Research Topics
| Shyam Sunder SharmaSummaryAffiliation: National Institute of Pharmaceutical Education and Research Country: India Publications
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Detail Information
Publications
Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in ratsMeenakshisundaram Thiyagarajan
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar 160 062, Punjab, India
Life Sci 74:969-85. 2004..These results suggest the neuroprotective potential of curcumin in cerebral ischemia and is mediated through its antioxidant activity...- Preclinical safety pharmacological studies on the amorphous formulation of celecoxibShyam Sunder Sharma
National Center for Safety Pharmacology, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab, India
Arzneimittelforschung 59:254-62. 2009..There were no CNS and GIT safety concerns raised with respect to use of CF except the arrythmogenic risk associated with QT interval prolongation upon the high dose of CF... 
Neuroprotective potential of combination of resveratrol and 4-amino 1,8 naphthalimide in experimental diabetic neuropathy: focus on functional, sensorimotor and biochemical changesShyam S Sharma
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Mohali, Punjab 160062, India
Free Radic Res 43:400-8. 2009..This study suggests the beneficial effect of combining resveratrol and 4-ANI in experimental diabetic neuropathy...- Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changesGeeta Negi
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sec 67, S A S Nagar, Mohali, Punjab 160062, India
Curr Neurovasc Res 8:294-304. 2011..This study supports the defensive role of Nrf2 in neurons under conditions of oxidative stress and also suggests that the NF-κB pathway is an important modulator of inflammatory damage in diabetic neuropathy... - Protective effects of 4-amino1,8-napthalimide, a poly (ADP-ribose) polymerase inhibitor in experimental diabetic neuropathyShyam S Sharma
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
Life Sci 82:570-6. 2008..4-ANI also attenuated PAR immunoreactivity and NAD depletion in nerves of diabetic animals. Results of present study suggest the potential of PARP inhibitors like 4-ANI in the treatment of diabetic neuropathy... - Neuroprotective effects of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in ratsShyam S Sharma
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
Neurol Res 29:304-9. 2007..In the present study, we have investigated the neuroprotective potential of 6hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), in middle cerebral artery occlusion (MCAO) induced focal cerebral ischemia... - Neuroprotective effect of MnTMPyP, a superoxide dismutase/catalase mimetic in global cerebral ischemia is mediated through reduction of oxidative stress and DNA fragmentationShyam S Sharma
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
Eur J Pharmacol 561:72-9. 2007..This study demonstrates that the neuroprotective effect of MnTMPyP in global ischemia is mediated through reduction in oxidative stress and DNA fragmentation... - FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbilsShyam S Sharma
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
Pharmacol Res 55:335-42. 2007..Results of this study demonstrates the neuroprotective activity of FeTPPS in global cerebral IR injury and its neuroprotective effects may be attributed to reduction in oxidative stress and DNA fragmentation... - Neuroprotective effect of peroxynitrite decomposition catalyst and poly(adenosine diphosphate-ribose) polymerase inhibitor alone and in combination in rats with focal cerebral ischemiaShyam S Sharma
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Punjab, India
J Neurosurg 101:669-75. 2004.... - GW1929: a nonthiazolidinedione PPARγ agonist, ameliorates neurological damage in global cerebral ischemic-reperfusion injury through reduction in inflammation and DNA fragmentationRavinder K Kaundal
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Sector 67, Punjab 160062, India
Behav Brain Res 216:606-12. 2011.... - Effects of resveratrol on nerve functions, oxidative stress and DNA fragmentation in experimental diabetic neuropathyAshutosh Kumar
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160062, India
Life Sci 80:1236-44. 2007..Results of the present study suggest the potential of resveratrol in treatment of diabetic neuropathy and its protective effect may be mediated through reduction in oxidative stress and DNA fragmentation... - Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathySufyan G Sayyed
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER, Sec-67, S.A.S. Nagar (Mohali, Punjab-160062, India
