Manas Kumar Santra
Affiliation: National Centre for Cell Science
Malonia S, Dutta P, Santra M, Green M. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A. 2015;112:8632-7 pubmed publisher
..In cells depleted of FBXO31, MDM2 is not degraded and p53 levels do not increase following genotoxic stress. Thus, FBXO31 is essential for the classic robust increase in p53 levels following DNA damage. ..
Gorai S, Paul D, Haloi N, Borah R, Santra M, Manna D. Mechanistic insights into the phosphatidylinositol binding properties of the pleckstrin homology domain of lamellipodin. Mol Biosyst. 2016;12:747-57 pubmed publisher
..Overall, these studies demonstrate an insight into how the Lpd-PH domain regulates cellular signals in a PI(3,4)P2 dependent manner. ..
Paul D, Bargale A, Rapole S, Shetty P, Santra M. Protein Phosphatase 1 Regulatory Subunit SDS22 Inhibits Breast Cancer Cell Tumorigenesis by Functioning as a Negative Regulator of the AKT Signaling Pathway. Neoplasia. 2018;21:30-40 pubmed publisher
..Overall, our results suggest that SDS22 could be a putative tumor suppressor and replenishment of SDS22 would be an important strategy to restrict the tumor progression. ..
Choppara S, Ganga S, Manne R, Dutta P, Singh S, Santra M. The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. J Biol Chem. 2018;293:16291-16306 pubmed publisher
..They further indicate that FBXO46-mediated regulation of FBXO31 is abrogated following genotoxic stress to promote increased FBXO31 levels for maintenance of genomic stability. ..
Paul D, Chanukuppa V, Reddy P, Taunk K, Adhav R, Srivastava S, et al
. Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma. J Proteomics. 2016;138:95-105 pubmed publisher
..Overall, this is the first comprehensive proteomic study on etoposide resistant cell line NCI-H460 to explore the mechanism of chemoresistance in lung cancer. ..
Manne R, Agrawal Y, Bargale A, Patel A, Paul D, Gupta N, et al
. A MicroRNA/Ubiquitin Ligase Feedback Loop Regulates Slug-Mediated Invasion in Breast Cancer. Neoplasia. 2017;19:483-495 pubmed publisher
..Together, these results establish the presence of interplay between microRNAs and the ubiquitination machinery, which together regulate cancer cell invasion. ..
Meshram S, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, et al
. FBXO32 activates NF-ÎºB through IÎºBÎ± degradation in inflammatory and genotoxic stress. Int J Biochem Cell Biol. 2017;92:134-140 pubmed publisher
..We also found that FBXO32 is required for physiological regulation of IÎºBÎ± levels in unstressed cells. Thus, we decipher the new role of FBXO32 in regulation of NF-ÎºB signaling pathway. ..