Ranbir C Sobti

Summary

Affiliation: Panjab University
Country: India

Publications

  1. request reprint
    Sobti R, Al Badran A, Sharma S, Sharma S, Krishan A, Mohan H. Genetic polymorphisms of CYP2D6, GSTM1, and GSTT1 genes and bladder cancer risk in North India. Cancer Genet Cytogenet. 2005;156:68-73 pubmed
    ..The results indicated that there is a 3-fold increase in risk of developing this cancer in the presence of one copy of the variant CYP2D6 (HEM) allele and null GSTT1. ..
  2. Sobti R, Singh N, Hussain S, Suri V, Bharti A, Das B. Overexpression of STAT3 in HPV-mediated cervical cancer in a north Indian population. Mol Cell Biochem. 2009;330:193-9 pubmed publisher
    ..Further investigations are needed to determine the influence of STAT3 expression on cervical carcinogenesis and its possible interaction with HPV infection status. ..
  3. request reprint
    Sobti R, Kaur P, Kaur S, Janmeja A, Jindal S, Kishan J, et al. No association of DNA ligase-I polymorphism with the risk of lung cancer in north-Indian population. DNA Cell Biol. 2006;25:484-9 pubmed
    ..8, 95% CI = 0.44-1.40) and (AA) (OR -0.8, 95% CI = 0.41-1.80) genotypes. The DNA repair gene (LIGI) may not be playing an important role in modulating the risk of lung cancer in the north Indian population. ..
  4. Sobti R, Berhane N, Mahdi S, Kler R, Hosseini S, Kuttiat V, et al. Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients. Mol Biol Rep. 2011;38:2945-52 pubmed publisher
    ..047, OR 1.71, 95% CI 1.00-2.93), indicating a possible role of susceptibility in reference to controls and disease progression when compared within cases. ..
  5. Sobti R, Maithil N, Thakur H, Sharma Y, Talwar K. Association of ACE and FACTOR VII gene variability with the risk of coronary heart disease in north Indian population. Mol Cell Biochem. 2010;341:87-98 pubmed publisher
    ..18, 95% CI 0.09-0.36, P < 0.001. Our study showed D allele of ACE to be associated with marginal risk of CHD, AA genotype of FACTOR VII R353Q and H6H7 and H7H7 genotypes of FACTOR VII VNTR showed protective effect for CHD. ..
  6. Singh N, Hussain S, Sharma U, Suri V, Nijhawan R, Bharadwaj M, et al. The protective role of the -1306C>T functional polymorphism in matrix metalloproteinase-2 gene is associated with cervical cancer: implication of human papillomavirus infection. Tumour Biol. 2016;37:5295-303 pubmed publisher
    ..These findings substantiate the functional role of MMP-2 C1306T polymorphism in a significant downregulation of MMP-2 protein in women with variant genotype (CT/TT) compared to the normal wild CC genotype. ..
  7. request reprint
    Sobti R, Shekari M, Tamandani D, Malekzadeh K, Suri V. Association of interleukin-18 gene promoter polymorphism on the risk of cervix carcinogenesis in north Indian population. Oncol Res. 2008;17:159-66 pubmed
    ..3, 95%CI 2.13-8.99, p = 0.00001). Our investigation suggests that IL-18 gene -137 in different genotypes, as also in passive smokers, may increase risk of cervix carcinogenesis in north Indian women. ..
  8. request reprint
    Sobti R, Sharma S, Joshi A, Jindal S, Janmeja A. Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. Mol Cell Biochem. 2004;266:1-9 pubmed
    ..008). Taken together, these findings, the first to be analyzed in north Indian population, suggest that combined GSTT1 , GSTM1 and CYP1A1 polymorphisms could be susceptible to lung cancer induced by bidi (an Indian cigarette) smoking. ..
  9. Sobti R, Kaur S, Sharma V, Singh S, Hosseini S, Kler R. Susceptibility of XPD and RAD51 genetic variants to carcinoma of urinary bladder in North Indian population. DNA Cell Biol. 2012;31:199-210 pubmed publisher
    ..51, 95% CI=0.27-0.99) and with those having G2 grade (OR=0.24, 95% CI=0.09-0.62) of bladder cancer. XPD polymorphism may be a predisposing factor, but the same cannot be said for RAD51 gene polymorphism. ..

