hormone receptor-related gene polymorphisms and prostate cancer risk in North Indian population
    Khadijeh Onsory
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 314:25-35. 2008
    ..43 for (95% CI, 0.13-1.39) and an OR for Tt genotype was 0.65 (95% CI, 0.36-1.16). Taken together, the results showed that in North Indian population, ERalpha and CYP19 genes may be playing a role in the risk of prostate cancer...
  39. ncbi request reprint Detection of human papillomavirus DNA, serum p53, and p53 antibodies in patients with cervical cancer
    Ranbir C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    J Environ Pathol Toxicol Oncol 21:79-85. 2002
    ..43% of the cases. This could mean the loss of p53 function as a result of either HPV-E6-mediated degradation or mutation in the p53 gene...
  40. ncbi request reprint Telomerase activation and incidence of HPV in human gastrointestinal tumors in North Indian population
    R C Sobti
    Department of Biotechnology, Panjab University, Chandigarh, India
    Mol Cell Biochem 217:51-6. 2001
    ..This suggests that activation of telomerase could be by a pathway independent of HPV activation, although both parameters could act as diagnostic and prognostic markers for gastrointestinal tract cancers...
  41. ncbi request reprint Expression and polimorphism of IFN-gamma gene in patients with cervical cancer
    M K Kordi Tamandani
    Department of Biotechnology, Panjab University, Chandigrah, India
    Exp Oncol 30:224-9. 2008
    ..Interferon gamma (IFN-gamma ) is a cytokine produced by activated T cells and natural killer (NK) cells that enhances cellular immune responses by increasing T-cell cytotoxicity and NK cell activity...
  42. ncbi request reprint Genetic relatedness of six North-Indian butterfly species (Lepidoptera :Pieridae) based on 16S rRNA sequence analysis
    Ranbir Chander Sobti
    Department of Biotechnology, Panjab University, Chandigarh, 160014, India
    Mol Cell Biochem 295:145-51. 2007
    ..The separate taxonomic grouping of these Indian species has been observed when compared with several species of Piernae and Coliadinae subfamilies from other country isolates...
  43. ncbi request reprint Impact of polymorphism in IL-1RA gene on the risk of cervical cancer
    Dor Mohammad Kordi Tamandani
    Department of Biotechnology, Panjab University, Chandigarh, India
    Arch Gynecol Obstet 277:527-33. 2008
    ..Several studies suggested that immunological components play a key role in the development of cervical cancer. Polymorphism in the IL-1RA gene was associated with various malignant diseases. Data are lacking for cervical cancer...
  44. ncbi request reprint Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population
    Mohammad Shekari
    Department of Biotechnology, Punjab University, Chandigarh, India
    Cancer Biomark 4:63-71. 2008
    ....
  45. ncbi request reprint Impact of polymorphism in sulfotransferase gene on the risk of lung cancer
    Suparna S Pachouri
    Department of Biotechnology, Panjab University, Chandigarh, India
    Cancer Genet Cytogenet 171:39-43. 2006
    ..78, P = 0.000002) or AA (OR = 3.9, 95% CI = 1.99-7.81, P = 0.0002), and lung cancer. The present study indicates that the SULT1A1 genotype may play an important role in the risk of developing lung cancer, especially in cigarette smokers...