Life Sci 79:777-83. 2006..Results of the present study suggest the potential of U83836E in treatment of diabetic neuropathy... - Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathyGeeta Negi
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
Neuropharmacology 58:585-92. 2010..The results of this study advocate that simultaneous inhibition of oxidative stress-PARP activation cascade may prove useful for the pharmacotherapy of DN... - Protective effects of pioglitazone against global cerebral ischemic-reperfusion injury in gerbilsRavinder K Kaundal
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, India
J Pharmacol Sci 109:361-7. 2009..This study demonstrates the neuroprotective activity of pioglitazone in global cerebral IR injury and its neuroprotective effects may be attributed to reduction in oxidative stress and DNA fragmentation... - Preventive and curative effect of edaravone on nerve functions and oxidative stress in experimental diabetic neuropathyAnuj Kumar Saini
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar Mohali, Punjab 160062, India
Eur J Pharmacol 568:164-72. 2007..Hence edaravone may be tried clinically for the treatment of diabetic neuropathy since it is clinically used in stroke patients... - Protective effects of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin releasing hormone analog in in vitro and in vivo models of cerebral ischemiaSatyendra Kumar Rajput
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Mohali, Punjab 160 062, India
Peptides 32:1225-31. 2011..These results suggest potential of NP-647 in the treatment of cerebral ischemia and its neuroprotective effect may be attributed to reduction of excitotoxicity, oxidative stress and inflammation... - Neuroprotective effect of 4-amino-1,8-napthalimide, a poly(ADP ribose) polymerase inhibitor in middle cerebral artery occlusion-induced focal cerebral ischemia in ratDhiraj G Kabra
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar Mohali, Punjab 160 062, India
Brain Res Bull 62:425-33. 2004..Our study suggests 4-ANI is a potent neuroprotective agent in focal cerebral ischemia and its neuroprotective effects may be attributed to reduction of NAD depletion and DNA fragmentation... - Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathyManish Arora
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar, Mohali, Punjab, India
Eur J Pharmacol 596:77-83. 2008..Aftermath of this study advocates the beneficial effects of peroxynitrite decomposition catalysts in experimental diabetic neuropathy... - Neuroprotective effects of trolox in global cerebral ischemia in gerbilsSangeetha Gupta
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab, India
Biol Pharm Bull 29:957-61. 2006..43+/-3.32 microM/mg of protein) and (8.98+/-0.89 microM/mg of protein) by trolox 10 and 30 mg/kg, i.p., respectively. This study demonstrates the neuroprotective potential of trolox in global cerebral ischemia in gerbils... - Concurrent targeting of nitrosative stress-PARP pathway corrects functional, behavioral and biochemical deficits in experimental diabetic neuropathyGeeta Negi
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160062, India
Biochem Biophys Res Commun 391:102-6. 2010..Thus, it can be concluded that treatment with the combination of a PDC and PARP inhibitor attenuates alteration in peripheral nerves in diabetic neuropathy (DN)... - Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in ratsSaurabh Gupta
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER, Sector 67, S.A.S. Nagar (Mohali) 160 062, Punjab, India
Neurol Res 26:103-7. 2004..Clinical availability and wide therapeutic margin of nicotinamide and melatonin make them a promising drug combination for clinical evaluation in stroke patients... - Neuropharmacological profile of L-pGlu-(1-benzyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog: effects on seizure models, sodium current, cerebral blood flow and behavioral parametersSatyendra Kumar Rajput
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
Epilepsy Res 87:223-33. 2009..NP-355 did not alter neurobehavioral parameters. This study demonstrates that NP-355 has potential antiepileptic activity and devoid of undesirable effects... - NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathyAshutosh Kumar
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160062, India
Biochem Biophys Res Commun 394:360-5. 2010..This study confirms the NF-kappaB inhibitory activity and anti-inflammatory activity of resveratrol which may contribute to neuroprotection in diabetic neuropathy apart from its antioxidant effect... - Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentationRavinder K Kaundal
