D Srinivasa Reddy
Affiliation: National Chemical Laboratory
Muthukumarasamy K, Handore K, Kakade D, Shinde M, Ranjan S, Kumar N, et al
. Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays. Org Biomol Chem. 2016;14:1569-78 pubmed publisher
..We synthesized several derivatives of this class of noreremophilanes and performed structure-activity relationship studies in zebrafish to identify more potent and less toxic analogs of the original structure. ..
Jachak G, Athawale P, Agarwal H, Barthwal M, Lauro G, Bifulco G, et al
. Total synthesis of the potent anti-inflammatory natural product solomonamide A along with structural revision and biological activity evaluation. Org Biomol Chem. 2018;16:9138-9142 pubmed publisher
..Thus, we further confirmed the revised structure of solomonamide A. ..
Kashinath K, Reddy D. One-pot quadruple/triple reaction sequence: a useful tool for the synthesis of natural products. Org Biomol Chem. 2015;13:970-3 pubmed publisher
..In line with this, here in this perspective we discuss a one-pot quadruple/triple reaction sequence comprising an enyne ring-closing metathesis/cross-metathesis/Diels-Alder/aromatization for the synthesis of natural products setting. ..
Ramesh R, Shingare R, Kumar V, Anand A, B S, Veeraraghavan S, et al
. Repurposing of a drug scaffold: Identification of novel sila analogues of rimonabant as potent antitubercular agents. Eur J Med Chem. 2016;122:723-730 pubmed publisher
..The sila analogue 18a was found to be the most potent antimycobacterial compound (MIC, 31 ng/mL) from this series with an excellent selectivity index. ..
Philkhana S, Mehrotra S, Murray T, Reddy D. Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection. Org Biomol Chem. 2016;14:8457-73 pubmed publisher
..The most potent compound from this series 20 was structurally simplified and readily accessible in good quantities for further biological profiling. ..
Philkhana S, Verma A, Jachak G, Hazra B, Basu A, Reddy D. Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin. Eur J Med Chem. 2017;135:89-109 pubmed publisher
..Furthermore, all possible isomers of lead compound 25 were synthesized, characterized and profiled in same set of assays and found that one of the enantiomer (-)-25a was superior among them. ..