Shyam Sunder Sharma

Summary

Affiliation: National Institute of Pharmaceutical Education and Research
Country: India

Publications

  1. ncbi request reprint Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms
    A Kumar
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sec 67, S A S Nagar, Mohali, Punjab 160062, India
    Curr Med Chem 20:4640-5. 2013
  2. ncbi request reprint Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Eur J Pharmacol 561:72-9. 2007
  3. ncbi request reprint Neuroprotective effects of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Neurol Res 29:304-9. 2007
  4. doi request reprint Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Life Sci 82:570-6. 2008
  5. ncbi request reprint Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    Meenakshisundaram Thiyagarajan
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160 062, Punjab, India
    Life Sci 74:969-85. 2004
  6. doi request reprint Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali, Punjab 160062, India
    Free Radic Res 43:400-8. 2009
  7. ncbi request reprint Preclinical safety pharmacological studies on the amorphous formulation of celecoxib
    Shyam Sunder Sharma
    National Center for Safety Pharmacology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab, India
    Arzneimittelforschung 59:254-62. 2009
  8. ncbi request reprint Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes
    Geeta Negi
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sec 67, S A S Nagar, Mohali, Punjab 160062, India
    Curr Neurovasc Res 8:294-304. 2011
  9. ncbi request reprint FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils
    Shyam S Sharma
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Pharmacol Res 55:335-42. 2007
  10. ncbi request reprint Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India
    J Neurosurg 101:669-75. 2004

Collaborators

  • Ravinder K Kaundal
  • Rahul Jain
  • A Kumar
  • Vivek Kumar
  • A Gulati
  • Sokindra Kumar
  • Jitendra N Singh
  • Geeta Negi
  • Satyendra Kumar Rajput
  • Anuj Kumar Saini
  • Chhuttan Lal Meena
  • Meenakshisundaram Thiyagarajan
  • Kanaiyalal D Prajapati
  • Navneet Kaur
  • Pramod Kumar
  • Vikramdeep Monga
  • Rohini Sharma
  • Sridhar Balasubramanyan
  • Manish Arora
  • Arun Kumar H S
  • Sufyan G Sayyed
  • Sangeetha Gupta
  • Chaman L Kaul
  • Saurabh Gupta
  • Dhiraj G Kabra
  • Maqsood Ahmad Siddiqui
  • Aditya Bhushan Pant
  • Nilanjan Roy
  • Shubhada Ingole
  • Sandeep More
  • Srinivasan Krishnamoorthy
  • Gaurav Jain
  • Chandrasekhar Pawar
  • Rashwin J Patel