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER, Sector-67, S.A.S. Nagar (Mohali, Punjab-160062, India
Life Sci 79:2293-302. 2006..Results of this study demonstrate the neuroprotective activity of NU1025 and suggest its potential in cerebral ischemia... - Amelioration of pulmonary dysfunction and neutrophilic inflammation by PPAR gamma agonist in LPS-exposed guinea pigsRohini Sharma
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar Mohali, Punjab 160062, India
Pulm Pharmacol Ther 22:183-9. 2009..Results from the present study have added to the emergent body of evidence that PPAR gamma agonists are effective in the therapy of inflammatory disease of the lungs... - Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathySokindra Kumar
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER, Sec-67, SAS Nagar, Punjab-160062, India
Neurol Res 27:60-6. 2005..p.). Histological changes observed in sciatic nerve were partially improved by the adenosinergic agents in diabetic rats. Results of the present study, suggest the potential of adenosinergic agents in the therapy of diabetic neuropathy... - Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathyShyam S Sharma
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
Clin Exp Pharmacol Physiol 33:1022-8. 2006..6. The results of the present study suggest the beneficial effects of trolox in experimental diabetic neuropathy... - Inhibition of sodium current by carbamazepine in dorsal root ganglion neurons in vitroJitendra N Singh
Electrophysiology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, S A S Nagar Mohali 160 062
Indian J Physiol Pharmacol 53:147-54. 2009..The depression of Na+ currents was found to be dose-dependant at -20 and -10 mV but not at 0 mV, It is concluded that the depression of Na+ currents by CBZ may be responsible for inhibiting the neurotransmitter release... - Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analogSatyendra Kumar Rajput
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
Epilepsy Behav 14:48-53. 2009..This study demonstrates that NP-647 has potential antiepileptic activity devoid of undesirable effects and, thus, can be exploited for the prevention and treatment of epilepsy... - Beneficial effects of pioglitazone on cognitive impairment in MPTP model of Parkinson's diseasePramod Kumar
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160062, India
Behav Brain Res 197:398-403. 2009..These results demonstrate the beneficial effects of pioglitazone on cognitive impairment in MPTP induced Parkinson's disease in rats... - Peroxisome proliferator-activated receptor gamma agonists as neuroprotective agentsRavinder K Kaundal
Department of Pharmacology and Toxicology of the National Institute of Pharmaceutical Education and Research NIPER, Mohali, Punjab, India
Drug News Perspect 23:241-56. 2010..This article discusses evidence and mechanisms supporting the neuroprotective effects of PPARgamma agonists in central nervous system disorders... - Protective effect of adenosine in diabetic neuropathic pain is mediated through adenosine A1-receptorsSridhar Balasubramanyan
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062, Punjab
Indian J Physiol Pharmacol 52:233-42. 2008..These results indicate that adenosine is an effective analgesics in a model of diabetic neuropathy, and the protection produced by adenosine is via stimulation of adenosine A1-receptors... - Upregulation of albumin expression in focal ischemic rat brainKanaiyalal D Prajapati
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar, Punjab 160 062, India
Brain Res 1327:118-24. 2010..This study paves the way for further investigation of signaling mechanisms leading to albumin overexpression, so that it can be exploited as a therapeutic intervention... - Ameliorative effects of GW1929, a nonthiazolidinedione PPARγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injuryRavinder K Kaundal
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Sector 67, Punjab 160062, India
Curr Neurovasc Res 8:236-45. 2011..In summary, these results suggested the neuroprotective potential of PPARγ agonists in cerebral IR injury and these effects may be attributed to their anti-inflammatory and anti-apoptotic potential... - Edaravone attenuates hydroxyl radical stress and augmented angiotensin II response in diabetic ratsAnuj Kumar Saini
Torrent Research Center, Gandhinagar, Gujarat, India
Pharmacol Res 54:6-10. 2006..From our results we infer that hydroxyl radical stress augments Ang II response in diabetic rat thoracic aorta and edaravone could be an ideal antioxidant adjuvant in the therapy of diabetic vascular complications...