More Information

Publications23

  1. request reprint
    Sobti R, Salih A, Nega B, Seyed A, Rupinder K, Vijesh K, et al. Insights into the role of IL-12B and IFN-gamma cytokine gene polymorphisms in HIV-1/AIDS infection. Folia Biol (Praha). 2010;56:110-5 pubmed
    ..The present study suggested that individuals with mutant homozygous IFN-gamma AA genotype were at risk of HIV-1/AIDS (OR = 1.88, 95% CI 1.14-3.10, P = 0.008). ..
  2. Sobti R, Singh N, Hussain S, Suri V, Bharadwaj M, Das B. Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. J Recept Signal Transduct Res. 2010;30:178-88 pubmed publisher
    ..001). We observed for the first time the differential expression pattern of STAT-5 isoforms in cervical cancer and that STAT-5 may play an important role in the progression of HPV-mediated cervical cancer. ..
  3. Sobti R, Maithil N, Thakur H, Sharma Y, Talwar K. VEGF and IL-4 gene variability and its association with the risk of coronary heart disease in north Indian population. Mol Cell Biochem. 2010;341:139-48 pubmed publisher
    ..34, 95% CI 0.14-0.82, P < 0.01) and central obesity (OR 0.15, 95% CI 0.04-0.56, P < 0.001). GG genotype of VEGF has also shown significant association with IL-4 (P2P2 and P1P2) genotypes. ..
  4. Sobti R, Gupta L, Singh S, Seth A, Kaur P, Thakur H. Role of hormonal genes and risk of prostate cancer: gene-gene interactions in a North Indian population. Cancer Genet Cytogenet. 2008;185:78-85 pubmed publisher
    ..This indicates the role of mutant allele of ER and CYP17 in the development and progression of prostate cancer and rules out any increased risk with PSA polymorphism in the north Indian population. ..
  5. request reprint
    Sobti R, Kaur P, Kaur S, Janmeja A, Jindal S, Kishan J, et al. Combined effect of GSTM1, GSTT1 and GSTP1 polymorphisms on histological subtypes of lung cancer. Biomarkers. 2008;13:282-95 pubmed
    ..However, the increased risk was limited to SqCC, and was not found for other histological subtypes. Further analyses on this topic are needed. ..
  6. request reprint
    Sobti R, Kordi Tamandani D, Shekari M, Kaur P, Malekzadeh K, Suri V. Interleukin 1 beta gene polymorphism and risk of cervical cancer. Int J Gynaecol Obstet. 2008;101:47-52 pubmed
    ..69; 95% CI, 2.61-12.50; P<0.001) compared with a nonsmoker with the A1/A1 genotype. This study provides evidence of an association between lL-1beta +3953 polymorphism and risk of cervical cancer. ..
  7. request reprint
    Sobti R, Kaur S, Kaur P, Singh J, Gupta I, Jain V, et al. Interaction of passive smoking with GST (GSTM1, GSTT1, and GSTP1) genotypes in the risk of cervical cancer in India. Cancer Genet Cytogenet. 2006;166:117-23 pubmed
    ..4, 95% CI = 2.25-18.38, P = 0.0005) have an increased risk of developing cervix cancer. It is thus concluded that cervical cancer risk is increased in passive smokers with GSTM1 (null), GSTT1 (null), and GSTP1 (ile/val) genotypes. ..
  8. request reprint
    Sobti R, Gupta L, Thakur H, Seth A, Singh S, Kaur P. CYP17 gene polymorphism and its association in north Indian prostate cancer patients. Anticancer Res. 2009;29:1659-63 pubmed
    ..The A2 allele of the CYP17 polymorphism is associated with an increased risk of prostate cancer and has a role in the development of prostate cancer in smokers and non-vegetarians. ..
  9. Sobti R, Kaur P, Kaur S, Janmeja A, Jindal S, Kishan J, et al. Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian population. DNA Cell Biol. 2009;28:443-9 pubmed publisher
    ..In conclusion, these findings suggest that the influence of NAT2 genotype, alone or in combination with p53 genotype, may confer increased susceptibility to lung cancer. ..
  10. request reprint
    Sobti R, Shekari M, Kordi Tamandani D, Kaur P, Suri V, Huria A. Effect of NBS1 gene polymorphism on the risk of cervix carcinoma in a northern Indian population. Int J Biol Markers. 2008;23:133-9 pubmed
    ..The risk was increased 2.4-fold in oral contraceptive users with a Glu/Gln genotype. We conclude that the risk of cervical cancer is increased in passive smokers and in users of oral contraceptives with certain NBS1 genotypes...
  11. request reprint
    Sobti R, Onsory K, Al Badran A, Kaur P, Watanabe M, Krishan A, et al. CYP17, SRD5A2, CYP1B1, and CYP2D6 gene polymorphisms with prostate cancer risk in North Indian population. DNA Cell Biol. 2006;25:287-94 pubmed
  12. Sobti R, Singh N, Hussain S, Suri V, Nijhawan R, Bharti A, et al. Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis. Cell Oncol (Dordr). 2011;34:533-43 pubmed publisher
    ..01). We demonstrate for the first time the transcriptional inactivation of SOCS-1 gene due to hypermethylation and synergism with HPV infection which may play an important role in cervical carcinoma. ..
  13. Sobti R, Berhane N, Melese S, Mahdi S, Gupta L, Thakur H, et al. Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population. Mol Cell Biochem. 2012;362:263-8 pubmed publisher
    ..The polymerase chain reaction and restrictive fragment length polymorphism techniques were implemented. Statistically non-significant increase risk of prostate cancer was observed with patients having Gln/Gln genotype (OR 1.62, 95% CI). ..
  14. request reprint
    Sobti R, Sharma V, Abitew A, Berhane N, Mahdi S, Askari M, et al. The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS. Acta Virol. 2011;55:353-6 pubmed
    ..The data of the present study suggest that IL-18 -137 G allele and G/G genotype seem to be involved in the pathogenesis of HIV-1 infection among North Indians...