Milind M Vaidya

Summary

Affiliation: Navi Mumbai
Country: India

Publications

  1. pmc Loss of keratin 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients
    Hunain Alam
    Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India
    PLoS ONE 6:e27767. 2011
  2. pmc Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines
    Sapna V Iyer
    Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai, India
    PLoS ONE 8:e53532. 2013
  3. pmc Alterations in keratins and associated proteins during 4- Nitroquinoline-1-oxide induced rat oral carcinogenesis
    Deepak Kanojia
    Department of Biological Science, University of South Carolina, Columbia, SC, USA
    J Carcinog 11:14. 2012
  4. ncbi request reprint Keratins: markers of cell differentiation or regulators of cell differentiation?
    Milind M Vaidya
    KS 110 111, Vaidya Lab, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410 210, India
    J Biosci 32:629-34. 2007
  5. pmc Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma
    Hunain Alam
    Advanced Centre for Treatment Research and Education in Cancer Tata Memorial Centre ACTREC, Kharghar, Navi Mumbai, India
    BMC Cancer 12:32. 2012
  6. doi request reprint Prognostic value of tissue polypeptide antigen in oral squamous cell carcinoma
    Sharada S Sawant
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, 410210 Maharashtra, India
    Oral Oncol 47:114-20. 2011
  7. doi request reprint Cytokeratin fragments in the serum: their utility for the management of oral cancer
    Sharada S Sawant
    Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai 410 210, Maharashtra, India
    Oral Oncol 44:722-32. 2008
  8. doi request reprint Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line
    Hunain Alam
    Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    J Cell Sci 124:2096-106. 2011
  9. pmc Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis
    Nileema Khapare
    Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
    PLoS ONE 7:e38561. 2012
  10. pmc Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells
    Hunain Alam
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    Mol Biol Cell 22:4068-78. 2011

Collaborators

Detail Information

Publications13

  1. pmc Loss of keratin 8 phosphorylation leads to increased tumor progression and correlates with clinico-pathological parameters of OSCC patients
    Hunain Alam
    Cancer Research Institute, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India
    PLoS ONE 6:e27767. 2011
    ..In the present study we have investigated the role of K8 phosphorylation in cell migration and/or neoplastic progression in OSCC...
  2. pmc Understanding the role of keratins 8 and 18 in neoplastic potential of breast cancer derived cell lines
    Sapna V Iyer
    Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai, India
    PLoS ONE 8:e53532. 2013
    ..Expression of the K8/18 pair is seen in the luminal cells of the breast epithelium, and its role in prognostication of breast cancer is not well understood...
  3. pmc Alterations in keratins and associated proteins during 4- Nitroquinoline-1-oxide induced rat oral carcinogenesis
    Deepak Kanojia
    Department of Biological Science, University of South Carolina, Columbia, SC, USA
    J Carcinog 11:14. 2012
    ..Keratins are being used as biomarkers in different epithelial disorders including cancer. They are associated with desmoplakin and α6β4 integrin which are components of desmosomes and hemidesmosomes respectively...
  4. ncbi request reprint Keratins: markers of cell differentiation or regulators of cell differentiation?
    Milind M Vaidya
    KS 110 111, Vaidya Lab, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, Maharashtra 410 210, India
    J Biosci 32:629-34. 2007
  5. pmc Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma
    Hunain Alam
    Advanced Centre for Treatment Research and Education in Cancer Tata Memorial Centre ACTREC, Kharghar, Navi Mumbai, India
    BMC Cancer 12:32. 2012
    ..Previously, we have demonstrated that fascin regulates actin polymerization and thereby promotes cell motility in K8-depleted OSCC cells. In the present study we have investigated the role of fascin in tumor progression of OSCC...
  6. doi request reprint Prognostic value of tissue polypeptide antigen in oral squamous cell carcinoma
    Sharada S Sawant
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, 410210 Maharashtra, India
    Oral Oncol 47:114-20. 2011
    ..Thus, our study indicates that TPA can be a useful tumour marker for the prediction of recurrence and poor prognosis in human oral cancer...
  7. doi request reprint Cytokeratin fragments in the serum: their utility for the management of oral cancer
    Sharada S Sawant
    Tata Memorial Centre, Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai 410 210, Maharashtra, India
    Oral Oncol 44:722-32. 2008
    ....
  8. doi request reprint Loss of keratins 8 and 18 leads to alterations in α6β4-integrin-mediated signalling and decreased neoplastic progression in an oral-tumour-derived cell line
    Hunain Alam
    Advanced Centre for Treatment, Research and Education in Cancer ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    J Cell Sci 124:2096-106. 2011
    ..Therefore, modulation of α6β4 integrin signalling might be one of the mechanisms by which K8 and K18 promote malignant transformation and/or progression in OSCCs...
  9. pmc Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis
    Nileema Khapare
    Tata Memorial Centre, Kharghar Node, Navi Mumbai, Maharashtra, India
    PLoS ONE 7:e38561. 2012
    ..These results suggest that a stabilisation of K8 filaments leading to an increase in migration and transformation may be one mechanism by which PKP3 loss leads to tumor progression and metastasis...
  10. pmc Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells
    Hunain Alam
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    Mol Biol Cell 22:4068-78. 2011
    ....
  11. ncbi request reprint Polymeric black tea polyphenols modulate the localization and activity of 12-O-tetradecanoylphorbol-13-acetate-mediated kinases in mouse skin: mechanisms of their anti-tumor-promoting action
    Gaurav Kumar
    Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    Free Radic Biol Med 53:1358-70. 2012
    ..Results suggest that the antipromoting effects of PBPs are due to modulation of TPA-induced PI3K-mediated signal transduction...
  12. pmc O-GlcNAcylation determines the solubility, filament organization, and stability of keratins 8 and 18
    Budnar Srikanth
    Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India
    J Biol Chem 285:34062-71. 2010
    ..These results strongly indicate the involvement of O-GlcNAc on K8/18 in regulating their solubility and stability, which may have a bearing on the functions of these keratins...
  13. ncbi request reprint 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis
    Deepak Kanojia
    Biochemistry and Cell Biology, Tata Memorial Hospital, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Kharghar, Navi Mumbai, Maharashtra 410 208, India
    Oral Oncol 42:655-67. 2006
    ..In the present review an attempt has been made to collate the information available on mechanisms of action of 4NQO, studies carried out for the development of biomarkers and chemopreventives agents using 4NQO animal models...