Detail Information

Publications37

  1. ncbi request reprint Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms
    A Kumar
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sec 67, S A S Nagar, Mohali, Punjab 160062, India
    Curr Med Chem 20:4640-5. 2013
    ..Futuristic therapies can be based on either resveratrol or its analogs with better bioavailability, or combining the resveratrol with existing therapies. ..
  2. ncbi request reprint Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentation
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Eur J Pharmacol 561:72-9. 2007
    ..This study demonstrates that the neuroprotective effect of MnTMPyP in global ischemia is mediated through reduction in oxidative stress and DNA fragmentation...
  3. ncbi request reprint Neuroprotective effects of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Neurol Res 29:304-9. 2007
    ..In the present study, we have investigated the neuroprotective potential of 6hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), in middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia...
  4. doi request reprint Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathy
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Life Sci 82:570-6. 2008
    ..4-ANI also attenuated PAR immunoreactivity and NAD depletion in nerves of diabetic animals. Results of present study suggest the potential of PARP inhibitors like 4-ANI in the treatment of diabetic neuropathy...
  5. ncbi request reprint Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
    Meenakshisundaram Thiyagarajan
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160 062, Punjab, India
    Life Sci 74:969-85. 2004
    ..These results suggest the neuroprotective potential of curcumin in cerebral ischemia and is mediated through its antioxidant activity...
  6. doi request reprint Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changes
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali, Punjab 160062, India
    Free Radic Res 43:400-8. 2009
    ..This study suggests the beneficial effect of combining resveratrol and 4-ANI in experimental diabetic neuropathy...
  7. ncbi request reprint Preclinical safety pharmacological studies on the amorphous formulation of celecoxib
    Shyam Sunder Sharma
    National Center for Safety Pharmacology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab, India
    Arzneimittelforschung 59:254-62. 2009
    ..There were no CNS and GIT safety concerns raised with respect to use of CF except the arrythmogenic risk associated with QT interval prolongation upon the high dose of CF...
  8. ncbi request reprint Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes
    Geeta Negi
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sec 67, S A S Nagar, Mohali, Punjab 160062, India
    Curr Neurovasc Res 8:294-304. 2011
    ..This study supports the defensive role of Nrf2 in neurons under conditions of oxidative stress and also suggests that the NF-κB pathway is an important modulator of inflammatory damage in diabetic neuropathy...
  9. ncbi request reprint FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils
    Shyam S Sharma
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Pharmacol Res 55:335-42. 2007
    ..Results of this study demonstrates the neuroprotective activity of FeTPPS in global cerebral IR injury and its neuroprotective effects may be attributed to reduction in oxidative stress and DNA fragmentation...
  10. ncbi request reprint Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemia
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India
    J Neurosurg 101:669-75. 2004
    ....
  11. doi request reprint GW1929: a nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentation
    Ravinder K Kaundal
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Sector 67, Punjab 160062, India
    Behav Brain Res 216:606-12. 2011
    ....
  12. ncbi request reprint Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathy
    Ashutosh Kumar
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160062, India
    Life Sci 80:1236-44. 2007
    ..Results of the present study suggest the potential of resveratrol in treatment of diabetic neuropathy and its protective effect may be mediated through reduction in oxidative stress and DNA fragmentation...
  13. ncbi request reprint Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy
    Sufyan G Sayyed
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sec 67, S A S Nagar Mohali, Punjab 160062, India
    Life Sci 79:777-83. 2006
    ..Results of the present study suggest the potential of U83836E in treatment of diabetic neuropathy...
  14. doi request reprint Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy
    Geeta Negi
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Neuropharmacology 58:585-92. 2010
    ..The results of this study advocate that simultaneous inhibition of oxidative stress-PARP activation cascade may prove useful for the pharmacotherapy of DN...
  15. ncbi request reprint Protective effects of pioglitazone against global cerebral ischemic-reperfusion injury in gerbils
    Ravinder K Kaundal
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, India
    J Pharmacol Sci 109:361-7. 2009
    ..This study demonstrates the neuroprotective activity of pioglitazone in global cerebral IR injury and its neuroprotective effects may be attributed to reduction in oxidative stress and DNA fragmentation...
  16. doi request reprint Protective effects of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin releasing hormone analog in in vitro and in vivo models of cerebral ischemia
    Satyendra Kumar Rajput
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
    Peptides 32:1225-31. 2011
    ..These results suggest potential of NP-647 in the treatment of cerebral ischemia and its neuroprotective effect may be attributed to reduction of excitotoxicity, oxidative stress and inflammation...
  17. ncbi request reprint Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathy
    Anuj Kumar Saini
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Eur J Pharmacol 568:164-72. 2007
    ..Hence edaravone may be tried clinically for the treatment of diabetic neuropathy since it is clinically used in stroke patients...
  18. doi request reprint Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy
    Manish Arora
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar, Mohali, Punjab, India
    Eur J Pharmacol 596:77-83. 2008
    ..Aftermath of this study advocates the beneficial effects of peroxynitrite decomposition catalysts in experimental diabetic neuropathy...
  19. ncbi request reprint Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in rat
    Dhiraj G Kabra
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar Mohali, Punjab 160 062, India
    Brain Res Bull 62:425-33. 2004
    ..Our study suggests 4-ANI is a potent neuroprotective agent in focal cerebral ischemia and its neuroprotective effects may be attributed to reduction of NAD depletion and DNA fragmentation...
  20. ncbi request reprint Neuroprotective effects of trolox in global cerebral ischemia in gerbils
    Sangeetha Gupta
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab, India
    Biol Pharm Bull 29:957-61. 2006
    ..43+/-3.32 microM/mg of protein) and (8.98+/-0.89 microM/mg of protein) by trolox 10 and 30 mg/kg, i.p., respectively. This study demonstrates the neuroprotective potential of trolox in global cerebral ischemia in gerbils...
  21. doi request reprint Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathy
    Geeta Negi
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160062, India
    Biochem Biophys Res Commun 391:102-6. 2010
    ..Thus, it can be concluded that treatment with the combination of a PDC and PARP inhibitor attenuates alteration in peripheral nerves in diabetic neuropathy (DN)...
  22. ncbi request reprint Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats
    Saurabh Gupta
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali 160 062, Punjab, India
    Neurol Res 26:103-7. 2004
    ..Clinical availability and wide therapeutic margin of nicotinamide and melatonin make them a promising drug combination for clinical evaluation in stroke patients...
  23. doi request reprint Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parameters
    Satyendra Kumar Rajput
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
    Epilepsy Res 87:223-33. 2009
    ..NP-355 did not alter neurobehavioral parameters. This study demonstrates that NP-355 has potential antiepileptic activity and devoid of undesirable effects...
  24. doi request reprint NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy
    Ashutosh Kumar
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
    Biochem Biophys Res Commun 394:360-5. 2010
    ..This study confirms the NF-kappaB inhibitory activity and anti-inflammatory activity of resveratrol which may contribute to neuroprotection in diabetic neuropathy apart from its antioxidant effect...
  25. ncbi request reprint Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation
    Ravinder K Kaundal
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Life Sci 79:2293-302. 2006
    ..Results of this study demonstrate the neuroprotective activity of NU1025 and suggest its potential in cerebral ischemia...
  26. doi request reprint Amelioration of pulmonary dysfunction and neutrophilic inflammation by PPAR gamma agonist in LPS-exposed guinea pigs
    Rohini Sharma
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
    Pulm Pharmacol Ther 22:183-9. 2009
    ..Results from the present study have added to the emergent body of evidence that PPAR gamma agonists are effective in the therapy of inflammatory disease of the lungs...
  27. ncbi request reprint Inhibition of sodium current by carbamazepine in dorsal root ganglion neurons in vitro
    Jitendra N Singh
    Electrophysiology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar Mohali 160 062
    Indian J Physiol Pharmacol 53:147-54. 2009
    ..The depression of Na+ currents was found to be dose-dependant at -20 and -10 mV but not at 0 mV, It is concluded that the depression of Na+ currents by CBZ may be responsible for inhibiting the neurotransmitter release...
  28. ncbi request reprint Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy
    Shyam S Sharma
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Clin Exp Pharmacol Physiol 33:1022-8. 2006
    ..6. The results of the present study suggest the beneficial effects of trolox in experimental diabetic neuropathy...
  29. ncbi request reprint Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy
    Sokindra Kumar
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sec 67, SAS Nagar, Punjab 160062, India
    Neurol Res 27:60-6. 2005
    ..p.). Histological changes observed in sciatic nerve were partially improved by the adenosinergic agents in diabetic rats. Results of the present study, suggest the potential of adenosinergic agents in the therapy of diabetic neuropathy...
  30. doi request reprint Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's disease
    Pramod Kumar
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160062, India
    Behav Brain Res 197:398-403. 2009
    ..These results demonstrate the beneficial effects of pioglitazone on cognitive impairment in MPTP induced Parkinson's disease in rats...
  31. doi request reprint Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog
    Satyendra Kumar Rajput
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
    Epilepsy Behav 14:48-53. 2009
    ..This study demonstrates that NP-647 has potential antiepileptic activity devoid of undesirable effects and, thus, can be exploited for the prevention and treatment of epilepsy...
  32. doi request reprint Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agents
    Ravinder K Kaundal
    Department of Pharmacology and Toxicology of the National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
    Drug News Perspect 23:241-56. 2010
    ..This article discusses evidence and mechanisms supporting the neuroprotective effects of PPARgamma agonists in central nervous system disorders...
  33. ncbi request reprint Protective effect of adenosine in diabetic neuropathic pain is mediated through adenosine A1-receptors
    Sridhar Balasubramanyan
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062, Punjab
    Indian J Physiol Pharmacol 52:233-42. 2008
    ..These results indicate that adenosine is an effective analgesics in a model of diabetic neuropathy, and the protection produced by adenosine is via stimulation of adenosine A1-receptors...
  34. doi request reprint Upregulation of albumin expression in focal ischemic rat brain
    Kanaiyalal D Prajapati
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
    Brain Res 1327:118-24. 2010
    ..This study paves the way for further investigation of signaling mechanisms leading to albumin overexpression, so that it can be exploited as a therapeutic intervention...
  35. ncbi request reprint Ameliorative effects of GW1929, a nonthiazolidinedione PPARγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury
    Ravinder K Kaundal
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Sector 67, Punjab 160062, India
    Curr Neurovasc Res 8:236-45. 2011
    ..In summary, these results suggested the neuroprotective potential of PPARγ agonists in cerebral IR injury and these effects may be attributed to their anti-inflammatory and anti-apoptotic potential...
  36. ncbi request reprint Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic rats
    Anuj Kumar Saini
    Torrent Research Center, Gandhinagar, Gujarat, India
    Pharmacol Res 54:6-10. 2006
    ..From our results we infer that hydroxyl radical stress augments Ang II response in diabetic rat thoracic aorta and edaravone could be an ideal antioxidant adjuvant in the therapy of diabetic vascular complications...